Engineering Commons^™

Deep Learning And Generative Ai Approaches For Automated Diagnosis And Personalized Treatment: Bridging Machine Learning, Medicine, And Biomechanics In Predicting Tissue Mechanics And Biomaterial Properties., Yasin Shokrollahi

Theses and Dissertations

Machine learning, particularly deep neural networks, has demonstrated significant potential in predicting high-dimensional tasks across various domains. This work encompasses a detailed review of Generative AI in healthcare and three studies integrating machine learning with finite element analysis for predicting biomechanical behaviors and properties. Initially, we provide a comprehensive overview of Generative AI applications in healthcare, focusing on Transformers and Denoising Diffusion models and suggesting potential research avenues to address existing challenges.

Subsequently, we addressed soccer-related ocular injuries by combining finite element analysis and machine learning to predict retinal mechanics following a soccer ball hit rapidly. The prediction errors are …

Digital Twins Of The Living Knee: From Measurements To Model, Thor Erik Andreassen

Electronic Theses and Dissertations

Modern medicine has dramatically improved the lives of many. In orthopaedics, robotic surgery has given clinicians superior accuracy when performing interventions over conventional methods. Nevertheless, while these and many other methods are available to ensure treatments are performed successfully, far fewer methods exist to predict the proper treatment option for a given person. Clinicians are forced to categorize individuals, choosing the best treatment on “average.” However, many individuals differ significantly from the “average” person, for which many of these treatments are designed. Going forward, a method of testing, evaluating, and predicting different treatment options' short- and long-term effects on an …

Computational Methodology For Generating Patient-Specific Soft Tissue Representations, Ahilan Anantha Krishnan

Electronic Theses and Dissertations

This dissertation focused on modeling specimen-specific soft tissue structures in the context of joint replacement surgery. The research addressed four key aspects. The first study involved developing a workflow for creating finite element models of the hip capsule to replicate its torque-rotational response. Experimental data from ten cadaveric hips were used to calibrate the models, resulting in improved accuracy and relevance for surgical planning and implant design. The second study tackled the challenge of expediting the calibration of mechanical properties of the hip capsule to match patient-specific laxities. A statistical shape function model was proposed to generate patient-specific finite element …

Machine Learning Approach To Activity Categorization In Young Adults Using Biomechanical Metrics, Nathan Q. C. Holland

Mechanical & Aerospace Engineering Theses & Dissertations

Inactive adults often have decreased musculoskeletal health and increased risk factors for chronic diseases. However, there is limited data linking biomechanical measurements of generally healthy young adults to their physical activity levels assessed through questionnaires. Commonly used data collection methods in biomechanics for assessing musculoskeletal health include but are not limited to muscle quality (measured as echo intensity when using ultrasound), isokinetic (i.e., dynamic) muscle strength, muscle activations, and functional movement assessments using motion capture systems. These assessments can be time consuming for both data collection and processing. Therefore, understanding if all biomechanical assessments are necessary to classify the activity …

Analysis Of Gait Parameters And Knee Angles In Ultimate Frisbee Players: Implications For Balance And Injury, Ethan Nikcevich

Master's Theses

Biomechanics research investigating gait and balance of ultimate frisbee players is an unexplored topic. Ultimate requires a wide range of motions that could improve balance and is also a sport prone to frequent injury. This study explores the impact of playing ultimate on gait parameters associated with balance and knee angles associated with joint injury. Gait trials were conducted on 8 ultimate players and 8 control participants between the ages of 18 and 23 to obtain total double support time, stance phase time, single support time, load response time, abduction-adduction (AA) angles, internal-external (IE) rotation angles, and flexion angles of …

Editorial: Intervertebral Disc Degeneration And Osteoarthritis: Mechanisms Of Disease And Functional Repair., Graciosa Q Teixeira, Jana Riegger, Raquel M Gonçalves, Makarand V. Risbud

Department of Orthopaedic Surgery Faculty Papers

No abstract provided.

Biomat (Biomechanics Multiactivity Transformer) Model, Mohsen Sharifi Renani

BioMAT (Biomechanics Multiactivity Transformer)

No abstract provided.

Detecting Lumbar Muscle Fatigue Using Nanocomposite Strain Gauges, Darci Ann Billmire

Theses and Dissertations

Introduction: Muscle fatigue can contribute to acute flare-ups of lower back pain with associated consequences such as pain, disability, lost work time, increased healthcare utilization, and increased opioid use and potential abuse. The SPINE Sense system is a wearable device with 16 high deflection nanocomposite strain gauge sensors on kinesiology tape which is adhered to the skin of the lower back. This device is used to correlate lumbar skin strains with the motion of the lumbar vertebrae and to phenotype lumbar spine motion. In this work it was hypothesized that the SPINE Sense device can be used to detect differences …

Mechanical Response Of The Craniofacial Skeleton To Subfracture Impacts In The Time And Frequency Domains, Paige Merko

Electronic Thesis and Dissertation Repository

Resonant frequencies have been suggested as a mechanism of brain injury since these vibrations can transfer energy into the brain. Study of the vibrational response of the craniofacial skeleton to impact is limited in literature. In this research, four cadaver specimens were impacted at five locations on the craniofacial skeleton. The mechanical response to each impact was compared in the time and frequency domains. Impacts to the maxilla and its associated soft tissues tended to be attenuated, while impacts to the cranial vault, specifically to the occipital, produced the most severe response. Results suggest that the facial skeleton and its …

Patient Movement Monitoring Based On Imu And Deep Learning, Mohsen Sharifi Renani

Electronic Theses and Dissertations

Osteoarthritis (OA) is the leading cause of disability among the aging population in the United States and is frequently treated by replacing deteriorated joints with metal and plastic components. Developing better quantitative measures of movement quality to track patients longitudinally in their own homes would enable personalized treatment plans and hasten the advancement of promising new interventions. Wearable sensors and machine learning used to quantify patient movement could revolutionize the diagnosis and treatment of movement disorders. The purpose of this dissertation was to overcome technical challenges associated with the use of wearable sensors, specifically Inertial Measurement Units (IMUs), as a …

Balance Assessment Using A Smartwatch Inertial Measurement Unit With Principal Component Analysis For Anatomical Calibration, Benjamin M. Presley, Jeffrey C. Sklar, Scott J. Hazelwood, Britta Berg-Johansen, Stephen M. Klisch

Biomedical Engineering

Balance assessment, or posturography, tracks and prevents health complications for a variety of groups with balance impairment, including the elderly population and patients with traumatic brain injury. Wearables can revolutionize state-of-the-art posturography methods, which have recently shifted focus to clinical validation of strictly positioned inertial measurement units (IMUs) as replacements for force-plate systems. Yet, modern anatomical calibration (i.e., sensor-to-segment alignment) methods have not been utilized in inertial-based posturography studies. Functional calibration methods can replace the need for strict placement of inertial measurement units, which may be tedious or confusing for certain users. In this study, balance-related metrics from a smartwatch …

Mitral Valve Imaging And Biomechanics: A Workflow Towards Computational Modeling And Validation, Sam Stephens

Graduate Theses and Dissertations

The mitral valve serves a critical role in healthy cardiac function by ensuring the unidirectional flow of oxygenated blood from the left atrium into the left ventricle. It experiences the highest pressures found within the heart and its closure is the result of a complex interaction of several different structures that, furthermore, are unique to each individual. Despite the valve’s vital role however, the specific function of these constituent structures is not fully understood. This, confounded by its asymmetric, personalized nature, make surgical interventions for the mitral valve far less effective than for its neighboring aortic valve. Efforts to overcome …

Effect Of Amputation On Muscle Structure Properties In A Rabbit Model, Roy Caleb Stubbs

Masters Theses

After amputation, muscles in the residual limb are detached from their insertion points and no longer span the missing joints. Our objective was to quantify the effect of amputation-induced disuse on residual muscle structure, an indirect indicator of muscle force-generating capacity. One hind paw was surgically removed at the ankle joint of ten rabbits. At two weeks (n=5) and 4 weeks (n=5) post-amputation and for select muscles (gastrocnemius, soleus, tibialis cranialis, extensor digitorum, and flexor digitorum superficialis), we measured and computed several muscle structure properties. Additionally, we qualitatively assessed the muscle fiber appearance of histological samples at each timepoint. At …

Making Sense Of Big (Kinematic) Data: A Comprehensive Analysis Of Movement Parameters In A Diverse Population, Naomi Wilma Nunis

University of the Pacific Theses and Dissertations

OBJECTIVE

The purpose of this study was to determine how kinematic, big data can be evaluated using computational, comprehensive analysis of movement parameters in a diverse population.

METHODS

Retrospective data was collected, cleaned, and reviewed for further analysis of biomechanical movement in an active population using 3D collinear resistance loads. The active sample of the population involved in the study ranged from age 7 to 82 years old and respectively identified as active in 13 different sports. Moreover, a series of exercises were conducted by each participant across multiple sessions. Exercises were measured and recorded based on 6 distinct biometric …

Amphisbaenian Head Movement And Burrowing Forces In Damp Granular Media, Jacob Newell

Williams Honors College, Honors Research Projects

Damp granular media is a difficult environment to study because it is both practically complex and it lacks equations which fully describe its behavior. In this study, an oscillatory lateral head movement and its effects while penetrating damp granular media were tested using a robophysical model. This experimental research was inspired by the burrowing behavior of the clade Amphisbaenia, a group of usually limbless squamates that employ a variety of different burrowing behaviors, but it can apply to a wide range of burrowers. This research could help with both human burrowing technologies and the further investigation of animal behaviors.

Atlas-Based Shared-Boundary Deformable Multi-Surface Models Through Multi-Material And Two-Manifold Dual Contouring, Tanweer Rashid, Sharmin Sultana, Mallar Chakravarty, Michel Albert Audette

Electrical & Computer Engineering Faculty Publications

This paper presents a multi-material dual “contouring” method used to convert a digital 3D voxel-based atlas of basal ganglia to a deformable discrete multi-surface model that supports surgical navigation for an intraoperative MRI-compatible surgical robot, featuring fast intraoperative deformation computation. It is vital that the final surface model maintain shared boundaries where appropriate so that even as the deep-brain model deforms to reflect intraoperative changes encoded in ioMRI, the subthalamic nucleus stays in contact with the substantia nigra, for example, while still providing a significantly sparser representation than the original volumetric atlas consisting of hundreds of millions of voxels. The …

Validation Of Experimental And Finite Element Biomechanical Evaluation Of Human Cadaveric Mandibles, Shirish M. Ingawale, Deepak G. Krishnan, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Background: Biomechanical analysis of human mandible is important not only to understand mechanical behavior and structural properties, but also to diagnose and develop treatment options for mandibular disorders. Therefore, the objective of this research was to generate analytical and experimental data on mandibles, construct custom 3D models, and compare the analytically derived maximum strains with strain gage data in five areas of interest for each mandible. Methods: We investigated the surface strains in the cadaveric human mandibles under different configurations of cyclic compressive loads in an experimental setting and compared these experimental strain data with results derived from computational finite …

An Improved Polynomial Chaos Expansion Based Response Surface Method And Its Applications On Frame And Spring Engineering Based Structures, Mhd A. Hafez

ETD Archive

In engineering fields, computational models provide a tool that can simulate a real world response and enhance our understanding of physical phenomenas. However, such models are often computationally expensive with multiple sources of uncertainty related to the model’s input/assumptions. For example, the literature indicates that ligament’s material properties and its insertion site locations have a significant effect on the performance of knee joint models, which makes addressing uncertainty related to them a crucial step to make the computational model more representative of reality. However, previous sensitivity studies were limited due to the computational expense of the models. The high computational …

Analysis Of Wheelchair Sprint Biomechanics On Two Elite Athletes On An Instrumented Drum Ergometer, Francesco Bettella, Biagio Beneduce, Mario Poletti, Nicola Petrone

International Sports Engineering Association – Engineering of Sport

No abstract provided.

Effect Of Silhouette Accuracy On Visual Hull Quality, Guido Ascenso, Thomas Allen, Moi Hoon Yap, Carl Payton, Simon Choppin

International Sports Engineering Association – Engineering of Sport

No abstract provided.

Development Of A Remote Wearables Laboratory Course, Patrick Mayerhofer, James Carter, Max Donelan

International Sports Engineering Association – Engineering of Sport

No abstract provided.

Educational Pedagogy In The Martial Arts And The Sciences, Daniel James, Andrew Sunter, James Lee, Simon Russell

International Sports Engineering Association – Engineering of Sport

No abstract provided.

Improvement Of Ex Vivo Testing Methods For Spine Biomechanical Characterization, Aubrie Lisa Taylor

Theses and Dissertations

This dissertation contributed three main areas to flexibility testing and biomechanical characterization of human spinal segments. The first was a literature review of existing testing methodology, the second examined common spine fixation procedures, and the third developed an improved fixation method. Spine biomechanical characterization is the primary technique for assessing the healthy, diseased, and surgically treated response of spinal tissues. However, despite decades of use, no standard testing protocol or reporting methodology for flexibility testing conditions has been established. As part of the present work, a comprehensive, systematic literature review was performed, and the methods sections of 242 relevant journal …

Midfoot Motion And Stiffness: Does Structure Predict Function?, Kirk Evans Bassett

Theses and Dissertations

In clinical settings, dynamic foot function is commonly inferred from static and passive foot measurements; however, there is little evidence that static foot structure can predict dynamic foot function during walking gait. Previous research seeking to find correlations between the two have focused primarily on sagittal plane midfoot angles even though the midfoot has triplanar motion, which misses potentially important information. Additionally, the focus on kinematics alone may miss the contributions that forces play in midfoot mechanics. To address the angle limitations, a novel Signed Helical Angle (SHA) was developed to capture the triplanar motion of the midfoot from a …

Recent Advances In Bone Research 2022 Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet

Publications and Research

More and more scientific and engineering applications in bone research make pivotal advances in treating patients with orthopedics issues. Hence, bone research in the 21st century combines, inter alia, biology, chemistry, mathematics, and mechanics with complementary characteristics that help a holistic approach to bone-related pathologies. Nowadays, it is hard to connect new evidence when jargoning and money remain two significant obstacles to sharing knowledge. “Recent Advances In Bone Research” is a free book – no money involved at any stage - that combines the most recent efforts in bone research from several experts with different backgrounds, every expert seeks to …

Development And Application Of 3d Kinematic Methodologies For Biomechanical Modelling In Adaptive Sports And Rehabilitation, Anne Marie Severyn

All Dissertations

Biomechanical analysis is widely used to assess human movement sciences, specifically using three-dimensional motion capture modelling. There are unprecedented opportunities to increase quantitative knowledge of rehabilitation and recreation for disadvantaged population groups. Specifically, 3D models and movement profiles for human gait analysis were generated with emphasis on post-stroke patients, with direct model translation to analyze equivalent measurements while horseback riding in use of the alternative form of rehabilitation, equine assisted activities and therapies (EAAT) or hippotherapy (HPOT). Significant improvements in gait symmetry and velocity were found within an inpatient rehabilitation setting for patients following a stroke, and the developed movement …

Insect Antennae As Bioinspirational Superstrong Fiber-Based Microfluidics, Griffin J. Donley

All Theses

Nature is frequently turned to for inspiration for the creation of new materials. Insect antennae are hollow, blood-filled fibers with complex shape, and are cantilevered at the head. The antenna is muscle-free, but the insect can controllably flex, twist, and maneuver it laterally. To explain this behavior, a comparative study of structural and tensile properties of the antennae of Periplaneta americana (American cockroach), Manduca sexta (Carolina hawkmoth), and Vanessa cardui (painted lady butterfly) was performed. These antennae demonstrate a range of distinguishable tensile properties, responding either as brittle fibers (Manduca sexta) or strain-adaptive fibers that stiffen when stretched (Vanessa cardui …

Finite Element Model Of The Pediatric Hip Joint During The Barlow Maneuver, Christina M. Zlock

Doctoral Dissertations and Master's Theses

Developmental Dysplasia of the Hip is the dysplasia or dislocation of an unstable femoral head in the acetabulum of the pelvis. This is a result of an abnormal or underdeveloped growth of the acetabulum and triradiate cartilages and/or an out of place and uncentered femoral head in the acetabulum. This underdevelopment, if not diagnosed and treated at an early age, may lead to abnormal and pain and osteoarthritis later in life. A common step in diagnosis is to perform a physical examination of the hip, one method is the Barlow maneuver.

The aim of the project is to use healthy …

Challenges In Kinetic-Kinematic Driven Musculoskeletal Subject-Specific Infant Modeling, Yeram Lim, Victor Huayamave, Tamara Chambers, Christine Walck, Safeer Siddicky, Erin Mannen

Publications

Musculoskeletal computational models provide a non-invasive approach to investigate human movement biomechanics. These models could be particularly useful for pediatric applications where in vivo and in vitro biomechanical parameters are difficult or impossible to examine using physical experiments alone. The objective was to develop a novel musculoskeletal subject-specific infant model to investigate hip joint biomechanics during cyclic leg movements. Experimental motion-capture marker data of a supine-lying 2-month-old infant were placed on a generic GAIT 2392 OpenSim model. After scaling the model using body segment anthropometric measurements and joint center locations, inverse kinematics and dynamics were used to estimate hip ranges …

A Novel Ultrasound Elastography Technique For Evaluating Tumor Response To Neoadjuvant Chemotherapy In Patients With Locally Advanced Breast Cancer, Niusha Kheirkhah

Electronic Thesis and Dissertation Repository

Breast cancer is the second most diagnosed cancer in women, estimated to affect 1 in 8 women during their lifetime. About 10% to 20% of new breast cancer cases are diagnosed with locally advanced breast cancer (LABC). LABC tumors are usually larger than 5 cm and/or attached to the skin or chest wall. It has been reported that when such cases are treated with surgery alone, metastasis and mortality rates are high, especially where skin involvement or attachment to the chest wall is extensive. As such, efficient treatment for this kind of breast cancer includes neoadjuvant chemotherapy (NAC) to shrink …