Open Access. Powered by Scholars. Published by Universities.®

Engineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Theses/Dissertations

Old Dominion University

Discipline
Keyword
Publication Year
Publication

Articles 1 - 30 of 1260

Full-Text Articles in Engineering

Cheiloscopy Examination And Classification Of Lip Prints With And Without Parafunctional Oral Habits: A Cross-Sectional Observation Study, Emily Smith Regan Oct 2023

Cheiloscopy Examination And Classification Of Lip Prints With And Without Parafunctional Oral Habits: A Cross-Sectional Observation Study, Emily Smith Regan

Dental Hygiene Theses & Dissertations

Problem: Lip prints are unique and have potential for use as a human identifier. The purpose of this study was to observe possible cheiloscopy differences of individuals with and without parafunctional oral habits. Additionally, inter-rater reliability (IRR) of lip print examiners was observed. Methods: This IRB approved blinded cross-sectional observational study collected lip prints from sixty-six individuals using lipstick and adhesive tape to transfer lip prints to white bond paper for viewing purposes. Each set of included lip prints was divided into quadrants and dichotomized as those with or without an oral parafunctional habit. Each quadrant sample was manually analyzed …


The Effect Of Through Thickness Reinforcement Angle On The Disbonding Behavior In Skin-Stringer Configuration, Christopher John Morris Oct 2023

The Effect Of Through Thickness Reinforcement Angle On The Disbonding Behavior In Skin-Stringer Configuration, Christopher John Morris

Mechanical & Aerospace Engineering Theses & Dissertations

Post-cure through thickness reinforcement is a method used to increase the mechanical properties of composite laminates in the transverse direction. This study conducted a test on skin-stringer structures bonded together in three configurations using an epoxy or thermoplastic adhesive at the interface with reinforcing pins inserted through the laminate thickness located at the edge of the stringer at differing angles between -30º and 30º. The fabrication of these samples in configurations B and C consisted of the use of carbon fiber prepeg laminate at a ply orientation of [02902]2s for the skin and [0 90] …


Studies Of Flowfields And Dynamic Stability Characteristics Of A Quadrotor, Engin Baris Oct 2023

Studies Of Flowfields And Dynamic Stability Characteristics Of A Quadrotor, Engin Baris

Mechanical & Aerospace Engineering Theses & Dissertations

Electric multirotor air vehicles have become a pervasive technology and research topic in industry, academia, and daily life, and small quadrotors are one of the most preferred designs in the multirotor marketplace. However, the configuration of the quadrotors makes aerodynamic interaction effects one of the key factors of the vehicle performance in both hover and non-axial forward flight conditions.

In the present work, aerodynamic characteristics of the cross-configured small quadrotor in hover, edgewise, and maneuvering flight modes were investigated in detail by performing static and dynamic wind tunnel tests at various RPM levels, wind speeds, pitch and yaw angles, and …


Framework For Implementing Advanced Radar Plotting Aid Capability For Small Maritime Vessels, Jason Stark Harris Oct 2023

Framework For Implementing Advanced Radar Plotting Aid Capability For Small Maritime Vessels, Jason Stark Harris

Electrical & Computer Engineering Theses & Dissertations

Every year in the United States many people are killed or injured when maritime vessels collide with other vessels or fixed objects. According to the United States Coast Guard, the top contributing factors to these collisions are operator inattention, operator inexperience and an improper lookout. Larger commercial vessels are required to have RADAR systems which support Automatic RADAR Plotting Aid (ARPA) which can automatically detect collisions and alert an operator to change course. These systems can be very expensive which put them out of reach of the average recreational boater. It is however possible to implement a low cost ARPA …


Fabrication Of Smooth Sac305 Thin Films Via Magnetron Sputtering And Evaluations Of Microstructure, Creep, And Electrical Resistivity, Manish Ojha Oct 2023

Fabrication Of Smooth Sac305 Thin Films Via Magnetron Sputtering And Evaluations Of Microstructure, Creep, And Electrical Resistivity, Manish Ojha

Mechanical & Aerospace Engineering Theses & Dissertations

SAC305 (96.5%Sn-3%Ag-0.5%Cu) is the leading alternative to the traditional Sn-Pb solder eutectic alloy owing to its low melting temperature, better compatibility with other components, and excellent mechanical/structural properties. In the realm of modern electronics, where devices are increasingly miniaturized, the design and characterization of thin solder joints become paramount. The orientation and size of the grains within the solder can influence its ability to withstand mechanical stresses. However, research on SAC thin films remains sparse, and these films present unique challenges and characteristics compared to their bulk counterparts, influenced by factors like interfaces, stresses, thickness, microstructure, and the nature of …


Optics Studies For Multipass Energy Recovery At Cebaf: Er@Cebaf, Isurumali Neththikumara Oct 2023

Optics Studies For Multipass Energy Recovery At Cebaf: Er@Cebaf, Isurumali Neththikumara

Physics Theses & Dissertations

Energy recovery linacs (ERLs), focus on recycling the kinetic energy of electron beam for the purpose of accelerating a newly injected beam within the same accelerating structure. The rising developments in the super conducting radio frequency technology, ERL technology has achieved several noteworthy milestones over the past few decades. In year 2003, Jefferson Lab has successfully demonstrated a single pass energy recovery at the CEBAF accelerator. Furthermore, they conducted successful experiments with IR-FEL demo and upgrades, as well as the UV FEL driver. This multi-pass, multi-GeV range energy recovery demonstration proposed to be carried out at CEBAF accelerator at Jefferson …


Framing Automation Trust: How Initial Information About Automated Driving Systems Influences Swift Trust In Automation And Trust Repair For Human Automation Collaboration, Scott Anthony Mishler Oct 2023

Framing Automation Trust: How Initial Information About Automated Driving Systems Influences Swift Trust In Automation And Trust Repair For Human Automation Collaboration, Scott Anthony Mishler

Psychology Theses & Dissertations

The study examines how trust in automation is influenced by initial framing of information before interaction and how later active calibration methods can further influence trust repair or dampening after an automation error in a three-experiment study. As more human drivers begin to use automated driving systems (ADSs) for the first time, their initial understanding of the system can influence their trust leading to a miscalibration of trust. Prior studies have investigated how trust develops through interactions with an automated system, but few have looked at integrating swift trust and framing to calibrate trust before interaction and investigate further active …


Machine Learning Approach To Activity Categorization In Young Adults Using Biomechanical Metrics, Nathan Q. C. Holland Oct 2023

Machine Learning Approach To Activity Categorization In Young Adults Using Biomechanical Metrics, Nathan Q. C. Holland

Mechanical & Aerospace Engineering Theses & Dissertations

Inactive adults often have decreased musculoskeletal health and increased risk factors for chronic diseases. However, there is limited data linking biomechanical measurements of generally healthy young adults to their physical activity levels assessed through questionnaires. Commonly used data collection methods in biomechanics for assessing musculoskeletal health include but are not limited to muscle quality (measured as echo intensity when using ultrasound), isokinetic (i.e., dynamic) muscle strength, muscle activations, and functional movement assessments using motion capture systems. These assessments can be time consuming for both data collection and processing. Therefore, understanding if all biomechanical assessments are necessary to classify the activity …


Investigation Of Nanosecond Pulsed Electric Fields (Nspef) Induced Anti-Cancer Mechanism And Enhanced B16f10 Melanoma Cancer Treatment, Kamal Asadipour Oct 2023

Investigation Of Nanosecond Pulsed Electric Fields (Nspef) Induced Anti-Cancer Mechanism And Enhanced B16f10 Melanoma Cancer Treatment, Kamal Asadipour

Biomedical Engineering Theses & Dissertations

The use of nanosecond pulsed electric fields (nsPEF) has emerged as a promising area of research with vast implications across various scientific disciplines. The ability to generate ultra-short, high-voltage electric pulses has paved the way for numerous applications, ranging from fundamental investigations of biological phenomena to the development of innovative medical therapies. The aim of this thesis is to highlight the importance of nsPEF in two critical areas: 1) Understanding the impact of subtle postpulse waveforms through a comprehensive analysis of two common pulse generators and 2) using this knowledge to advance melanoma treatment by enhancing the therapeutic effect of …


Switching Methods For Three-Dimensional Rotational Dynamics Using Modified Rodrigues Parameters, Matthew Jarrett Banks Oct 2023

Switching Methods For Three-Dimensional Rotational Dynamics Using Modified Rodrigues Parameters, Matthew Jarrett Banks

Mechanical & Aerospace Engineering Theses & Dissertations

A rigid body in space has three degrees of rotational freedom. As a result, a minimum of three independent parameters is required to define the three-dimensional orientation of a rigid body. As is well known, every set of three independent parameters has at least one orientation where mathematical or geometrical singularities are encountered; therefore, when the use of a three-parameter representation is desired, a method for singularity avoidance must also be considered. A common practice for singularity avoidance is to switch between parameter sets whose singularities occur at different orientations. With this in mind, modified Rodrigues parameters (MRP) are considered …


Faster, Cheaper, And Better Cfd: A Case For Machine Learning To Augment Reynolds-Averaged Navier-Stokes, John Peter Romano Ii Oct 2023

Faster, Cheaper, And Better Cfd: A Case For Machine Learning To Augment Reynolds-Averaged Navier-Stokes, John Peter Romano Ii

Mechanical & Aerospace Engineering Theses & Dissertations

In recent years, the field of machine learning (ML) has made significant advances, particularly through applying deep learning (DL) algorithms and artificial intelligence (AI). The literature shows several ways that ML may enhance the power of computational fluid dynamics (CFD) to improve its solution accuracy, reduce the needed computational resources and reduce overall simulation cost. ML techniques have also expanded the understanding of underlying flow physics and improved data capture from experimental fluid dynamics.

This dissertation presents an in-depth literature review and discusses ways the field of fluid dynamics has leveraged ML modeling to date. The author selects and describes …


Reinforcing Digital Trust For Cloud Manufacturing Through Data Provenance Using Ethereum Smart Contracts, Trupti Narayan Rane Aug 2023

Reinforcing Digital Trust For Cloud Manufacturing Through Data Provenance Using Ethereum Smart Contracts, Trupti Narayan Rane

Engineering Management & Systems Engineering Theses & Dissertations

Cloud Manufacturing(CMfg) is an advanced manufacturing model that caters to fast-paced agile requirements (Putnik, 2012). For manufacturing complex products that require extensive resources, manufacturers explore advanced manufacturing techniques like CMfg as it becomes infeasible to achieve high standards through complete ownership of manufacturing artifacts (Kuan et al., 2011). CMfg, with other names such as Manufacturing as a Service (MaaS) and Cyber Manufacturing (NSF, 2020), addresses the shortcoming of traditional manufacturing by building a virtual cyber enterprise of geographically distributed entities that manufacture custom products through collaboration.

With manufacturing venturing into cyberspace, Digital Trust issues concerning product quality, data, and intellectual …


Design And Implementation Of A Launching Method For Free To Oscillate Dynamic Stability Testing, Kristen M. Carey Aug 2023

Design And Implementation Of A Launching Method For Free To Oscillate Dynamic Stability Testing, Kristen M. Carey

Mechanical & Aerospace Engineering Theses & Dissertations

Magnetic Suspension and Balance Systems (MSBS) allow for static, forced oscillation and free to oscillate dynamic stability testing in a wind tunnel without the need for a physical support. The objectives of study are to assist in the application of the free to oscillate testing method in an MSBS to determine dynamic stability characteristics for various re-entry capsule designs.

This thesis discusses the development and testing of a launching method called the grabber for use in the MSBS Subsonic Wind Tunnel at NASA Langley Research Center. Aerodynamic tests were run to support the use of this method and compare the …


Study Of Microphonic Effects On The C100 Cryomodule For High Energy Electron Beam Accelerators, Caleb James Hull Aug 2023

Study Of Microphonic Effects On The C100 Cryomodule For High Energy Electron Beam Accelerators, Caleb James Hull

Mechanical & Aerospace Engineering Theses & Dissertations

The Continuous Electron Beam Accelerator Facility (CEBAF) at Thomas Jefferson National Laboratory (JLab) is a particle accelerator which can accelerate an electron beam to relativistic speeds and apply the beam onto target samples. The C100 superconducting radio frequency (SRF) cavity is the primary accelerating structure of the C100 cryomodule, one of the many cryomodules which compose the CEBAF linear accelerator. SRF cavities are particularly sensitive to internal and external vibrations that can result in a phenomenon called microphonics which degrade the operational stability of a cryomodule.

The purpose of this thesis is to investigate the significance of mechanical disturbances on …


Data-Driven Predictive Modeling To Enhance Search Efficiency Of Glowworm-Inspired Robotic Swarms In Multiple Emission Source Localization Tasks, Payal Nandi Aug 2023

Data-Driven Predictive Modeling To Enhance Search Efficiency Of Glowworm-Inspired Robotic Swarms In Multiple Emission Source Localization Tasks, Payal Nandi

Mechanical & Aerospace Engineering Theses & Dissertations

In time-sensitive search and rescue applications, a team of multiple mobile robots broadens the scope of operational capabilities. Scaling multi-robot systems (< 10 agents) to larger robot teams (10 – 100 agents) using centralized coordination schemes becomes computationally intractable during runtime. One solution to this problem is inspired by swarm intelligence principles found in nature, offering the benefits of decentralized control, fault tolerance to individual failures, and self-organizing adaptability. Glowworm swarm optimization (GSO) is unique among swarm-based algorithms as it simultaneously focuses on searching for multiple targets. This thesis presents GPR-GSO—a modification to the GSO algorithm that incorporates Gaussian Process Regression (GPR) based data-driven predictive modeling—to improve the search efficiency of robotic swarms in multiple emission source localization tasks. The problem formulation and methods are presented, followed by numerical simulations to illustrate the working of the algorithm. Results from a comparative analysis show that the GPR-GSO algorithm exceeds the performance of the benchmark GSO algorithm on evaluation metrics of swarm size, search completion time, and travel distance.


Chemical And Physical Interaction Mechanisms And Multifunctional Properties Of Plant Based Graphene In Carbon Fiber Epoxy Composites, Daniel W. Mulqueen Aug 2023

Chemical And Physical Interaction Mechanisms And Multifunctional Properties Of Plant Based Graphene In Carbon Fiber Epoxy Composites, Daniel W. Mulqueen

Mechanical & Aerospace Engineering Theses & Dissertations

Graphene has generated substantial interest as a filler due to its exceptional strength, flexibility, and conductivity but faces obstacles in supply and implementation. A renewable, plant-based graphene nanoparticle (pGNP) presents a more accessible and sustainable filler with the same properties as mineral graphenes. In this study, the mechanisms of graphene reinforcement in carbon fiber reinforced plastic (CFRP) were examined, along with the resulting improvements to mechanical strength, resistance to crack propagation, electrical and thermal conductivity at elevated temperatures. pGNP, produced from renewable biomass, was shown to have a graphitic structure with flakes 3-10 layers thick and a median lateral size …


Towards A Robust Defense: A Multifaceted Approach To The Detection And Mitigation Of Neural Backdoor Attacks Through Feature Space Exploration And Analysis, Liuwan Zhu Aug 2023

Towards A Robust Defense: A Multifaceted Approach To The Detection And Mitigation Of Neural Backdoor Attacks Through Feature Space Exploration And Analysis, Liuwan Zhu

Electrical & Computer Engineering Theses & Dissertations

From voice assistants to self-driving vehicles, machine learning(ML), especially deep learning, revolutionizes the way we work and live, through the wide adoption in a broad range of applications. Unfortunately, this widespread use makes deep learning-based systems a desirable target for cyberattacks, such as generating adversarial examples to fool a deep learning system to make wrong decisions. In particular, many recent studies have revealed that attackers can corrupt the training of a deep learning model, e.g., through data poisoning, or distribute a deep learning model they created with “backdoors” planted, e.g., distributed as part of a software library, so that the …


Towards Intelligent Runtime Framework For Distributed Heterogeneous Systems, Polykarpos Thomadakis Aug 2023

Towards Intelligent Runtime Framework For Distributed Heterogeneous Systems, Polykarpos Thomadakis

Computer Science Theses & Dissertations

Scientific applications strive for increased memory and computing performance, requiring massive amounts of data and time to produce results. Applications utilize large-scale, parallel computing platforms with advanced architectures to accommodate their needs. However, developing performance-portable applications for modern, heterogeneous platforms requires lots of effort and expertise in both the application and systems domains. This is more relevant for unstructured applications whose workflow is not statically predictable due to their heavily data-dependent nature. One possible solution for this problem is the introduction of an intelligent Domain-Specific Language (iDSL) that transparently helps to maintain correctness, hides the idiosyncrasies of lowlevel hardware, and …


A Comparative Study Of Vinti-Based Orbit Propagation And Estimation For Cubesats In Very Low Earth Orbits, Ethan Michael Senecal Aug 2023

A Comparative Study Of Vinti-Based Orbit Propagation And Estimation For Cubesats In Very Low Earth Orbits, Ethan Michael Senecal

Mechanical & Aerospace Engineering Theses & Dissertations

In recent years, there has been a growing interest in CubeSats and very low Earth orbit (VLEO) space missions. Mission SeaLion, a collaborative CubeSat mission between Old Dominion University, the U.S. Coast Guard Academy, and U.S. Air Force Institute of Technology, planned to launch a 3U CubeSat into VLEO. The VLEO mission is a particularly challenging environment for navigation and orbit propagation because drag introduces a significant perturbation for orbit models such as SGP4. Additionally, mission requirements left no capacity for attitude determination or control, further reducing knowledge of drag behavior of the satellite in flight. This deficiency is a …


Assessing The Prevalence And Archival Rate Of Uris To Git Hosting Platforms In Scholarly Publications, Emily Escamilla Aug 2023

Assessing The Prevalence And Archival Rate Of Uris To Git Hosting Platforms In Scholarly Publications, Emily Escamilla

Computer Science Theses & Dissertations

The definition of scholarly content has expanded to include the data and source code that contribute to a publication. While major archiving efforts to preserve conventional scholarly content, typically in PDFs (e.g., LOCKSS, CLOCKSS, Portico), are underway, no analogous effort has yet emerged to preserve the data and code referenced in those PDFs, particularly the scholarly code hosted online on Git Hosting Platforms (GHPs). Similarly, Software Heritage is working to archive public source code, but there is value in archiving the surrounding ephemera that provide important context to the code while maintaining their original URIs. In current implementations, source code …


Ultrasensitive Tapered Optical Fiber Refractive Index Glucose Sensor, Erem Ujah Aug 2023

Ultrasensitive Tapered Optical Fiber Refractive Index Glucose Sensor, Erem Ujah

Biomedical Engineering Theses & Dissertations

Refractive index (RI) sensors are of great interest for label-free optical biosensing. A tapered optical fiber (TOF) RI sensor with micron-sized waist diameters can dramatically enhance sensor sensitivity by reducing the mode volume over a long distance. Here, a simple and fast method is used to fabricate extremely sensitive refractive index sensors based on localized surface plasmon resonance (LSPR). Two TOFs (l = 5 mm) with waist diameters of 5 µm and 12 µm demonstrated sensitivity enhancement at λ = 1559 nm for glucose sensing (5–45 wt%) at room temperature. The optical power transmission decreased with increasing glucose concentration due …


Development, Experimental Validation, And Progressive Failure Modeling Of An Ultra-Thin High Stiffness Deployable Composite Boom For In-Space Applications, Jimesh D. Bhagatji Aug 2023

Development, Experimental Validation, And Progressive Failure Modeling Of An Ultra-Thin High Stiffness Deployable Composite Boom For In-Space Applications, Jimesh D. Bhagatji

Mechanical & Aerospace Engineering Theses & Dissertations

To maximize the capabilities of nano- and micro-class satellites, which are limited by their size, weight, and power, advancements in deployable mechanisms with a high deployable surface area to packaging volume ratio are necessary. Without progress in understanding the mechanics of high-strain materials and structures, the development of compact deployable mechanisms for this class of satellites would be difficult. This research focuses on fabrication, experimental testing, and progressive failure modelling to study the deformation of an ultra-thin composite beam. The research study examines deformation modes of a boom under repetitive pure bending loads using 4-point bending setup. The material and …


Biocrude Production From Lignin In Hydrothermal Medium: Effect Of Rapid Heating And Short Residence Time, Kyoko Hirayama Aug 2023

Biocrude Production From Lignin In Hydrothermal Medium: Effect Of Rapid Heating And Short Residence Time, Kyoko Hirayama

Civil & Environmental Engineering Theses & Dissertations

This study aims to address knowledge gaps in the production of valuable products from waste streams generated during lignocellulosic biofuel production. The primary objective is to develop a process that converts lignin, a byproduct of bioethanol refineries, into a sustainable biolubricant.

The first chapter examines recent advancements in synthesizing biolubricants and investigates their scalability. It explores innovative materials, catalysts, chemical modification approaches, and additives that have emerged in the field. A particular hurdle is the oxidative stability of biolubricants derived from plant oils, which are prone to autooxidation due to their C=C bonds. To overcome this, the study aims to …


Evaluating Direct Filtration As An Alternative To Conventional Carbon-Based Advanced Treatment For Indirect Potable Reuse, Savannah M. Flemmer Aug 2023

Evaluating Direct Filtration As An Alternative To Conventional Carbon-Based Advanced Treatment For Indirect Potable Reuse, Savannah M. Flemmer

Civil & Environmental Engineering Theses & Dissertations

Hampton Roads Sanitation District (HRSD) is recharging purified wastewater into the Potomac Aquifer via the Sustainable Water Initiative for Tomorrow (SWIFT) project. Conventional SWIFT treatment applies coagulation, flocculation, sedimentation, ozonation, biofiltration, granular activated carbon (GAC) adsorption, and ultraviolet disinfection to secondary effluent to produce water that meets drinking water standards for managed aquifer recharge. HRSD is considering implementing direct filtration as an alternative to conventional treatment for two additional SWIFT facilities. Direct filtration presents an opportunity for significant cost savings by eliminating sedimentation, shortening flocculation detention time, and reducing coagulant usage. Without upstream removal of solids and organics, however, biofilters …


Attention And Task Engagement During Automated Driving, James Richard Unverricht Aug 2023

Attention And Task Engagement During Automated Driving, James Richard Unverricht

Psychology Theses & Dissertations

Many young drivers suffer fatal crashes each year in the United States at a rate approximately three times greater than more experienced drivers. Automated driving systems may serve to mitigate young drivers high crash rates but remain underexplored in research. This dissertation project examined the effects of levels of automation and interestingness of auditory clips on latent hazard anticipation in young drivers during simulated driving. Participants drove a vehicle at varying levels of vehicle automation (SAE Level 0, 2, or 3) in simulated scenarios, each containing a latent hazard event during which a boring, neutral, or interesting auditory clip was …


Experimental And Computational Aerodynamic Studies Of Axially-Oriented Low-Fineness-Ratio Cylinders, Forrest Miller Aug 2023

Experimental And Computational Aerodynamic Studies Of Axially-Oriented Low-Fineness-Ratio Cylinders, Forrest Miller

Mechanical & Aerospace Engineering Theses & Dissertations

For the successful completion of atmospheric entry, descent, and landing (EDL) missions, a body geometry must be selected which provides favorable dynamic aerodynamic properties. The types of experimental facilities capable of collecting information on these properties are limited; however, their numbers are growing thanks to the continued work by the aerodynamics community. NASA Langley Research Center (LaRC) is conducting dynamic aerodynamic testing using a subsonic magnetic suspension and balance system (MSBS), with the end goal of implementing a supersonic MSBS facility at NASA Glenn Research Center. MSBSs are also currently used at the Institute of Fluid Science (IFS) at Tohoku …


Generation Of Plasma With A Rotating Electric Field, Franklin Price Mosely May 2023

Generation Of Plasma With A Rotating Electric Field, Franklin Price Mosely

Electrical & Computer Engineering Theses & Dissertations

Nonthermal plasma generation is an important area of research that has many applications ranging from semiconductor production to medical applications including the treatment of cancers and sterilization of surfaces. Specific radicals and excited species and discharge powers are critical for the successful completion of these processes. It is important that these excited species are shown to be achievable for a given discharge system without leading to instabilities such as arcing.

The present thesis details the design, fabrication, testing, and analysis of a novel plasma generation system based on multiphase excitation. As predicted by theory, the experimental results demonstrate that a …


Nanosecond Pulsed Electric Field Modulates Electron Transport And Mitochondrial Structure And Function, Lucas Nelson Potter May 2023

Nanosecond Pulsed Electric Field Modulates Electron Transport And Mitochondrial Structure And Function, Lucas Nelson Potter

Biomedical Engineering Theses & Dissertations

Pulsed power treatment has been used to induce regulated cell death (RCD) in cells or ablate tumors in animals. A subset of pulsed power as electroporation with high voltage and pulse duration of milliseconds is used for biomedical treatment to induce pores in the plasma membrane of cells. Nanosecond Pulsed Electric Fields (nsPEFs)– an extension of electroporation, uses waveforms with pulse durations on the order of 10-900 nanoseconds. nsPEF treatment has demonstrated intracellular effects for potential biomedical applications. In this work, nsPEF treatment is used to demonstrate changes that affect viability, plasma membrane permeability ROS (Reactive Oxygen Species) in the …


E-Cadherin Force Transmission And Stiffness Sensing, Mazen Mezher May 2023

E-Cadherin Force Transmission And Stiffness Sensing, Mazen Mezher

Mechanical & Aerospace Engineering Theses & Dissertations

E-cadherin is the chief mediator of cell-cell adhesion between epithelial cells and is a known mechanosensor. Force transmission and stiffness sensing are two crucial aspects of E-cadherin mechanobiology.

E-cadherin has an extracellular adhesive region, a transmembrane region and an intracellular region that binds to adhesion-associated proteins. Here, we assessed how different factors affect the level of force transmission (i) from inside the cell such as adhesion-associated proteins, (ii) on the cell membrane, such as growth factor receptors and (iii) outside the cell, such as different binding partners in adhesion. To study the level of force transmission inside the cell, we …


Nb3Sn Coating Of Twin Axis Cavity And Other Complex Srf Cavity Structures, Jayendrika Kumari Tiskumara May 2023

Nb3Sn Coating Of Twin Axis Cavity And Other Complex Srf Cavity Structures, Jayendrika Kumari Tiskumara

Physics Theses & Dissertations

In the field of Accelerator Science, for the low cost and increased quality factor, thin films coated niobium cavities are used in the modern SRF research. Within the potential substances, Nb3Sn has shown higher critical temperature than niobium. Here the tin vapor diffusion method is used as the preferred technique to coat niobium cavities. So far, only elliptical cavities have been coated with Nb3Sn and this technique has not yet been applied to cavities with complex geometries, which are also helpful in the accelerator science field. The Half-wave resonator could provide us data across frequencies of …