Engineering Commons^™

Cyclophilin D Is A Sensor Of Nano-Pulse Stimulation, Brittney Ruedlinger, Bani Hani Maisoun, Lucas Potter, Nicola Lai, Stephen J. Beebe

The Graduate School Posters

Nano-Pulse Stimulation (NPS), a pulsed power-derived technology, stimulates structural and functional changes in plasma membranes and cellular organelles. NPS induces a Ca²⁺ influx and opening of the mitochondrial permeability transition pore (mPTP) that dissipates the mitochondrial membrane potential (ΔΨ_m) and, when sustained, induces regulated cell death. Here we show that in rat cardiomyoblasts (H9C2) cyclophilin D (CypD) is a mitochondrial sensor for NPS as defined by observations that loss of ΔΨ_m is Ca²⁺ and mitochondrial reactive oxygen species (mROS) dependent and cyclosporin A (CsA)-sensitive, which are diagnostic qualities for effects on CypD and the mPTP ...

Trials And Tribulations Of Humanizing Mice For Cancer Research, Brittney Ruedlinger, Steven Warsof, Eric Feliberti, Mary Beth Hughes, Ayobami ‘Edwin’ Oshin, Chunqi Jiang, Brittany P. Lassiter, Siqi Guo, Stephen J. Beebe

The Graduate School Posters

Cancers are aggressive, evasive, and ruthless killers, claiming millions of lives every year. Cancers are heterogeneous and there is often no single, clearly defined problem as they harness and manipulate a multitude of fundamental mechanisms at the very essence of life. To investigate these mechanisms and vet potential interventive therapies, humanized mice offer a unique model as a prelude to the use of nanosecond pulse stimulation (NPS), a pulse power technology applying nanosecond duration, high electric field pulses, to ablate human tumors. Immunodeficient mouse strains, NSG and NSG-SGM3, were engrafted with human immune cells and human tumors, which would allow ...

Computational Aerodynamics Of A Wing Mounted Propeller, Sarah Agam

College of Engineering & Technology (Batten) Posters

Computational fluid dynamics (CFD) is a vital component in aerospace engineering. A major use of CFD is analyzing the flow properties to determine outputs like aerodynamic lift and drag over an airfoil or compute engine efficiency. It is more practical to conduct a CFD analysis first before doing experimental work as CFD allows for rapid and diverse testing of propeller shapes at a lower cost. CFD also allows for a wider range of testing parameters; for example, an airfoil can be subjected to steady, unsteady, incompressible, or high velocity flows.

Propellers are extensively used in the aircraft industry, especially in ...

Data-Limited Domain Adaptation And Transfer Learning For Learning Latent Expression Labels Of Child Facial Expression Images, Megan Witherow, Winston Shields, Manar Samad, Khan Iftekharuddin

College of Engineering & Technology (Batten) Posters

While state-of-the-art deep learning models have demonstrated success in adult facial expression classification by leveraging large, labeled datasets, labeled data for child facial expression classification is limited. Due to differences in facial morphology and development in child and adult faces, deep learning models trained on adult data do not generalize well to child data. Recent deep domain adaptation approaches have improved the generalizability of models trained on a source domain to a target domain with few labeled samples. We propose that incorporating steps of deep transfer learning, e.g. weights initialization from the pre-trained source model and freezing model layers ...

3d Lidar Human Skeleton Estimation For Long Range Identification, Alexander Glandon, Lasitha Vidyaratne, Nasrin Sadeghzadehyazdi, Nibir Dhar, Jide Familoni, Scott Acton, Khan Iftekharuddin

College of Engineering & Technology (Batten) Posters

This research project is the continuation of an effort by the Vision Lab to understand human gait and motion using special-purpose imaging sensors and novel computer vision algorithms. The project began using a Motion Capture (MoCap) system which measures 3D human skeleton information in real-time by attaching markers to a human subject and viewing the human motion with a set of cameras at different angles. We developed an algorithm to determine the gender of a subject wearing these sensors. The current phase of this project extends this work using a state-of-the-art flash Lidar sensor. This sensor scans the surface of ...

Musculoskeletal Modeling Of The Pelvis And Lumbar Spine During Running, Ruth Higgins, Maryam Moeini, Hunter Bennett, Stacie Ringleb

College of Engineering & Technology (Batten) Posters

Musculoskeletal modeling provides an alternative to in-vivo characteristics that are difficult to directly measure for movements such as running, especially for trunk muscles and joints. The full-body-lumbar-spine (FBLS) model by Raabe and Chaudhari, 2016 is an OpenSim model created for simulations of jogging. The lifting full-body (LFB) model by Beaucage-Gauvreau et al., 2018 is an adaptation of the FBLS created for estimating spinal loads during lifting. PURPOSE: Determine validity of the FBLS and LFB models in simulating pelvis and lumbar spine kinematics during running. METHODS: Inverse Kinematics were executed using experimental data for the FBLS and LFB models. To obtain ...

Unsupervised Multivariate Time Series Clustering, Md Monibor Rahman, Lasitha Vidyaratne, Alex Glandon, Khan Iftekharuddin

College of Engineering & Technology (Batten) Posters

Clustering is widely used in unsupervised machine learning to partition a given set of data into non-overlapping groups. Many real-world applications require processing more complex multivariate time series data characterized by more than one dependent variables. A few works in literature reported multivariate classification using Shapelet learning. However, the clustering of multivariate time series signals using Shapelet learning has not explored yet. Shapelet learning is a process of discovering those Shapelets which contain the most informative features of the time series signal. Discovering suitable Shapelets from many candidates Shapelet has been broadly studied for classification and clustering of univariate time ...

Automatic Generation And Novel Validation Of Patient-Specific, Anatomically Inclusive Scoliosis Models For Biomechanics-Informed Surgical Planning, Austin Tapp, Michel Audette, James Bennett

College of Engineering & Technology (Batten) Posters

Scoliosis is an abnormal spinal curvature of greater than 10 degrees. Severe scoliotic deformities are addressed with highly invasive procedures: anterior or posterior spinal fusion approaches. This invasiveness is due, in part, to the constraints of current surgical planning, which utilizes computed tomography (CT) scans unable to discern spinal ligaments that are dissected to make the spine sufficiently compliant for correction. If localization of ligaments and soft tissues were achieved pre-operatively, corrective procedures could become safer and more efficient by using finite element (FE) biomechanical simulations to determine decreased incidences of ligament releases. This research aims to achieve ligament localization ...

Nanopore Guided Regional Assembly, Eleni Adam, Desh Ranjan, Harold Riethman

College of Sciences Posters

The telomeres are the “caps” of the chromosomes and their vital role is to protect them. Possible telomere dysfunction caused by telomere rearrangements can be fatal for the cell and result in age-related diseases, including cancer. The telomeres and subtelomeres are regions that are hard to investigate. The current technology cannot provide their complete sequence, instead the DNA is given in multiple pieces. Current methods of assembling the pieces of these regions are not accurate enough due to the region’s high variability and complex repeated patterns. We propose a hybrid assembly method, the NPGREAT, which utilizes two of the ...

Non-Equilibrium Behavior Of Large-Scale Axial Vortex Cores, Robert L. Ash, Irfan R. Zardadkhan

Mechanical & Aerospace Engineering Faculty Publications

A logical basis for incorporating pressure non-equilibrium and turbulent eddy viscosity in an incompressible vortex model is presented. The infrasonic acoustic source implied in our earlier work has been examined. Finally, this non-equilibrium turbulent vortex core is shown to dissipate mechanical energy more slowly than a Burgers vortex, helping us to explain the persistence of axial vortices in nature. Recent molecular dynamics simulations replicate aspects of this non-equilibrium pressure behavior.

Fmri Feature Extraction Model For Adhd Classification Using Convolutional Neural Network, Senuri De Silva, Sanuwani Udara Dayarathna, Gangani Ariyarathne, Dulani Meedeniya, Sampath Jayarathna

Computer Science Faculty Publications

Biomedical intelligence provides a predictive mechanism for the automatic diagnosis of diseases and disorders. With the advancements of computational biology, neuroimaging techniques have been used extensively in clinical data analysis. Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder, with the symptomology of inattention, impulsivity, and hyperactivity, in which early diagnosis is crucial to prevent unwelcome outcomes. This study addresses ADHD identification using functional magnetic resonance imaging (fMRI) data for the resting state brain by evaluating multiple feature extraction methods. The features of seed-based correlation (SBC), fractional amplitude of low-frequency fluctuation (fALFF), and regional homogeneity (ReHo) are comparatively applied to ...

Assessment Of Cable Length Limit For Effective Protection By Z-Source Circuit Breakers In Dc Power Networks, Ruiyun Fu, Sagar Bhatta, Joseph M. Keller, Yucheng Zhang

Electrical & Computer Engineering Faculty Publications

This paper introduces groundbreaking research on how to assess the Cable Length Limit (CLL) to ensure effective protection by Z-source Circuit Breakers (ZCBs) in DC power networks. It has been revealed that the line parameters of power cables have a significant impact on the cutoff performance of ZCBs. The question of assessing the CLL has been raised as an unsolved problem. In this paper, a method of CLL assessment is proposed based on physical models and simulation tests. To verify the proposed method, two studies were performed to assess the Cable Length Limits depending on fault levels and power delivery ...

Generation Of Excited Species In A Streamer Discharge, Shirshak K. Dhali

Electrical & Computer Engineering Faculty Publications

At or near atmospheric pressure, most transient discharges, particularly in molecular gases or gas mixture containing molecular gases, result in a space charge dominated transport called a streamer discharge. The excited species generation in such discharges forms the basis for plasma chemistry in most technological applications. In this paper, we simulate the propagation of streamers in atmospheric pressure N₂ to understand the energy partitioning in the formation of various excited species and compare the results to a uniform Townsend discharge. The model is fully two-dimensional with azimuthal symmetry. The results show a significantly larger fraction of the energy goes ...

Matlab Modeling Of Ofdm Modulation Technique Across A 24 Khz, 48 Khz, And 3 Mhz Bandwidth In The High-Frequency Radio Band (3-30) Mhz, Josiah Myer, Tyler Collins, Sarah Taylor, Natalia Anglero

Faculty-Sponsored Student Research & Capstones

The goal of this project is to use MATLAB to model orthogonal frequency division multiplexing (OFDM) modulation technique across 24 kHz, 48 kHz, and 3 MHz bandwidths in the high frequency (HF) radio band (3-30 MHz). The purpose of our design is to make HF long distance communication faster and more reliable so that every part of the world, including the most remote parts, will have access to high speed, long distance wireless communication. Our MATLAB model will allow us to modify the bandwidth, carrier frequency, modulation type, signal to noise ratio (SNR), and image size to determine which combination ...

2-Ns Electrostimulation Of Ca2+ Influx Into Chromaffin Cells: Rapid Modulation By Field Reversal, Josette Zaklit, Gale L. Craviso, Normand Leblanc, P. Thomas Vernier, Esin B. Sözer

Bioelectrics Publications

Cellular effects of nanosecond pulsed electric field exposures can be attenuated by an electric field reversal, a phenomenon called bipolar pulse cancellation. Our investigations of this phenomenon in neuroendocrine adrenal chromaffin cells show that a single 2 ns, 16 MV/m unipolar pulse elicited a rapid, transient rise in intracellular Ca²⁺ levels due to Ca²⁺ influx through voltage-gated calcium channels. The response was eliminated by a 2 ns bipolar pulse with positive and negative phases of equal duration and amplitude, and fully restored (unipolar-equivalent response) when the delay between each phase of the bipolar pulse was 30 ns ...

Numerical Analysis Of A Roadway Piezoelectric Harvesting System, Abdul Rahman Badawi

Mechanical & Aerospace Engineering Theses & Dissertations

Highways, streets, bridges, and sidewalks with heavy traffic dissipate a considerable amount of waste mechanical energy every day. Piezoelectric energy harvesting devices are a very promising technology that can convert the waste mechanical energy to clean and renewable energy to enhance the sustainability of infrastructures. Research efforts in large-scale energy harvesting have led to the advancement of piezoelectric devices to the point that large-scale implementation is starting to become more feasible. The energy harvested by these devices can be used in many ways such as providing heating or cooling, melting ice, monitoring structural conditions in bridges and tunnels, and powering ...

Conical Orbital Mechanics: A Rework Of Classic Orbit Transfer Mechanics, Cian Anthony Branco

Mechanical & Aerospace Engineering Theses & Dissertations

Simple orbital maneuvers obeying Kepler’s Laws, when taken with respect to Newton’s framework, require considerable time and effort to interpret and understand. Instead of a purely mathematical approach relying on the governing relations, a graphical geometric conceptual representation provides a useful alternative to the physical realities of orbits. Conic sections utilized within the full scope of a modified cone (frustum) were employed to demonstrate and develop a geometric approach to elliptical orbit transformations. The geometric model in-question utilizes the rotation of a plane intersecting the orbital frustum at some angle β (and the change in this angle) in ...

A Parametric Analysis Of A Turbofan Engine With An Auxiliary Bypass Combustion Chamber – The Turboaux Engine, Kaleab Fetahi

Mechanical & Aerospace Engineering Theses & Dissertations

A parametric study of a novel turbofan engine with an auxiliary combustion chamber, nicknamed the TurboAux engine is presented. The TurboAux engine is conceived as an extension of a low-bypass turbofan engine with an auxiliary bypass annular combustion chamber around the core stream. The study presented in this thesis is motivated by the need to facilitate clean secondary burning of fuel at temperatures higher than conventionally realized, from air exiting the low-pressure compressor. The parametric study starts by analyzing the turbojet engine and its performance with and without an afterburner segment attached. Following that, the conventional turbofan and its mixing ...

Onboard Autonomous Controllability Assessment For Fixed Wing Suavs, Brian Edward Duvall

Mechanical & Aerospace Engineering Theses & Dissertations

Traditionally fixed-wing small Unmanned Arial Vehicles (sUAV) are flown while in direct line of sight with commands from a remote operator. However, this is changing with the increased popularity and ready availability of low-cost flight controllers. Flight controllers provide fixed-wing sUAVs with functions that either minimize or eliminate the need for a remote operator. Since the remote operator is no longer controlling the sUAV, it is impossible to determine if the fixed-wing sUAV has proper control authority. In this work, a controllability detection system was designed, built, and flight-tested using COTS hardware. The method features in-situ measurement and analysis of ...

Using Interacting Multiple Model Filters To Indicate Program Risk, Amy Sunshine Smith-Carroll

Engineering Management & Systems Engineering Theses & Dissertations

Technology development has increased exponentially. Program managers are pushed to accelerate development. There are many resources available to program managers that enable acceleration, such as: additional resources in the form of funding, people and technology. There are also negative impacts to acceleration, such as: inclusion, inexperience program managers, and communication. This research seeks to identify the limit to which a program or project can be accelerated before the program manager begins to accept an unacceptable amount of pre-determined risk.

This research will utilize estimation algorithms used by sensor systems to estimate the current and future state of objects in space ...

Cyber Defense Remediation In Energy Delivery Systems, Kamrul Hasan

Computational Modeling and Simulation Engineering Theses & Dissertations

The integration of Information Technology (IT) and Operational Technology (OT) in Cyber-Physical Systems (CPS) has resulted in increased efficiency and facilitated real-time information acquisition, processing, and decision making. However, the increase in automation technology and the use of the internet for connecting, remote controlling, and supervising systems and facilities has also increased the likelihood of cybersecurity threats that can impact safety of humans and property. There is a need to assess cybersecurity risks in the power grid, nuclear plants, chemical factories, etc. to gain insight into the likelihood of safety hazards. Quantitative cybersecurity risk assessment will lead to informed cyber ...

An Investigation On The Effectiveness Of A Problem Structuring Method In A Group Decision-Making Process, Ying Thaviphoke

Engineering Management & Systems Engineering Theses & Dissertations

There is no shortage of methods to address messy problems. A messy problem is a system of problems with multiple stakeholders who may hold different views of what is feasible or desirable. Decision-makers in a messy problem are prone to committing an error – especially the Type III error. One of the ways to mitigate the chance of committing the error in a messy problem is to reach a group consensus. Problem Structuring Methods (PSM) are the collections of participatory modeling methods that aim to tackle a messy problem. Despite the positive reports, literature indicates some challenges and criticisms of the ...

Nanosecond Stimulation And Defibrillation Of Langendorff-Perfused Rabbit Hearts, Johanna Neuber

Biomedical Engineering Theses & Dissertations

The search for novel defibrillation methodologies focuses on minimizing deposition of energy to the heart, as this is an indicator for side effects including pain and tissue death. In this work, we investigate the effect of reducing the duration of the applied shocks from low milliseconds to the nanosecond range.

300 ns defibrillation was observed and confirmed to require lower energy than monophasic shocks by almost an order of magnitude with no tissue damage. Additionally, the safety factor, the ratio of median effective doses for electroporative damage and defibrillation, was similar for both durations. To predict how defibrillation shocks of ...

Hardware Development For The Generation Of Large-Volume High Pressure Plasma By Spatiotemporal Control Of Space Charge, Nikhil Boothpur

Electrical & Computer Engineering Theses & Disssertations

While generating a plasma under laboratory conditions, any attempt to scale the pressure and volume leads to instabilities due to the build-up of localized space-charge. This poses a challenge in the design of the discharge chamber, type of excitation field, and the type of gas that is used in the discharge. This work investigates a spatially and temporally varying electric field to control the formation of space-charge in large-volume (greater than 5 mm in the smallest dimension) near atmospheric pressure. The simulations show that in a space-charge dominated transport, the charged species disperse both in azimuthal and radial directions in ...

Space-Based Countermeasure For Hypersonic Glide Vehicle, Robert Joseph Fowler Iv

Mechanical & Aerospace Engineering Theses & Dissertations

The purpose of this thesis is to investigate the effectiveness of a space-based laser weapon system for countering a hypersonic glide vehicle. Hypersonic glide vehicles are an emerging type of weapon system which combine the range of ballistic missiles with the maneuverability of cruise missiles. These systems pose a unique threat to military assets not only for their expanded capabilities but also for the lack of an effective defensive countermeasure. Space-based laser weapon systems may offer a solution to this problem. The dynamics of a space-based laser system defending against a hypersonic glide vehicle are modeled first. The governing equations ...

The Effect Of Compaction Temperature And Pressure On Mechanical Properties Of 3d Printed Short Glass Fiber Composites, Pushpashree Jain Ajith Kumar Jain

Mechanical & Aerospace Engineering Theses & Dissertations

Among many thermoplastics that are used in engineering, polyamide 6 (nylon 6) is an extremely versatile engineering thermoplastic. Nylon filled with glass fibers has higher mechanical strength and high wear resistance than general purpose nylon. 3D printed composites, based on fused filament modeling, typically suffer from poor bead-to-bead bonding and relatively high void content, limiting their mechanical properties

This thesis explores the effect of compaction pressure and temperature on improving the mechanical properties of 3D printed composites. Engineering moduli in the printing and transverse to printing direction, as well as ultimate strength were measured using the tensile testing with Digital ...

Parametric Study Of Residual Stresses In Wire And Arc Additive Manufactured Parts, Hisham Khaled Jamil Abusalma

Mechanical & Aerospace Engineering Theses & Dissertations

Wire and Arc Additive Manufacturing (WAAM) is a cost-effective additive manufacturing process due to its capability to fabricate large metal parts with high deposition rate and low equipment cost. Although this method is gaining popularity in manufacturing industry, more research is needed to understand process parameters’ effects on residual stress (RS) distribution and part distortion. As such, a 3D thermo-elastic-plastic transient model was established in ABAQUS and employed to investigate the effect of process parameters such as the torch speed, the deposition power and the interlayer dwell time on RS distribution and distortion in WAAM part. The numerical model utilized ...

Detailed Modeling Of The Flash Hydrolysis Of Algae For Biofuel-Production In Comsol Multiphysics, Noah Joseph Legrand

Mechanical & Aerospace Engineering Theses & Dissertations

Algae-derived biofuels are being commercialized as an important renewable energy source. Like any new technology, conversion improvements are desired, including reductions in process complexity and better utilization of the entire microalgae feedstock. The Old Dominion Biomass Laboratory has focused on flash hydrolysis for algae biofuel production. That process involves rapidly heating algae and water mixed as a slurry to a subcritical state. Results from small-scale bench tests are promising, but process scale up is a challenge. Currently there exists a pilot laboratory scale system utilizing induction heating in order to reach controlled reaction temperatures with a reaction duration of 10 ...

Parallelization Of The Advancing Front Local Reconnection Mesh Generation Software Using A Pseudo-Constrained Parallel Data Refinement Method, Kevin Mark Garner Jr.

Computer Science Theses & Dissertations

Preliminary results of a long-term project entailing the parallelization of an industrial strength sequential mesh generator, called Advancing Front Local Reconnection (AFLR), are presented. AFLR has been under development for the last 25 years at the NSF/ERC center at Mississippi State University. The parallel procedure that is presented is called Pseudo-constrained (PsC) Parallel Data Refinement (PDR) and consists of the following steps: (i) use an octree data-decomposition scheme to divide the original geometry into subdomains (octree leaves), (ii) refine each subdomain with the proper adjustments of its neighbors using the given refinement code, and (iii) combine all subdomain data ...

Standards For Technological And Engineering Literacy: Addressing Trends And Issues Facing Technology And Engineering Education, Johnny J. Moye, Philip A. Reed

STEMPS Faculty Publications

The article offers information on addressing trends and issues facing technology and engineering education. It mentions future challenges, students need to "have a broad conceptual understanding of technology and its place in society, enabling them to be active participants in the technological world and careful creators and users of technology.