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Articles 61 - 90 of 148
Full-Text Articles in Engineering
Left Atrial Model, Borna Sobati, Sarah Porello, Tess Pate
Left Atrial Model, Borna Sobati, Sarah Porello, Tess Pate
Biomedical Engineering
The objective is to produce an electrophysiological model of an adult human left atrium. This model will be used to test mapping probe catheters used for locating cardiac arrhythmias against current technology used in practice. Dr. Chris Porterfield requested this model and other physicians or probe catheter manufacturers may also use this product in the future. Dr. Porterfield also discussed the possibility of future senior project groups using the model as a bench test for designing new catheter tips. The model will precisely simulate electrical behaviors of the heart in normal as well as arrhythmic conditions. Ideally, the model will …
Concussion Indication Device, Taylor O'Donoghue, Isabel Jellen, Eric Shechter
Concussion Indication Device, Taylor O'Donoghue, Isabel Jellen, Eric Shechter
Biomedical Engineering
In this document we summarize our intent to design and manufacture a device that will be used in conjunction with a football helmet, will detect impact forces to the head, and notify the user to seek out further medical attention when subjected to forces large enough to cause concussions. We describe the large market including all levels of football players and the need for improved technology that will not only be effective in elucidating risks but encouraging players to use the device over the alternatives. To design the device, we have researched the problem of concussions in football and have …
Parkinson's Freezing Of Gait Device Attachment, Reagan Burns, Sidney Collin, Hadley Rose
Parkinson's Freezing Of Gait Device Attachment, Reagan Burns, Sidney Collin, Hadley Rose
Biomedical Engineering
The Freezing of Gait Project aims to design and develop an attachment mechanism for a medical device to help Parkinson’s patients overcome freezing of gait (FOG). The mechanism will allow the device to attach to a variety of canes or walkers, while being easy for Parkinson’s patients to use. It will interface with a device produced by De Oro Devices. The project includes an analysis of current competitive devices, a summary of customer needs, design of experiments to test significant features of the attachment, and project plan. The customer needs are translated to engineering metrics. Failures and mitigation of risks …
Slit Lamp Ophthalmoscope Redesign, Michael Hostetler, Austin Mattmiller, Alexis Brewer
Slit Lamp Ophthalmoscope Redesign, Michael Hostetler, Austin Mattmiller, Alexis Brewer
Biomedical Engineering
The slit lamp ophthalmoscope is used by ophthalmologists for diagnosis of pathologies in the eye. The device is used for identifying ocular diseases or indications of other possible systemic diseases to treat them before the diseases progress. Redesign of the ergonomics and adjustment mechanisms of the slit lamp ophthalmoscope will attempt to improve the compatibility of the device across a greater variety of patients. The wider headrest tower of 12.75 inches, the wider table cutout of 12 inches, and the 12 inches of extension of the headrest tower creates a better ergonomic fit for the patient and doctor. The wider …
Heat Stress Identification, Nathanial Nyberg, Christina Santini, Zachary Miller
Heat Stress Identification, Nathanial Nyberg, Christina Santini, Zachary Miller
Biomedical Engineering
This document contains all information pertinent to the creation of the desired product and how the desired product fulfills the problem statement. This document clearly defines the customer requirements and how they relate to engineering specifications, metrics that will define the boundaries that the desired product must lie within. This document will then reveal all concepts that were considered during the design phase of this project and how those concepts were compared. This includes all quantitative parameters that provided a clear front-runner concept and the rationale for those parameters and the values and weight assigned to them.
Then this document …
Ideomotion Gait Training Thigh Prompt, Kristin Schmidt, Elizabeth Peterson, Dalton Jennings
Ideomotion Gait Training Thigh Prompt, Kristin Schmidt, Elizabeth Peterson, Dalton Jennings
Biomedical Engineering
This document serves as our project report at its completion for developing thigh prompts to be used with the LiftWalker. In this document we outline our project from its beginning to end. We describe our process from understanding the background and our customer requirements, transforming these customer requirements into engineering specifications, performing the stage gate process, developing and evolving the design, testing the design, and finally drawing conclusions and making recommendations for the future.
Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson
Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson
Biomedical Engineering
This Final Project Report provides the reader with a comprehensive detailing of all of the actions and work that has been completed for this Senior Design Project. In this report, the Cal Poly Biomedical Engineering Senior Project Team will discuss some background on the existing Mark I Flash-Mold Machine currently in use by Gesea Biosciences, background information on Gesea Biosciences, the Customer Requirements and Design Specifications of the new machine, Quality Engineering considerations, design concepts discussed, design concepts chosen, safety considerations, prototype development, manufacturing, testing protocols, and testing results, etc.
Plga Scaffold Device, Tyler D. Tackabery, Bryce Powada, Tate Morell
Plga Scaffold Device, Tyler D. Tackabery, Bryce Powada, Tate Morell
Biomedical Engineering
No abstract provided.
Automated Microscope Stage, Corin Nishimoto, Alison Flesch, Theo Anastos
Automated Microscope Stage, Corin Nishimoto, Alison Flesch, Theo Anastos
Biomedical Engineering
This document seeks to describe the background information, customer requirements, design specifications, indications for use, selected materials, proposed budget, prototypes, final design, manufacturing processes, and testing methods regarding the CellOptimizer automated microscope stage product.
Foot Support Taping Device For Off-Loading Wounds, Andres Fojaco Gomez, Mikaela Williams, Josh Pelegrin
Foot Support Taping Device For Off-Loading Wounds, Andres Fojaco Gomez, Mikaela Williams, Josh Pelegrin
Biomedical Engineering
No abstract provided.
Fluid Delivery System For A Cell Culture On A Microfluidic Chip, Austin J. Roeder, Colleen A. Richards, Emily A. Matteson
Fluid Delivery System For A Cell Culture On A Microfluidic Chip, Austin J. Roeder, Colleen A. Richards, Emily A. Matteson
Biomedical Engineering
This project report provides a description of the progress made in the development of a fluid delivery system for a microfluidic cell culture on a chip. The system is intended to be used in a humidified incubator in a university laboratory and the fluid delivery system is required to exist and operate within that incubator for extended periods of time. Therefore, the system will be gravity-driven and contain no electronic components. The key specification of the system is to provide fluid flow at a constant velocity.
After manufacturing and testing the device, all specifications were met except for the fluid …
Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal
Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal
Biomedical Engineering
This document describes a background on current ultrasound technologies and the troubles that have inspired the need for a hands-free ultrasound transducer device, as well as the regulatory requirements, like patents and standard codes, for the intended invention. It also explains the Stage Gate Review process used to project plan the design of the device, a description of the final design and how it was developed, and the IQ/OQ/PQ. The objectives necessary to design this device, in order to meet all the requirements of the sponsor, are also summarized here. The design process including manufacturing instructions, prototype evolution, and the …
Esophageal Mapping And Temperature Regulation For Catheter Ablation, Madison J. Keith, Morgan A. Jawitz, Sarah L. Sanders
Esophageal Mapping And Temperature Regulation For Catheter Ablation, Madison J. Keith, Morgan A. Jawitz, Sarah L. Sanders
Biomedical Engineering
The purpose of this document is to provide a development summary for a proposed esophageal temperature mapping device used during catheter ablation. Catheter ablation therapy is performed in the left atria with hot or cold materials to create scar tissue to treat atrial fibrillation. However, utilized temperatures and absorbed energies from the catheter can cause undesired esophageal damage. Therefore, this medical device is designed to monitor esophageal temperature and map its location during catheter ablation. If dangerous temperatures are reached, the device will alarm the surgeon.
This document provides an in-depth overview of the esophageal temperaturemapping device’s development and contains …
Accelerated Wear Reactor Testing, Tristan Frisella, Daniel Alanis, Kian Ashoubi
Accelerated Wear Reactor Testing, Tristan Frisella, Daniel Alanis, Kian Ashoubi
Biomedical Engineering
Carbon dioxide accounts for a large amount of global greenhouse gases released into the environment. Because plastic degradation emits carbon dioxide, there has been interest to investigate how much carbon dioxide various plastics generate as they degrade. We have been tasked to create a dehumidifier and carbon dioxide sensor assembly for an accelerated wear testing apparatus that degrades plastic. Several products and literature currently exist that share similarity with our assembly but have not been manufactured to achieve the same combination of measurements we are expecting of our accelerated wear testing device. The following report shall introduce these products and …
Pressure Cylinder Controlled Release Valve, Alexa Dominique Balbuena
Pressure Cylinder Controlled Release Valve, Alexa Dominique Balbuena
Biomedical Engineering
This project aims to integrate an automatic gas release system in a pre-existing scaffold fabrication process for tissue engineering applications.
To form the proper scaffold structure, the fabrication process is heavily influenced by the change in its surrounding pressure. The current production involves a pressure transducer and electric valve that is managed manually to create a suitable pressure environment for the scaffold. This method, although functional, proves to be ineffective when creating several batches; the user needs to constantly monitor the developing pressure profile and alter voltage parameters accordingly to create a linear gas release under a predetermined slope.
To …
Upright Sleep Device For Patients Required To Sleep Upright Post Surgery/Medical Procedure, Kristin J. Abele, Madeleine H. Hummel, Tayler R. Kastlunger
Upright Sleep Device For Patients Required To Sleep Upright Post Surgery/Medical Procedure, Kristin J. Abele, Madeleine H. Hummel, Tayler R. Kastlunger
Biomedical Engineering
No abstract provided.
Virtual Stethoscope/Otoscope Duo, Camila P. Monchini, Paige R. Mazur, Christian Navarro
Virtual Stethoscope/Otoscope Duo, Camila P. Monchini, Paige R. Mazur, Christian Navarro
Biomedical Engineering
The virtual stethoscope/otoscope duo is a medical device intended to allow patients to be seen by their medical provider via internet consultations from the comfort of their own home. This device allows patients to substitute in-person doctor visits by checking a patient’s cardiovascular, respiratory, and auditory health. This document is the statement of work for the virtual stethoscope/otoscope duo and contains information on similar products, patents, and relevant literatures containing virtual technologies that assist in patient diagnosis. Product specifications and other details for the device such as performance evaluation review techniques can also be found within this document outlining the …
Influence Of Fibroblasts On Functional Arteriogenesis In A Murine Chronic Hindlimb Ischemia Model, Ashli A. Santos
Influence Of Fibroblasts On Functional Arteriogenesis In A Murine Chronic Hindlimb Ischemia Model, Ashli A. Santos
Biomedical Engineering
Peripheral arterial occlusive disease (PAOD) occurs when there is a narrowing or blockage – usually a buildup of plaque - within the arteries that reduces blood flow to tissues which can chronic ischemia. As with most diseases, early detection and proactive treatment are important to maximize prognosis. Exercise effectively treats PAOD, but due to ischemic pain in the limbs, or intermittent claudication (IC), exercise can become painful and difficult. Due to the buildup of plaque, occlusions create an ischemic environment that changes the pressure distribution in collateral networks and increases the shear stress in transverse collaterals. Those two responses signal …
Redesign Of The Medtronic Kyphon Bone Cement Mixer For Vertebral Compression Fractures, Mollie Benson, Sarah Freesemann, Aj Konnath, Benjamin Murray
Redesign Of The Medtronic Kyphon Bone Cement Mixer For Vertebral Compression Fractures, Mollie Benson, Sarah Freesemann, Aj Konnath, Benjamin Murray
Biomedical Engineering
The complete senior project report was submitted to the project advisor and sponsor. The results of this project are of a confidential nature and will not be published at this time.
Wheelieking Trainer Project Report, Harold Hall Iii, Nathaniel Fox, Thomas Niemisto
Wheelieking Trainer Project Report, Harold Hall Iii, Nathaniel Fox, Thomas Niemisto
Biomedical Engineering
In this report we will detail the design and implementation process of the WheelieKing Trainer project, a device that helps people learn how to do wheelies on a bicycle by preventing backward falls. Formal project requirements are specified, followed by the ideation and iteration process to meet those requirements. The components and methods used to create the device are described in detail. The results of the development process and usage test results of the device are included. Appendices at the end of this report include references, supporting analyses, and project management and timeline details.
Isolation And Culture Of Myofiber-Derived Cells From The Extensor Digitorum Longus Muscle, Ethan M. Tietze
Isolation And Culture Of Myofiber-Derived Cells From The Extensor Digitorum Longus Muscle, Ethan M. Tietze
Biomedical Engineering
Peripheral arterial occlusive disease (PAOD) involves distal artery occlusion by atherosclerotic plaques, which restricts blood flow and leads to ischemia in downstream tissues. Increased blood flow through preexisting collateral vessels leads to increased shear stress that triggers an outward remodeling of the vessel called arteriogenesis. In some cases this natural compensatory mechanism is able to sufficiently restore blood flow following arterial occlusion. However, for many individuals this process is insufficient to relieve peripheral ischemia, and patients experience intermittent claudication, or limb pain with locomotion or exercise. Without treatment, reduced blood flow can lead to tissue necrosis and potentially amputation. The …
Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson
Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson
Biomedical Engineering
Peripheral arterial occlusive disease (PAOD) occurs when there is narrowing or blockage of the peripheral arteries that carry blood to the extremities, most commonly the legs. The most common symptom of PAOD is intermittent claudication, or ischemic pain during exercise. Women with PAOD experience a greater extremity functional impairment than men. Since impaired vasodilation might cause the ischemic pain from PAOD, we should evaluate vasodilation post ligation in males and females in collateral vessels, which connect two arterial segments to maintain blood flow to an otherwise hypoxic area. First, we need to examine collateral vasodilation in unoperated male and female …
Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo
Prosthetic Leg Kit For Deployment In Developing Countries, Brian Murphy, Dominique Porcincula, Derek Morgan, Kendall Ruggles, Christian Aguayo
Biomedical Engineering
The World Health Organization estimates that over 30 million people require some sort of prosthetic technology. However, traditional prosthetic fitting practices take a lot of time and cost a lot of money, making them inaccessible to millions of people around the world. StandUP Worldwide is an interdisciplinary project team devoted to creating low-cost prosthetic technologies for use around the world, especially in resource poor areas. They are currently developing a low cost, below-the-knee prosthetic kit that can be easily deployed in a resource-poor area. The following presents their solution for a below-the-knee prosthetic socket, foot, and leg.
Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan
Portable Sensory Room For The West Orange County Consortium For Special Education, Lindsey Chase, Emma Eskildsen, Alex Fox, Claire Francis, Nate Hoffman, Kaylee Keck, Sarah Sullivan
Biomedical Engineering
This report discusses the development of a Portable Sensory Room to be used at Newland Elementary School in Huntington Beach. Newland Elementary has an exceptional Special Needs program that teaches the children with the most severe cases of autism in its school district. People with autism typically also have sensory processing disorders, which can be extremely disruptive for a child’s development and can make it difficult for a child to be able to concentrate long enough to gain necessary life skills. The idea behind a Sensory Rooms is to create a place to calm the students and to expose them …
Final Project Report: Motorized "Hover Board", Gabriele Pregadio
Final Project Report: Motorized "Hover Board", Gabriele Pregadio
Biomedical Engineering
No abstract provided.
Cal Poly On-Site Water Treatment Project Proposal, Tanner Wingo
Cal Poly On-Site Water Treatment Project Proposal, Tanner Wingo
Biomedical Engineering
This report is based off of a competition hosted by the Environmental Protection Agency (EPA): the 2015 Campus RainWorks Challenge. Student teams were encouraged to design an infrastructure that could manage storm water, benefit campus life, and promote sustainability. The report summarizes the engineering aspects that support the competition submittal. The design is to treat campus wastewater on-site and to a suitable level for either reuse or discharge into Brizzolara Creek.
The Effect Of Neurostimulation On Ischemic Pain And Methods Of Assessing Pain, Kaylee Keck
The Effect Of Neurostimulation On Ischemic Pain And Methods Of Assessing Pain, Kaylee Keck
Biomedical Engineering
Peripheral arterial disease (PAD) impacts approximately eight million people in the United States [1]. Disease progression leads to chronic ischemic pain, hindering quality of life. Pharmaceuticals are a typical treatment for pain associated with PAD; but as few as 30% of patients have a significant reduction of pain (≥50%) [2].
Neurostimulation is commonly used as a treatment for various diseases and injuries, including Parkinson’s disease and sports-related back and knee injuries [2]. The objective of the study was to explore neurostimulation and its effect on pain and paresthesia for a model of acute peripheral ischemia in young college students.
Pain …
Assessing Functional Vasodilation In The Gracilis Collateral Arteriole, Megan T. Chu
Assessing Functional Vasodilation In The Gracilis Collateral Arteriole, Megan T. Chu
Biomedical Engineering
Peripheral arterial occlusive disease (PAOD) involves arterial occlusion due to the formation of atherosclerotic plaques. It is suggested that intermittent claudication, the most frequent clinical presentation of PAOD, is caused by impaired vasodilation. Current treatments for PAOD are not directed at improving vascular reactivity and are often insufficient. Stimulating arteriogenesis in collateral arterioles has therapeutic potential for PAOD, but because arterioles are the primary site of blood flow resistance, it is important that these treatments do not impair collateral vasodilation. Before this can be evaluated, the effects of arteriogenesis on collateral function must be studied in untreated collaterals. There is …
Measuring Blood Flow In The Skeletal Muscle Microcirculation Using Laser Speckle Flowmetry, Kenneth Howard Gouin Iii
Measuring Blood Flow In The Skeletal Muscle Microcirculation Using Laser Speckle Flowmetry, Kenneth Howard Gouin Iii
Biomedical Engineering
The presence of a native collateral circulation, which serves as a natural bypass for blood flow around an occlusion, improves prognosis for patients with ischemic diseases, such as peripheral arterial occlusive disease (PAOD). However, not all patients have a native collateral circulation, and animal models suggest a genetic basis for this variability. In mice, such as the BALB/c, that lack native arteriolar collaterals, neocollateral formation from capillaries that connect two arterial trees can occur after arterial occlusion, resulting in reperfusion of the ischemic watershed. Immature arterialized collateral capillaries (ACCs) at 7 days post arterial occlusion do not vasodilate in response …
A Comprehensive Review Of The Food And Drug Administration, The 510(K) Application Process, And Fda Certification For A Diagnostic Device, Taylor Davis
Biomedical Engineering
The company G-Force CRC LLC is currently experiencing the dichotomy of the FDA's conflicting role right now as they begin to approach FDA approval. G-Force CRC LLC is a small medical device company headquartered in San Diego, CA. The owner of the company, Dr. Ian Purcell, is an Otoneurologist apart of Alvarado Hospital. His medical practice mainly deals with patients who have balance disorders and therefore the devices that he has developed over the last 6+ years are primarily used to assist in the diagnosis of those balance disorders. G-Force CRC LLC was officially created in the summer of 2013 …