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Articles 1 - 18 of 18
Full-Text Articles in Engineering
Electrical Double Layer In Nanopores For Detection And Identification Of Molecules And Submolecular Units, Guigen Zhang, Samuel Bearden
Electrical Double Layer In Nanopores For Detection And Identification Of Molecules And Submolecular Units, Guigen Zhang, Samuel Bearden
Biomedical Engineering Faculty Patents
Systems for detecting analytes in electrical double layer nanopore devices and methods of use are provided.
Compact Low-Cost Fiberless Diffuse Speckle Contrast Flow-Oximeter, Guoqiang Yu, Chong Huang, J. Todd Hastings
Compact Low-Cost Fiberless Diffuse Speckle Contrast Flow-Oximeter, Guoqiang Yu, Chong Huang, J. Todd Hastings
Biomedical Engineering Faculty Patents
A low-cost compact fiberless diffuse speckle contrast flow-meter includes a small laser diode and a 2-dimensional imaging device such as a charge coupled device (CCD) or complementary metal oxide semiconductor (CMOS) for directly contacting the tissue and measuring a parameter such as blood flow in a deep/thick volume of tissue (up to 10 mm depth). The small laser diode is fixed at a certain distance (0 to 20 mm) from the imaging device and directly contacts the tissue. Light emitted from the laser diode penetrates through the tissue and reflects back to the imaging device without passing through any lenses …
Small Molecule Drug Release Form In Situ Forming Degradable Scaffolds Incorporating Hydrogels And Bioceramic Microparticles, David A. Puleo, Todd A. Milbrandt, J. Zach Hilt, Paul Fisher, Vishwas Talwalkar
Small Molecule Drug Release Form In Situ Forming Degradable Scaffolds Incorporating Hydrogels And Bioceramic Microparticles, David A. Puleo, Todd A. Milbrandt, J. Zach Hilt, Paul Fisher, Vishwas Talwalkar
Biomedical Engineering Faculty Patents
The present invention relates to an injectable system combining a hydrogel, a bioceramic and a degradable matrix that provides for sustained drug delivery and structural support to recovering tissue, such as bone and the periodontium.
Bilayered Calcium Sulfate/Calcium Phosphate Space-Making Composites With Multiple Drug Delivery Capabilities, David A. Puleo, Bryan R. Orellana, Mike Mcquinn
Bilayered Calcium Sulfate/Calcium Phosphate Space-Making Composites With Multiple Drug Delivery Capabilities, David A. Puleo, Bryan R. Orellana, Mike Mcquinn
Biomedical Engineering Faculty Patents
The present invention provides for bilayered composites that provide for sustained drug delivery and support to recovering tissue(s) and areas surrounding, such as with bone tissue. The two layers degrade at separate rates, thereby providing sustained mechanical support and tailored drug delivery.
Noncontact Three-Dimensional Diffuse Optical Imaging Of Deep Tissue Blood Flow Distribution, Guoqiang Yu, Yu Lin, Chong Huang
Noncontact Three-Dimensional Diffuse Optical Imaging Of Deep Tissue Blood Flow Distribution, Guoqiang Yu, Yu Lin, Chong Huang
Biomedical Engineering Faculty Patents
The present invention provides for three-dimensional reflectance diffuse optical imaging of deep tissue blood flow distribution that removes the need for probe-tissue contact, thereby allowing for such technology to be applied to sensitive, vulnerable, damaged, or reconstructive tissue. The systems utilize noncontact application and detection of near-infrared light through optical lens and detection through a linear array or two-dimensional array of avalanche photodiodes or a two-dimensional array of detectors provided by charge-coupled-device (CCD). Both further feature a finite-element-method (FEM) based facilitation to provide for three-dimensional flow image reconstruction in deep tissues with arbitrary geometries.
Polymeric Prodrug, David A. Puleo, Thomas D. Dziubla, Theodora Asafo-Adjei
Polymeric Prodrug, David A. Puleo, Thomas D. Dziubla, Theodora Asafo-Adjei
Biomedical Engineering Faculty Patents
The presently-disclosed subject matter includes compounds that comprise an initiator and an active agent that is covalently bonded to the initiator through a ring-opening polymerization process, an atom-transfer radical polymerization process, a Michael addition reaction, or a ring-opening metathesis polymerization process. In some embodiments the active agent includes simvastatin. The presently-disclosed subject matter also includes methods for making the compositions and methods for using the compositions to treat tissue wounds.
Method And Device For Removal Of Cryoprotectant From Cryopreserved Biological Cells And Tissues, Dayong Gao, Xiangdong Cui
Method And Device For Removal Of Cryoprotectant From Cryopreserved Biological Cells And Tissues, Dayong Gao, Xiangdong Cui
Biomedical Engineering Faculty Patents
Novel methods and devices for removing cryoprotectant from cryoprotectant-containing liquids, and from cells residing therein, are disclosed. In one aspect, the method comprises passing the cryoprotectant-containing liquid through at least one semipermeable hollow fiber membrane contained in a hollow module in a first direction, while passing a liquid which is substantially free of cryoprotectant through the hollow module in a second direction to remove cryoprotectant across a diffusion gradient. In another aspect, a device is described for removing cryoprotectant from a liquid, comprising a hollow module with at least one semipermeable hollow fiber membrane therein for accomplishing such counter-current diffusion …
Implant Pre-Treated For Reducing The Generation Of Wear Particulates, David A. Pienkowski, Kwon-Yong Lee
Implant Pre-Treated For Reducing The Generation Of Wear Particulates, David A. Pienkowski, Kwon-Yong Lee
Biomedical Engineering Faculty Patents
A method is provided for reducing the amount of wear particulates generated by a total joint orthopaedic implant. The implant consists of two matched articulating components wherein at least one of the components is made of polymer or other material with similar physical properties. The method includes the steps of placing the total joint orthopaedic implant in a fluid bath and articulating the implant in the fluid bath for at least 1,000 cycles. The articulation may be performed in three stages. In the first, the implant is articulated under a load of substantially 0.1-500 Newtons with sliding speeds of substantially …
Method For Improving Consolidation Of Powder Resin, David A. Pienkowski, Eric A. Grulke, Robert J. Jacob
Method For Improving Consolidation Of Powder Resin, David A. Pienkowski, Eric A. Grulke, Robert J. Jacob
Biomedical Engineering Faculty Patents
A method for improving consolidation of powder resin is provided. The method broadly includes the steps of: (1) sorting particles of the powder resin according to their diameter; (2) combining the sorted particles having a first diameter D1 with the sorted particles having a second diameter D2 so as to form a particle mixture; (3) applying a vibration to the particle mixture; (4) heating the particle mixture; and (5) delivering the particle mixture through a nozzle or into a mold. The particle diameters D1 and D2 are chosen so that once combined there is optimal close packing of the three-dimensional …
Multidirectional Ecg Coherent Optimal Timing Of Defibrillation Shocks, Abhijit R. Patwardhan, Fabio M. Leonelli
Multidirectional Ecg Coherent Optimal Timing Of Defibrillation Shocks, Abhijit R. Patwardhan, Fabio M. Leonelli
Biomedical Engineering Faculty Patents
A method for of delivering a defibrillation shock to a heart at an optimal time to stop ventricular fibrillation which involves obtaining an electrocardiogram of a heart in at least two directions, determining a time-coherency of the electrocardiogram based upon each of the at least two directions, and computing a tracking function from the time-coherency. An optimal time to apply a defibrillation shock to the heart is determined by locating a local maximum on the tracking function. The method utilizes spacia characteristics of the ventricular fibrillation. The method can be incorporated into implantable cardioverter defibrillators utilizing existing hardware technology.
Method For Reducing The Generation Of Wear Particulates From An Implant, David A. Pienkowski, Kwon-Yong Lee
Method For Reducing The Generation Of Wear Particulates From An Implant, David A. Pienkowski, Kwon-Yong Lee
Biomedical Engineering Faculty Patents
A method is provided for reducing the amount of wear particulates generated by a total joint orthopaedic implant. The implant consists of two matched articulating components wherein at least one of the components is made of polymer or other material with similar physical properties. The method includes the steps of placing the total joint orthopaedic implant in a fluid bath and articulating the implant in the fluid bath for at least 1,000 cycles. The articulation may be performed in three stages. In the first, the implant is articulated under a load of substantially 0.1-500 Newtons with sliding speeds of substantially …
Implant Having Reduced Generation Of Wear Particulates, David A. Pienkowski
Implant Having Reduced Generation Of Wear Particulates, David A. Pienkowski
Biomedical Engineering Faculty Patents
A method is provided for reducing the amount of wear particulates generated by a total joint orthopaedic implant. The implant consists of two matched articulating components. The method includes the steps of placing the total joint orthopaedic implant in a fluid bath and articulating the implant in the fluid bath for at least 1,000 cycles. The articulation may be performed in three stages. In the first, the implant is articulated under a load of substantially 0.1-500 Newtons with sliding speeds of substantially 0.01-0.5 meters per second. During a second stage the articulation takes place under a load of substantially 200-2,500 …
Method For Reducing The Generation Of Wear Particulates From An Implant, David A. Pienkowski
Method For Reducing The Generation Of Wear Particulates From An Implant, David A. Pienkowski
Biomedical Engineering Faculty Patents
A method is provided for reducing the amount of wear particulates generated by a total joint orthopaedic implant. The implant consists of two matched articulating components. The method includes the steps of placing the total joint orthopaedic implant in a fluid bath and articulating the implant in the fluid bath for at least 1,000 cycles. The articulation may be performed in three stages. In the first, the implant is articulated under a load of substantially 0.1-500 Newtons with sliding speeds of substantially 0.01-0.5 meters per second. During a second stage the articulation takes place under a load of substantially 200-2,500 …
Process For Converting Serial Image To The Sterolithography Apparatus (Sla) Slice File With Automatic Base And Support Generation, Charles F. Knapp, P. L. Charles Fischer, Samuel V. Duplessis
Process For Converting Serial Image To The Sterolithography Apparatus (Sla) Slice File With Automatic Base And Support Generation, Charles F. Knapp, P. L. Charles Fischer, Samuel V. Duplessis
Biomedical Engineering Faculty Patents
Method and apparatus for converting a series of serial section images of an object into a three-dimensional model. The method includes acquiring and storing the series of serial section images, converting, zooming, and interpolating serial section images. The method further includes discriminating the series of serial section images to form a binary image, which is then compressed, and filtered. Further, support data for floating or cantilevered portions of the object and base data are generated, the filtered binary image is translated to produce a plurality of vectors representing pixels of the object, and a three-dimensional model of the object is …
Dynamic Childbirth Simulator For Teaching Maternity Patient Care, Charles F. Knapp, George S. Eades
Dynamic Childbirth Simulator For Teaching Maternity Patient Care, Charles F. Knapp, George S. Eades
Biomedical Engineering Faculty Patents
A programmable patient simulator for teaching maternity patient care includes a life size manikin with a pelvis, vaginal canal, uterus, placenta, umbilical cord, and a fetal doll from which heart sounds are emitted. A programmable electro-pneumatic system controls the simulated uterine contractions, position of the uterus, rupture of membranes, expulsion of fetal doll, and fetal heart rate during labor and delivery sequence. The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare.
Dynamic Childbirth Simulator For Teaching Maternity Patient Care, Charles F. Knapp, George S. Eades
Dynamic Childbirth Simulator For Teaching Maternity Patient Care, Charles F. Knapp, George S. Eades
Biomedical Engineering Faculty Patents
A programmable patient simulator for teaching maternity patient care includes a life size manikin with a pelvis, vaginal canal, uterus, placenta, umbilical cord, and a fetal doll from which heart sounds are emitted. A programmable electro-pneumatic system controls the simulated uterine contractions, position of the uterus, rupture of membranes, expulsion of fetal doll, and fetal heart rate during labor and delivery sequence. The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare.
Dynamic Childbirth Simulator For Teaching Maternity Patient Care, Charles F. Knapp, George S. Eades
Dynamic Childbirth Simulator For Teaching Maternity Patient Care, Charles F. Knapp, George S. Eades
Biomedical Engineering Faculty Patents
A programmable patient simulator for teaching maternity patient care includes a life size manikin with a pelvis, vaginal canal, uterus, placenta, umbilical cord, and a fetal doll from which heart sounds are emitted. A programmable electro-pneumatic system controls the simulated uterine contractions, position of the uterus, rupture of membranes, expulsion of fetal doll, and fetal heart rate during labor and delivery sequence. The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare.
Dynamic Childbirth Simulator For Teaching Maternity Patient Care, Charles F. Knapp, George S. Eades
Dynamic Childbirth Simulator For Teaching Maternity Patient Care, Charles F. Knapp, George S. Eades
Biomedical Engineering Faculty Patents
A programmable patient simulator for teaching maternity patient care includes a life size manikin with a pelvis, vaginal canal, uterus, placenta, umbilical cord, and a fetal doll from which heart sounds are emitted. A programmable electro-pneumatic system controls the simulated uterine contractions, position of the uterus, rupture of membranes, expulsion of fetal doll, and fetal heart rate during labor and delivery sequence.