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Full-Text Articles in Engineering
Analyzing Moment Arm Profiles In A Full-Muscle Rat Hindlimb Model, Fletcher Young, Christian Rode, Alexander Hunt, Roger Quinn
Analyzing Moment Arm Profiles In A Full-Muscle Rat Hindlimb Model, Fletcher Young, Christian Rode, Alexander Hunt, Roger Quinn
Mechanical and Materials Engineering Faculty Publications and Presentations
Understanding the kinematics of a hindlimb model is a fundamental aspect of modeling coordinated locomotion. This work describes the development process of a rat hindlimb model that contains a complete muscular system and incorporates physiological walking data to examine realistic muscle movements during a step cycle. Moment arm profiles for selected muscles are analyzed and presented as the first steps to calculating torque generation at hindlimb joints. A technique for calculating muscle moment arms from muscle attachment points in a three-dimensional (3D) space has been established. This model accounts for the configuration of adjacent joints, a critical aspect of biarticular …
Biomechanical Analysis Of Concealed Pack Load Influences On Terrorist Gait Signatures Derived From Gröbner Basis Theory, Sean S. Kohles, Anum Barki, Kimberly D. Kendricks, Ronald F. Tuttle
Biomechanical Analysis Of Concealed Pack Load Influences On Terrorist Gait Signatures Derived From Gröbner Basis Theory, Sean S. Kohles, Anum Barki, Kimberly D. Kendricks, Ronald F. Tuttle
Biology Faculty Publications and Presentations
This project examines kinematic gait parameters as forensic predictors of the influence associated with individuals carrying concealed weighted packs up to 20% of their body weight. An initial inverse dynamics approach combined with computational algebra provided lower limb joint angles during the stance phase of gait as measured from 12 human subjects during normal walking. The following paper describes the additional biomechanical analysis of the joint angle data to produce kinetic and kinematic parameters further characterizing human motion. Results include the rotational velocities and accelerations of the hip, knee, and ankle as well as inertial moments and kinetic energies produced …
Novel Computational Approaches Characterizing Knee Physiotherapy, Wangdo Kim, Antonio P. Veloso, Duarte Araújo, Sean S. Kohles
Novel Computational Approaches Characterizing Knee Physiotherapy, Wangdo Kim, Antonio P. Veloso, Duarte Araújo, Sean S. Kohles
Biology Faculty Publications and Presentations
A knee joint’s longevity depends on the proper integration of structural components in an axial alignment. If just one of the components is abnormally off-axis, the biomechanical system fails, resulting in arthritis. The complexity of various failures in the knee joint has led orthopedic surgeons to select total knee replacement as a primary treatment. In many cases, this means sacrificing much of an otherwise normal joint. Here, we review novel computational approaches to describe knee physiotherapy by introducing a new dimension of foot loading to the knee axis alignment producing an improved functional status of the patient. New physiotherapeutic applications …
Ultrasonic Wave Propagation Assessment Of Native Cartilage Explants And Hydrogel Scaffolds For Tissue Engineering, Sean S. Kohles, Shelley S. Mason, Anya P. Adams, Robert J. Berg, Jessica Blank, Fay Gibson, Johnathan Righetti, Lesha S. Washington, Asit K. Saha
Ultrasonic Wave Propagation Assessment Of Native Cartilage Explants And Hydrogel Scaffolds For Tissue Engineering, Sean S. Kohles, Shelley S. Mason, Anya P. Adams, Robert J. Berg, Jessica Blank, Fay Gibson, Johnathan Righetti, Lesha S. Washington, Asit K. Saha
Mechanical and Materials Engineering Faculty Publications and Presentations
Non-destructive techniques characterising the mechanical properties of cells, tissues, and biomaterials provide baseline metrics for tissue engineering design. Ultrasonic wave propagation and attenuation has previously demonstrated the dynamics of extracellular matrix synthesis in chondrocyte-seeded hydrogel constructs. In this paper, we describe an ultrasonic method to analyse two of the construct elements used to engineer articular cartilage in real-time, native cartilage explants and an agarose biomaterial. Results indicated a similarity in wave propagation velocity ranges for both longitudinal (1500-1745 m/s) and transverse (350-950 m/s) waveforms. Future work will apply an acoustoelastic analysis to distinguish between the fluid and solid properties including …
Manipulation Of Suspended Single Cells By Microfluidics And Optical Tweezers, Nathalie Neve De Mevergnies, Sean S. Kohles, Shelley R. Winn, Derek C. Tretheway
Manipulation Of Suspended Single Cells By Microfluidics And Optical Tweezers, Nathalie Neve De Mevergnies, Sean S. Kohles, Shelley R. Winn, Derek C. Tretheway
Mechanical and Materials Engineering Faculty Publications and Presentations
Chondrocytes and osteoblasts experience multiple stresses in vivo. The optimum mechanical conditions for cell health are not fully understood. This paper describes the optical and microfluidic mechanical manipulation of single suspended cells enabled by the μPIVOT, an integrated micron resolution particle image velocimeter (μPIV) and dual optical tweezers instrument (OT). In this study, we examine the viability and trap stiffness of cartilage cells, identify the maximum fluid-induced stresses possible in uniform and extensional flows, and compare the deformation characteristics of bone and muscle cells. These results indicate cell photodamage of chondrocytes is negligible for at least 20 min for laser …