Engineering Commons^™

Investigating The Combined Effects Of Whole Body Vibration And Vestibular Stimulation On Spasticity And Dystonia In Cerebral Palsy, Peter A. Michael

Dissertations

This study identifies and addresses three voids and potential shortcomings associated with the classification, assessment and management of Cerebral Palsy (CP). These concerns should not undermine the significant advancement that has been made in this specific branch of rehabilitation, but addressing them is necessary. Cerebral Palsy is a group of motor impairments due to hypoxic-ischemic brain damage around the time of birth and very commonly manifests as excessive muscle tone and poor motor control. There are classifications within CP including spasticity and dystonia.

First, a level of discrepancy is present in the classification of CP between the clinical and research …

Comparison Of Longitudinal Changes In Resting State Functional Magnetic Resonance Imaging Between Alzheimer’S And Healthy Controls, Berk Can Yilmaz

Theses

Resting State Functional Magnetic Resonance Imaging (rs-fMRI) is a technique that is widely used for analyzing brain function using different approaches and methods. This study involves rs-fMRI analysis of Blood Oxygenation Level Dependent (BOLD) signals acquired from Alzheimer’s disease (AD) Patients and Healthy Controls (HC). Each subject in the study had both functional and anatomical images with at least one rs-fMRI scan with their Anatomical (T1) scans. Previous rs-fMRI studies have demonstrated that AD shows differences in Amplitude of Low Frequency (<0.1 Hz) Fluctuations (ALFF), and Regional Homogeneity (ReHo) measures according to HCs.

The aim of the study is to investigate individual and group level differences using ReHo and mALFF related …

Towards Practical Homomorphic Encryption And Efficient Implementation, Gyana R. Sahu

Dissertations

Cloud computing has gained significant traction over the past few years and its application continues to soar as evident from its rapid adoption in various industries. One of the major challenges involved in cloud computing services is the security of sensitive information as cloud servers have been often found to be vulnerable to snooping by malicious adversaries. Such data privacy concerns can be addressed to a greater extent by enforcing cryptographic measures. Fully homomorphic encryption (FHE), a special form of public key encryption has emerged as a primary tool in deploying such cryptographic security assurances without sacrificing many of the …

Microglia Induced Neuroinflammation Through The Nlrp3 Inflammasome Following Blast Traumatic Brain Injury, Daniel Younger

Dissertations

The incidence of traumatic brain injury (TBI) among military personnel have been steadily increasing with modern conflicts. A recent RAND report estimated 320,000 service members, totaling 20% of deployed forces, suffer from TBI. However, of this population roughly 60% have not seen a medical professional specifically for TBI. Unlike the civilian population, the primary cause of TBI for active-duty military personnel is blast exposure. Blasts now account for over 70% of all US military casualties in operation Iraqi Freedom (OIF) and Operation enduring freedom (OEF) and are the major cause of TBI. Among many pathological mechanisms associated with blast TBI, …

Biomechanical Loading Changes Between Species In Mild Blast-Induced Traumatic Brain Injury, Jose Juan Rodriguez

Dissertations

Blast-induced traumatic brain injury (bTBI) has become one of the leading injury modalities in military personnel and is considered a signature injury in veterans returning from conflicts in the Middle East. One of the main concerns in studying bTBI is translating animal experiments to clinical applications that can service veterans. Significant advances have been made using animal models in relating external shock waves to emerging neuropathophysiological and behavioral outcomes. However, it is unknown if these results are applicable to humans; and if so, can an interspecies transfer function be developed based on size, shape, and material response. This work aims …

A Model For Thermal Diffusion And Local Tissue Damage From The Measurement Of Temperature In Electrosurgical Incision, Marek Vira

Theses

The extremely high temperatures applied over extremely short time intervals that are characteristic of electrosurgery result in a unique tissue damage pattern. Cesarean delivery and hysterectomy, the two most frequently performed procedures in obstetrics and gynecology (OB/GYN), commonly employ electrosurgical incision. While it is controversial, it has been suggested that tissue damage produced by electrosurgery could increase surgical site infection rates. While recommendations for the settings in the use of the electrosurgical unit do exist, there is no current technique for real time assessment of the viability of tissue around the site of the electrosurgical incision. Current methods for analyzing …

Error Correction For Asynchronous Communication And Probabilistic Burst Deletion Channels, Chen Yi

Dissertations

Short-range wireless communication with low-power small-size sensors has been broadly applied in many areas such as in environmental observation, and biomedical and health care monitoring. However, such applications require a wireless sensor operating in "always-on" mode, which increases the power consumption of sensors significantly. Asynchronous communication is an emerging low-power approach for these applications because it provides a larger potential of significant power savings for recording sparse continuous-time signals, a smaller hardware footprint, and a lower circuit complexity compared to Nyquist-based synchronous signal processing.

In this dissertation, the classical Nyquist-based synchronous signal sampling is replaced by asynchronous sampling strategies, i.e., …

Studies Of Two-Phase Flow With Soluble Surfactant, Ryan Peter Atwater

Dissertations

Numerical methods are developed for accurate solution of two-phase flow in the zero Reynolds number limit of Stokes flow, when surfactant is present on a drop interface and in its bulk phase interior. The methods are designed to achieve high accuracy when the bulk Péclet number is large, or equivalently when the bulk phase surfactant has small diffusivity

In the limit of infinite bulk Péclet number the advection-diffusion equation that governs evolution of surfactant concentration in the bulk is singularly perturbed, indicating a separation of spatial scales. A hybrid numerical method based on a leading order asymptotic reduction in this …

Computational Modeling Of Recycled Aggregate Concrete Systems, Anuruddha Jayasuriya

Dissertations

Using recycled concrete aggregates (RCA) as a substitution in concrete materials is an excellent way to improve the sustainability of concrete production. However, due to a lack of globally accepted technical guidance, and high material variability, the usage of recycled aggregate concrete (RAC) systems is not readily practiced within most structural engineering applications.

To date, the majority of the experimental findings in the literature indicate that RAC is a weaker composite material when compared to a natural aggregate concrete system in terms of mechanical properties such as compressive strength, elastic modulus, tensile strength, flexural strength, fracture energy, and toughness. However, …

Compound Flooding In Coastal Areas Emanating From Inland And Offshore Events, Hamed Behzad Koochaksaraii

Dissertations

The vulnerability of urban populations to natural hazards and climate change is a major theme in many reports on coastal cities with flooding ranking highly among the climate change concerns. Flooding could occur as a result of runoff for inland rainfall that accumulates at the mouth of the estuary to the sea or it could occur due to a storm surge emanating from the ocean. The techniques for modeling the flooding from these events are very different, as they were developed in different scientific fields: hydrology and hydraulic engineering for inland rainfall versus coastal oceanography and coastal engineering for offshore …

Stress-State And Injection-Rate Dependent Damage Processes During The Hydraulic Fracturing Of Granite, Gayani Sasendrika Gunarathna

Dissertations

Hydraulic fracturing is a well-stimulation technique that is employed in field applications, such as enhanced geothermal systems (EGS) and shale oil/gas extraction. This research experimentally investigates the effect of the state of stress and injection rate on the hydraulic fracturing processes. In addition, a displacement discontinuity method (DDM) code, FROCK, is used to model the crack initiation and propagation in a granite specimen under hydraulic fracturing conditions. In order to conduct the experimental work, a test setup capable of applying a triaxial state of stress and water pressure inside pre-fabricated flaws cut in prismatic granite specimens is developed. Additionally, the …

Modeling Single Microtubules As A Colloidal System To Measure The Harmonic Interactions Between Tubulin Dimers In Bovine Brain Derived Versus Cancer Cell Derived Microtubules, Arooj Aslam

Dissertations

The local properties of tubulin dimers dictate the properties of the larger microtubule assembly. In order to elucidate this connection, tubulin-tubulin interactions are be modeled as harmonic interactions to map the stiffness matrix along the length of the microtubule. The strength of the interactions are measured by imaging and tracking the movement of segments along the microtubule over time, and then performing a fourier transform to extract the natural vibrational frequencies. Using this method the first ever reported experimental phonon spectrum of the microtubule is reported. This method can also be applied to other biological materials, and opens new doors …

Modulation Of Cerebellar Purkinje Cell Activity With Low Intensity Electric And Ultrasound Stimulation, Ahmet S. Asan

Dissertations

Non-invasive brain stimulation (NIBS) techniques garner significant interest due to their potential to offer instantaneous and region-specific treatments to neurological disorders. The cerebellum is one of the target sites for NIBS methods due to its central role in motor and cognitive functions. Among several modulation techniques, transcranial electric stimulations (tEs), in particular, transcranial direct and alternating current stimulations (tDCs/tACs), and low intensity focused ultrasound stimulation (LIFUS) show encouraging outcomes in clinical applications. tDCs and tACs are favored due to their low cost and accessibility while LIFUS offers high spatial resolution and deeper penetration without affecting the surrounding structures. In order …

Subspace Portfolios: Design And Performance Comparison, Anqi Xiong

Dissertations

Data processing and engineering techniques enable people to observe and better understand the natural and human-made systems and processes that generate huge amounts of various data types. Data engineers collect data created in almost all fields and formats, such as images, audio, and text streams, biological and financial signals, sensing and many others. They develop and implement state-of-the art machine learning (ML) and artificial intelligence (AI) algorithms using big data to infer valuable information with social and economic value. Furthermore, ML/AI methodologies lead to automate many decision making processes with real-time applications serving people and businesses. As an example, mathematical …

Efficient Hardware Implementations Of Bio-Inspired Networks, Anakha Vasanthakumaribabu

Dissertations

The human brain, with its massive computational capability and power efficiency in small form factor, continues to inspire the ultimate goal of building machines that can perform tasks without being explicitly programmed. In an effort to mimic the natural information processing paradigms observed in the brain, several neural network generations have been proposed over the years. Among the neural networks inspired by biology, second-generation Artificial or Deep Neural Networks (ANNs/DNNs) use memoryless neuron models and have shown unprecedented success surpassing humans in a wide variety of tasks. Unlike ANNs, third-generation Spiking Neural Networks (SNNs) closely mimic biological neurons by operating …

Mechanical Characterization Of Animal Derived Starting Materials For Tissue Engineering, Bin Zhang

Dissertations

Animal derived starting materials are well established in the production of Tissue Engineered Medical Devices. Porcine specifically can be found in products ranging in application from hernia repair to breast reconstruction. Although this material has been largely accepted in the Tissue Engineering industry, little is known of its material properties and mechanical characteristics. A review of the scientific literature describes limited mechanical measures only on uncontrolled research grade material. The objective of this work is to mechanically characterize porcine starting material used in the medical device industry. Porcine skin is provided by Midwest Research Swine, LLC (MRS) an established supplier …

Communications With Spectrum Sharing In 5g Networks Via Drone-Mounted Base Stations, Liang Zhang

Dissertations

The fifth generation wireless network is designed to accommodate enormous traffic demands for the next decade and to satisfy varying quality of service for different users. Drone-mounted base stations (DBSs) characterized by high mobility and low cost intrinsic attributes can be deployed to enhance the network capacity. In-band full-duplex (IBFD) is a promising technology for future wireless communications that can potentially enhance the spectrum efficiency and the throughput capacity. Therefore, the following issues have been identified and investigated in this dissertation in order to achieve high spectrum efficiency and high user quality of service.

First, the problem of deploying DBSs …

Scanless Optical Coherence Tomography For High-Speed 3d Biomedical Microscopy, Yahui Wang

Dissertations

Optical coherence tomography (OCT) is a high-resolution cross-sectional imaging modality that has found applications in a wide range of biomedical fields, such as ophthalmology diagnosis, interventional cardiology, surgical guidance, and oncology. OCT can be used to image dynamic scenes, in quantitative blood flow sensing and visualization, dynamic optical coherence elastography, and large-scale neural recording. However, the spatiotemporal resolution of OCT for dynamic imaging is limited by the approach it takes to scan the three-dimensional (3-D) space. In a typical OCT system, the incident light is focused to a point at the sample. The OCT system uses mechanical scanners (galvanometers or …

Identification Of Neurobiological Mechanisms Associated With Attention Deficits In Adults Post Traumatic Brain Injury, Ziyan Wu

Dissertations

Traumatic Brain Injury (TBI) is one of the major public health concerns with approximately 70 million new cases occurring worldwide per year. It is often caused by a forceful bump, blow, or jolt to the head, resulting in brain tissue damage and normal brain functions disruption. All grades of TBI, ranging from mild to severe, can cause wide-ranging and long-term effects on affected individuals, resulting in physical impairments, and neurocognitive consequences that permanently affect their abilities to perform daily activities. Attention deficits are the most common persisting neurocognitive consequences following TBI, which significantly contribute to poor academic and social functioning, …

Numerical And Analytical Methods To Predict Behavior Of Reinforced Ductile Concrete Composites, Mandeep Pokhrel

Dissertations

Structural components constructed with ductile concrete composites, such as high-performance fiber-reinforced cementitious composites (HPFRCC), are known to perform exceptionally well under extreme mechanical and environmental loading conditions compared to traditional concrete. HPFRCC flexural components exhibit enhanced performance in terms of displacement ductility, energy dissipation capacity, and damage tolerance capacity. However, recent research suggests that the flexural behavior of reinforced HPFRCCs in terms of crack progression, reinforcement plasticity, and failure mechanism is significantly different than conventional reinforced concrete. Specifically, the failure mode of flexural members is found to be predominantly through the fracture of longitudinal reinforcement rather than compression crushing of …

Coding Against Stragglers In Distributed Computation Scenarios, Malihe Aliasgari

Dissertations

Data and analytics capabilities have made a leap forward in recent years. The volume of available data has grown exponentially. The huge amount of data needs to be transferred and stored with extremely high reliability. The concept of "coded computing", or a distributed computing paradigm that utilizes coding theory to smartly inject and leverage data/computation redundancy into distributed computing systems, mitigates the fundamental performance bottlenecks for running large-scale data analytics.

In this dissertation, a distributed computing framework, first for input files distributedly stored on the uplink of a cloud radio access network architecture, is studied. It focuses on that decoding …

Calculating Elastic Properties Of Confined Simple Fluids, Christopher D. Dobrzanski

Dissertations

Confinement in nanoporous materials is known to affect many properties of the fluids confined within their pores. The elastic properties are no exception. This dissertation begins with an overview of the relevant literature on ways of obtaining elastic properties of confined fluids. It outlines some fundamental gaps in our understanding. The chapters following address some of these gaps in understanding elastic properties of the confined fluid, in particular, how the shape of the confining pore matters, how supercriticality effects the properties, how an equation of state designed for confined fluids can be used to calculate elastic properties, and if an …

Neurobiological Markers For Remission And Persistence Of Childhood Attention-Deficit/Hyperactivity Disorder, Yuyang Luo

Dissertations

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders in children. Symptoms of childhood ADHD persist into adulthood in around 65% of patients, which elevates the risk for a number of adverse outcomes, resulting in substantial individual and societal burden. A neurodevelopmental double dissociation model is proposed based on existing studies in which the early onset of childhood ADHD is suggested to associate with dysfunctional subcortical structures that remain static throughout the lifetime; while diminution of symptoms over development could link to optimal development of prefrontal cortex. Current existing studies only assess basic measures including regional brain activation …

The Impact Of Conversion On The Durability Of Calcium Aluminate Cement Concrete Systems, Marwa Mohsen Korayem

Dissertations

The deterioration of infrastructure in North America has resulted in a significant need for concrete repair materials that can be used to maintain service life of these structures. Hydraulic cement based rapid repair materials can be used to repair pavement and bridge deterioration with minimal impact on economic activities such as freight handling or public transportation. While there are many options for use in repair situations, calcium aluminate cements have become more popular recently, particularly in situations where repairs must be completed rapidly.

Calcium aluminate cement (CAC) is a cement characterized by its rapid strength gain, even at low temperatures …

Deep Learning For Quantitative Motion Tracking Based On Optical Coherence Tomography, Peter Abdelmalak

Theses

Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. OCT has been widely used in diagnostic ophthalmology and has found applications in other biomedical fields such as cancer detection and surgical guidance.

In the Laboratory of Biophotonics Imaging and Sensing at New Jersey Institute of Technology, we developed a unique needle OCT imager based on a single fiber probe for breast cancer imaging. The needle OCT imager with sub-millimeter diameter can be inserted into tissue for minimally invasive in situ breast imaging. OCT imaging provides spatial resolution similar to histology and has the potential …

Model-Based Deep Siamese Autoencoder For Clustering Single Cell Rna-Seq Data, Zixia Meng

Theses

In the biological field, the smallest unit of organisms in most biological systems is the single cell, and the classification of cells is an everlasting problem. A central task for analysis of single-cell RNA-seq data is to identify and characterize novel cell types. Currently, there are several classical methods, such as K-means algorithm, spectral clustering, and Gaussian Mixture Models (GMMs), which are widely used to cluster the cells. Furthermore, typical dimensional reduction methods such as PCA, t-SNE, and ZIDA have been introduced to overcome “the curse of dimensionality”. A more recent method scDeepCluster has demonstrated improved and promising performances in …

Recovery Of Valuable Metals From Spent Lithium-Ion Batteries Using Organic Acids: Assessment Of Technoeconomic Feasibility, Leqi Lin

Theses

Lithium ion batteries (LIBs) are used in diverse electronic products with anticipated over 500 thousand tonnes of the waste LIBs globally in 2020. To protect the environment and also recover valuable materials such as lithium (Li) and cobalt (Co), our research employed a hydrometallurgy method and demonstrated that exposure of spent LIBs to Organic Aqua Regia (OAR) could leach Li and Co without the pre-separation of cathode from Al foil using organic solvents such as Dimethylformamide (DMF) and N-Methyl-2-pyrrolidone (NMP). The leaching efficiency of 99% and 94% for Li and Co were obtained with a leaching rate of 0.021, 0.167 …

Enhanced Removal Of Perfluorooctanoic Acid (Pfoa) Via Microwave-Fenton-Reactive Membrane Filtration, Fangzhou Liu

Theses

Perfluorooctanoic Acid (PFOA), one of the common per- and poly fluorinated alkylated substances (PFASs), is increasingly detected in the environment due to the diverse industrial applications and high resistance to degradation processes. This study evaluated degradation of PFOA in microwave-assistant catalytic membrane filtration, a process that integrates microwave catalytic reactions into a ceramic membrane filtration. First, water permeation of the pristine and catalyst-coated membranes were examined under the influence of microwave irradiation to analyse the impacts of the coating layer and water temperature increase on permeate flux, which were well interpreted by three models. Then, the PFOA removal was first …

An Information Theoretic Approach To Assess Perceived Audio Quality Using Eeg With Reduced Number Of Electrodes, Sansit Das

Theses

Electroencephalograph(EEG) is a process mainly used in medical and research fields to study the electrical activities in a brain. In this technique, 128 or 256 electrodes are attached to the scalp and the electrical activities of the human brain is recorded with the help of a software. In the global scenario, the EEG responses are studied and analysed to acknowledge any disorders in the brain, such as epilepsy or head injury.

Recent studies performed by researchers, have focused on analysing these electrical activities to access perceived audio quality from users by using information theoretic approaches, such as mutual information. Experiments …

Spectral 3d Reconstruction Based On Macroscopic Oct Imaging, Xingyu Zhou

Theses

Various optical technologies have been utilized to improve art conservation by art conservators, such as laser triangulation, stereophotogrammetry, structured light, laser scanner and time of flight sensors. These methods have been deployed to capture the 3D or surface topography information of sculptures and architectures. Optical coherence tomography (OCT) has introduced new imaging methods to study the surface features and subsurface structures of delicate cultural heritage objects. However, despite its higher spatial resolution, the field of view (FOV) of OCT severely limits the size of the scanning area and does not allow macroscopic examination. To solve this issue, we develop and …