Engineering Commons^™

Scanless Optical Coherence Tomography For High-Speed 3d Biomedical Microscopy, Yahui Wang

Dissertations

Optical coherence tomography (OCT) is a high-resolution cross-sectional imaging modality that has found applications in a wide range of biomedical fields, such as ophthalmology diagnosis, interventional cardiology, surgical guidance, and oncology. OCT can be used to image dynamic scenes, in quantitative blood flow sensing and visualization, dynamic optical coherence elastography, and large-scale neural recording. However, the spatiotemporal resolution of OCT for dynamic imaging is limited by the approach it takes to scan the three-dimensional (3-D) space. In a typical OCT system, the incident light is focused to a point at the sample. The OCT system uses mechanical scanners (galvanometers or …

Deep Learning For Quantitative Motion Tracking Based On Optical Coherence Tomography, Peter Abdelmalak

Theses

Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. OCT has been widely used in diagnostic ophthalmology and has found applications in other biomedical fields such as cancer detection and surgical guidance.

In the Laboratory of Biophotonics Imaging and Sensing at New Jersey Institute of Technology, we developed a unique needle OCT imager based on a single fiber probe for breast cancer imaging. The needle OCT imager with sub-millimeter diameter can be inserted into tissue for minimally invasive in situ breast imaging. OCT imaging provides spatial resolution similar to histology and has the potential …