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Articles 91 - 96 of 96
Full-Text Articles in Engineering
A New Method And Python Toolkit For General Access To Spatiotemporal N-Dimensional Raster Data, Riley Chad Hales
A New Method And Python Toolkit For General Access To Spatiotemporal N-Dimensional Raster Data, Riley Chad Hales
Theses and Dissertations
Scientific datasets from global-scale scientific models and remote sensing instruments are becoming available at greater spatial and temporal resolutions with shorter lag times. These data are frequently gridded measurements spanning two or three spatial dimensions, the time dimension, and often several data dimensions which vary by the specific dataset. These data are useful in many modeling and analysis applications across the geosciences. Unlike vector spatial datasets, raster spatial datasets lack widely adopted conventions in file formats, data organization, and dissemination mechanisms. Raster datasets are often saved using the Network Common Data Format (NetCDF), Gridded Binary (GRIB), Hierarchical Data Format (HDF), …
Engineering Cell-Free Protein Expression Systems For Biotherapeutics And Biosensing, John Porter Hunt
Engineering Cell-Free Protein Expression Systems For Biotherapeutics And Biosensing, John Porter Hunt
Theses and Dissertations
Therapeutic proteins have become a cornerstone of modern medicine since the FDA approval of recombinant human insulin in 1982. Likewise, biosensors transform chemical detection and disease diagnostics by identifying biomarkers, chemical contaminants, and infective agents. Long-standing methods for creating therapeutics and biosensors employ whole cells such as Escherichia coli (E. coli). Alternatively, cell-free protein synthesis (CFPS) employs the enzymatic reactions necessary for protein production and biosensing within a cell, but in an engineered reactor environment facilitating unprecedented access to and control over biochemical machinery, preservation by cryodesiccation for portable deployment, and functionality in cytotoxic applications. This dissertation reports advances in …
Evaluation Of Concrete Bridge Decks Comprising Twisted Steel Micro Rebar, Aubrey Lynne Hebdon
Evaluation Of Concrete Bridge Decks Comprising Twisted Steel Micro Rebar, Aubrey Lynne Hebdon
Theses and Dissertations
The objective of this research was to investigate the effects of twisted steel micro rebar (TSMR) fibers on 1) the mechanical properties of concrete used in bridge deck construction and 2) the early cracking behavior of concrete bridge decks. This research involved the evaluation of four newly constructed bridge decks through a series of laboratory and field tests. At each location, one deck was constructed using a conventional concrete mixture without TSMR, and one was constructed using the same conventional concrete mixture with an addition of 40 lb of TSMR per cubic yard of concrete. Regarding laboratory testing, the conventional …
Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith
Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith
Theses and Dissertations
Proteins that have been modified by attaching them to a surface or to a polyethylene glycol (PEG) molecule can see many uses in therapeutics and diagnostics -- these unique proteins are called protein devices. Current techniques can perform these functionalizations at a specific residue on the protein, but what remains is identifying what happens to protein structure when mutated, and where to perform the attachment. Both of these issues can be examined using molecular dynamic (MD) simulations. Currently, simulations of the unnatural amino acid (uAA) mutations necessary for protein device functionalization cannot be executed, and full-protein screens of all possible …
Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith
Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith
Theses and Dissertations
Proteins that have been modified by attaching them to a surface or to a polyethylene glycol (PEG) molecule can see many uses in therapeutics and diagnostics -- these unique proteins are called protein devices. Current techniques can perform these functionalizations at a specific residue on the protein, but what remains is identifying what happens to protein structure when mutated, and where to perform the attachment. Both of these issues can be examined using molecular dynamic (MD) simulations. Currently, simulations of the unnatural amino acid (uAA) mutations necessary for protein device functionalization cannot be executed, and full-protein screens of all possible …
Effects Of Static And Dynamic Thermal Gradients In Gas Chromatography, Samuel Avila
Effects Of Static And Dynamic Thermal Gradients In Gas Chromatography, Samuel Avila
Theses and Dissertations
Gas chromatography (GC) is an analytical chemistry tool used to determine the chemical composition of a gas sample by separating sample analytes as they travel through a GC column. Recent efforts have been made to understand and control gas chromatography separations with a negative thermal gradient on the column. The present work presents results from thermal gradient GC separations on two GC columns in different configurations (serpentine and radial) in a stainless-steel plate. Methods to fabricate the GC systems capable of isothermal, temperature programmed and thermal gradient separations are presented. Isothermal experimental data from the serpentine column were used to …