Engineering Commons^™

Development And Evaluation Of A Modeling Platform For Evaluating Immunotherapeutic Efficacy In The Tumor Microenvironment., Dylan Andrew Goodin

Electronic Theses and Dissertations

The tumor microenvironment (TME) represents the complex outcome of numerous tumor, stromal, and immune interactions, and whose composition can significantly affect treatment response. Particularly, immunotherapeutic efficacy is subject to multiple tumor-specific TME interactions that may be difficult to evaluate/predict clinically. Mathematical modelling has been formulated to evaluate specific aspects of the TME, including vasculature, ECM deposition, and immune-tumor interactions. However, the computational challenge of simulating multiple TME interactions has led to sacrificing varying degrees of model generalizability and clinical relevance. This work describes increased computational performance of a 3D continuum model that simulates tumor tissue, ECM, and vasculature using a …

Smart Manufacturing Of Cement: From Lab-Scale Simulation And Testing To Industry-Scale Deployment., Juan David Tabares Tamayo

Electronic Theses and Dissertations

Cement kilns are controlled by experienced process operators who follow experience-based industry guidelines using data collected and fundamental knowledge. The manufacturing process, which is equipped with sensors and equipment, transfers data/information to the operators to aid standardized decision-making operations. In contrast, companies have used such data to develop and implement digital solutions for predictive control systems; in effect, FLSmidth and Rockwell Automation. However, despite the availability of automated control systems and investigation in automation for process monitoring and optimization, opportunities to radically optimize cement manufacturing are still abundant and in need of implementation. Therefore, this research developed simulation models and …

Electrokinetic Particle Trapping Performance Of Conductive Nanofiber Mats In Microfluidic Wells., Jacob Hunter West

Electronic Theses and Dissertations

The frequency dependence of electrokinetic particle trapping using large-area (>mm²) conductive carbon nanofiber (CNF) mat electrodes is investigated. The fibers provide nanoscale geometric features for the generation of high electric field gradients, which is necessary for particle trapping via dielectrophoresis (DEP). A device was fabricated with an array of microfluidic wells for repeated experiments; each well included a CNF mat electrode opposing an aluminum electrode. Fluorescent microspheres (1 µm) were trapped at various electric field frequencies between 30 kHz – 1 MHz. Digital images of each well were analyzed to quantify particle trapping. DEP trapping by the …

Context Dependent Training Data Selection For Automatic Target Detection., Tylman Michael

Electronic Theses and Dissertations

An Automatic Target Detection (ATD) algorithm is capable of identifying the location of targets of interest captured by Infra-Red imagery in vastly different contexts. ATD is often a precursor in a 2-stage methodology in order to ascertain the location and nature of a target in both military and civilian applications. In order to train an ATD algorithm, a large amount of data from varied sources is required. One drawback of this requirement is that some sources of data may harm the performance of the method in different contexts. This thesis explores utilizing an unsupervised method to identify a subset of …

Fly Ash Based Geopolymer: Water, Curing Temperature And, Cao Content Effects On Microstructure And Compressive Strength., Lujain Salem

Electronic Theses and Dissertations

Geopolymer, an emerging alternative to Portland cement-based concrete, relies on alumina and silica-rich precursors like fly ash for its formation. Geopolymerization is a chemical process that creates a three-dimensional polymer network by reacting with an alkaline activator. While fly ash's calcium oxide (CaO) content is crucial in its classification, it behaves differently in geopolymerization, where it competes with hydration. Therefore, a better understanding of the impact of CaO content in fly ash on geopolymerization is needed to effectively utilize fly ash. This study investigates the effects of CaO content, water, and curing temperature on geopolymerization. Using fly ash from a …

Novel Designs Of Soft Tactile Sensor And Robot Finger Manipulator Based On Optical Fibers., Seokyoung Han

Electronic Theses and Dissertations

Robotic manipulation is one of the main types of automated labor that humans want to achieve in order to free ourselves from mundane and hazardous tasks. The range of realizations could be very broad, from massive industrial robots to highly advanced medical devices for human healthcare. Given the critical nature of these application spaces, they require robust, safe, and most of all versatile designs. In that direction, one of the most interesting topics is the anthropomorphic robotic manipulator. Since it is inspired by human hands’ function and structure, it is able to achieve the aforementioned system requirements. However, the perfect …

A Design Science And Implementation Framework For Studying Interruptions And Its Application In A Dental Clinic., Carsten Ziegler

Electronic Theses and Dissertations

Interruptions during dental treatment are frequent, and often have detrimental effects on quality of care, patient safety and processing times, and have an impact on provider satisfaction and performance. Interruptions can significantly increase the cognitive load on dental providers, making it hard for them to concentrate on complex procedures. Frequent interruptions also disrupt the workflow in general, leading to delays in treatment, which can reduce the overall throughput of a clinic. Unfortunately, there is no comprehensive approach to collectively (i) analyze interruptions in dental healthcare, (ii) design an intervention, and (iii) implement and sustain it. This research proposes a comprehensive …

Teacher Identity Matters: The Influence Of Identity On Student/Teacher Relationships And Special Education Student Performance., Nada Baili

Electronic Theses and Dissertations

For over a decade, Deep Neural Networks (DNNs) have been rapidly progressing and achieving great success, forming a robust foundation of state of the art machine learning algorithms that impacted various domains. The advances in data acquisition and processing have undeniably played a major role in these breakthroughs. Data is a crucial component in building successful DNNs, as it enables machine learning models to optimize complex architectures, necessary to perform certain difficult tasks. However, acquiring large-scale data sets is not enough to learn robust models with generalizable features. Instead, an ideal training set should be diverse enough and contain enough …

Multithreaded Applications On The Heterogeneous Research Computing Environment., Sungbo Jung

Electronic Theses and Dissertations

Bioinformatics is a domain that has experienced rapid research growth in recent years, as evidenced by the increasing number of articles in biomedical databases such as PubMed, which adds over a million publications every year. However, this also poses a challenge for researchers who need to find relevant citations for their work. Therefore, developing efficient indexing and searching methods for text data is crucial for Bioinformatics. One key technique for information retrieval is document inversion, which involves creating an inverted index to enable efficient searching through vast collections of text or documents. This Ph.D. research aims to design the research …

Rockin’ Rehab: Novel Rocking Chair For Children With Spinal Cord Injury To Enable Trunk Muscle Activation And Detect Muscle Activation Patterns., Johnathan Jay George

Electronic Theses and Dissertations

Introduction: Activity-based locomotor training improves trunk control in children with spinal cord injury (SCI), and there is need for additional activities to allow these children to activate trunk muscles. The purpose of this research was to design, fabricate, and evaluate a rocking chair for children with SCI, and to investigate the activation of muscles during use. Sensorization of the chair to confirm muscle activation is also explored. Methods: Quality Function Deployment (QFD) design methodologies identified and ranked needs and features for the rocking chair. A design was developed and evaluated via finite element analysis. The chair was fabricated and tested …

Quantifying Impacts Of Climate Change On Headwater Streamflow Regime In Robinson Forest: Insights From 35-Years Of Data Collection., Lauren Brown

Electronic Theses and Dissertations

Climate change may shift patterns of streamflow permanence in headwater systems by altering the frequency, magnitude, duration, timing, and rate of change of surface streamflow, impacting both local ecosystems as well as regional water budgets and availability. While much uncertainty surrounds modeling-based methods to quantify the impacts of climate change on water budgets, long-term hydrologic data collected from headwaters in experimental research forests serve as critical evidence to reduce such uncertainty. The objective of this study is to quantify shifts in frequency, magnitude, duration, timing, and rate of change of streamflow in two headwater catchments with relatively little recent disturbance …

Synergistic Strategies In Sinter-Based Material Extrusion (Mex) 3d Printing Of Copper: Process Development, Product Design, Predictive Maps And Models., Kameswara Pavan Kumar Ajjarapu

Electronic Theses and Dissertations

3D printing pure copper with high electrical conductivity and exceptional density has long been challenging. While laser-based additive manufacturing technologies suffered due to copper's highly reflective nature towards laser beams, parts printed via binder-assisted technologies failed to reach over 90% IACS (International Annealed Copper Standard), electrical conductivity. Although promising techniques such as binder jetting, filament, and pellet-based 3D printing that can print copper exist, they however still face difficulties in achieving both high sintered densities and electrical conductivity values. This is due to a lack of comprehensive understanding of property evolution from green to sintered states and the strategies that …

Quantification Of Tumor Biophysical Heterogeneity Through Mechanical And Ultrastructural Analysis., Bradley James Mahaffey

Electronic Theses and Dissertations

Glioblastoma (GBM) is a highly invasive, aggressive brain cancer that carries a median survival of 15 months. This poor prognosis is due, in part, to its resistance to standard therapeutic intervention. Recent studies have demonstrated that tumor heterogeneity plays a critical role in facilitation therapy resistance by mediating tumor adaptation through microenvironmental cues. Efforts to describe these microenvironmental differences may aid in the development of strategies to combat resistance. GBM can be separated into two distinct regions – a core and a rim, which are thought to drive specific aspects of tumor evolution. The core is proliferative as evidenced by …

Automated Usability Evaluation Utilizing Log Files And Data Mining Techniques., Sima Shafaei

Electronic Theses and Dissertations

Usability evaluation is one of the essential aspects of software production. This evaluation should be done during the entire life cycle of a software application, from pre-production to production and post-production. However, the collection and evaluation of usability data can be a very challenging, time-consuming, and expensive task to be conducted manually, particularly for certain types of products and working conditions. These challenges may include the need to recruit participants fully engage and motivate them during evaluation, and factor in environmental conditions. Other challenges may include collecting data in real-world environments, especially when the users are geographically dispersed, minimizing evaluator …

A Modular Framework For Surface-Embedded Actuation And Optical Sensing In Soft Robots., Paul Bupe Jr

Electronic Theses and Dissertations

This dissertation explores the development and integration of modular technologies in soft robotics, with a focus on the OptiGap sensor system. OptiGap serves as a simple, flexible, cost-effective solution for real-time sensing of bending and deformation, validated through simulation and experimentation. Working as part of an emerging category of soft robotics called Soft, Curved, Reconfigurable, Anisotropic Mechanisms, or SCRAMs, this research also introduces the Thermally-Activated SCRAM Limb (TASL) technology, which employs shape-memory alloy (SMA) wire embedded in curved sheets for surface actuation and served as the initial inspiration for OptiGap. In addition, the EneGate system is presented as a complementary …

A Study Of Group Effectiveness In A Virtual Reality Environment., Dalton Clay Sparks

Electronic Theses and Dissertations

Virtual Reality (VR) technology has revolutionized the study of team effectiveness, yet many studies in this domain lack a comprehensive approach, focusing narrowly on performance metrics. This thesis investigates VR team effectiveness by integrating traditional Team Effectiveness frameworks with VR-specific dynamics. Utilizing Data Envelopment Analysis (DEA) and Group Style Inventory (GSI), this study assesses teams within a VR environment, specifically a multiplayer submarine simulation game, IronWolfVR. Fifteen groups, totaling 45 participants, were observed for their collaborative gameplay, incorporating physiological measures (Heart Rate and Electrodermal Activity), team coordination dynamics, and various survey-based assessments (demographics, System Usability Scale, Simulator Sickness Questionnaire, and …

Investigating Mems Devices In Flow Conditions Relevant To Flow-Through Systems., Mohammad Shafquatul Islam

Electronic Theses and Dissertations

Advancements in microscale actuating technologies has substantially expanded the possibilities of interacting with the surrounding environment. Microstructures that deflect in response to mechanical forces are one of the largest application areas of microelectromechanical systems (MEMS). MEMS devices, functioning as sensors, actuators, and support structures, find applications in inertial sensors, pressure sensors, chemical sensors, and robotics, among others. Driven by the critical role of catalytic membrane reactors, this dissertation aims to evaluate enzyme activity on polymeric membranes and explore how fabrication methods from the field of Electrical and Computer Engineering (ECE) can incorporate sensing and actuation into these porous surfaces. Toward …

Adaptive Personalized Drug Delivery Method For Warfarin And Anemia Management: Modeling And Control., Affan Affan

Electronic Theses and Dissertations

Personalized precision medicine aims to develop the appropriate treatments for suitable patients at the right time to obtain optimal results. Personalized medicine is challenging due to inter- and intra-patient variability, narrow therapeutic window, the effect of other medications, comorbidity (more than one disease at a time), nonlinear patient dynamics, and time-varying patient dose response characteristics which include bleeding (internal and external). This research aims to develop a framework for an adaptive personalized modeling and control method with minimum clinical patient specific dose response data for optimal drug dosing. The proposed methodology is applied to anemia and warfarin management. It is …

Design, Fabrication, And Integration Of Robotic Skin Sensors For Human Robot Interaction., Olalekan Olakitan Olowo

Electronic Theses and Dissertations

Enhancing physical human-robot interaction in modern robotics relies on refining the tactile perception of robot skin sensors. This research focuses on crucial aspects of the development process, including fabrication techniques, miniaturization, and integration for a more efficient collaborative human-robot interface. The fabrication process of robot skin sensors, designed to mimic human skin, is explored both within and outside cleanroom environments. An enhanced technique is presented to increase fabrication yield and create more miniaturized sensor designs with feature sizes in the tens of microns. These sensors function as piezoresistive arrays using organic polymers like PEDOT: PSS as the pressure-sensing medium. Various …

Novel Breath Collection Techniques For Detection Of Covid-19., James Morris

Electronic Theses and Dissertations

Volatile Organic Compounds (VOC) generated endogenously in the human body can be used to detect diseases that induce oxidative stress and inflammation. Breath analysis has been used for the detection of diseases such as COPD, Depression, Lung Cancer and most recently COVID-19. Methods such as Exhaled Breath Condensate (EBC), Sorbent Tubes, Solid Phase Microextraction (SPME), and silicon microreactors have shown considerable capability in extracting and concentrating trace VOC’s present in human breath. Silicon microreactors functionalized with capture agents to derivatize carbonyl compounds are effective but the overall maximum flow rate of breath sample possible during analysis is low, making direct …

Visibility Based Hospital Inpatient Unit Design., Uttam Karki

Electronic Theses and Dissertations

Patient fall is one of the adverse events in an inpatient unit of a hospital that can lead to disability and/or mortality. Healthcare literature suggests that increased visibility of patients by unit nurses is essential to improve patient monitoring and, in turn, reduce falls. However, such research has been descriptive in nature and does not provide an understanding of the characteristics of an optimal inpatient unit layout from a visibility-standpoint. This dissertation fills significant voids in this domain and adds much-needed realism to develop insights that hospital decision-makers can use to design their inpatient unit layout. Our first contribution (Chapter …

A Data-Driven Multi-Regime Approach For Predicting Real-Time Energy Consumption Of Industrial Machines., Abdulgani Kahraman

Electronic Theses and Dissertations

This thesis focuses on methods for improving energy consumption prediction performance in complex industrial machines. Working with real-world industrial machines brings several challenges, including data access, algorithmic bias, data privacy, and the interpretation of machine learning algorithms. To effectively manage energy consumption in the industrial sector, it is essential to develop a framework that enhances prediction performance, reduces energy costs, and mitigates air pollution in heavy industrial machine operations. This study aims to assist managers in making informed decisions and driving the transition towards green manufacturing. The energy consumption of industrial machinery is substantial, and the recent increase in CO2 …

Cad System For Early Diagnosis Of Diabetic Retinopathy Based On 3d Extracted Imaging Markers., Ahmed Sleman

Electronic Theses and Dissertations

This dissertation makes significant contributions to the field of ophthalmology, addressing the segmentation of retinal layers and the diagnosis of diabetic retinopathy (DR). The first contribution is a novel 3D segmentation approach that leverages the patientspecific anatomy of retinal layers. This approach demonstrates superior accuracy in segmenting all retinal layers from a 3D retinal image compared to current state-of-the-art methods. It also offers enhanced speed, enabling potential clinical applications. The proposed segmentation approach holds great potential for supporting surgical planning and guidance in retinal procedures such as retinal detachment repair or macular hole closure. Surgeons can benefit from the accurate …

Measurement Of Conduction, Radiation, And Convection Thermal Energy To Assess Baking Performance In Residential Ovens., Sean Simpson

Electronic Theses and Dissertations

Residential ovens are complicated thermal environments capable of delivering convection, conduction, and radiation heat transfer to food. The amount and mode of heat transfer can change based on the design of the oven cavity, cooling systems, and oven cycle algorithms. Studies have shown that the changes in one heat transfer mode can have an impact on the quality of baked goods. The many variables involved make designing residential ovens a time consuming and costly process. The goal of this study is to adapt thermal energy sensing technology to collect energy data from a residential oven and develop correlations to quality …

Experimental And Numerical Studies Of Laser Powder-Bed Fusion Process With Ti-6al-4v Powder: (1) Porosity And Mechanical Properties, And (2) Transient Phenomena In One- And Two-Dimensional Fabrications., Santosh K. Rauniyar

Electronic Theses and Dissertations

Laser powder bed fusion (L-PBF) process represents a form of metal additive manufacturing (AM) where micron-level powdered material is selectively melted and fused layer by layer to create intricate three-dimensional parts. This process involves rapid melting and solidification, leading to intense thermocapillary convection within the molten pool. The melt pool is a crucial element of the L-PBF process and refers to the localized region where the powder particles are melted and solidified to form each layer of the printed part. The shape and dimensions of the melt pool directly influence the accuracy and surface finish of the printed part. Precise …

Development And Application Of A Microfluidic Platform For Quantifying Intra-Tumoral Compressive Stress., Zachary P. Fowler

Electronic Theses and Dissertations

Cancer progression is linked to the emergence of aberrant mechanical signaling in the tumor microenvironment. Modulation of extrinsic signals, such as ECM stiffness and composition, have been thoroughly explored. However, the development of solid stresses within the tumor remains poorly understood. To address this, we have developed a microfluidic platform that generates deformable alginate microbeads that allow for the quantification of compressive stresses generated within a growing glioblastoma (GBM) tumorsphere. PDMS microfluidic devices were fabricated via SU-8 mold with channels ranging from 10µm-40µm in diameter. Fluorescently labeled sodium alginate underwent a cross-linking reaction within the device to generate monodisperse beads …

Investigation Of Possible Inflammatory Response After Ultrasound And Microbubble Procedure In The Spinal Cord., Jenna Wilkerson

Electronic Theses and Dissertations

The purpose of this experiment is to explore the inflammatory effects of focused ultrasound paired with intravenously delivered microbubbles when used in the lumbar spinal cord. There are currently very few pharmaceuticals that can successfully enter the blood spinal cord barrier (BSCB). This technique used at the lumbar enlargement might allow targeted treatment of pathologies involving the spinal cord.

To test the possible inflammatory response of this technique, an animal experiment was performed. 15 animals were given a T12 laminectomy and allowed to fully recover. Once recovered, all animals received FUS+MB at L2 and were euthanized in groups of five …

Design And Evaluation Of A Multi-Functional Surgical Device For Microgravity Surgeries., Sienna Shacklette

Electronic Theses and Dissertations

No abstract provided.

Addition Of Process Control Experiment To Unit Operations Ii Laboratory., Bradley Esselman

Electronic Theses and Dissertations

Process control is an essential aspect of manufacturing, contributing to improved process safety, efficiency, product consistency, and energy optimization. Chemical engineers are often responsible for ensuring the safe, efficient, and cost-effective operation of industrial processes, and process control plays a pivotal role in accomplishing this.

Chemical engineering students at the University of Louisville complete the course, Elements of Process Control, during the second semester of their fourth year. This lecture-based course offers limited hands-on, practical experience. To supplement the lack of hands-on experience in the classroom, a new process control experiment was designed and implemented into the Unit Operations …

Changes To Water Quality And Discharge In An Urban Stream In Southwest Jefferson County., Karina Henson

Electronic Theses and Dissertations

Mill Creek is the largest watershed in Southwest Jefferson County, where thousands of people live and work. Streams in the watershed have historically been channelized and altered to promote drainage, and stream health is of major concern. Louisville MSD is currently developing a watershed plan for Mill Creek by seeking understanding of current stream conditions. This paper will focus on historical trends in stream discharge and water quality. Peak and daily discharge, dissolved oxygen, specific conductance, and temperature data from USGS gages at Mill Creek and the Mill Creek Cutoff was analyzed to understand how water quality and flow rates …