Engineering Commons^™

Experimental Verification Of Source Temperature Modulation Via A Thermal Switch In Thermal Energy Harvesting, Robin Mccarty, D. Monaghan, Kevin P. Hallinan, Brian Sanders

Kevin Hallinan

This paper provides a description of research seeking to experimentally verify the effectiveness of a thermal switch used in series with TE devices for waste heat recovery for constant and variable source heat input and for variable source thermal capacitance (mass). Using an experimental set-up comprised serially of a fixed heat source, a variable thermal resistance air gap serving as a thermal switch, a thermoelectric device and a heat sink, the time-averaged power output to power input ratios improved up to 15% and 30% respectively for constant and variable heat input in certain design space conditions. The experimental results, as …

Industrial Solid-State Energy Harvesting: Mechanisms And Examples, Matthew Kocoloski, Carl Eger, Robin Mccarty, Kevin P. Hallinan, J. Kelly Kissock

Kevin Hallinan

This paper explores the potential for solid-state energy harvesting in industrial applications. In contrast to traditional heat recovery, the output of solid-state devices is electricity, which can be readily used in virtually any plant. The progress in harvesting waste heat via thermoelectric and thermionic generators is described. With second law efficiencies now approaching 50% and 80% respectively, we show that these technologies are on the cusp of practical use. Finally, we present an example of energy harvesting using thermionic devices in an industrial application. The example considers energy harvesting from a furnace at a glass manufacturing facility where exhaust gases …

Energy Information Augmented Community-Based Energy Reduction, Kevin P. Hallinan, Harvey Enns, Stephenie Ritchey, Phil Brodrick, Nathan Lammers, Nichole Hanus, Mark Rembert, Tony Rainsberger

Kevin Hallinan

More than one-half of all U.S. states have instituted energy efficiency mandates requiring utilities to reduce energy use. To achieve these goals, utilities have been permitted rate structures to help them incentivize energy reduction projects. This strategy is proving to be only modestly successful in stemming energy consumption growth. By the same token, community energy reduction programs have achieved moderate to very significant energy reduction. The research described here offers an important tool to strengthen the community energy reduction efforts—by providing such efforts energy information tailored to the energy use patterns of each building occupant. The information provided most importantly …

Electro-Hydrodynamic Pumped Hydraulic Actuation With Application To Active Vibration Control, Ahmad Reza Kashani, Sung Kang, Kevin P. Hallinan

Kevin Hallinan

A new type of actuation device has been conceptualized that meets the needs of both large displacement, force and bandwidth within a package more compact than currently available magnetostrictive and stack-type piezoelectric actuators of similar rating. This concept relies on micro-scale electrohydrodynamic (EHD) pumping of a dielectric liquid within small channels. Configured as an actuator, the EHD pump(s) would be used to move fluid between two reservoirs—each having a compliant membrane that interfaces to the world to provide the means to achieve vibration cancellation or micro actuation. Ordinarily limited to generating flow in macroscale applications, the EHD pump, when operating …

A Study Of The Fundamental Operations Of A Capillary Driven Heat Transfer Device In Both Normal And Low Gravity Part 1-Liquid Slug Formation In Low Gravity, Jeffrey S. Allen, Kevin P. Hallinan, Jack Lekan

Kevin Hallinan

Research has been conducted to observe the operation of a capillary pumped loop (CPL) in both normal and low gravity environments in order to ascertain the causes of device failure. The failures of capillary pumped heat transport devices in low gravity; specifically; evaporator dryout, are not understood and the available data for analyzing the failures is incomplete. To observe failure in these devices an idealized experimental CPL was configured for testing in both a normal-gravity and a low-gravity environment. The experimental test loop was constructed completely of Pyrex tubing to allow for visualization of system operations. Heat was added to …

Clean Energy Infrastructure Educational Initiative, Kevin P. Hallinan, James A. Menart, Robert Gilbert

Kevin Hallinan

The Clean Energy Infrastructure Educational Initiative represents a collaborative effort by the University of Dayton, Wright State University and Sinclair Community College. This effort above all aimed to establish energy related programs at each of the universities while also providing outreach to the local, state-wide, and national communities. At the University of Dayton, the grant has aimed at: solidfying a newly created Master's program in Renewable and Clean Energy; helping to establish and staff a regional sustainability organization for SW Ohio. As well, as the prime grantee, the University of Dayton was responsible for ensuring curricular sharing between WSU and …

Characterization Of Ear-Canal Feedback Pressure Due To Umbo-Drive Forces: Finite-Element Vs. Circuit Models, Morteza Khaleghi, Kevin N. O’Connor, Sunil Puria

Morteza Khaleghi

An Immersed Boundary Geometric Preprocessor For Arbitrarily Complex Terrain And Geometry, Inanc Senocak, Micah Sandusky, Rey Deleon, Derek Wade, Kyle Felzien, Marianna Budnikova

Inanc Senocak

There is a growing interest to apply the immersed boundary method to compute wind fields over arbitrarily complex terrain. The computer implementation of an immersed boundary module into an existing flow solver can be accomplished with minor modifications to the rest of the computer program. However, a versatile preprocessor is needed at the first place to extract the essential geometric information pertinent to the immersion of an arbitrarily complex terrain inside a 3D Cartesian mesh. Errors in the geometric information can negatively impact the correct implementation of the immersed boundary method as part of the solution algorithm. Additionally, the distance …

Combining Dynamic Stretch And Tunable Stiffness To Probe Cell Mechanobiology In Vitro, Angela Quinlan, Leslie Sierad, Andrew Capulli, Laura Firstenberg, Kristen Billiar

Kristen L. Billiar

Cells have the ability to actively sense their mechanical environment and respond to both substrate stiffness and stretch by altering their adhesion, proliferation, locomotion, morphology, and synthetic profile. In order to elucidate the interrelated effects of different mechanical stimuli on cell phenotype in vitro, we have developed a method for culturing mammalian cells in a two-dimensional environment at a wide range of combined levels of substrate stiffness and dynamic stretch. Polyacrylamide gels were covalently bonded to flexible silicone culture plates and coated with monomeric collagen for cell adhesion. Substrate stiffness was adjusted from relatively soft (G' = 0.3 kPa) to …

Fgf2-Induced Effects On Transcriptome Associated With Regeneration Competence In Adult Human Fibroblasts, Olga Kashpur, David Lapointe, Sakthikumar Ambady, Elizabeth Ryder, Tanja Dominko

Sakthikumar Ambady

BACKGROUND: Adult human fibroblasts grown in low oxygen and with FGF2 supplementation have the capacity to tip the healing outcome of skeletal muscle injury - by favoring regeneration response in vivo over scar formation. Here, we compare the transcriptomes of control adult human dermal fibroblasts and induced regeneration-competent (iRC) fibroblasts to identify transcriptional changes that may be related to their regeneration competence. RESULTS: We identified a unique gene-expression profile that characterizes FGF2-induced iRC fibroblast phenotype. Significantly differentially expressed genes due to FGF2 treatment were identified and analyzed to determine overrepresented Gene Ontology terms. Genes belonging to extracellular matrix components, adhesion …

Getting To The Root Of Bacterial Hairs: What Is “S”?, Rebecca Gaddis, Samantha O'Conner, Evan Anderson, Terri Camesano, Nancy Burnham

Nancy A. Burnham

An atomic force microscope (AFM) was used to measure the steric forces of lipopolysaccharides (LPS) on the biofilm-forming bacteria, Pseudomonas aeruginosa. It is well known that LPS play a vital role in biofilm formation. These forces were characterized with a modified version of the Alexander and de Gennes (AdG) model for polymers, which is a function of equilibrium brush length, L, probe radius, R, temperature, T, separation distance, D, and an indefinite density variable, s. This last parameter was originally distinguished by de Gennes as the root spacing or mesh spacing depending upon the type of polymer adhesion; however since …

A Case Study: Data Management In Biomedical Engineering, Glenn Gaudette, Donna Kafel

Glenn R. Gaudette

In a biomedical engineering lab at Worcester Polytechnic Institute, co-author Dr. Glenn R. Gaudette and his research team are investigating the effects of stem cell therapy on the regeneration of function in damaged cardiac tissue in laboratory rats. Each instance of stem cell experimentation on a rat yields hundreds of data sets that must be carefully captured, documented and securely stored so that the data will be easily accessed and retrieved for papers, reports, further research, and validation of findings, while meeting NIH guidelines for data sharing. After a brief introduction to the bioengineering field and stem cell research, this …

Muscle Synergies Improve Estimation Of Knee Contact Forces During Walking, Benjamin Fregly, Jonathan Walter, Allison Kinney, Scott Banks, Darryl D'Lima, Thor Besier, David Lloyd

Allison Kinney

This study investigates whether use of subject-specific muscle synergies can improve optimization predictions of muscle excitation patterns and knee contact forces during walking. Muscle synergies describe how a small number of neural commands generated by the nervous system can be linearly combined to produce the broad range of muscle electromyographic (EMG) signals measured experimentally. By quantifying the interdependence of individual EMG signals, muscle synergies provide dimensionality reduction for the neural control redundancy problem. Our hypothesis was that use of subjectspecific muscle synergies to limit muscle excitation patterns would improve prediction of muscle EMG patterns at the hip, knee, and ankle …

Muscle Synergy Constraints Improve Prediction Of Knee Contact Force During Gait, Benjamin Fregly, Jonathan Walter, Allison Kinney, Scott Banks, Darryl D'Lima, Thor Besier, David Lloyd

Allison Kinney

Knowledge of patient-specific muscle and joint contact forces during activities of daily living could improve the treatment of movement-related disorders (e.g., osteoarthritis, stroke, cerebral palsy, Parkinson’s disease). Unfortunately, it is currently impossible to measure these quantities directly under common clinical conditions, and calculation of these quantities using computer models is limited by the redundant nature of human neural control (i.e., more muscles than theoretically necessary to actuate the available degrees of freedom in the skeleton). Walking is a particularly important task to understand, since loss of mobility is associated with increased morbidity and decreased quality of life. Though numerous musculoskeletal …

Evaluation Of Different Optimal Control Problem Formulations For Solving The Muscle Redundancy Problem, Friedl De Groote, Allison Kinney, Anil Rao, Benjamin Fregly

Allison Kinney

This study evaluates several possible optimal control problem formulations for solving the muscle redundancy problem with the goal of identifying the most efficient and robust formulation. One novel formulation involves the introduction of additional controls that equal the time derivative of the states, resulting in very simple dynamic equations. The nonlinear equations describing muscle dynamics are then imposed as algebraic constraints in their implicit form, simplifying their evaluation. By comparing different problem formulations for computing muscle controls that can reproduce inverse dynamic joint torques during gait, we demonstrate the efficiency and robustness of the proposed novel formulation.

Material Properties And Microstructural Characterization Of Specimens, T.J. Silverman, Allison Kinney, B. South, W. Yong, J.H. Koo

Allison Kinney

The HiQ upgrade to the 3D Systems Vanguard selective laser sintering (SLS) machine incorporates a revised thermal calibration system and new software. This paper quantifies differences in mechanical and morphological properties of specimens built first using a Vanguard HS (high-speed) system and again using the same system with the HiQ upgrade applied. Standard specimens are built from DuraForm PA material and tested for tensile modulus, tensile strength, elongation at break, flexural modulus and Izod impact strength. The design of the specimen battery, the conduction of the tests and the significance of the results are discussed. The upgrade is found to …

Synergies Controls Improve Prediction Of Knee Contact Forces And Muscle Excitations During Gait, Benjamin Fregly, Jonathan Walter, Allison Kinney, Scott Banks, Darryl D'Lima, Thor Besier, David Lloyd

Allison Kinney

This study investigates whether use of muscle excitation controls constructed from subjectspecific muscle synergy information can improve optimization prediction of knee contact forces and muscle excitations during walking. Muscle synergies quantify how a large number of experimental muscle electromyographic (EMG) signals can be reconstructed by linearly mixing a much smaller number of neural commands generated by the nervous system. Our hypothesis was that controlling all muscle excitations with a small set of experimentally calculated neural commands would improve prediction of knee contact forces and leg muscle excitations compared to using independently controlled muscle excitations.

Comparison Of Material Properties And Microstructure Of Specimens Built Using The 3d Systems Vanguard Hs And Vanguard Hiq+Hs Sls Systems, T.J. Silverman, Allison Kinney, W. Yong, J.H. Koo

Allison Kinney

The HiQ upgrade to the 3D Systems Vanguard selective laser sintering (SLS) machine incorporates a revised thermal calibration system and new control software. The paper compares the tensile modulus, tensile strength, elongation at break, flexural modulus, Izod impact resistance and microstructure of two batteries of standard specimens built from recycled Duraform PA (Nylon 12). The first set is built on a Vanguard HS system and the second on the same system with the HiQ upgrade installed. The upgrade reduces user intervention, decreases total build time and improves surface finish. However, using the default processing parameters, tensile, flexure and impact properties …

Science Panel Discussion Presentation: "Data Management In Biomedical Engineering: Needs And Implementation", Glenn Gaudette

Glenn R. Gaudette

Glenn Gaudette, PhD, is an Associate Professor, Department of Biomedical Engineering, Worcester Polytechnic Institute. He discussed data management in his research laboratory, which is focused on regenerating mechanical and electrophysiological function in hearts with cardiovascular disease.

Energy Issues Affecting Corn/Soybean Systems: Challenges For Sustainable Production, Douglas L. Karlen, David Archer, Adam Liska, Seth Meyer

Douglas L Karlen

Quantifying energy issues associated with agricultural systems, even for a two-crop corn (Zea mays L.) and soybean (Glycine max [L.] Merr.) rotation, is not a simple task. It becomes even more complicated if the goal is to include all aspects of sustainability (i.e., economic, environmental, and social). This Issue Paper examines energy issues associated with and affecting corn/soybean rotations by first defining the size of the system from both a U.S. and global perspective and then establishing boundaries based on the Farm Bill definition of sustainability. This structured approach is essential to help quantify energy issues within corn/soybean systems that …

Effectiveness Of Group Kickboxing As A Means To Improve Gait And Balance In Individuals With Ms, Kurt Jackson, Kimberly Edginton Bigelow, Christina Cooper, Harold L. Merriman

Harold L. Merriman

In recent years, there has been a particular emphasis on identifying and delivering appropriate therapeutic interventions that address the significant balance and gait impairments that affect individuals with multiple sclerosis (MS). Group interventions implemented in community settings have been especially of interest, including tai chi classes. Recently, the authors conducted a preliminary study to examine whether group kick-boxing, which requires more vigorous movements, might be a feasible intervention. Initial findings showed promise and led the authors to pursue a more rigorous follow-up study, with the objective of determining whether a 5-week group kickboxing class improved clinical measures of balance and …

Hybrid Femtosecond/Picosecond Coherent Anti-Stokes Raman Scattering For High-Speed Gas-Phase Thermometry, Joseph D. Miller, Mikhail N. Slipchenko, Terrence R. Meyer, Hans U. Stauffer, James R. Goird

Terrence R Meyer

We demonstrate hybrid femtosecond/picosecond (fs/ps) coherent anti-Stokes Raman scattering for high-speed thermometry in unsteady high-temperature flames, including successful comparisons with a time- and frequencyresolved theoretical model. After excitation of the N2 vibrational manifold with 100 fs broadband pump and Stokes beams, the Raman coherence is probed using a frequency-narrowed 2:5 ps probe beam that is time delayed to suppress the nonresonant background by 2 orders of magnitude. Experimental spectra were obtained at 500 Hz in steady and pulsed H2–air flames and exhibit a temperature precision of 2.2% and an accuracy of 3.3% up to 2400 K. Strategies for real-time gas-phase …

Probe-Pulse Optimization For Nonresonant Suppression In Hybrid Fs/Ps Coherent Anti-Stokes Raman Scattering At High Temperature, Joseph D. Miller, Mikhail N. Slipchenko, Terrence R. Meyer

Terrence R Meyer

Hybrid femtosecond/picosecond coherent anti-Stokes Raman scattering (fs/ps CARS) offers accurate thermometry at kHz rates for combustion diagnostics. In high-temperature flames, selection of probe-pulse characteristics is key to simultaneously optimizing signal-to-nonresonant-background ratio, signal strength, and spectral resolution. We demonstrate a simple method for enhancing signal-to-nonresonant-background ratio by using a narrowband Lorentzian filter to generate a time-asymmetric probe pulse with full-width-half-maximum (FWHM) pulse width of only 240 fs. This allows detection within just 310 fs after the Raman excitation for eliminating nonresonant background while retaining 45% of the resonant signal at 2000 K. The narrow linewidth is comparable to that of a …

الگو و دستورالعمل تهيه و تدوين پايان نامه کارشناسي ارشد, Dr Alireza Zolfaghari

Dr Alireza Zolfaghari

No abstract provided.

Biocompatible Flavone-Based Fluorogenic Probes For Quick Wash-Free Mitochondria! Imaging In Living Cells, Bin Liu, Mickey Shah, Ge Zhang, Qin Liu, Yi Pang

Yi Pang

Mitochondria, vital organelles existing in almost all eukaryotic cells, play a crucial role in energy metabolism and apoptosis of aerobic organisms. In this work, we report two new flavone-based fluorescent probes, MC-Mito1 and MC-Mito2, for monitoring mitochondria in living cells. These two probes exhibit remarkably low toxicity, good cell permeability, and high specificity; these probes complement the existing library of mitochondrial imaging agents. The new dyes give nearly no background fluorescence, and their application does not require tedious postwashing after cell staining. The appreciable tolerance of MC-Mito2 encourages a broader range of biological applications for understanding the cell degeneration and …

Concept Frequency Distribution In Biomedical Text Summarization, Lawrence H. Reeve, Hyoil Han, Saya V. Nagori, Jonathan C. Yang, Tamara A. Schwimmer, Ari D. Brooks

Hyoil Han

Text summarization is a data reduction process. The use of text summarization enables users to reduce the amount of text that must be read while still assimilating the core information. The data reduction offered by text summarization is particularly useful in the biomedical domain, where physicians must continuously find clinical trial study information to incorporate into their patient treatment efforts. Such efforts are often hampered by the high-volume of publications. Our contribution is two-fold: 1) to propose the frequency of domain concepts as a method to identify important sentences within a full-text; and 2) propose a novel frequency distribution model …

Tailoring Material Properties Of Cardiac Matrix Hydrogels To Induce Endothelial Differentiation Of Human Mesenchymal Stem Cells, Megan Jeffords, Jinglei Wu, Michey Shah, Yi Hong, Ge Zhang

Ge Zhang

Cardiac matrix hydrogel has shown great promise as an injectable biomaterial due to the possession of cardiac-specific extracellular matrix composition. A cardiac matrix hydrogel facilitating neovascularization will further improve its therapeutic outcomes in cardiac repair. In this study, we explored the feasibility of tailoring material properties of cardiac matrix hydrogels using a natural compound, genipin, to promote endothelial differentiation of stem cells. Our results demonstrated that the genipin cross-linking could increase the mechanical properties of the cardiac matrix hydrogel to a stiffness range promoting endothelial differentiation of human mesenchymal stem cells (hMSCs). It also decreased the swelling ratio and prolonged …

Biocompatible Flavone-Based Fluorogenic Probes For Quick Wash-Free Mitochondria! Imaging In Living Cells, Bin Liu, Mickey Shah, Ge Zhang, Qin Liu, Yi Pang

Ge Zhang

Mitochondria, vital organelles existing in almost all eukaryotic cells, play a crucial role in energy metabolism and apoptosis of aerobic organisms. In this work, we report two new flavone-based fluorescent probes, MC-Mito1 and MC-Mito2, for monitoring mitochondria in living cells. These two probes exhibit remarkably low toxicity, good cell permeability, and high specificity; these probes complement the existing library of mitochondrial imaging agents. The new dyes give nearly no background fluorescence, and their application does not require tedious postwashing after cell staining. The appreciable tolerance of MC-Mito2 encourages a broader range of biological applications for understanding the cell degeneration and …

De Novo Design Of Self-Assembled Hexapeptides As Β-Amyloid (Aβ) Peptide Inhibitors, Jie Zheng, Ge Zhang, Mingzhen Zhang, Qiuming Wang, Guizhao Liang, Mingzhen Zhang, Jun Zhao, Kunal Patel, Xiang Yu, Chao Zhao, Binrong Ding, Feimeng Zhou

Ge Zhang

The ability of peptides to construct specific secondary structures provides a useful function for biomaterial design that cannot be achieved with traditional organic molecules and polymers. Inhibition of amyloid formation is a promising therapeutic approach for the treatment of neurodegenerative diseases. Existing peptide-based inhibitors are mainly derived from original amyloid sequences, which have very limited sequence diversity and activity. It is highly desirable to explore other peptide-based inhibitors that are not directly derived from amyloid sequences. Here, we develop a hybrid high-throughput computational method to efficiently screen and design hexapeptide inhibitors against amyloid-β (Aβ) aggregation and toxicity from the first …

Magnetic Labeling Of Bm-Msc-Derived Smcs Maintains Their Pro-Elastogenic Trophic Effects On Aneurysmal Smcs, G. Swaminathan, B. Sivaraman, I. Stoilov, Mickey Shah, Ge Zhang, R.P. Mecham, A. Ramamurthi

Ge Zhang

No abstract provided.