Digital Commons Network^™

Development Of Novel Protein Digestion And Quantitation Methods For Mass Spectrometic Analysis, Yongling Ai

Dissertations

Proteins are the workhorses of biology, playing multifaceted roles in maintaining cellular function, signaling, and response to environmental cues. Understanding their abundance and dynamics is pivotal for unraveling the complexities of biological processes, which underpins the foundations of molecular and cellular biology. Accurate measurement of protein quantities provides insights into cellular homeostasis, facilitates the discovery of biomarkers, and sheds light on the molecular mechanisms of diseases, bridging the gap between the molecular intricacies of proteins and their functional consequences in health and disease. The evolution of protein quantitation methodologies, from classical colorimetric assays to sophisticated mass spectrometry-based approaches, has expanded …

Depressurization Characteristics Of Steam-Based Reciprocating Vacuum Pump, Hongling Deng

Dissertations

This dissertation introduces a novel vacuum technology that leverages low-pressure saturated steam and cooling-controlled condensation, offering an efficient way to utilize low-grade thermal energy sources like waste heat, steam, or solar energy. At the heart of this technology is a unique duo-chamber vacuum pump system, featuring a reciprocating piston and a heat-conductive wall, designed to generate a vacuum through steam-condensation and cooling processes.

The core of this research lies in developing and validating mechanistic models for the steam-condensation depressurization process, a complex phenomenon involving phase change and transport mechanisms. Prior to this work, these mechanisms were not sufficiently modeled or …

The Role Of Semaphorins In Response To Injury In C. Elegans Neurons, Maria Belen Harreguy Alfonso

Dissertations

When neural tissue is injured by trauma, delicate neuronal processes such as axons and dendrites are prone to lesion damage and often disconnect. The molecular, cellular, and circuit mechanisms that underlie the regrowth and reconnection of these processes and the recovery of behavior are major challenges in the fields of neuroscience, regeneration, and resilience. At the molecular and cellular levels, signaling pathways that mediate neuronal growth cone guidance during development can play a role in neuronal regeneration and recovery from injury. One family of signaling proteins involved in this process comprises the highly conserved semaphorins and their receptors, the plexins. …

5g New Radio Access And Core Network Slicing For Next-Generation Network Services And Management, Abdullah Ridwan Hossain

Dissertations

In recent years, fifth-generation New Radio (5G NR) has attracted much attention owing to its potential in enhancing mobile access networks and enabling better support for heterogeneous services and applications. Network slicing has garnered substantial focus as it promises to offer a higher degree of isolation between subscribers with diverse quality-of-service requirements. Integrating 5G NR technologies, specifically the mmWave waveform and numerology schemes, with network slicing can unlock unparalleled performance so crucial to meeting the demands of high throughput and sub-millisecond latency constraints.

While conceding that optimizing next-generation access network performance is extremely important, it needs to be acknowledged that …

Model-Based Deep Autoencoders For Clustering Single-Cell Rna Sequencing Data With Side Information, Xiang Lin

Dissertations

Clustering analysis has been conducted extensively in single-cell RNA sequencing (scRNA-seq) studies. scRNA-seq can profile tens of thousands of genes' activities within a single cell. Thousands or tens of thousands of cells can be captured simultaneously in a typical scRNA-seq experiment. Biologists would like to cluster these cells for exploring and elucidating cell types or subtypes. Numerous methods have been designed for clustering scRNA-seq data. Yet, single-cell technologies develop so fast in the past few years that those existing methods do not catch up with these rapid changes and fail to fully fulfil their potential. For instance, besides profiling transcription …

Assessing The Feasibility And Mechanism Of Destructive Removal Of Per- And Polyfluoroalkyl Substances (Pfas) From Water, Kaushik Vinaykumar Londhe

Dissertations

One of the most pertinent challenges faced by the drinking water community is the widespread contamination of per- and polyfluoroalkyl substances (PFAS). These anthropogenic chemicals have been ubiquitously used in everyday products such as carpets, stain repellents, dyes, shampoos, non-stick cookware as well as in aqueous firefighting foams. PFAS are linked with adverse health effects in humans such as thyroid disease, obesity, immunological and reproductive disorders and linked to cancer in adults and low birth weight and developmental defects in infants.

Conventional water treatment technologies have proven to be largely ineffective in PFAS remediation, due to their extreme stability and …

Novel Photobase Generators For Photoinduced Polymerization And Ph Regulation, Shupei Yu

Dissertations

Photochemistry encompasses the investigation of chemical processes instigated by light absorption. As important branches of photochemistry, photosensitive and optical materials have attracted extensive research interests in both academia and industry. Photosensitive and optical materials are composed of polymers / small molecules with photo-responsive properties. These materials not only can absorb light in the desired energy spectrum, but also exhibit chemical / physical reactions, which can be applied to different fields such as photoredox, photo-heat, phototherapy, solar cells, diodes, etc. Among them, photobase generators (PBGs) are a series of photosensitive compounds, which absorb the incident light, then release the basic species …

La Incidencia En El Desarrollo De Competencias Digitales De Los Estudiantes De Una Universidad Virtual En Texas, Elga D. Sepulveda Suarez

Theses and Dissertations

El propósito de este estudio cuantitativo fue indagar en la incidencia en el desarrollo de las competencias digitales de los estudiantes de una universidad virtual en Texas. Durante el mes de marzo del año 2023 se administró un cuestionario a los estudiantes subgraduados con el fin de conocer sobre el desarrollo de las competencias digitales. El estudio reflejó la importancia en buscar herramientas que ayuden a que el estudiante pueda estimular su creatividad, desarrollar su pensamiento crítico y discernir sobre el uso y manejo de herramientas digitales. Esta fue una investigación tuvo un diseño cuantitativo no experimental, tipo transeccional descriptivo. …

To Make Or Buy: How Does Strategic Team Selection And Shared Leadership Strategy Interact To Impact Nba Team Effectiveness?, Brandon Purvis

Industrial-Organizational Psychology Dissertations

The study of shared leadership is growing to address the challenges faced in an increasingly dynamic and interdependent workplace. Shared leadership under the right conditions has been found to be related to team adaptability, creativity, and effectiveness. However, there is growing research on the conditions that limit or enhance the effectiveness of shared leadership. Specifically, it was proposed that teams which are more made than bought (internally developed) should adopt a shared leadership model. In contrast, teams that are more bought than made (developed externally) should use a traditional hierarchical team leadership model. Using data from the National Basketball Association …

Assessing Neurobehavioral Deficits And Neuroinflammation Following Rllb In A Transgenic Mouse Model, Aakaash Gosain

Theses

As global conflicts are escalating, military personnel have long faced the constant threat of explosions, heightening the risk of blast-induced traumatic brain injury (bTBI). The recent increase in war conflicts and combat zones worldwide not only puts the military, service members, and police forces at risk but also innocent civilians who are caught in the crossfire. While moderate to severe bTBIs have been extensively studied, the pathology of repeated low-level blasts (rLLB) remains less understood. This research addresses the gap in knowledge regarding the long-term consequences of rLLB injuries in the neural anatomy. A transgenic mouse model was subjected to …

Covalent Inhibition Of Enzyme Sortase A As A New Pathway Against Bacterial Resistance Of Staphylococcus Aureus, Umyeena Bashir

Master's Theses

The continued rise of antibiotic-resistant bacteria, such as MRSA (methicillin-resistant Staphylococcus aureus), has made the discovery of novel antibiotics critical. While bacteriostatic and bactericidal antibiotics inevitably exert evolutionary pressure on bacteria to develop resistance, small molecules that target mechanisms of bacterial virulence present a promising alternative for treatment. Sortase A (Srt A), a cysteine protease of S. aureus, promotes bacterial virulence by covalently attaching proteins such as pilin to the bacterial surface, enabling bacterial adhesion to mammalian cells. Inhibitory studies of this enzyme have gained prominent interest as a new pathway for drug development since blocking this enzyme's ability to …

The Effects Of Blue Light From Digital Displays On Visual Fatigue, Victor Taboadela

Theses

With the ever-increasing viewing time of digital displays, the potential effects of blue light emitted from these displays on eye health and eye fatigue are a real concern. This study presents a literature review of six laboratory studies conducted between 2014 and 2022 on the effect of using filters to attenuate the harmful effects of blue light. The review delves into smartphone and computer screen effects, recent literature reviews on blue light, and potential hazards associated with short-wavelength light. Although the majority of the studies recommended blue light filters, only three of the six laboratory studies (Shi et al. 2021, …

Gen-Acceleration: Pioneering Work For Hardware Accelerator Generation Using Large Language Models, Durga Lakshmi Venkata Deepak Vungarala

Theses

Optimizing computational power is critical in the age of data-intensive applications and Artificial Intelligence (AI)/Machine Learning (ML). While facing challenging bottlenecks, conventional Von-Neumann architecture with implementing such huge tasks looks seemingly impossible. Hardware Accelerators are critical in efficiently deploying these technologies and have been vastly explored in edge devices. This study explores a state-of-the-art hardware accelerator; Gemmini is studied; we leveraged the open-sourced tool. Furthermore, we developed a Hardware Accelerator in the study we compared with the Non-Von-Neumann architecture. Gemmini is renowned for efficient matrix multiplication, but configuring it for specific tasks requires manual effort and expertise. We propose implementing …

The School Of SharīʿA Judges: SharīʿA Courts’ Reform And Legal Modernization In Egypt (1907-1927), Yamen Nouh

Theses and Dissertations

This thesis studied the history of the school of sharīʿa judges (1907-1927) as an essential episode of the reform of Sharīʿa courts in Egypt in the early 20th century. The thesis studied the school in connection with the broader context of legal modernization of the Egyptian legal system. The study explored the institutional, pedagogical, and legal aspects of the reform that the school advocated. The study analyzed the impact of the school’s pedagogy on the practice of the Islamic judiciary and the theoretical conception of Sharīʿa. The study used a significant yet understudied historical source: the judicial press. A comparative …

Novel Anti-Influenza Monoclonal Antibodies, Ozlem Gurses

NYMC Student Theses and Dissertations

There is a continual public threat of influenza virus infections. This is related to viruses evolving in multiple animal reservoirs, making infection prevention in humans difficult to achieve and leading to seasonal epidemics and the semi-regular emergence of pandemics. Novel antibody-based therapies are of great interest to researchers because of a dramatic increase in drug resistant strains of influenza viruses. The identification of cross-reactive and broadly protective monoclonal antibodies targeting the influenza proteins presents a promising prospect for the development of a universal therapy. Although the research related to the monoclonal antibodies targeting the viral internal proteins is limited, multiple …

Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail

Theses and Dissertations

Non-enzymatic glucose sensing holds promise to overcome limitations associated with glucose oxidase, such as oxygen dependence and short shelf life. This study explores the potential sensing capabilities of borophene and graphene through direct interaction with various compounds, including β-glucose, uric acid, ascorbic acid, fructose, and acetaminophen. Using Density Functional Theory (DFT), we calculated binding energies and the respective Density of States (DOS) for these adsorbates on both graphene and borophene surfaces. Preliminary results suggest that borophene might exhibit nearly twice the affinity for β-glucose compared to graphene. Moreover, the calculated Density of States reveals distinct distortions in the electronic states …

Qualitative Study Exploring The Risk Factors Of Burnout: Pennsylvania Social Work Professionals In Child Welfare, Nicole Ukaegbu

Social Work Doctoral Dissertations

Burnout is a concern that impacts many professionals in the workplace. This study focused on the risk factors of burnout for social work professionals in Pennsylvania’s child welfare industry. The study was conducted with 10 professionals at children and youth services (CYS) agencies in Pennsylvania, where each of the professionals were interviewed to gain perspective on the problem of burnout. This study used a qualitative approach and was rooted in grounded theory to unravel the findings.

Four risk factor themes, nine risk factor subthemes, and two additional findings themes were generated during the data analysis process. Findings from the 10 …

Rans-Dns Simulations For Uncertainty Quantification In Dns Data Of Turbulent Mixing Layer, Mohamed Abuhegazy

Mechanical Engineering ETDs

Mixing layer flow is one of the canonical free shear flows in fluid dynamics. Such a flow is formed when two fluid streams move along one another with different velocities. Investigation of this flow development has been an active topic of research for many decades not only due to a wide range of environmental and technological applications where this flow may be observed, but also because of large discrepancies in the results obtained experimentally and numerically regardless this flow simple geometry. In this dissertation, the quality and uncertainty of extracted turbulent statistics of mixing layer flow are analyzed by applying …

Evaluating The Symptoms And Treatment-Related Knowledge Of Cancer Patients Receiving Chemotherapy In A Tertiary Care Hospital, Kiran Nawaz Ali

Theses & Dissertations

Background: Cancer has become the leading source of mortality and morbidity worldwide. Its prevalence is rising and high-risk behaviours are being adopted by the people in society. Knowledge about cancer and its management helps in adjusting the resource allocations and in terms of public health policy. Moreover, patient education about symptoms, treatment, and side effects is crucial and must be addressed.
Knowledge about cancer, its side effects, and the possible treatment outcomes is essential, as it helps in deciding about adherence to the treatment. It is observed that many oncology patients have information gaps related to cancer and chemotherapy. However, …

Assessing Medication Compliance And The Usage Of Complementary Therapies Effecting Hba1c Among Patients With Type 2 Diabetes Mellitus In A Tertiary Care Hospital In Karachi, Pakistan, Neelam Nasruddin

Theses & Dissertations

Background: Diabetes Mellitus is a chronic illness. It remains to be a major public health matter and a financial burden on the medical system worldwide. This condition can be managed and better treatment strategies and compliance can reduce the risk of complications. In 2022, there will be around 33,000,000 new cases of diabetes worldwide, with 26.7% of the adults in Pakistan being affected, predicts the (International Diabetes Federation, 2022). However, it is observed that most individuals turn to complementary and alternative methods (CAM)/Traditional medicine because of the rising cost of therapy, adverse effects of anti-diabetic medications, and accessibility concerns.
Purpose: …

Uncertainty Quantification Of Live Load Effect In Buried Rc Box Culverts, Mohd Firoj

Dissertations and Theses

Although buried and mostly invisible to the traveling public, bridge-sized culverts (i.e., culverts with span around or longer than 20 ft) account for a large proportion of state-managed bridges. As per Oregon Department of Transportation inventory, there are approximately 35,000 culverts in the state highway system. Among them, 10,862 are in poor conditions and need to be analyzed for load rating purposes. The prediction and understanding of live load effects in culverts are crucial to the design, evaluation, and life-cycle maintenance of culverts. These live load effects include maximum bending moments and shear forces at different critical cross sections.

This …

Examining The Relationship Between School Academic Optimism, Enabling School Structures, And Student Achievement In New Jersey Public Schools During The Post-Pandemic Period, Mark Schwarz

Seton Hall University Dissertations and Theses (ETDs)

This study investigated the relationships between student achievement and the school characteristics of academic optimism and enabling structures. Perceptual data were collected from a sample of 496 faculty members across 67 schools in 25 districts in northern NJ. These data were then merged with demographic and student achievement data from the New Jersey Department of Education for analysis through descriptive and inferential statistics. The study was modeled after prior studies outside of New Jersey and before the onset of the SARS-CoV-2 pandemic.

The study found that enabling structures were well correlated with school academic optimism and that optimism, in turn, …

Going Green To Sell, N'Dja D. N'Guessan

Student Theses and Dissertations

The following thesis project discusses green communication strategies that can be implemented across industries to improve sales while aligning with consumers’ environmental values. It incorporates practical ideas and techniques within the reach of for-profit organizations when creating, developing, and promoting green products. The environmental, social, and governance expectations have challenged organizations across industries for years. By producing and interpreting the results of a meta-analysis of green business strategies found in existing research, Going Green to Sell offers ideas to new and growing organizations on how to market their products, using functional communication strategies that have worked before, focusing on green …

Unlocking The Potential Of Earned Value Management In Construction: A Comparative Study, Mohamed Elsaid

Theses and Dissertations

The implementation of earned value management (EVM) in the construction industry faces challenges when it comes to application, accuracy, and interpretability of results, with potential enhancements yet to be realized. In light of technological advancements, there is an opportunity to develop a controlled EVM approach for improved project management. The goal of this research is to enhance the application and accuracy of earned value techniques in Egyptian construction projects through a comprehensive evaluation of Earned Duration, Earned Schedule, and Planned Value methods. The key challenge that is addressed in this research lies in selecting an optimal technique considering the variations …

Information-Rich 6d Single-Molecule Imaging Design Using Optimization, Tingting Wu

McKelvey School of Engineering Theses & Dissertations

When studying biochemical processes, localizing the targets alone will not paint a complete picture. We also need techniques to probe how biomolecules interact with one another, including how molecules are organized into larger structures, how they are oriented with respect to surrounding molecules, and how local chemical parameters, like pH and hydrophobicity, vary spatially and temporally. My dissertation focuses on single-molecule orientation localization microscopy (SMOLM, Chapter 1). The objective is to develop imaging techniques for measuring how molecules are oriented with respect to their surrounding molecules, namely, 3D orientation. Achieving optimal imaging performance requires careful design of both the forward …

Multi-Layer Strip Ionization Chamber For Proton Quality Assurance And Imaging, Shuang Zhou

McKelvey School of Engineering Theses & Dissertations

Proton therapy is the most advanced radiation treatment modality. Proton treatment is delivered via pencil beam scanning (PBS) technique, in which a pencil beam scans the target spot-by-spot and layer-by-layer. An effective quality assurance (QA) device is needed to verify the quality of treatment dose delivery. Current clinical practice employs films or a two-dimensional (2D) detector to measure the dose at one or a few arbitrarily selected depths, which is insensitive to delivery error and time-consuming. A 3D dosimeter that can measure the 3D dose distribution is needed to improve the effectiveness and efficiency of proton QA. Furthermore, preclinical studies …

Education For Primary Care Providers On Advance Care Planning: A Systematic Literature Review, Lindsey Ward

DNP Qualifying Manuscripts

Background: Healthcare providers in primary care treat patients at various stages of life. As patients age, it becomes necessary for providers to support their older patients throughout the aging process and address patient care even into life’s end stages. Primary care providers (PCPs) are well-positioned to provide this support and can do so through incorporating end-of-life (EOL) conversations in practice. Such discussions are called advance care planning (ACP). Though PCPs can play a crucial role in their patients’ EOL care decisions, providers report their limited knowledge of ACP as a barrier to its application.Consequently, further education for providers on utilizing …

The Future Teacher Academy Grow Your Own: A Comprehensive And Collectivistic Model, Gricel Escobedo-Kingwell

Dissertations, Theses, and Projects

While the U.S. has seen an increase of students of color in K-12 schools, the teaching profession faces a shortage of teachers of color. A range of issues, including engaging and retaining teachers of color, learning outcomes, and ensuring academic success for students, all contribute to the shortage. Teaching focused Grow Your Own (GYO) programs have gained popularity as a grassroots effort to diversify the teaching profession to reflect current student demographics. This study examined existing teaching GYO collaboration models within a K-12 district and a post-secondary institution. The qualitative and exploratory study reviewed the benefits of the GYO Future …

Community Resilience And Creating Capacities For Risk Reduction In First Nations Communities, Case Study In Minegoziibe Anishinabe (Pine Creek First Nation), Brittany S. Lavallee

Capstone Collection

The colonization of Indigenous peoples in Canada has serious consequences on First Nations, including forced removal and displacement from their ancestral lands, environmental degradation, declining resources and capacities, and human rights violations. First Nations communities are currently facing the amplified effects of human-driven climate change. Sustainability of the environment is not just a concept, but a practiced way of life, that recognizes the interdependence of all living things. This deep respect for Aki (earth) is at the foundation of First Nations cultures and continues to guide their actions to insure better futures for Seven Generations. The community of Minegoziibe Anishinabe …

Exemplar Trans-Affirmative Therapists: A Consensual Qualitative Research Study, Shannon Skaistis

Dissertations (1934 -)

The consensus approach for psychotherapy with transgender and nonbinary clients (TNB) has come to be known as trans-affirmative psychotherapy (TAP). TAP is influenced by a collection of guidelines and models (American Counseling Association [ACA], 2010; APA, 2015; Chang et al., 2017; Singh & dickey, 2017) and a small number of empirical studies related to psychotherapy with transgender clients (e.g., Elder, 2016; McCullough et al., 2017, Mizock & Lundquist, 2016, Morris et al., 2020). However, the limited empirical research and guidelines provide minimal direction to clinicians working in-session with TNB clients. This study sought to investigate the perceptions of exemplar clinicians’ …