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Cell Apoptosis And Proliferation In Rat Brains After Intracerebral Hemorrhage: Role Of Wnt/\Beta-Catenin Signaling Pathway, Ling Zhou, Li Deng, Neng Bin Chang, Ling Dou, Chao Xian Yang Jan 2014

Cell Apoptosis And Proliferation In Rat Brains After Intracerebral Hemorrhage: Role Of Wnt/\Beta-Catenin Signaling Pathway, Ling Zhou, Li Deng, Neng Bin Chang, Ling Dou, Chao Xian Yang

Turkish Journal of Medical Sciences

To investigate the role of Wnt/\beta-catenin signaling pathway in cell apoptosis and proliferation in intracerebral hemorrhage (ICH) in rats. Materials and methods: The ICH rats were established by stereotaxic infusion of 50 µL autologous arterial blood into the right striatum. Pathological characteristics of brain tissue was assessed by hematoxylin and eosin and TUNEL staining, and the expressions of proliferating cell nuclear antigen (PCNA) and Wnt3a/\beta-catenin/cyclin D1 were investigated by immunohistochemistry or reverse-transcription polymerase chain reaction. Results: The number of apoptotic cells and PCNA-positive cells kept increasing from the day following the ICH induction and reached a peak on the 3rd …


A Pilot Experimental Study Of A Catheter To Facilitate Treatment For Penetrating Cardiac Injury, Mahmut Tokur, Mehmet Ergi̇n, İbrahi̇m Can Kürkçüoğlu, Zerri̇n Defne Dündar Jan 2014

A Pilot Experimental Study Of A Catheter To Facilitate Treatment For Penetrating Cardiac Injury, Mahmut Tokur, Mehmet Ergi̇n, İbrahi̇m Can Kürkçüoğlu, Zerri̇n Defne Dündar

Turkish Journal of Medical Sciences

Penetrating heart injuries result in high mortality. We designed a new catheter to facilitate the treatment of penetrating cardiac injuries and provide more effective initial bleeding control and fluid replacement. Materials and methods: The cardiac injury model was applied to 8 female 1-year-old Sus domesticus pigs. Subjects were grouped according to whether a Foley catheter or a newly designed catheter was placed into the heart through cardiac lacerations. Changes in systolic blood pressures, mortality, and problems encountered during surgery and other intraoperative findings were recorded. Results: There were higher mean blood pressure measurements in the newly designed catheter group during …


Effects Of Short-Term Hyperglycemia On The Vasoconstriction Of The Aorta, Soner Dönmez, Osman Gökalp, Mustafa Doğan, Hüseyi̇n Vural, Barbaros Yi̇ği̇t Jan 2014

Effects Of Short-Term Hyperglycemia On The Vasoconstriction Of The Aorta, Soner Dönmez, Osman Gökalp, Mustafa Doğan, Hüseyi̇n Vural, Barbaros Yi̇ği̇t

Turkish Journal of Medical Sciences

To investigate vasoconstrictor responses of healthy blood vessels to short-term hyperglycemic conditions such as postprandial hyperglycemia, gestational diabetes mellitus, and steroid-induced diabetes. Materials and methods: Female Wistar rat aorta rings were incubated in normal (11 mM) and high (22 mM and 44 mM) glucose concentrations for 4 h. Responses of vasoconstriction were measured in reaction to serotonin (10-5 M), phenylephrine (10-6 M), and KCl (60 mM) compared to the ambient condition, including different glucose concentrations. Results: While the responses of vasoconstriction to KCl were increased in the presence of Krebs' solution with high glucose, no statistically significant changes were observed …


Effects Of Oral Hormone Replacement Therapy On Mean Platelet Volume In Postmenopausal Women, İkbal Kaygusuz, Serap Aynur Si̇mavli, Ayla Eser, İlknur İnegöl Gümüş, Selcen Yüksel, Zehra Candan İltemi̇r Duvan, Hasan Kafali Jan 2014

Effects Of Oral Hormone Replacement Therapy On Mean Platelet Volume In Postmenopausal Women, İkbal Kaygusuz, Serap Aynur Si̇mavli, Ayla Eser, İlknur İnegöl Gümüş, Selcen Yüksel, Zehra Candan İltemi̇r Duvan, Hasan Kafali

Turkish Journal of Medical Sciences

To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV …


The Increase Of Mean Platelet Volume In Patients With Alzheimer Disease, Emi̇ne Rabi̇a Koç, Ertuğrul Uzar, Yasemi̇n Çirak, Yasemi̇n Parlak Demi̇r, Ati̇lla İlhan Jan 2014

The Increase Of Mean Platelet Volume In Patients With Alzheimer Disease, Emi̇ne Rabi̇a Koç, Ertuğrul Uzar, Yasemi̇n Çirak, Yasemi̇n Parlak Demi̇r, Ati̇lla İlhan

Turkish Journal of Medical Sciences

Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors. Materials and methods: A total of 109 outpatients with AD and 81 healthy controls were included in this study. Diagnosis of AD was made according to defined criteria. The Turkish version of the Mini …


An Examination Of The Symptoms Of Anxiety And Parental Attitude In Children With Hemophilia, Osman Abali, Osman Bülent Zülfi̇kar, Sevcan Karakoç Demi̇rkaya, Hamza Ayaydin, Fuat Kircelli̇, Meltap Duman Jan 2014

An Examination Of The Symptoms Of Anxiety And Parental Attitude In Children With Hemophilia, Osman Abali, Osman Bülent Zülfi̇kar, Sevcan Karakoç Demi̇rkaya, Hamza Ayaydin, Fuat Kircelli̇, Meltap Duman

Turkish Journal of Medical Sciences

Hemophilia is an inherited disease with serious repercussions. Psychiatric symptoms are frequently seen in children and adolescents with hemophilia. The aim of this study was to assess symptoms of anxiety in children with hemophilia and parental attitude towards children with hemophilia. Materials and methods: 42 boys were assessed according to child and adolescent psychiatry. Anxiety symptoms and parental attitude were obtained by the State-Trait Anxiety Scale, the Self-Report for Childhood Anxiety Related Disorders (SCARED) and the Parent Attitude Research Instrument (PARI). Results: The mean age was 11.6 ± 2.5 (range; 7-16). State anxiety scores (44.02 ± 6.9) were higher than …


Prohepcidin In Maternal Circulation: Is It Related To Spontaneous Preterm Labor?, Yüksel Onaran, Esra Aktepe Keski̇n, Zehra Candan İltemi̇r Duvan, Serap Aynur Si̇mavli, Cemi̇le Koca, Hasan Kafali, Ni̇lgün Turhan Jan 2014

Prohepcidin In Maternal Circulation: Is It Related To Spontaneous Preterm Labor?, Yüksel Onaran, Esra Aktepe Keski̇n, Zehra Candan İltemi̇r Duvan, Serap Aynur Si̇mavli, Cemi̇le Koca, Hasan Kafali, Ni̇lgün Turhan

Turkish Journal of Medical Sciences

To investigate whether spontaneous preterm labor (PTL) with intact membranes is associated with changes in maternal serum prohepcidin concentrations. Materials and methods: The study consisted of patients with spontaneous PTL with intact membranes (n = 25), a control group of healthy pregnant women between the 24th and 37th gestational weeks (n = 22), and uncomplicated term pregnancies in spontaneous labor (n = 19). Blood samples were collected from patients at the time of clinical diagnosis. Levels of prohepcidin, hemoglobin, serum ferritin, serum iron, unsaturated iron binding capacity, total iron binding capacity, transferrin and transferrin saturation, C reactive protein, and interleukin-6 …


Evaluation Of Scleral-Fixated Intraocular Lens Position Anomalies By Anterior Segment Optical Coherence Tomography, Ni̇hat Polat, Kemaletti̇n Kazim Devranoğlu, Mehmet Aki̇f Özdamar, Ceyhun Arici Jan 2014

Evaluation Of Scleral-Fixated Intraocular Lens Position Anomalies By Anterior Segment Optical Coherence Tomography, Ni̇hat Polat, Kemaletti̇n Kazim Devranoğlu, Mehmet Aki̇f Özdamar, Ceyhun Arici

Turkish Journal of Medical Sciences

To measure the positions of scleral-fixated intraocular lenses (IOLs) using anterior segment optical coherence tomography (OCT) and to evaluate the influence of the position of scleral-fixated IOL on the quality of vision. Materials and methods: Twenty-six eyes of 26 patients were included in the study. The average age was 57.5 (11 to 78) years. Anterior segment images were taken using slit lamp optical coherence tomography (SL-OCT) and were used to evaluate the position of the IOL. Results: The average amounts of tilt and decentration were 2.25° ± 1.93° and 359.28 ± 194.70 µm, respectively. There was a positive and moderate …


A New Knot-Supporting Instrument And Knot Technique For Laparoscopic Surgery, Hasan Börekci̇, Eli̇f Börekci̇, Hakan Ak, Kürşad Zengi̇n, Tugay Atalay, Serhat Tanik Jan 2014

A New Knot-Supporting Instrument And Knot Technique For Laparoscopic Surgery, Hasan Börekci̇, Eli̇f Börekci̇, Hakan Ak, Kürşad Zengi̇n, Tugay Atalay, Serhat Tanik

Turkish Journal of Medical Sciences

We report here an instrument designed by Dr Hasan Börekci that provides support to the knot to facilitate knot tying in laparoscopic procedures. We call the device the 'Börekci knot-supporting instrument' and the technique 'Börekci's knot technique'. Materials and methods: To evaluate the efficacy of this instrument, 17 surgeons performing laparoscopic surgery tied 3 knots using the classical intracorporeal method and then using the intracorporeal knot-supporting instrument. The times required to tie each knot were recorded and compared statistically. Results: Comparing the 2 knotting methods, the time spent tying the knots was shorter with the knot-supporting instrument in all 3 …