Digital Commons Network^™

The Herpes Simplex Virus Type-1 (Hsv-1), Vc2 Live-Attenuated Vaccine Strain Induces Robust Antitumor Immune Responses And Ameliorates Intra-Tumor Immunosuppression In An Immunocompetent B16f10-Derived Murine Melanoma Model, Ifeanyi Kingsley Uche

LSU Doctoral Dissertations

Current cancer immunotherapies include immune checkpoint inhibitors, adoptive cellular therapy, and cancer vaccines. While some of these therapies have met with great clinical success, they are associated with several limitations. Oncolytic virotherapy (OVT) has emerged as a bonafide promising immunotherapy, that uses viral infection to liberate tumor antigens in an immunogenic context to promote the development of anti-tumor immune responses. At present, Talimogene laherparepvec (T-VEC; Imlygic™), a modified type 1 herpes simplex virus (HSV-1) is the only FDA approved OVT for human cancer treatment (melanoma). While T-VEC is associated with limited response rates, its modest efficacy supports the continued development …

Digital Discrimination In The Sharing Economy: Evidence, Policy, And Feature Analysis, Miroslav Tushev

LSU Doctoral Dissertations

Applications (apps) of the Digital Sharing Economy (DSE), such as Uber, Airbnb, and TaskRabbit, have become a main facilitator of economic growth and shared prosperity in modern-day societies. However, recent research has revealed that the participation of minority groups in DSE activities is often hindered by different forms of bias and discrimination. Evidence of such behavior has been documented across almost all domains of DSE, including ridesharing, lodging, and freelancing. However, little is known about the under- lying design decisions of DSE systems which allow certain demographics of the market to gain unfair advantage over others. To bridge this knowledge …

Evaluation Of Hippocampal Allostatic Load-Associated Factors In Animal Models Of Post-Traumatic Stress Disorder: Relevance To Human Ptsd, Dennis Parker Kelley

LSU Doctoral Dissertations

Post-traumatic stress disorder (PTSD) is associated with elevated allostatic load, nearly double the risk for metabolic syndrome, reduced hippocampal volume, and contextual memory processing deficits. Emerging evidence suggests that these stress effects may predispose individuals to the development of PTSD, and there is a known relationship between chronic stress and metabolic dysfunction. In this work, we utilized two rat models of PTSD to explore these connections. We used an acute predator odor stressor to investigate the relationship between PTSD-like behaviors and mitochondrial dysfunction in the hippocampus of rats, and we observed that conditioned place avoidance was associated with reduced mitochondrial …

My Favorite Murder As Discursive Performance, Taylor Dawson

LSU Doctoral Dissertations

My Favorite Murder as Discursive Performance uses performance-centered discourse analysis to explore the major narratives informing the popular true crime comedy podcast, My Favorite Murder (MFM). Hosts, Karen and Georgia draw from podcast, comedy, true crime, feminist, and mental health discourse to create a unique discursive space where “murderinos” (fans of the podcast) express and explore aspects of their own life experiences. I explore the performative strategies MFM uses and the effects of those choices, drawing on some of my own experiences as a murderino. Ultimately I argue that a performance lens reveals some of the imperfect but powerful ways …

Infrared Investigation Of Lithium Ion Electrolytes: Characterization Of Structure And Dynamics Via Linear And Nonlinear Spectroscopy, Jeramie Christopher Rushing

LSU Doctoral Dissertations

Lithium ion batteries are widely employed in energy storage, but the connection between the molecular interactions in their electrolytes and the macroscopic properties remains elusive. Across three vastly different electrolytes, speciation and dynamics were studied via linear and nonlinear infrared spectroscopy to shed light on this relationship. The impact of mixed solvation on ionic speciation was studied from the perspective of the anion, which revealed a significant energetic favorability for the formation of contact ion pairs in linear carbonate solvents over cyclic carbonates. Infrared spectroscopy and density functional theory calculations described a complete inversion of the speciation due to solvent …

Inhibition Of Biotin Carboxylase By Three Antibacterial Compounds, Matt Craft

LSU Doctoral Dissertations

The rise of antibacterial resistant bacteria is a major problem in the United States of America and around the world. Millions of patients are infected with antimicrobial resistant bacteria each year. Novel antibacterial agents are needed to combat the growing and present crisis. Acetyl-CoA carboxylase (ACC), the multi-subunit complex which catalyses the first committed step in fatty acid synthesis, is a validated target for antibacterial agents. However, there are at present, no commercially available antibiotics that target ACC. Ethyl 4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulfonylamino]benzoate (SABA1) is a compound that has been shown to have antibacterial properties against Pseudomonas aeruginosa and Escherichia coli. SABA1 inhibits …

Deformed No-Core Shell Model And Symplectic Effective Field Theory, David Kekejian

LSU Doctoral Dissertations

Most nuclei are deformed! This simple fact has been established since Bohr and Mot- telson, and successfully demonstrated from first principles by nuclear structure calculations carried out using the ab-initio Symmetry-Adapted No-Core Shell Model (SA-NCSM) us- ing realistic interactions. This simple fact has been the main driver towards understanding the underlying physics; namely, that symplectic symmetry describes deformation and is a dominant symmetry in all nuclei independent of A (nucleon number) and of the realistic interaction used. These two simple observations laid the foundation of this thesis work to explore the applications of symplectic symmetry towards defining a deformed symplectic …

Drug Resistance In The Canine Filarial Parasite, Dirofilaria Immitis: Emergence And Clinical Epidemiology In The Lower Mississippi River Alluvial Valley, Cassan Nicole Pulaski

LSU Doctoral Dissertations

Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to macrocyclic lactone (ML) preventive drugs have been increasingly reported in dogs by practicing veterinarians since 2005 in the Lower Mississippi Delta region. If proven, and not controlled in the early stages, the emergence of ML drug resistance threatens to become a widespread problem in the US that may limit the effectiveness of current preventive drug treatment methods. To validate practice reports, a statewide survey of Louisiana veterinarians was done to define the extent of the problem and identify focal ‘hotspots’ of reported ML LOEs using Geographic Information Systems (GIS) …

A Necessary Shift? A Qualitative Exploration Of Black Women’S Experiences With Altering Self-Presentation For Job Attainment, Dorothy Rachael Kemp

LSU Doctoral Dissertations

The purpose of this study was to explore how Black women describe their experiences with shifting for job attainment, including their perception of identity, and how they interpret and negotiate any outcomes of shifting. The study was guided by the following research questions: (1) How do Black women describe their experiences with shifting for job attainment? (2) How do Black women interpret and negotiate any outcomes of shifting? (3) How do Black women perceive their identity in terms of their experiences with shifting?

Ten participants shared their personal experiences shifting throughout their job attainment process. Each participant self-identified as Black …

Interpretable And Anti-Bias Machine Learning Models For Human Event Sequence Data, Zihan Zhou

LSU Doctoral Dissertations

Growing volumes and varieties of human event sequence data are available in many applications such as recommender systems, social network, medical diagnosis, and predictive policing. Human event sequence data is usually clustered and exhibits self-exciting properties. Machine learning models especially deep neural network models have shown great potential in improving the prediction accuracy of future events. However, current approaches still suffer from several drawbacks such as model transparency, unfair prediction and the poor prediction accuracy due to data sparsity and bias. Another issue in modeling human event data is that data collected from real word is usually incomplete, and even …

Using Memory Forensics To Analyze Programming Language Runtimes, Modhuparna Manna

LSU Doctoral Dissertations

The continued increase in the use of computer systems in recent times has led to a significant rise in the capabilities of malware and attacker toolkits that target different operating systems and their users. Over the last several years, cybersecurity threat reports have documented numerous instances of users that were targeted by governments, intelligence agencies, and criminal groups, and the result was that the victims ended up having highly sophisticated malware installed on their systems. Unfortunately, the rise of these threats has not been met with equal research and development of defensive mechanisms that can detect and analyze such malware. …

Design And Fabrication Of A Low-Cost, Portable, Battery-Operated Surface Enhanced Raman Scattering (Sers) Optical Device, Blessing Adewumi

LSU Doctoral Dissertations

Raman Spectroscopy is a time-honored, non-invasive method for analyzing and identifying the molecular composition of materials. However, unenhanced Raman Spectroscopy has extremely low sensitivity which limits its sensing capability. SERS brings rough nano-metallic surfaces in contact with the material molecules to enormously enhance the Raman signals.

The sensitivity of SERS can be exploited in probe applications where the spectrometer needs to be brought near the specimen. For example, a long optical fiber coupled to a SERS device can be used to characterize and identify easy-to-reach cancerous tissues in organisms. Unfortunately, background signals in a long fiber can easily mask any …

Ecology Of Periphyton In A Subtropical River Floodplain, Kamela De Gallardo

LSU Doctoral Dissertations

The Atchafalaya River Basin (ARB) in southcentral Louisiana, USA, is a large and biologically diverse floodplain surrounding the Atchafalaya River (AR), which is the largest distributary of the Mississippi River, receiving 30% of the combined daily discharge of the Mississippi and Red Rivers. Annual flooding facilitates exchange between the AR and its floodplain and is thought to give rise to the high productivity of the river-floodplain system. Primary production within the aquatic ARB is driven by periphytic algae, phytoplankton, and aquatic macrophytes, however, very little is known about periphytic algal assemblages in floodplain systems. In this study, artificial substrates were …

The Lived Experiences Of Migrant Domestic Workers In Taiwan, Li-Yu Liao

LSU Doctoral Dissertations

The constantly increasing demand of domestic workers in developed and newly industrialized countries had prompted many women of less developed countries migrating to engage in transnational domestic work. Among these newly industrialized countries (NICs) in Asia, Taiwan is one of them with burgeoning market of domestic work. In 2019, Taiwan accommodated 261,457 foreign domestic workers. Indonesian, Filipino, and Vietnamese women constitute the three major groups of the population. Compare to their counterparts in other host countries in Asia such as Hong Kong and Singapore, migrant domestic workers in Taiwan were understudied. This research was committed to explore the experiences of …

Moisture-Tolerant And Operationally Simple Synthesis Of Synthetic Polypeptides And Polypeptoids By Ring-Opening Polymerization Of N-Thiocarboxyanhydrides, David Siefker

LSU Doctoral Dissertations

ABSTRACT

This work aims to develop a new synthetic strategy for synthesizing advanced functional This work aims to develop a new synthetic strategy for synthesizing advanced functional pseudo-peptidic polymers. Pseudo-peptidic polymers mimic poly(glycine) backbone with substituents on either the α-carbon or the nitrogen, appealing properties for various biomedical applications. One of the critical challenges in pseudo-peptidic polymers research is the synthesis of functional pseudo-peptidic polymers under mild conditions. We developed a system based on ring-opening polymerization (ROP) of N-Thiocarboxyanhydrides (NTAs) initiated by primary amines to synthesize polypeptides with a wide range of controlled molecular weights …