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Minimally Invasive Therapies In The Treatment Of Arthropathy, Steven Bateman Apr 2024

Minimally Invasive Therapies In The Treatment Of Arthropathy, Steven Bateman

Physician Assistant Scholarly Project Papers

It is estimated that 27% of adults over 45 years of age suffer from osteoarthritis of the hip secondary to articular cartilage damage over the lifespan. Joint pain diminishes life quality, limits range of motion and overall activity, and frequently impairs basic ambulation. These functional deficits worsen the progression of comorbidities that are often referred to as lifestylerelated chronic disease as physical activity subsequently declines. This literature review explores the efficacy of minimally invasive therapies that precede and delay surgical intervention in adult patients experiencing functional limitations and pain in major joints. The study examines the effectiveness of various interventions, …


Investigation Of Cyclic Gaseous Solvent Injection For Enhanced Oil Recovery In Unconventional Formations, Samuel Asante Afari Aug 2023

Investigation Of Cyclic Gaseous Solvent Injection For Enhanced Oil Recovery In Unconventional Formations, Samuel Asante Afari

Theses and Dissertations

Unconventional resources have been known to hold vast quantities of hydrocarbons. However, exploiting the oil and gas they hold was previously challenging due to their low permeabilities. Recent advances in horizontal well drilling and hydraulic fracturing have enabled oil and gas production from these reservoirs, leading to significant increases in energy supply to meet the growing energy demand. However, despite the relative technological success, considerable obstacles persist; oil production from unconventional wells often declines by more than 20% of their initial production rate within the first two years, leaving significant volumes of residual oil trapped in the formations. This overarching …


Blood-Based Versus Stool-Based Biomarker Accuracy In Detection Of Colorectal Cancer And Impact Of Non-Invasive Tests On Patient Participation, Allison Obritsch Jul 2023

Blood-Based Versus Stool-Based Biomarker Accuracy In Detection Of Colorectal Cancer And Impact Of Non-Invasive Tests On Patient Participation, Allison Obritsch

Physician Assistant Scholarly Project Papers

Colorectal cancer is a very treatable cancer when detected early, therefore patient adherence and colorectal cancer screening is key to decrease mortality. The purpose of this research and systematic literature review was to determine how the accuracy of blood-based and stool-based biomarkers compared in the detection of colorectal cancer and how noninvasive testing modalities influence patient participation in colorectal cancer screening. Only articles published within the past 10 years were included. A combination of keywords and MeSH phrases to include but not limited to “adherence,” “SEPT9,” “colonoscopy,” “multitarget stool,” and “colorectal cancer” were used to find relevant articles for each …


Preparation, Performance, And Experience Evaluation Of "Symmetrical Structures" By Giorgi Papiashvili, Ana Galdavadze May 2023

Preparation, Performance, And Experience Evaluation Of "Symmetrical Structures" By Giorgi Papiashvili, Ana Galdavadze

Theses and Dissertations

No abstract provided.


Encouraging Equal Musical Collaboration : A Guide For Collaborative Pianists In Facilitating Effective Rehearsals, Michelle Ann Henning May 2023

Encouraging Equal Musical Collaboration : A Guide For Collaborative Pianists In Facilitating Effective Rehearsals, Michelle Ann Henning

Theses and Dissertations

No abstract provided.


An Examination Of The Bass Trombone Works Of Eric Ewazen, Zhangzejie Xu May 2023

An Examination Of The Bass Trombone Works Of Eric Ewazen, Zhangzejie Xu

Theses and Dissertations

No abstract provided.


The History, Evolution, And Maintenance Of Violin Strings, Iva Pecotić May 2023

The History, Evolution, And Maintenance Of Violin Strings, Iva Pecotić

Theses and Dissertations

No abstract provided.


A Conductor’S Study And Resource Guide Of Four Band And Chamber Wind Compositions, Juana Caballero Casas May 2023

A Conductor’S Study And Resource Guide Of Four Band And Chamber Wind Compositions, Juana Caballero Casas

Theses and Dissertations

No abstract provided.


A Comparison Of Pharmacotherapy Versus Complementary Medicine In The Treatment Of Migraines, Samantha Braaten Apr 2023

A Comparison Of Pharmacotherapy Versus Complementary Medicine In The Treatment Of Migraines, Samantha Braaten

Physician Assistant Scholarly Project Papers

Migraine headache is a common, universal neurological disorder that can be complicated to treat. Despite the wide availability of treatments used as prophylactic agents against migraines, outcomes have been inconsistent, and a number of patients do not respond to prophylactic medications. Therefore, it is important to investigate new non-pharmacological modalities accompanied with less adverse effects and maximal efficacy. To determine if complementary medicine modalities such as acupuncture, botulinum toxin-A, or cognitive behavioral therapy can be as effective as traditional pharmacotherapy for the treatment of migraines, a literature review was completed using meta-analyses and clinical trial reviews. Despite the fact there …


Chronic Exertional Compartment Syndrome: Surgical Treatment Vs Conservative Care, Molly Ruebke Apr 2023

Chronic Exertional Compartment Syndrome: Surgical Treatment Vs Conservative Care, Molly Ruebke

Physician Assistant Scholarly Project Papers

Chronic exertional compartment syndrome (CECS) is a relatively rare pathology characterized by pain, tightness, and/or numbness in the affected calf upon performance of repetitive physical activity, most commonly with running or serving in the military. CECS usually has a delay in diagnosis due to low levels of awareness among clinicians and a wide range of differential diagnoses for chronic exertional leg pain. The natural course of CECS is often not self-limiting and therefore requires intervention, as symptoms can be severely debilitating and eventually force patients to avoid any provoking activity. The purpose of this literature review is to take a …


Benzimidazole Adjuvant Therapy: A Review Of Efficacy And Safety In Patients With Cancer, Jared Mouw Apr 2023

Benzimidazole Adjuvant Therapy: A Review Of Efficacy And Safety In Patients With Cancer, Jared Mouw

Physician Assistant Scholarly Project Papers

This literature review aims to compile previous studies’ data and explore the effects of benzimidazoles as an adjuvant therapy and its relationship to a patient’s cancer biomarkers, tumor progression, and quality of life. In addition to the aforementioned, we will attempt to review data to identify the safety and toxicity profile of benzimidazoles within a population of patients currently diagnosed with cancer to determine if this class of medications could be implemented along with current cancer treatment regimens to increase efficacy and tolerance. To determine this, the databases of CINAHL, ClinicalKey, and PubMed were searched with the keywords mentioned below. …


A Comparison Of Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies And Standard Migraine Prophylaxis In Those With Episodic Migraines, Alexie Harms Apr 2023

A Comparison Of Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies And Standard Migraine Prophylaxis In Those With Episodic Migraines, Alexie Harms

Physician Assistant Scholarly Project Papers

The purpose of this research study is to determine if anti-calcitonin gene related peptide monoclonal antibodies (CGRP mAbs) more effective and tolerable in reducing the number of migraine days in comparison to conventional migraine prophylactic use of Propranolol, Amitriptyline, and Topiramate. Migraines are debilitating and a frequent reason for primary care visits interfering with an individual’s work, school, and daily life. Standard of care treatment options for migraine prophylaxis are drugs initially developed for other diseases and can lead to unnecessary and unwanted side effects decreasing treatment adherence in the prevention of migraines. In this literature review, electronic search databases …


Aspirin Vs. Pravastatin For Prevention Of Preterm Delivery In Patients At Risk For Pre-Eclampsia, Mary Weisberg Apr 2023

Aspirin Vs. Pravastatin For Prevention Of Preterm Delivery In Patients At Risk For Pre-Eclampsia, Mary Weisberg

Physician Assistant Scholarly Project Papers

This literature review is an examination of the use of low-dose aspirin therapy versus the use of pravastatin therapy to prevent preterm delivery in women at risk of developing preeclampsia. Preeclampsia is defined as new onset hypertension after 20 weeks of gestation with evidence of maternal organ or uteroplacental dysfunction or proteinuria. Preeclampsia is a serious condition that affects pregnant women and their growing fetuses which may lead to maternal or fetal demise. The Prevention of preeclampsia with the use of low-dose aspirin in the first 12-16 weeks is currently the mainstay of treatment for women with moderate to severe …


Home-Based Cardiac Rehab Vs. Center-Based Cardiac Rehab In Rural Areas, Timothy Fresonke Apr 2023

Home-Based Cardiac Rehab Vs. Center-Based Cardiac Rehab In Rural Areas, Timothy Fresonke

Physician Assistant Scholarly Project Papers

Cardiac rehabilitation in rural areas can present unique challenges. The main challenge is the locations patients must travel to receive such care. Some patients are expected to travel more then an hour away, on multiple occasions during the week, to undergo therapy. This can be an issue for many patients and something that has been studied and is starting to be addressed in various countries. A literature review was done to see if there was a safe and effective alternative to the traditional center-based cardiac rehabilitation. The electronic search databases PubMed, Embase and CINAHL Complete were utilized to search for …


Comparison Of Urethral Bulking Injection Therapy And Surgical Midurethral Sling Placement For Treatment Of Stress Urinary Incontinence In Women, Ashley Black Apr 2023

Comparison Of Urethral Bulking Injection Therapy And Surgical Midurethral Sling Placement For Treatment Of Stress Urinary Incontinence In Women, Ashley Black

Physician Assistant Scholarly Project Papers

This literature review aims to assess the comparative efficacy and safety of urethral bulking injection therapy and surgical midurethral sling intervention in the treatment of stress incontinence in women. A comprehensive search of the existing literature was conducted and includes studies from PubMed, an electronic search databases. The findings indicate that both urethral bulking injection therapy and surgical midurethral sling intervention are suitable interventions to be considered for the treatment of stress incontinence in women. Current research available regarding the efficacy of urethral bulking agents versus midurethral slings suggests that the placement of a miduerthral sling has the highest incidence …


Cognitive Behavior Therapy Versus Internet Cognitive Behavior Therapy In Adults With Anxiety Or Depression, Heather Greenwood Apr 2023

Cognitive Behavior Therapy Versus Internet Cognitive Behavior Therapy In Adults With Anxiety Or Depression, Heather Greenwood

Physician Assistant Scholarly Project Papers

According to the American Psychiatric Association, the prevalence of anxiety and depression in adults in their lifetime are nearly 30% and 16.6% respectively. The combination of pharmacotherapy and psychotherapy interventions (including talk therapy or cognitive behavior therapy (CBT)) are considered best practice, but in recent years there has been an increase in the popularity of applications and web-based services categorized as “internet cognitive behavior therapy”, or ICBT. The question proposed is, are these services as good for patient outcomes as traditional in-person CBT? A literature review was performed using electronic medical database PubMed with key word searches for cognitive behavior …


The Effectiveness Of The Gut-Brain-Axis Versus Ssri For Treatment And Management Of Depression, Jenni Hetleved Apr 2023

The Effectiveness Of The Gut-Brain-Axis Versus Ssri For Treatment And Management Of Depression, Jenni Hetleved

Physician Assistant Scholarly Project Papers

Major Depressive Disorder (MDD) is a crippling condition that affects millions of people worldwide. Serotonin reuptake inhibitors (SSRIs) are the staple treatment adjunct to psychotherapy. Recently, the connection between gut health, specifically the gut brain axis, has been researched to look at the connection between gut microbiota and it’s effect on depressive symptoms. A literature review was performed using electronic databases such as PubMed, PsychINFO, and embase. This meta-analysis evaluates the connection between gut microbiota and depression as well as the effectiveness of SSRI therapy on depression. Results show a significant change in gut microbiota with short term change to …


Evaluating And Comparing The Safety And Efficacy Of Rimegepant Versus Lasmiditan In Aborting Acute Migraine Headaches In The Adult Migraineur, Anthony Douthit Apr 2023

Evaluating And Comparing The Safety And Efficacy Of Rimegepant Versus Lasmiditan In Aborting Acute Migraine Headaches In The Adult Migraineur, Anthony Douthit

Physician Assistant Scholarly Project Papers

Migraine headaches are one of the most common causes of primary headaches. Worldwide, migraines are one of the leading causes of disability and while the mechanism of migraines are not entirely understood, they result in significant disability for those who experience them. Dihydroergotamine was introduced for migraine treatment in the 1920s and in the 1990s triptans were introduced and have been the mainstay of acute migraine treatment since their introduction. In recent years, there have been several developments in the acute treatment and prophylaxis of migraine headaches. Some of the more widely studied and recently developed interventions include calcitonin gene …


Long-Term Control Of Type Ii Diabetes Mellitus And Weight Through Roux-En-Y Gastric Bypass Surgery Versus Weight Loss Medication, Alexandra Laber Apr 2023

Long-Term Control Of Type Ii Diabetes Mellitus And Weight Through Roux-En-Y Gastric Bypass Surgery Versus Weight Loss Medication, Alexandra Laber

Physician Assistant Scholarly Project Papers

Type II diabetes mellitus (T2DM) affects hundreds of millions of individuals in the United States and is only becoming more common. The disease can damage organs all throughout the body and even lead to death. The goal of treatment is to lower blood glucose, but since T2DM tends to be associated with obesity, another common goal in treatment is weight loss. However, this is difficult for many people to achieve, and intense medical treatment is sometimes needed. Since T2DM is a lifelong disease, interventions must be considered in the long term. The purpose of this project is to compare long-term …


Manual Vs. Mechanical Chest Compressions In Adult Cardiac Arrest, Brittany Ann Almquist Apr 2023

Manual Vs. Mechanical Chest Compressions In Adult Cardiac Arrest, Brittany Ann Almquist

Physician Assistant Scholarly Project Papers

The purpose of this literature review is to compare the use of manual versus mechanical chest compressions during cardiopulmonary resuscitation (CPR) in the treatment of adult cardiac arrest patients. A literature review was performed using the databases CINAHL, Embase, and PubMed. Studies chosen were peer reviewed randomized controlled trials, respective reviews, a cross-over controlled trial, and an experimental trial. Only articles from the last seven years were included in this review. After exclusion criteria were applied, ten articles were relevant and utilized. Four themes were identified in the literature review specific to studies of cardiac arrest with utilization of CPR …


Liraglutide Versus Semaglutide: Long Term Weight Loss Management In Obese Individuals, Mckenzie Burke Apr 2023

Liraglutide Versus Semaglutide: Long Term Weight Loss Management In Obese Individuals, Mckenzie Burke

Physician Assistant Scholarly Project Papers

Obesity has been a source of complications affecting multiple aspects from a physiological and psychological standpoint which has been steadily growing. There are a multitude of weight loss programs and medications with the idea of sustaining consistent weight loss to include use of the pharmaceuticals discussed within this review. The purpose of this literature review is to compare the efficacy and safety with use of liraglutide versus semaglutide (GLP-1 receptor agonists) in respect to long term weight loss management while in conjunction to lifestyle modifications within the obese population. Thorough research has been done with the aid of health science …


Alternative Treatment Modalities For Plantar Fasciitis, Chelsey Clark Apr 2023

Alternative Treatment Modalities For Plantar Fasciitis, Chelsey Clark

Physician Assistant Scholarly Project Papers

Plantar Fasciitis is a common and frequent condition in adult patients. The purpose of this literature review is to determine whether evidence exists for alternative treatments in the regimen of plantar fasciitis that has not been resolved with the standard treatment. The review was done using Pubmed, CINAHL and SportDiscus. Research was included on the following alternative treatments of PF: corticosteroid injections, extracorporeal shockwave, dry needling, Platelet-Rich Plasma (PRP), Autologous Blood Injection (ABI), cupping, custom insoles, and ultrasound therapy. A total of 12 research articles were included in this review. The alternative treatments considered within this literature review had some …


Efficacy Of Transcutaneous Electrical Nerve Stimulation Vs. Calcitonin Gene Related Peptides In The Application Of Migraine Prophylaxis, Matthew Davis Apr 2023

Efficacy Of Transcutaneous Electrical Nerve Stimulation Vs. Calcitonin Gene Related Peptides In The Application Of Migraine Prophylaxis, Matthew Davis

Physician Assistant Scholarly Project Papers

Worldwide migraines affect millions of people everyday causing significant impact on patient’s lives. Oftentimes, these patients have failed several first-line therapies for migraine prophylaxis causing pharmaceutical companies to develop newer therapies. The purpose of this systematic literature review is to evaluate the effectiveness and tolerability of transcutaneous electrical nerve stimulator (TENS) devices versus calcitonin gene related peptide (CGRP) antagonists in the application of migraine prophylaxis. PubMed and ClinicalKey were searched with key terms, 17 sources were selected that were published after 2016. Sources included meta-analysis, literature review, and randomized control trials. The data showed that TENS devices as well as …


Proning Versus Respiratory Pharmacotherapeutics In Hospitalized Covid-19 Patients, Sasha Marie Hopfauf Apr 2023

Proning Versus Respiratory Pharmacotherapeutics In Hospitalized Covid-19 Patients, Sasha Marie Hopfauf

Physician Assistant Scholarly Project Papers

The purpose of this research and literature review is to compare the use of prone positioning and respiratory pharmacotherapeutics within hospitalized COVID-19 patients and the outcomes associated with each. A literature review was performed using the databases PubMed, Clinical Key, DynaMed, and CINAHL. A variety of key terms were used when searching. Studies chosen were retrospective reviews, a cross sectional study, an interventional study, and a pilot study. Articles within the last three years were utilized after exclusion criteria was applied. A total of thirteen articles were included within this project. The research shows that pulmonary vasodilators such as inhaled …


Gabapentin As An Effective Treatment Option For Alcohol Use Disorder, Monica Hurst Apr 2023

Gabapentin As An Effective Treatment Option For Alcohol Use Disorder, Monica Hurst

Physician Assistant Scholarly Project Papers

The purpose of this literature review is to determine whether gabapentin is an effective treatment option for alcohol use disorder (AUD). Utilizing data sourced primarily from published clinical trials, gabapentin’s effect on heavy drinking, abstinence, withdrawal symptoms and alcohol cravings will be explored. This review will also compare gabapentin’s efficacy against currently approved AUD treatment options, along with what dosages are most efficacious while contributing the fewest adverse effects. The data presented in this literature review undeniably demonstrates a positive effect of gabapentin on alcohol use disorder; Specifically, the data shows that gabapentin at multiple dosages helps to decrease heavy …


Active Toxoplasmosis Infection: Efficacy And Safety Of Treatment Options, Daniele Krouse Apr 2023

Active Toxoplasmosis Infection: Efficacy And Safety Of Treatment Options, Daniele Krouse

Physician Assistant Scholarly Project Papers

This literature review intends to investigate the safety and efficacy of two different drug treatment regimens, pyrimethamine versus trimethoprim-sulfamethoxazole, for active toxoplasmosis infections. Affecting nearly 11% of the United States population and up to 80% of the populations of tropical countries, Toxoplasmosis infection is the second leading cause of death from food borne illness. Current classic management of active infection with pyrimethamine is correlated with numerous undesirable side effects, high cost and need for complex use of adjunctive medications. It is necessary to identify alternative treatment options with fewer side effects, less complex regimens, lower cost, and easier access for …


Perimenopausal Depression Screening And Treatment Efficacy Between Antidepressants And/Or Hormone Replacement Therapy, Mandy Stenehjem Apr 2023

Perimenopausal Depression Screening And Treatment Efficacy Between Antidepressants And/Or Hormone Replacement Therapy, Mandy Stenehjem

Physician Assistant Scholarly Project Papers

During the menopause transition (MT), also known as perimenopause, women are at a significantly increased risk of depression. Although the pathophysiology is not fully understood, it is likely to be complex and multifactorial. Data evaluating the involvement of HPA axis dysregulation and correlating female reproductive hormone fluctuations, specifically estradiol, are factors that may contribute to this incidence. Currently antidepressants are the treatment for depression but with biological changes occurring during perimenopause, hormone replacement therapy alone or in combination may have comparable antidepressant effects. The combination of menopause symptoms, depressive symptoms, and psychosocial challenges, make recognition and treatment depend on many …


Impact Of Circadian Rhythm On Attention-Deficit Hyperactivity Disorder, Tyson Williams Apr 2023

Impact Of Circadian Rhythm On Attention-Deficit Hyperactivity Disorder, Tyson Williams

Physician Assistant Scholarly Project Papers

The purpose of this research and systematic literature review is to determine if altering the circadian rhythm in people with Attention-Deficit Hyperactivity Disorder (ADHD) improves their symptoms. Up to 75% of people with childhood-onset ADHD exhibit a delayed circadian rhythm phase. This can cause difficulty in initiating and maintaining sleep, which in turn can cause excessive daytime sleepiness and further exacerbate ADHD symptoms, especially hyperactivity. Journal articles were searched in the databases of PubMed that concerned treatment aspects that would affect circadian rhythm and ADHD. Topics were further divided into themes that included melatonin, light therapy (LT), sleep hygiene intervention, …


The Effect Of Metformin Vs Lifestyle Modifications On The Prevention Of Prediabetes Progressing To Type Ii Diabetes, Brittany Mcpherson Apr 2023

The Effect Of Metformin Vs Lifestyle Modifications On The Prevention Of Prediabetes Progressing To Type Ii Diabetes, Brittany Mcpherson

Physician Assistant Scholarly Project Papers

Prediabetes is a common disease among American adults that is the predecessor to type 2 diabetes (T2D). T2D is a serious disease that causes long term damage to the heart, blood vessels, and kidneys if uncontrolled. This literature review looks at the effectiveness of medication (metformin), diet alone, exercise alone, and diet and exercise in combination in preventing the progression from prediabetes to a diagnosis of T2D. The literature review was performed using an electronic search database to identify literature related to preventing the conversion of prediabetes to T2D using either lifestyle modifications or metformin within the past five years. …


Weight Loss For Bariatric Patients: Arterial Embolization Versus Gastric Bypass, Morgan Bernhardt Apr 2023

Weight Loss For Bariatric Patients: Arterial Embolization Versus Gastric Bypass, Morgan Bernhardt

Physician Assistant Scholarly Project Papers

The primary aim of this systematic literature review is to determine the safety and efficacy of left gastric artery embolization (LGAE) in comparison to Roux-en-Y gastric bypass (RYGB) for bariatric patients. A total of four prospective studies focusing on left gastric artery embolization were selected and reviewed. A total of five studies were selected that discussed Roux-en-Y gastric bypass. All studies used have a publication date of 10 years or less. The research shows evidence that RYGB, an invasive surgical operation, has been proven to result in long-term efficacy of weight loss but can be associated with a higher risk …