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Svm-Based Negative Data Mining To Binary Classification, Fuhua Jiang
Svm-Based Negative Data Mining To Binary Classification, Fuhua Jiang
Computer Science Dissertations
The properties of training data set such as size, distribution and the number of attributes significantly contribute to the generalization error of a learning machine. A not well-distributed data set is prone to lead to a partial overfitting model. Two approaches proposed in this dissertation for the binary classification enhance useful data information by mining negative data. First, an error driven compensating hypothesis approach is based on Support Vector Machines (SVMs) with (1+k)-iteration learning, where the base learning hypothesis is iteratively compensated k times. This approach produces a new hypothesis on the new data set in which each label is …
Shape-Dependent Molecular Recognition Of Specific Sequences Of Dna By Heterocyclic Cations, Yi Miao
Shape-Dependent Molecular Recognition Of Specific Sequences Of Dna By Heterocyclic Cations, Yi Miao
Chemistry Dissertations
SHAPE-DEPENDENT MOLECULAR RECOGNITION OF SPECIFIC SEQUENCES OF DNA BY HETEROCYCLIC CATIONS by YI MIAO Under the Direction of Dr. W. David Wilson ABSTRACT DB921 and DB911 are biphenyl-benzimidazole-diamidine isomers with a central para- and meta-substituted phenyl group, respectively. Unexpectedly, linear DB921 has much stronger binding affinity with DNA than its curved isomer, DB911. This is quite surprising and intriguing since DB911 has the classical curved shape generally required for strong minor groove binding while DB921 clearly does not match the groove shape. Several biophysical techniques including thermal melting (Tm), circular dichroism (CD), biosensor-surface plasmon resonance (SPR), and isothermal titration calorimetry …
Modeling The Power Evolution Of Classical Double Radio Galaxies Over Cosmological Scales, Paramita Barai
Modeling The Power Evolution Of Classical Double Radio Galaxies Over Cosmological Scales, Paramita Barai
Physics and Astronomy Dissertations
During the quasar era (redshifts between 1 and 3) Radio Galaxies (RGs) have been claimed to have substantially influenced the growth and evolution of large scale structures in the universe. In this dissertation I test the robustness of these exciting claims. In order to probe the impacts in more detail, good theoretical models for such RG systems are required. With this motivation, I seek to develop an essentially analytical model for the evolution of Fanaroff-Riley Class II radio galaxies both as they age individually and as their numbers vary with cosmological epoch. To do so, I first compare three sophisticated …
Kinematics Of The Narrow-Line Regions In The Seyfert Galaxies Ngc 4151 And Ngc 1068, Varendra Das
Kinematics Of The Narrow-Line Regions In The Seyfert Galaxies Ngc 4151 And Ngc 1068, Varendra Das
Physics and Astronomy Dissertations
We present a study of high-resolution long-slit spectra of the Narrow-Line Regions (NLRs) of NGC 4151 (a Seyfert 1 galaxy) and NGC 1068 (a Seyfert 2 galaxy) obtained with the Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope (HST). The spectra were retrieved from the Multimission Archive at Space Telescope (MAST) and were obtained from five and seven orbits of HST time resulting in five and seven parallel slit configurations at position angles of 52 degrees and 38 degrees for NGC 4151 and NGC 1068 respectively. The spectra have a spatial resolution of 0.2 arcsecond across and 0.1 …
Inferring The Structure Of Signal Transduction Networks From Interactions Between Cellular Components And Inferring Haplotypes From Informative Snps, Kelly Anthony Westbrooks
Inferring The Structure Of Signal Transduction Networks From Interactions Between Cellular Components And Inferring Haplotypes From Informative Snps, Kelly Anthony Westbrooks
Computer Science Theses
Many problems in bioinformatics are inference problems, that is, the problem objective is to infer something based upon a limited amount of information. In this work we explore two different inference problems in bioinformatics. The first problem is inferring the structure of signal transduction networks from interactions between pairs of cellular components. We present two contributions towards the solution to this problem: an mixed integer program that produces and exact solution, and an implementation of an approximation algorithm in Java that was originally described by DasGupta et al. An exact solution is obtained for a problem instance consisting of real …
Ic2mpi: A Platform For Parallel Execution Of Graph-Structured Iterative Computations, Harnish Botadra
Ic2mpi: A Platform For Parallel Execution Of Graph-Structured Iterative Computations, Harnish Botadra
Computer Science Theses
Parallelization of sequential programs is often daunting because of the substantial development cost involved. Various solutions have been proposed to address this concern, including directive-based approaches and parallelization platforms. These solutions have not always been successful, in part because many try to address all types of applications. We propose a platform for parallelization of a class of applications that have similar computational structure, namely graph-structured iterative applications. iC2mpi is a unique proof-of-concept prototype platform that provides relatively easy parallelization of existing sequential programs and facilitates experimentation with static partitioning and dynamic load balancing schemes. We demonstrate with various generic application …
Assessing The Effect Of Prior Distribution Assumption On The Variance Parameters In Evaluating Bioequivalence Trials, Dawud A. Ujamaa
Assessing The Effect Of Prior Distribution Assumption On The Variance Parameters In Evaluating Bioequivalence Trials, Dawud A. Ujamaa
Mathematics Theses
Bioequivalence determines if two drugs are alike. The three kinds of bioequivalence are Average, Population, and Individual Bioequivalence. These Bioequivalence criteria can be evaluated using aggregate and disaggregate methods. Considerable work assessing bioequivalence in a frequentist method exists, but the advantages of Bayesian methods for Bioequivalence have been recently explored. Variance parameters are essential to any of theses existing Bayesian Bioequivalence metrics. Usually, the prior distributions for model parameters use either informative priors or vague priors. The Bioequivalence inference may be sensitive to the prior distribution on the variances. Recently, there have been questions about the routine use of inverse …
Clustering System And Clustering Support Vector Machine For Local Protein Structure Prediction, Wei Zhong
Clustering System And Clustering Support Vector Machine For Local Protein Structure Prediction, Wei Zhong
Computer Science Dissertations
Protein tertiary structure plays a very important role in determining its possible functional sites and chemical interactions with other related proteins. Experimental methods to determine protein structure are time consuming and expensive. As a result, the gap between protein sequence and its structure has widened substantially due to the high throughput sequencing techniques. Problems of experimental methods motivate us to develop the computational algorithms for protein structure prediction. In this work, the clustering system is used to predict local protein structure. At first, recurring sequence clusters are explored with an improved K-means clustering algorithm. Carefully constructed sequence clusters are used …
Implementation Of Vertical Handoff Algorithm Between Ieee802.11 Wlan And Cdma Cellular Network, Mary Narisetti
Implementation Of Vertical Handoff Algorithm Between Ieee802.11 Wlan And Cdma Cellular Network, Mary Narisetti
Computer Science Theses
Today’s wireless users expect great things from tomorrow’s wireless networks. These expectations have been fueled by hype about what the next generations of wireless networks will offer. The rapid increase of wireless subscribers increases the quality of services anytime, anywhere, and by any-media becoming indispensable. Integration of various networks such as CDMA2000 and wireless LAN into IP-based networks is required in these kinds of services, which further requires a seamless vertical handoff to 4th generation wireless networks. The proposed handoff algorithm between WLAN and CDMA2000 cellular network is implemented. The results of the simulation shows the behavior of the handoff …
On Some Aspects Of The Differential Operator, Panakkal Jesu Mathew
On Some Aspects Of The Differential Operator, Panakkal Jesu Mathew
Mathematics Theses
The Differential Operator D is a linear operator from C1[0,1] onto C[0,1]. Its domain C1[0,1] is thoroughly studied as a meager subspace of C[0,1]. This is analogous to the status of the set of all rational numbers Q in the set of the real numbers R. On the polynomial vector space Pn the Differential Operator D is a nilpotent operator. Using the invariant subspace and reducing subspace technique an appropriate basis for the underlying vector space can be found so that the nilpotent operator admits its Jordan Canonical form. The study of D on Pn is completely carried out. Finally, …
Some Significant Results In The Classification Analysis Of The Spectroscopic Evaluation Of Cervical Cancer, C Shen
Mathematics Theses
Cervical Cancer is the second most common type of cancer in women worldwide (500,000 cases/year) and one of the leading causes of cancer-related mortality in women in developing countries (230,000 cases/year). The Spectrx LightTouch™ device uses light to detect chemical and structural changes in cervical tissue. Light responds differently when exposed to normal cells and cancerous cells. The purpose of this research is to find the best model that can be used to diagnose the early cervical cancerous conditions. To achieve this goal, we first tried to reduce the number of variables. We use statistical and non-statistical methods to search …
An Automated Xpath To Sql Transformation Methodology For Xml Data, Sandeep Jandhyala
An Automated Xpath To Sql Transformation Methodology For Xml Data, Sandeep Jandhyala
Computer Science Theses
In this thesis we present an automated system that allows users to execute XPATH queries against an XML data source. The system exploits the shared-inlining mapping from XML to Relational data. At the core of the system is an XPATH to SQL transformation algorithm that produces corresponding SQL queries for a subset of XPATH. This approach allows one to utilize standard relational databases to store XML data. Given a DTD, the system creates appropriate relational tables based on the shared-inlining method. The system is capable of transforming an XML data source that conforms to the DTD into relational data. The …
Crystallographic Analysis And Kinetic Studies Of Hiv-1 Protease And Drug-Resistant Mutants, Yunfeng Tie
Crystallographic Analysis And Kinetic Studies Of Hiv-1 Protease And Drug-Resistant Mutants, Yunfeng Tie
Chemistry Dissertations
HIV-1 protease is the most effective target for drugs to treat AIDS, however, the long-term therapeutic efficiency is restricted by the rapid development of drug resistant variants. To better understand the molecular basis of drug resistance, crystallographic and kinetic studies were applied to wild-type HIV-1 protease (PR) and drug-resistant mutants, PRV82A, and PRI84V, in complex with substrate analogues, the current drug saquinavir and the new inhibitor UIC-94017 (TMC-114). UIC-94017 was also studied with mutants PRD30N and PRI50V. The drug-resistant mutations V82A, I84V, D30N and I50V participate in substrate binding. Eighteen crystal structures were refined at resolutions of 0.97-1.60A. The high …
On The Mechanistic Roles Of The Protein Positive Charge Close To The N(1)Flavin Locus In Choline Oxidase, Mahmoud Ghanem
On The Mechanistic Roles Of The Protein Positive Charge Close To The N(1)Flavin Locus In Choline Oxidase, Mahmoud Ghanem
Chemistry Dissertations
Choline oxidase catalyzes the oxidation of choline to glycine betaine. This reaction is of considerable medical and biotechnological applications, because the accumulation of glycine betaine in the cytoplasm of many plants and human pathogens enables them to counteract hyperosmotic environments. In this respect, the study of choline oxidase has potential for the development of a therapeutic agent that can specifically inhibit the formation of glycine betaine, and therefore render pathogens more susceptible to conventional treatment. The study of choline oxidase has also potential for the improvement of the stress resistance of plant by introducing an efficient biosynthetic pathway for glycine …
Statistical Genetic Interval-Valued Type-2 Fuzzy System And Its Application, Yu Qiu
Statistical Genetic Interval-Valued Type-2 Fuzzy System And Its Application, Yu Qiu
Computer Science Theses
In recent years, the type-2 fuzzy sets theory has been used to model and minimize the effects of uncertainties in rule-base fuzzy logic system. In order to make the type-2 fuzzy logic system reasonable and reliable, a new simple and novel statistical method to decide interval-valued fuzzy membership functions and a new probability type reduced reasoning method for the interval-valued fuzzy logic system are proposed in this thesis. In order to optimize this particle system’s performance, we adopt genetic algorithm (GA) to adjust parameters. The applications for the new system are performed and results have shown that the developed method …
Wharves To Waterfalls: A Geographical Analysis Of The Massachusetts Political Economy: 1763 - 1825., David Joseph Doran
Wharves To Waterfalls: A Geographical Analysis Of The Massachusetts Political Economy: 1763 - 1825., David Joseph Doran
Geosciences Theses
This research assesses how political legislation served as the catalyst in the transformation of Massachusetts through four specific economic stages from 1763 to 1825: fishing, privateering, global maritime commerce, and textile manufacturing. The objective of this analysis is to examine how politics forced coastal merchants to invest their commercial wealth into the burgeoning interior textile industry of the New England hinterland. Vance's mercantile model best explains European settlement of New England since multiple communities developed along the Atlantic coastline of the Massachusetts Bay region. Boston, Salem, and Newburyport emerged as entrepots, which acted as intermediaries between Europe and the frontier. …
Algebraic Concepts In The Study Of Graphs And Simplicial Complexes, Christopher Michael Zagrodny
Algebraic Concepts In The Study Of Graphs And Simplicial Complexes, Christopher Michael Zagrodny
Mathematics Theses
This paper presents a survey of concepts in commutative algebra that have applications to topology and graph theory. The primary algebraic focus will be on Stanley-Reisner rings, classes of polynomial rings that can describe simplicial complexes. Stanley-Reisner rings are defined via square-free monomial ideals. The paper will present many aspects of the theory of these ideals and discuss how they relate to important constructions in commutative algebra, such as finite generation of ideals, graded rings and modules, localization and associated primes, primary decomposition of ideals and Hilbert series. In particular, the primary decomposition and Hilbert series for certain types of …
The Relative Importance Of Input Encoding And Learning Methodology On Protein Secondary Structure Prediction, Arnshea Clayton
The Relative Importance Of Input Encoding And Learning Methodology On Protein Secondary Structure Prediction, Arnshea Clayton
Computer Science Theses
In this thesis the relative importance of input encoding and learning algorithm on protein secondary structure prediction is explored. A novel input encoding, based on multidimensional scaling applied to a recently published amino acid substitution matrix, is developed and shown to be superior to an arbitrary input encoding. Both decimal valued and binary input encodings are compared. Two neural network learning algorithms, Resilient Propagation and Learning Vector Quantization, which have not previously been applied to the problem of protein secondary structure prediction, are examined. Input encoding is shown to have a greater impact on prediction accuracy than learning methodology with …
The Timing And Causes Of Illite Formation In The Cretaceous Marias River Shale, Disturbed Belt, Montana, Stephen Gerard Osborn
The Timing And Causes Of Illite Formation In The Cretaceous Marias River Shale, Disturbed Belt, Montana, Stephen Gerard Osborn
Geosciences Theses
The clay mineralogy data and K-Ar ages of I/S measured in this study agree with previous work conducted within the Disturbed Belt (Hoffman, 1976) and show that diagenetic I/S formed quickly at several different places in response to thrust sheet burial during the Laramide orogeny. The averages of concordant age values for clay sub-fractions separated from three bentonites of Cretaceous and Jurassic depositional age increase from southeast (53.6 Ma) to northwest (56.7 Ma) along the trend of the Disturbed Belt. This northwestward increase of mean ages of I/S is consistent with a thrust sheet emplacement model for the Disturbed Belt …
An Indexation And Discovery Architecture For Semantic Web Services And Its Application In Bioinformatics, Liyang Yu
Computer Science Theses
Recently much research effort has been devoted to the discovery of relevant Web services. It is widely recognized that adding semantics to service description is the solution to this challenge. Web services with explicit semantic annotation are called Semantic Web Services (SWS). This research proposes an indexation and discovery architecture for SWS, together with a prototype application in the area of bioinformatics. In this approach, a SWS repository is created and maintained by crawling both ontology-oriented UDDI registries and Web sites that hosting SWS. For a given service request, the proposed system invokes the matching algorithm and a candidate set …
High Pressure Chemical Vapor Deposition: A Novel Approach For The Growth Of Inn, Vincent Timothy Woods
High Pressure Chemical Vapor Deposition: A Novel Approach For The Growth Of Inn, Vincent Timothy Woods
Physics and Astronomy Dissertations
The development of next generation devices for high speed switching, high efficiency energy conversion, spintronic devices require the development of advanced material systems. While conventional group IV, group II-VI and group III-V based materials systems have served as a base material in many modern device structures, they posses fundamental materials properties that limit their suitability in next generation device structures. The group III-N material system is very promising for the development of advanced device structures. GaN is currently widely used in high efficiency lighting applications. However, the development of this material system has been limited to material systems with limited …
X-Irradiation Of Dna Components In The Solid State: Experimental And Computational Studies Of Stabilized Radicals In Guanine Derivatives, Nayana Kumudini Jayatilaka
X-Irradiation Of Dna Components In The Solid State: Experimental And Computational Studies Of Stabilized Radicals In Guanine Derivatives, Nayana Kumudini Jayatilaka
Physics and Astronomy Dissertations
Single crystals of sodium salt of guanosine dihydrate and 9 Ethyl Guanine were X-irradiated with the objective of identifying the radical products. Study with K-band EPR, ENDOR, and ENDOR-Induced EPR techniques indicated at least four radical species to appear in both crystals in the temperature range of 6K to room temperature. Three of these radicals (Radicals R1, R2, and R3) were present immediately after irradiation at 6K. Computational chemistry and EPR spectrum simulation methods were also used to assist in radical identifications. Radical R1, the product of net hydrogen addition to N7, and Radical R2, the product of electron loss …
Granular Support Vector Machines Based On Granular Computing, Soft Computing And Statistical Learning, Yuchun Tang
Granular Support Vector Machines Based On Granular Computing, Soft Computing And Statistical Learning, Yuchun Tang
Computer Science Dissertations
With emergence of biomedical informatics, Web intelligence, and E-business, new challenges are coming for knowledge discovery and data mining modeling problems. In this dissertation work, a framework named Granular Support Vector Machines (GSVM) is proposed to systematically and formally combine statistical learning theory, granular computing theory and soft computing theory to address challenging predictive data modeling problems effectively and/or efficiently, with specific focus on binary classification problems. In general, GSVM works in 3 steps. Step 1 is granulation to build a sequence of information granules from the original dataset or from the original feature space. Step 2 is modeling Support …
Rational Realizations Of The Minimum Rank Of A Sign Pattern Matrix, Selcuk Koyuncu
Rational Realizations Of The Minimum Rank Of A Sign Pattern Matrix, Selcuk Koyuncu
Mathematics Theses
A sign pattern matrix is a matrix whose entries are from the set {+,-,0}. The minimum rank of a sign pattern matrix A is the minimum of the rank of the real matrices whose entries have signs equal to the corresponding entries of A. It is conjectured that the minimum rank of every sign pattern matrix can be realized by a rational matrix. The equivalence of this conjecture to several seemingly unrelated statements are established. For some special cases, such as when A is entrywise nonzero, or the minimum rank of A is at most 2, or the minimum rank …
Implications Of Late Pleistocene Climatic Change On The Morphological Variations Of The Neanderthal, Dawn Marie Bradley
Implications Of Late Pleistocene Climatic Change On The Morphological Variations Of The Neanderthal, Dawn Marie Bradley
Geosciences Theses
In this research, the relationship of climatic changes between 130k to 28k years BP to concurrent morphological variations in Neanderthals was tested. Traditional anthropological studies attribute robust Neanderthal morphological traits as an adaptation to a cold environment. A database of previously completed terrestrial paleoclimatic reconstructions in Europe and the Mediterranean was compiled and used to create a series of GIS-generated timeslice maps. Regional climatic conditions were then related to changes in Neanderthal appearances, morphology and disappearances as evident in the archaeological record. To establish climatic conditions, existing studies were compiled from two regions: Europe and the Mediterranean. The European data …
Simulating A Pipelined Reconfigurable Mesh On A Linear Array With A Reconfigurable Pipelined Bus System, Mathura Gopalan
Simulating A Pipelined Reconfigurable Mesh On A Linear Array With A Reconfigurable Pipelined Bus System, Mathura Gopalan
Computer Science Theses
Due to the unidirectional nature of propagation and predictable delays, optically pipelined buses have been gaining more attention. There have been many models proposed over time that use reconfigurable optically pipelined buses. The reconfigurable nature of the models makes them capable of changing their component’s functionalities and structure that connects the components at every step of computation. There are both one dimensional as well as k –dimensional models that have been proposed in the literature. Though equivalence between various one dimensional models and equivalence between different two dimensional models had been established, so far there has not been any attempt …
Topology Control, Routing Protocols And Performance Evaluation For Mobile Wireless Ad Hoc Networks, Hui Liu
Topology Control, Routing Protocols And Performance Evaluation For Mobile Wireless Ad Hoc Networks, Hui Liu
Computer Science Dissertations
A mobile ad-hoc network (MANET) is a collection of wireless mobile nodes forming a temporary network without the support of any established infrastructure or centralized administration. There are many potential applications based the techniques of MANETs, such as disaster rescue, personal area networking, wireless conference, military applications, etc. MANETs face a number of challenges for designing a scalable routing protocol due to their natural characteristics. Guaranteeing delivery and the capability to handle dynamic connectivity are the most important issues for routing protocols in MANETs. In this dissertation, we will propose four algorithms that address different aspects of routing problems in …
Semidefinite Programming And Stability Of Dynamical System, Kazumi Niki Stovall
Semidefinite Programming And Stability Of Dynamical System, Kazumi Niki Stovall
Mathematics Theses
In the first part of the thesis we present several interior point algorithms for solving certain positive definite programming problems. One of the algorithms is adapted for finding out whether there exists or not a positive definite matrix which is a real linear combination of some given symmetric matrices A1,A2, . . . ,Am. In the second part of the thesis we discuss stability of nonlinear dynamical systems. We search using algorithms described in the first part, for Lyapunov functions of a few forms. A suitable Lyapunov function implies the existence of a hyperellipsoidal attraction region for the dynamical system, …
A Prototype Visible To Near-Infrared Spectrograph For The Chara Array, A Long-Baseline Stellar Interferometer, Chad Elliott Ogden
A Prototype Visible To Near-Infrared Spectrograph For The Chara Array, A Long-Baseline Stellar Interferometer, Chad Elliott Ogden
Physics and Astronomy Dissertations
This work is a description of the Visible to near Infrared Spectrograph system for the CHARA array. The CHARA Array is a 6-telescope interferometer at the Mount Wilson Observatory in the mountains north of Pasadena, California. It combines the light from the 1-meter telescopes, and measures the visibility of the resulting interference fringes, which gives information about the source intensity distribution on the sky. The resolution of the instrument is proportional to the telescope separation, or baseline, divided by the wavelength. The VIS system operates in the 600-1000~nm wavelength range, a factor of 3 to 4 shorter than the standard …
A System For Rapid Configuration Of Distributed Workflows Over Web Services And Their Handheld-Based Coordination, Jaimini Joshi
A System For Rapid Configuration Of Distributed Workflows Over Web Services And Their Handheld-Based Coordination, Jaimini Joshi
Computer Science Theses
Web services technology has lately stirred tremendous interest in industry as well as the academia. Web services are self-contained, platform independent functionality which is available over the internet. Web services are defined, discovered & accessed using a standard protocols like WSDL, UDDI & SOAP. With the advent of Service-Oriented Architecture and need for more complex application, it became eminent to have a way in which these independent entities could collaborate in a coherent manner to provide a high level functionality. But the problem of service composition is not an easy one. One reason being the self-contained and loosely coupled interaction …