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X-Irradiation Of Dna Components In The Solid State: Experimental And Computational Studies Of Stabilized Radicals In Guanine Derivatives, Nayana Kumudini Jayatilaka
X-Irradiation Of Dna Components In The Solid State: Experimental And Computational Studies Of Stabilized Radicals In Guanine Derivatives, Nayana Kumudini Jayatilaka
Physics and Astronomy Dissertations
Single crystals of sodium salt of guanosine dihydrate and 9 Ethyl Guanine were X-irradiated with the objective of identifying the radical products. Study with K-band EPR, ENDOR, and ENDOR-Induced EPR techniques indicated at least four radical species to appear in both crystals in the temperature range of 6K to room temperature. Three of these radicals (Radicals R1, R2, and R3) were present immediately after irradiation at 6K. Computational chemistry and EPR spectrum simulation methods were also used to assist in radical identifications. Radical R1, the product of net hydrogen addition to N7, and Radical R2, the product of electron loss …