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Flour For Home Baking: A Cross-Sectional Analysis Of Supermarket Products Emphasising The Whole Grain Opportunity, Jaimee Hughes, Verena Vaiciurgis, Sara J. Grafenauer Jan 2020

Flour For Home Baking: A Cross-Sectional Analysis Of Supermarket Products Emphasising The Whole Grain Opportunity, Jaimee Hughes, Verena Vaiciurgis, Sara J. Grafenauer

Faculty of Science, Medicine and Health - Papers: Part B

Flour, typically derived from wheat, rye, corn and rice is a pantry staple, providing structure to bread and baked goods. This study aimed to provide a cross-sectional analysis of flour for home baking, highlighting the nutrition composition of whole grain flour and identifying novel categories. An audit was undertaken in February 2020, in four major supermarkets in metropolitan Sydney (Aldi, Coles, IGA and Woolworths). Ingredient lists, Nutrition Information Panel, claims, and country of origin were collected. The median and range were calculated for energy, protein, fat, saturated fat, carbohydrate, sugars, dietary fibre and sodium. Overall, 130 products were collected, including …


Nutritional Status According To The Mini Nutritional Assessment Predicts Speed And Degree Of Functional Improvement And Discharge Outcomes In Rehabilitation Patients, Kelly Lambert, Emily Taylor, Steven Bowden, Karen E. Charlton Jan 2020

Nutritional Status According To The Mini Nutritional Assessment Predicts Speed And Degree Of Functional Improvement And Discharge Outcomes In Rehabilitation Patients, Kelly Lambert, Emily Taylor, Steven Bowden, Karen E. Charlton

Faculty of Science, Medicine and Health - Papers: Part B

This retrospective observational study evaluated the association between nutritional status, functional ability and discharge outcomes. Data from 1430 older rehabilitation patients (43% male, median age 79 years, interquartile range: 74–84) were analyzed. One fifth (20.6%, n = 294) of patients were malnourished on admission to rehabilitation. Three important findings were evident. Firstly, nutritional status on admission to rehabilitation was associated with reduced functional, motor, cognitive and feeding scores on admission and discharge (all P < 0.05). Secondly, malnutrition at admission was associated with significantly slower gains in rehabilitation. Finally, malnutrition at admission was associated with significantly higher odds of a decline in functional ability during admission (OR 3.95; 95% CI: 2.14–7.27), and almost three times greater odds of additional care requirements on discharge (OR: 2.9 ((95% CI: 1.02–8.3). The nutritional status of patients on admission to inpatient rehabilitation is a predictor of both the speed and degree of rehabilitation gains and discharge outcomes.


Analysis Of Global Collection Of Group A Streptococcus Genomes Reveals That The Majority Encode A Trio Of M And M-Like Proteins, Hannah Frost, Mark Davies, Valerie Delforge, Dalila Lakhloufi, Martina L. Sanderson-Smith, Velusamy Srinivasan, Andrew Steer, Mark Walker, Bernard Beall, Anne Botteaux, Pierre Smeesters Jan 2020

Analysis Of Global Collection Of Group A Streptococcus Genomes Reveals That The Majority Encode A Trio Of M And M-Like Proteins, Hannah Frost, Mark Davies, Valerie Delforge, Dalila Lakhloufi, Martina L. Sanderson-Smith, Velusamy Srinivasan, Andrew Steer, Mark Walker, Bernard Beall, Anne Botteaux, Pierre Smeesters

Faculty of Science, Medicine and Health - Papers: Part B

Copyright 2020 Frost et al. The core Mga (multiple gene activator) regulon of group A Streptococcus (GAS) contains genes encoding proteins involved in adhesion and immune evasion. While all GAS genomes contain genes for Mga and C5a peptidase, the intervening genes encoding M and M-like proteins vary between strains. The genetic make-up of the Mga regulon of GAS was characterized by utilizing a collection of 1,688 GAS genomes that are representative of the global GAS population. Sequence variations were examined with multiple alignments, and the expression of all core Mga regulon genes was examined by quantitative reverse transcription-PCR in a …


What Is Underneath The Juvenile Ordovician Macquarie Arc (Eastern Australia)? A Question Resolved Using Silurian Intrusions To Sample The Lower Crust, Qing Zhang, Allen Phillip Nutman, Solomon Buckman, Vickie C. Bennett Jan 2020

What Is Underneath The Juvenile Ordovician Macquarie Arc (Eastern Australia)? A Question Resolved Using Silurian Intrusions To Sample The Lower Crust, Qing Zhang, Allen Phillip Nutman, Solomon Buckman, Vickie C. Bennett

Faculty of Science, Medicine and Health - Papers: Part B

2020 International Association for Gondwana Research The Ordovician intra-oceanic Macquarie Arc of eastern Australia collided with the eastern Gondwanan margin at ~440 Ma. However, the deep crustal architecture resulting from this assembly is poorly known. This is addressed here by a zircon U-Pb-Hf study of the post-assembly Silurian Browns Creek Intrusive Complex and Davies Creek Granite dykes that intrude into the arc, and not adjacent Gondwanan sedimentary sequences. Zircon U[sbnd]Pb dating integrated with CL imagery indicate two igneous phases at 430-437 Ma and 420-426 Ma and a zircon recrystallisation phase at 395-396 Ma attributed to a late thermal event. The …


Archaeological Evidence For Two Separate Dispersals Of Neanderthals Into Southern Siberia, Kseniya Kolobova, Richard G. Roberts, Victor P. Chabai, Zenobia Jacobs, Maciej T. Krajcarz, Alena V. Shalagina, Audrey I. Krivoshapkin, Bo Li, Thorsten Uthmeier, Sergey V. Markin, Mike W. Morley, Kieran O'Gorman, Natalia A. Rudaya, Sahra Talamo, Bence Viola, Anatoly Derevianko Jan 2020

Archaeological Evidence For Two Separate Dispersals Of Neanderthals Into Southern Siberia, Kseniya Kolobova, Richard G. Roberts, Victor P. Chabai, Zenobia Jacobs, Maciej T. Krajcarz, Alena V. Shalagina, Audrey I. Krivoshapkin, Bo Li, Thorsten Uthmeier, Sergey V. Markin, Mike W. Morley, Kieran O'Gorman, Natalia A. Rudaya, Sahra Talamo, Bence Viola, Anatoly Derevianko

Faculty of Science, Medicine and Health - Papers: Part B

Neanderthals were once widespread across Europe and western Asia. They also penetrated into the Altai Mountains of southern Siberia, but the geographical origin of these populations and the timing of their dispersal have remained elusive. Here we describe an archaeological assemblage from Chagyrskaya Cave, situated in the Altai foothills, where around 90,000 Middle Paleolithic artifacts and 74 Neanderthal remains have been recovered from deposits dating to between 59 and 49 thousand years ago (age range at 95.4% probability). Environmental reconstructions suggest that the Chagyrskaya hominins were adapted to the dry steppe and hunted bison. Their distinctive toolkit closely resembles Micoquian …


The Mrna-Based Reprogramming Of Fibroblasts From A Sod1E101g Familial Amyotrophic Lateral Sclerosis Patient To Induced Pluripotent Stem Cell Line Uowi007, Rachelle Balez, Tracey Berg, Monique Bax, Sonia Sanz Munoz, Mauricio E Castro Cabral Da Silva, Martin Engel, Phuong Dzung Do-Ha, Claire H. Stevens, Dominic Rowe, Shu Yang, Ian Blair, Lezanne Ooi Jan 2020

The Mrna-Based Reprogramming Of Fibroblasts From A Sod1E101g Familial Amyotrophic Lateral Sclerosis Patient To Induced Pluripotent Stem Cell Line Uowi007, Rachelle Balez, Tracey Berg, Monique Bax, Sonia Sanz Munoz, Mauricio E Castro Cabral Da Silva, Martin Engel, Phuong Dzung Do-Ha, Claire H. Stevens, Dominic Rowe, Shu Yang, Ian Blair, Lezanne Ooi

Faculty of Science, Medicine and Health - Papers: Part B

2020 The Authors Dermal fibroblasts were donated by a 43 year old male patient with clinically diagnosed familial amyotrophic lateral sclerosis (ALS), carrying the SOD1E101G mutation. The induced pluripotent stem cell (iPSC) line UOWi007-A was generated using repeated mRNA transfections for pluripotency transcription factors Oct4, Klf4, Sox2, c-Myc, Lin28 and Nanog. The iPSCs carried the SOD1E101G genotype and had a normal karyotype, expressed expected pluripotency markers and were capable of in vitro differentiation into endodermal, mesodermal and ectodermal lineages. This iPSC line may be useful for investigating familial ALS resulting from a SOD1 E101G mutation.


Spectral Sizing Of A Coarse-Spectral-Resolution Satellite Sensor For Xco2, Jonas S. Wilzewski, Anke Roiger, Johan Strandgren, Jochen Landgraf, Dietrich Feist, Voltaire A. Velazco, Nicholas M. Deutscher, Isamu Morino, Hirofumi Ohyama, Yao Té, Rigel Kivi, Thorsten Warneke, Justus Notholt, Mavendra Dubey, Ralf Sussmann, Markus Rettinger, Frank Hase, Kei Shiomi, André Butz Jan 2020

Spectral Sizing Of A Coarse-Spectral-Resolution Satellite Sensor For Xco2, Jonas S. Wilzewski, Anke Roiger, Johan Strandgren, Jochen Landgraf, Dietrich Feist, Voltaire A. Velazco, Nicholas M. Deutscher, Isamu Morino, Hirofumi Ohyama, Yao Té, Rigel Kivi, Thorsten Warneke, Justus Notholt, Mavendra Dubey, Ralf Sussmann, Markus Rettinger, Frank Hase, Kei Shiomi, André Butz

Faculty of Science, Medicine and Health - Papers: Part B

Verifying anthropogenic carbon dioxide (CO2) emissions globally is essential to inform about the progress of institutional efforts to mitigate anthropogenic climate forcing. To monitor localized emission sources, spectroscopic satellite sensors have been proposed that operate on the CO2 absorption bands in the shortwave-infrared (SWIR) spectral range with ground resolution as fine as a few tens of meters to about a hundred meters. When designing such sensors, fine ground resolution requires a trade-off towards coarse spectral resolution in order to achieve sufficient noise performance. Since fine ground resolution also implies limited ground coverage, such sensors are envisioned to fly in fleets …


The First Australian Plant Foods At Madjedbebe, 65,000-53,000 Years Ago, S Florin, Andrew Fairbairn, May Nango, Djaykuk Djandjomerr, Ben Marwick, Richard Fullagar, Mike Smith, Lynley Wallis, Christopher Clarkson Jan 2020

The First Australian Plant Foods At Madjedbebe, 65,000-53,000 Years Ago, S Florin, Andrew Fairbairn, May Nango, Djaykuk Djandjomerr, Ben Marwick, Richard Fullagar, Mike Smith, Lynley Wallis, Christopher Clarkson

Faculty of Science, Medicine and Health - Papers: Part B

2020, The Author(s). There is little evidence for the role of plant foods in the dispersal of early modern humans into new habitats globally. Researchers have hypothesised that early movements of human populations through Island Southeast Asia and into Sahul were driven by the lure of high-calorie, low-handling-cost foods, and that the use of plant foods requiring processing was not common in Sahul until the Holocene. Here we present the analysis of charred plant food remains from Madjedbebe rockshelter in northern Australia, dated to between 65 kya and 53 kya. We demonstrate that Australia's earliest known human population exploited a …


The Support Needs Of Australian Primary Health Care Nurses During The Covid‐19 Pandemic, Elizabeth J. Halcomb, Anna Williams, Christine Ashley, Susan Mcinnes, Catherine Stephen, Kaara Ray Calma, Sharon James Jan 2020

The Support Needs Of Australian Primary Health Care Nurses During The Covid‐19 Pandemic, Elizabeth J. Halcomb, Anna Williams, Christine Ashley, Susan Mcinnes, Catherine Stephen, Kaara Ray Calma, Sharon James

Faculty of Science, Medicine and Health - Papers: Part B

Aim To identify Australian primary healthcare nurses immediate support needs during the COVID‐19 pandemic. Background COVID‐19 has had widespread implications for primary healthcare nurses. Supporting these nurses’ capacity to deliver quality care ensures that ongoing health needs can be met. Methods Primary healthcare nurses were recruited to an online survey via social media and professional organisations in April 2020. Results Six‐hundred and thirty‐seven responses were included in analysis. Participants provided 1213 statements about perceived supports required to provide quality clinical care. From these, seven key categories emerged, namely; personal protective equipment, communication, funding, industrial issues, self‐care, workplace factors and valuing …


Why Has Covid-19 Not Hit The Countries Like Nepal Yet?, Krishna P. Pathak, Tara Gaire, Mu-Hsing Ho, H.C. Chang Jan 2020

Why Has Covid-19 Not Hit The Countries Like Nepal Yet?, Krishna P. Pathak, Tara Gaire, Mu-Hsing Ho, H.C. Chang

Faculty of Science, Medicine and Health - Papers: Part B

Noble CORONA Virus (COVID-19) is an infectious disease similar form of pneumonia/ SARS-CoV-2- impacting globally. The fear of coronavirus looks pandemic, but its severity is uncertain. Nepal was one of the first nine countries outside of China to report a COVID-19 case. Also, its unpredictability of mode or range of surface, the lifespan of the virus, objects of transmission (a distance of air/air currents, living duration in air, humidity, duration on objects, surface). The first case was found in Wuhan in December 2019 in China. The purpose is to summarize the current information about COVID-19 and to explore in terms …


Exploring The Use Of Ageing Simulation To Enable Nurses To Gain Insight Into What It Is Like To Be An Older Person, Alera Bowden, Valerie J. Wilson, Victoria Traynor, H.C. Chang Jan 2020

Exploring The Use Of Ageing Simulation To Enable Nurses To Gain Insight Into What It Is Like To Be An Older Person, Alera Bowden, Valerie J. Wilson, Victoria Traynor, H.C. Chang

Faculty of Science, Medicine and Health - Papers: Part B

Aim and objectives To explore the thoughts and experiences of aged care nurses following participation in an ageing‐suit simulation intervention. Background Globally, people are living longer, and for nurses, there are increasing challenges to meet the needs of the higher numbers of older people in hospital. Educating nurses to understand the ageing process and the experiences of older people in hospital is crucial to addressing these challenges. Ageing‐suits were identified as a possible approach to assist with these educational needs. Design This study adopted a qualitative descriptive design. Method A convenience sample of nurses (n = 15) were selected from …


A Unified Call To Action From Australian Nursing And Midwifery Leaders: Ensuring That Black Lives Matter, L Geia, K Baird, K Bail, Lesley M. Barclay, James E. Bennett, O Best, M Birks, L Blackley, R Blackman, A Bonner, R Bryant, C Buzzacott, S Campbell, Christine Catling, C Chamberlain, L Cox, W Cross, M Cruickshank, A Cummins, H Dahlen, J Daly, Philip Darbyshire, Patricia M. Davidson, Elizabeth Denney-Wilson, R De Souza, K Doyle, A Drummond, J Duff, C Duffield, T Dunning, Leah East, D Elliott, R Elmir, D Fergie, Caleb Ferguson, Ritin S. Fernandez, D Flower, M Foureur, Cathrine Fowler, M Fry, E Gorman, J Grant, Joanne Gray, Elizabeth J. Halcomb, B Hart, D Hartz, M Hazelton, L Heaton, Louise Hickman, C Homer, C Hungerford, A Hutton, Debra Jackson, A Johnson, Margaret Kelly, A Kitson, S Knight, Tracy Levett-Jones, D Lindsay, Raymond W. Lovett, Lauretta Luck, Luke J. Molloy, E Manias, Judy Mannix, A Marriott, M Martin, D Massey, Andrea Mccloughen, S Mcgough, L Mcgrath, J Mills, Brett Mitchell, J Mohamed, J Montayre, Tracey Moroney, Wendy Moyle, Lorna Moxham, H Northam, S Nowlan, A O'Brien, O Ogunsiji, C Paterson, K Pennington, Kathleen Peters, Jane Phillips, Tamara Power, Nicholas Procter, Lucie Ramjan, N Ramsay, B Rasmussen, J Rihari-Thomas, B Rind, M Robinson, Michael Roche, K Sainsbury, Yenna Salamonson, J Sherwood, L Shields, Jenny Sim, J Skinner, G Smallwood, R Smallwood, L Stewart, S Taylor, K Usher, C Virdun, J Wannell, R Ward, C West, R West, Lesley Wilkes, R Williams, Rhonda Wilson, D Wynaden, R Wynne Jan 2020

A Unified Call To Action From Australian Nursing And Midwifery Leaders: Ensuring That Black Lives Matter, L Geia, K Baird, K Bail, Lesley M. Barclay, James E. Bennett, O Best, M Birks, L Blackley, R Blackman, A Bonner, R Bryant, C Buzzacott, S Campbell, Christine Catling, C Chamberlain, L Cox, W Cross, M Cruickshank, A Cummins, H Dahlen, J Daly, Philip Darbyshire, Patricia M. Davidson, Elizabeth Denney-Wilson, R De Souza, K Doyle, A Drummond, J Duff, C Duffield, T Dunning, Leah East, D Elliott, R Elmir, D Fergie, Caleb Ferguson, Ritin S. Fernandez, D Flower, M Foureur, Cathrine Fowler, M Fry, E Gorman, J Grant, Joanne Gray, Elizabeth J. Halcomb, B Hart, D Hartz, M Hazelton, L Heaton, Louise Hickman, C Homer, C Hungerford, A Hutton, Debra Jackson, A Johnson, Margaret Kelly, A Kitson, S Knight, Tracy Levett-Jones, D Lindsay, Raymond W. Lovett, Lauretta Luck, Luke J. Molloy, E Manias, Judy Mannix, A Marriott, M Martin, D Massey, Andrea Mccloughen, S Mcgough, L Mcgrath, J Mills, Brett Mitchell, J Mohamed, J Montayre, Tracey Moroney, Wendy Moyle, Lorna Moxham, H Northam, S Nowlan, A O'Brien, O Ogunsiji, C Paterson, K Pennington, Kathleen Peters, Jane Phillips, Tamara Power, Nicholas Procter, Lucie Ramjan, N Ramsay, B Rasmussen, J Rihari-Thomas, B Rind, M Robinson, Michael Roche, K Sainsbury, Yenna Salamonson, J Sherwood, L Shields, Jenny Sim, J Skinner, G Smallwood, R Smallwood, L Stewart, S Taylor, K Usher, C Virdun, J Wannell, R Ward, C West, R West, Lesley Wilkes, R Williams, Rhonda Wilson, D Wynaden, R Wynne

Faculty of Science, Medicine and Health - Papers: Part B

Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than …


Determining A Global Mid-Upper Arm Circumference Cut-Off To Assess Underweight In Adults (Men And Non-Pregnant Women), Alice M. Tang, Mei Chung, Kimberly R. Dong, Paluku Bahwere, Kaushik Bose, Raja Chakraborty, Karen E. Charlton, Priyanka Das, Mihir Ghosh, Md I. Hossain, Phuong Nguyen, Cecilie B. Patsche, Tania Sultana, Megan Deitchler, Zeina Maalouf-Manasseh Jan 2020

Determining A Global Mid-Upper Arm Circumference Cut-Off To Assess Underweight In Adults (Men And Non-Pregnant Women), Alice M. Tang, Mei Chung, Kimberly R. Dong, Paluku Bahwere, Kaushik Bose, Raja Chakraborty, Karen E. Charlton, Priyanka Das, Mihir Ghosh, Md I. Hossain, Phuong Nguyen, Cecilie B. Patsche, Tania Sultana, Megan Deitchler, Zeina Maalouf-Manasseh

Faculty of Science, Medicine and Health - Papers: Part B

No abstract provided.


Intercomparison Of Low- And High-Resolution Infrared Spectrometers For Ground-Based Solar Remote Sensing Measurements Of Total Column Concentrations Of Co2, Ch4, And Co, Mahesh K. Sha, Martine De Maziere, Justus Notholt, Thomas Blumenstock, Huilin Chen, Angelika Dehn, David W. T Griffith, Frank Hase, Pauli Heikkinen, Christian Hermans, Alex Hoffmann, Marko Huebner, Nicholas B. Jones, Rigel Kivi, Bavo Langerock, Christof Petri, Francis Scolas, Qiansi Tu, Damien Weidmann Jan 2020

Intercomparison Of Low- And High-Resolution Infrared Spectrometers For Ground-Based Solar Remote Sensing Measurements Of Total Column Concentrations Of Co2, Ch4, And Co, Mahesh K. Sha, Martine De Maziere, Justus Notholt, Thomas Blumenstock, Huilin Chen, Angelika Dehn, David W. T Griffith, Frank Hase, Pauli Heikkinen, Christian Hermans, Alex Hoffmann, Marko Huebner, Nicholas B. Jones, Rigel Kivi, Bavo Langerock, Christof Petri, Francis Scolas, Qiansi Tu, Damien Weidmann

Faculty of Science, Medicine and Health - Papers: Part B

© Author(s) 2020. The Total Carbon Column Observing Network (TCCON) is the baseline ground-based network of instruments that record solar absorption spectra from which accurate and precise column-averaged dry-air mole fractions of CO2 (XCO2), CH4(XCH4), CO (XCO), and other gases are retrieved. The TCCON data have been widely used for carbon cycle science and validation of satellites measuring greenhouse gas concentrations globally. The number of stations in the network (currently about 25) is limited and has a very uneven geographical coverage: the stations in the Northern Hemisphere are distributed mostly in North America, Europe, and Japan, and only 20% of …


Validation Of Carbon Trace Gas Profile Retrievals From The Noaa-Unique Combined Atmospheric Processing System For The Cross-Track Infrared Sounder, Nicholas R. Nalli, Changyi Tan, Juying Warner, Murty Divakarla, Antonia Gambacorta, Michael Wilson, Tong Zhu, Tianyuan Wang, Zigang Wei, Ken Pryor, Satya Kalluri, Lihang Zhou, Colm Sweeney, Bianca Baier, Kathryn Mckain, Debra Wunch, Nicholas M. Deutscher, Frank Hase, Laura T. Iraci, Rigel Kivi, Isamu Morino, Justus Notholt, Hirofumi Ohyama, David Pollard, Yao Te, Voltaire A. Velazco, Thorsten Warneke, Ralf Sussmann, Markus Rettinger Jan 2020

Validation Of Carbon Trace Gas Profile Retrievals From The Noaa-Unique Combined Atmospheric Processing System For The Cross-Track Infrared Sounder, Nicholas R. Nalli, Changyi Tan, Juying Warner, Murty Divakarla, Antonia Gambacorta, Michael Wilson, Tong Zhu, Tianyuan Wang, Zigang Wei, Ken Pryor, Satya Kalluri, Lihang Zhou, Colm Sweeney, Bianca Baier, Kathryn Mckain, Debra Wunch, Nicholas M. Deutscher, Frank Hase, Laura T. Iraci, Rigel Kivi, Isamu Morino, Justus Notholt, Hirofumi Ohyama, David Pollard, Yao Te, Voltaire A. Velazco, Thorsten Warneke, Ralf Sussmann, Markus Rettinger

Faculty of Science, Medicine and Health - Papers: Part B

This paper provides an overview of the validation of National Oceanic and Atmospheric Administration (NOAA) operational retrievals of atmospheric carbon trace gas profiles, specifically carbon monoxide (CO), methane (CH4) and carbon dioxide (CO2), from the NOAA-Unique Combined Atmospheric Processing System (NUCAPS), a NOAA enterprise algorithm that retrieves atmospheric profile environmental data records (EDRs) under global non-precipitating (clear to partly cloudy) conditions. Vertical information about atmospheric trace gases is obtained from the Cross-track Infrared Sounder (CrIS), an infrared Fourier transform spectrometer that measures high resolution Earth radiance spectra from NOAA operational low earth orbit (LEO) satellites, including the Suomi National Polar-orbiting …


High Body Mass Index Is Associated With An Increased Overall Survival In Rectal Cancer, Karolina Juszczyk, Sharlyn Kang, Soni Putnis, Robert Winn, James Chen, Morteza Aghmesheh, Glaucia Fylyk, Daniel Brungs Jan 2020

High Body Mass Index Is Associated With An Increased Overall Survival In Rectal Cancer, Karolina Juszczyk, Sharlyn Kang, Soni Putnis, Robert Winn, James Chen, Morteza Aghmesheh, Glaucia Fylyk, Daniel Brungs

Faculty of Science, Medicine and Health - Papers: Part B

© Journal of Gastrointestinal Oncology. All rights reserved. Background: The impact of increased body mass index (BMI) on clinical outcomes in locoregional rectal cancer is unknown. Methods: This is a retrospective cohort study which included 453 consecutive rectal cancer patients undergoing definitive treatment, with confirmed stage I, II or III rectal adenocarcinoma. The association of BMI at diagnosis with overall survival (OS), cancer specific survival (CSS) and disease-free survival (DFS) was explored, controlling for key covariates using multivariable analyses. BMI as defined by the World Health Organization (WHO) is as follows: BMI <18.5-underweight; 18.5-24.9-normal; 25.0-29.9-pre-obesity; >30-obese. Results: Overweight and obese patients had significantly …


Salt And Potassium Intake Among Adult Ghanaians: Who-Sage Ghana Wave 3, Elias Menyanu, Barbara Corso, Nadia Minicuci, Ilaria Rocco, Joanna Russell, Lisa Ware, Richard Biritwum, Paul Kowal, Aletta Schutte, Karen E. Charlton Jan 2020

Salt And Potassium Intake Among Adult Ghanaians: Who-Sage Ghana Wave 3, Elias Menyanu, Barbara Corso, Nadia Minicuci, Ilaria Rocco, Joanna Russell, Lisa Ware, Richard Biritwum, Paul Kowal, Aletta Schutte, Karen E. Charlton

Faculty of Science, Medicine and Health - Papers: Part B

© 2020 The Author(s). Though Ghana has high hypertension prevalence, the country lacks current national salt consumption data required to build and enhance advocacy for salt reduction. We explored the characteristics of a randomly selected sub sample that had valid urine collection, along with matched survey, anthropometric and BP data (n = 839, mean age = 60y), from the World Health Organization's Study on global AGEing and adult health (WHO-SAGE), Ghana Wave 3, n = 3053). We also investigated the relationship between salt intake and blood pressure (BP) among the cohort. BP was measured in triplicate and 24 h urine …


Antibiotic-Induced Mutagenesis: Under The Microscope, Sarah Revitt-Mills, Andrew Robinson Jan 2020

Antibiotic-Induced Mutagenesis: Under The Microscope, Sarah Revitt-Mills, Andrew Robinson

Faculty of Science, Medicine and Health - Papers: Part B

Copyright 2020 Revitt-Mills and Robinson. The development of antibiotic resistance poses an increasing threat to global health. Understanding how resistance develops in bacteria is critical for the advancement of new strategies to combat antibiotic resistance. In the 1980s, it was discovered that certain antibiotics induce elevated rates of mutation in bacteria. From this, an "increased evolvability" hypothesis was proposed: antibiotic-induced mutagenesis increases the genetic diversity of bacterial populations, thereby increasing the rate at which bacteria develop antibiotic resistance. However, antibiotic-induced mutagenesis is one of multiple competing factors that act on bacterial populations exposed to antibiotics. Its relative importance in shaping …


Taxonomic Revision Of Australian Amobia Robineau-Desvoidy, 1830 (Sarcophagidae: Miltogramminae): Integrating Morphology And Genetics Finds A New Species And Tackles Old Problems, Nikolas Johnston, James F. Wallman, Mark P. Dowton, Krzysztof Szpila, Thomas Pape Jan 2020

Taxonomic Revision Of Australian Amobia Robineau-Desvoidy, 1830 (Sarcophagidae: Miltogramminae): Integrating Morphology And Genetics Finds A New Species And Tackles Old Problems, Nikolas Johnston, James F. Wallman, Mark P. Dowton, Krzysztof Szpila, Thomas Pape

Faculty of Science, Medicine and Health - Papers: Part B

2020, Museum National d'Histoire Naturelle. All rights reserved. A taxonomic revision of the Australian species of Amobia Robineau-Desvoidy, 1830 (Diptera: Sarcophagidae: Miltogramminae) is completed using an integrated approach combining four molecular loci (three mitochondrial, COI, ND4 and CYTB; one nuclear, EF1α) and morphological data. A new species, Amobia (s. str.) serpenta sp. nov., endemic to Australia, is described, and Amobia auriceps (Baranov, 1935) and Amobia burnsi (Malloch, 1930) are re-described. Molecular data are used to reconstruct inter-specific and generic relationships and support morphological species hypotheses. Phylogenetic analysis places all three Australian Amobia species together with Amobia signata (Meigen, 1824) (a …


Severe Childhood And Adulthood Stress Associates With Neocortical Layer-Specific Reductions Of Mature Spines In Psychiatric Disorders, Dominic Kaul, Caine C. Smith, Julia Stevens, Anna S. Fröhlich, Elisabeth B. Binder, Naguib Mechawar, Sibylle G. Schwab, Natalie Matosin Jan 2020

Severe Childhood And Adulthood Stress Associates With Neocortical Layer-Specific Reductions Of Mature Spines In Psychiatric Disorders, Dominic Kaul, Caine C. Smith, Julia Stevens, Anna S. Fröhlich, Elisabeth B. Binder, Naguib Mechawar, Sibylle G. Schwab, Natalie Matosin

Faculty of Science, Medicine and Health - Papers: Part B

Severe stress exposure causes the loss of dendritic spines on cortical pyramidal neurons and induces psychiatric-like symptoms in rodent models. These effects are strongest following early-life stress and are most persistent on apical dendrites. However, the long-term impacts and temporal effects of stress exposure on the human brain remain poorly understood. Using a novel postmortem cohort of psychiatric cases with severe stress experienced in childhood, adulthood, or no severe stress, and matched controls, we aimed to determine the impact of stress timing on pyramidal neuron structure in the human orbitofrontal cortex (OFC). We performed Golgi Cox staining and manually measured …


Rapid High-Yield Expression And Purification Of Fully Post-Translationally Modified Recombinant Clusterin And Mutants, Sandeep Satapathy, Rebecca Dabbs, Mark R. Wilson Jan 2020

Rapid High-Yield Expression And Purification Of Fully Post-Translationally Modified Recombinant Clusterin And Mutants, Sandeep Satapathy, Rebecca Dabbs, Mark R. Wilson

Faculty of Science, Medicine and Health - Papers: Part B

The first described and best known mammalian secreted chaperone, abundant in human blood, is clusterin. Recent independent studies are now exploring the potential use of clusterin as a therapeutic in a variety of disease contexts. In the past, the extensive post-translational processing of clusterin, coupled with its potent binding to essentially any misfolded protein, have meant that its expression as a fully functional recombinant protein has been very difficult. We report here the first rapid and high-yield system for the expression and purification of fully post-translationally modified and chaperone-active clusterin. Only 5–6 days is required from initial transfection to harvest …


Five-Membered Cyclic Sulfamidate Imines: Versatile Scaffolds For Organic Synthesis, Quoc Hoang Pham, Christopher J. T Hyland, Stephen G. Pyne Jan 2020

Five-Membered Cyclic Sulfamidate Imines: Versatile Scaffolds For Organic Synthesis, Quoc Hoang Pham, Christopher J. T Hyland, Stephen G. Pyne

Faculty of Science, Medicine and Health - Papers: Part B

In recent years, five-membered ring cyclic sulfamidate imines (5H-1,2,3-oxathiazole 2,2-dioxides) have received increasing attention as useful precursors for the stereoselective synthesis of many valuable heterocycles. Bearing a reactive N-sulfonyl imine moiety as part of the stereodefined skeleton, this sulfamidate imine platform has been utilised as a substrate in many reactions, including nucleophilic additions and reductions, to prepare highly functionalised cyclic sulfamidates. In addition, cyclic sulfamidate imines can also readily participate as nucleophiles in many chemical transformations, owing to the reactivity of the acidic proton(s) adjacent to the imine moiety. This short review highlights recent developments involving cyclic sulfamidate imines, including …


Single-Molecule Live-Cell Imaging Reveals Recb-Dependent Function Of Dna Polymerase Iv In Double Strand Break Repair, Sarah Henrikus, Camille Henry, Amy E. Mcgrath, Slobodan Jergic, John Mcdonald, Yvonne Hellmich, Steven Bruckbauer, Matthew Ritger, Megan Cherry, Elizabeth Wood, Phuong Pham, Myron Goodman, Roger Woodgate, Michael Cox, Antoine M. Van Oijen, Harshad Ghodke, Andrew Robinson Jan 2020

Single-Molecule Live-Cell Imaging Reveals Recb-Dependent Function Of Dna Polymerase Iv In Double Strand Break Repair, Sarah Henrikus, Camille Henry, Amy E. Mcgrath, Slobodan Jergic, John Mcdonald, Yvonne Hellmich, Steven Bruckbauer, Matthew Ritger, Megan Cherry, Elizabeth Wood, Phuong Pham, Myron Goodman, Roger Woodgate, Michael Cox, Antoine M. Van Oijen, Harshad Ghodke, Andrew Robinson

Faculty of Science, Medicine and Health - Papers: Part B

© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. Several functions have been proposed for the Escherichia coli DNA polymerase IV (pol IV). Although much research has focused on a potential role for pol IV in assisting pol III replisomes in the bypass of lesions, pol IV is rarely found at the replication fork in vivo. Pol IV is expressed at increased levels in E. coli cells exposed to exogenous DNA damaging agents, including many commonly used antibiotics. Here we present live-cell single-molecule microscopy measurements indicating that double-strand breaks induced by antibiotics strongly stimulate …


Determining The Plio-Quaternary Uplift Of The Southern French Massif Central; A New Insight For Intraplate Orogen Dynamics, Oswald Malcles, Philippe Vernant, Jean Chery, Pierre Camps, Gael Cazes, Jean Ritz, David Fink Jan 2020

Determining The Plio-Quaternary Uplift Of The Southern French Massif Central; A New Insight For Intraplate Orogen Dynamics, Oswald Malcles, Philippe Vernant, Jean Chery, Pierre Camps, Gael Cazes, Jean Ritz, David Fink

Faculty of Science, Medicine and Health - Papers: Part B

© Author(s) 2020. The evolution of intraplate orogens is still poorly understood. Yet, it is of major importance for understanding the Earth and plate dynamics, as well as the link between surface and deep geodynamic processes. The French Massif Central is an intraplate orogen with a mean elevation of 1000 m, with the highest peak elevations ranging from 1500 to 1885 m. However, active deformation of the region is still debated due to scarce evidence either from geomorphological or geodetic and seismologic data. We focus our study on the southern part of the Massif Central, known as the Cévennes and …


Whole Grain And High-Fibre Grain Foods: How Do Knowledge, Perceptions And Attitudes Affect Food Choice?, Eden Barrett, Shara Foster, Eleanor J. Beck Jan 2020

Whole Grain And High-Fibre Grain Foods: How Do Knowledge, Perceptions And Attitudes Affect Food Choice?, Eden Barrett, Shara Foster, Eleanor J. Beck

Faculty of Science, Medicine and Health - Papers: Part B

The health benefits of whole grains and dietary fibre are well established, however intakes of both remain low across the globe. Innovative added-fibre refined grain products may present a solution to increase fibre intakes given potential sensory barriers to whole grain intake. However, to consider the efficacy of such products, or potential alternative measures, an awareness of consumer knowledge, perceptions and attitudes towards both whole grain and added-fibre grain foods is needed. Focus groups (with adults with no formal nutrition education) were conducted to explore factors affecting consumer grain choice. Discussions were transcribed verbatim and analysed using inductive thematic analysis. …


Intensive Care Nurses On Social Media: An Exploration Of Knowledge Exchange On An Intensive Care Virtual Community Of Practice, Kaye D. Rolls, Margaret Hansen, Debra Jackson, Doug Elliott Jan 2020

Intensive Care Nurses On Social Media: An Exploration Of Knowledge Exchange On An Intensive Care Virtual Community Of Practice, Kaye D. Rolls, Margaret Hansen, Debra Jackson, Doug Elliott

Faculty of Science, Medicine and Health - Papers: Part B

Aims and objectives

To explore the nature of knowledge exchange on a multi‐disciplinary Australasian intensive care virtual community of practice, “ICUConnect.”

Background

Current organisational structures and cultures constrain the social networks of healthcare professionals, limiting access to contemporary best practice knowledge. While virtual communities can facilitate knowledge and clinical expertise exchange in professional networks, their effectiveness has not been established.

Design

A sequential mixed‐methods design with a quantitative core and qualitative supplementary component was used to explore the content of discussions from an intensive care virtual community. SRQR has been used to report this study.

Methods

Email archives of an …


The Effect Of Residual Signal On Dose Measurements Using Met-Pirir Signals From K-Feldspar, Xue Rui, Bo Li, Yujie Guo Jan 2020

The Effect Of Residual Signal On Dose Measurements Using Met-Pirir Signals From K-Feldspar, Xue Rui, Bo Li, Yujie Guo

Faculty of Science, Medicine and Health - Papers: Part B

© 2020 Elsevier B.V. Overestimation in dose recovery results was observed at high doses (>1000 Gy) when a single-aliquot regenerative-dose (SAR) procedure is applied to the multiple-elevated-temperature post-IR IRSL (MET-pIRIR) signals from potassium-rich feldspar (K-feldspar) grains from the Nihewan Basin. Such overestimation results from the non-bleachable (residual) signals that were not appropriately corrected for. A signal-subtraction method was proposed to solve this problem, which involves building growth curves for the bleachable and non-bleachable signals. Here we modelled the effect of residual signal on equivalent dose (De) and found that even a small amount of residual signal may give rise …


Likeness, Familiarity, And The Ambient Portrait Average, Susan Hayes, Peter Caputi, T Zaracostas, Maggie Henderson, Julie Telenta, Elspeth Mccombe, Kim Christopher, Emma Calvert, Donna Abbati, Odette Smith, Emma Medwell, Joyce Wilcock Jan 2020

Likeness, Familiarity, And The Ambient Portrait Average, Susan Hayes, Peter Caputi, T Zaracostas, Maggie Henderson, Julie Telenta, Elspeth Mccombe, Kim Christopher, Emma Calvert, Donna Abbati, Odette Smith, Emma Medwell, Joyce Wilcock

Faculty of Science, Medicine and Health - Papers: Part B

© The Author(s) 2020. This artist-led research project involved 10 visual artists producing 10 ambient portraits and a portrait average of a locally familiar Sitter, and 10 ambient portraits and a portrait average of a less locally familiar Sitter. All were then assessed for likeness by more than 150 members of the general public attending an exhibition during Australia’s 2018 National Science Week. The results of this study are that portrait averages can be highly shape accurate and tend to be seen as a good likeness by all viewers. However, the portrait average is not necessarily the best likeness. Extending …


Discrimination Between Protonation Isomers Of Quinazoline By Ion Mobility And Uv-Photodissociation Action Spectroscopy, Samuel Marlton, Benjamin Mckinnon, Boris Ucur, James Bezzina, Stephen Blanksby, Adam J. Trevitt Jan 2020

Discrimination Between Protonation Isomers Of Quinazoline By Ion Mobility And Uv-Photodissociation Action Spectroscopy, Samuel Marlton, Benjamin Mckinnon, Boris Ucur, James Bezzina, Stephen Blanksby, Adam J. Trevitt

Faculty of Science, Medicine and Health - Papers: Part B

The influence of oriented electric fields on chemical reactivity and photochemistry is an area of increasing interest. Within a molecule, different protonation sites offer the opportunity to control the location of charge and thus orientation of electric fields. New techniques are thus needed to discriminate between protonation isomers in order to understand this effect. This investigation reports the UV-photodissociation action spectroscopy of two protonation isomers (protomers) of 1,3-diazanaphthalene (quinazoline) arising from protonation of a nitrogen at either the 1- or 3-position. It is shown that these protomers are separable by field-asymmetric ion mobility spectrometry (FAIMS) with confirmation provided by UV-photodissociation …


A Chronological Model For The Late Paleolithic At Shuidonggou Locality 2, North China, Fei Peng, Sam C. Lin, Ilaria Patania, Vladimir Levchenko, Jialong Guo, Huimin Wang, Xing Gao Jan 2020

A Chronological Model For The Late Paleolithic At Shuidonggou Locality 2, North China, Fei Peng, Sam C. Lin, Ilaria Patania, Vladimir Levchenko, Jialong Guo, Huimin Wang, Xing Gao

Faculty of Science, Medicine and Health - Papers: Part B

The site of Shuidonggou Locality 2 offers important evidence for the Late Paleolithic sequence of north China. The site not only contains one of the earliest instances of ornamental freshwater shell and ostrich eggshell beads in the region, but also stone artifacts with features arguably resembling the Initial Upper Paleolithic (IUP) blade technology found farther north. The appearance of these innovative archaeological forms have been attributed to the arrival of hominin populations, possibly modern humans, into the region during Marine Isotope Stage 3. Yet, the chronology of the site remains debated due to ambiguities in the existing dates. In this …