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A Mixed Methods Assessment Of Menstrual Hygiene Management And School Attendance Among Schoolgirls In Edo State, Nigeria., Madeline Tomlinson
A Mixed Methods Assessment Of Menstrual Hygiene Management And School Attendance Among Schoolgirls In Edo State, Nigeria., Madeline Tomlinson
Electronic Theses and Dissertations
Menstrual hygiene in lower-middle-income countries (LMICs) is limited and has been linked to many health, educational and social effects. However, the prevalence, details, and impact of menstrual hygiene management have not been well characterized in rural and peri-urban settings across Nigeria. The overall purpose of this research was to investigate menstrual hygiene management (MHM) among adolescent schoolgirls in peri-urban areas of Edo State, Nigeria; and to determine the educational consequences associated with poor MHM. MHM was measured using previously validated questions that were adapted after a formative assessment of MHM within the Edo State community. We used a mixed methods …
Models And Algorithms For Trauma Network Design., Sagarkumar Dhirubhai Hirpara
Models And Algorithms For Trauma Network Design., Sagarkumar Dhirubhai Hirpara
Electronic Theses and Dissertations
Trauma continues to be the leading cause of death and disability in the US for people aged 44 and under, making it a major public health problem. The geographical maldistribution of Trauma Centers (TCs), and the resulting higher access time to the nearest TC, has been shown to impact trauma patient safety and increase disability or mortality. State governments often design a trauma network to provide prompt and definitive care to their citizens. However, this process is mainly manual and experience-based and often leads to a suboptimal network in terms of patient safety and resource utilization. This dissertation fills important …
Changing Public Perception Of Dementia: The Effect And Credibility Of Three Informational Models., Diana Hedrick
Changing Public Perception Of Dementia: The Effect And Credibility Of Three Informational Models., Diana Hedrick
Electronic Theses and Dissertations
Background: Since the 1970s, Alzheimer’s disease and dementia have been portrayed in a medicalized, symptom-focused manner to help spread awareness, improve diagnosis, and push for treatment research. In recent decades, there has been movement towards a biopsychosocial, person-centered approach that considers social and psychological factors that interact with biological diseases processes. Common biopsychosocial approaches retain an emphasis on deficits and symptoms. New research has integrated positive psychology constructs and dementia. This integration of positive psychology principles and dementia care and research has the potential to more accurately capture the experience of having dementia. Objectives: This dissertation tested how the portrayal …
Iot In Smart Communities, Technologies And Applications., Muhammad Zaigham Abbas Shah Syed
Iot In Smart Communities, Technologies And Applications., Muhammad Zaigham Abbas Shah Syed
Electronic Theses and Dissertations
Internet of Things is a system that integrates different devices and technologies, removing the necessity of human intervention. This enables the capacity of having smart (or smarter) cities around the world. By hosting different technologies and allowing interactions between them, the internet of things has spearheaded the development of smart city systems for sustainable living, increased comfort and productivity for citizens. The Internet of Things (IoT) for Smart Cities has many different domains and draws upon various underlying systems for its operation, in this work, we provide a holistic coverage of the Internet of Things in Smart Cities by discussing …
Understanding Racial Disparate Treatment Of Juvenile Interpersonal Violent Offenders In The Juvenile Justice System Using Focal Concerns Theory., Suzanne Overstreet
Understanding Racial Disparate Treatment Of Juvenile Interpersonal Violent Offenders In The Juvenile Justice System Using Focal Concerns Theory., Suzanne Overstreet
Electronic Theses and Dissertations
Disproportionate minority contact (DMC) is a salient issue that has been found at every stage of the decision-making process in the juvenile justice system (Hawkins & Kempf-Leonard, 2005; Kempf-Leonard, 2007; Bishop, 2005; Leiber, Bishop, & Chamlin, 2010; Leiber & Stairs, 1999). Existing research indicates that DMC influences adjudication for drug, property, and personal crimes (Fergusson, Horwood, & Swain-Campbell, 2003; Frazier, Bishop, & Henretta, 1992; Leiber & Jamieson, 1995; Leiber & Mack, 2003; Hawkins & Kempf-Leonard, 2005; Leiber, 2015). Because intimate partner violence (IPV) is a major public health problem and global concern (Djamba & Kimuna, 2008; Goo & Harlow, 2012; …
Increasing Self-Determination Skill Through Behavioral Skills Training For Individuals With Extensive Support Needs To Examine Reversible Contraceptive Choices., Jennifer Pollard
Increasing Self-Determination Skill Through Behavioral Skills Training For Individuals With Extensive Support Needs To Examine Reversible Contraceptive Choices., Jennifer Pollard
Electronic Theses and Dissertations
There is a long history of individuals with extensive support needs (ESN) being sterilized without their knowledge and consent. Students with ESN are defined as individuals who need continuous and widespread supports necessary for academic, communication, and/or daily living skills. These individuals typically have more than one diagnosis including a developmental disability (DD), intellectual disability (ID), and/or traumatic brain injury (Kurth et al., 2019; Taub et al., 2017). Part of the reason this is able to occur is due to a lack of education about sexual development and a lack of interventions to build skills related to self-determination or informed …
The Effects Of Stigma On Quality Of Life And Psychological Outcomes In Participants With Varying Reports Of Subjective Cognitive Decline., Lauren Flaherty
The Effects Of Stigma On Quality Of Life And Psychological Outcomes In Participants With Varying Reports Of Subjective Cognitive Decline., Lauren Flaherty
Electronic Theses and Dissertations
Background: Diagnostic labels such as cognitive impairment, dementia or MCI often carry associated stigmatization. Stigma can lead to social isolation and rejection; increasing the likelihood of loneliness, depression, and anxiety. Depression and anxiety can be predictive of cognitive function; depression and anxiety are linked to stigma. Subjective cognitive decline (SCD) can be indicative of actual cognitive impairment. Subjective impairment and stigma can significantly predict quality of life. The aim of the proposed dissertation study was to explore whether higher SCD scores associate with more internalized stigma, and if this stigma mediates the relationship between SCD and depression, SCD and …
Examining The Effects Of Npra Antagonist Anantin On Sci-Induced Ployuria., Lindsey Zipperer
Examining The Effects Of Npra Antagonist Anantin On Sci-Induced Ployuria., Lindsey Zipperer
Electronic Theses and Dissertations
Polyuria, or the over production of urine, is a prevalent condition that significantly impacts the quality of life in individuals suffering from a spinal cord injury (SCI). Post-SCI induced polyuria is thought to have been associated with altered levels of vasopressin (AVP), atrial natriuretic peptide (ANP), and natriuretic peptide receptor A (NPRA). In the present study, the function of NPRA was analyzed in the rat contusion model using anantin, an NPRA antagonist. A daily dose of either 100 µg of anantin or vehicle was administered intraperitoneally immediately following the SCI surgery and continued until termination, 4 weeks post injury (wpi). …
Understanding Neuroanatomy In A Virtual 3d Environment: Creation And Use Of A New Survey Tool To Evaluate The Effectiveness Of 3d Software In Neuroanatomy Education For Understanding Superficial And Deep Brain Structures., Akash Khare
Electronic Theses and Dissertations
Studying cross-sections is a critical approach to learning and testing knowledge in neuroanatomy and the role of 3D technologies have been gradually increasing in medical education, especially after the COVID-19 pandemic. A study was conducted in a quasi-experimental one-group pre-post interventional design in an online setting by creating and evaluating the effectiveness of a virtual lab in neuroanatomy for all neuroscience students enrolled in the Fundamentals of Neuroscience course in our department at the University of Louisville. Study modules were created using the 2D resources used in previous years and 3D web applications of Visible Body and AnatomyLearning.com software. A …
Ideas In Communities: A Micro-Perspective On Entrepreneurial Ecosystems., Malcolm Muhammad
Ideas In Communities: A Micro-Perspective On Entrepreneurial Ecosystems., Malcolm Muhammad
Electronic Theses and Dissertations
Entrepreneurial ecosystems are seen as a stimulant of regional economic growth. Theory-building efforts on entrepreneurial ecosystems has sufficiently established an understanding of the macro-environment; the environmental infrastructure and conditions that support productive entrepreneurship. However, there has been a disproportionate lack of focus on the micro- and group-level dynamics that impact individual entrepreneurs and ventures within ecosystem. This has limited the availability of evidence to explain how and when ecosystems emerge and function at a high level. Therefore, this dissertation examines three distinct microfoundations that can be found in entrepreneurial ecosystem literature – community, learning, and venture development – to move …
Death Of A Bacterium: Exploring The Inhibition Of Staphylococcus Aureus By Burkholderia Cenocepacia., Tiffany Brandt
Death Of A Bacterium: Exploring The Inhibition Of Staphylococcus Aureus By Burkholderia Cenocepacia., Tiffany Brandt
Electronic Theses and Dissertations
Antimicrobial resistance is a phenomenon of increasing concern as antimicrobial overuse and misuse eliminate current therapeutic options, ushering society into a post-antimicrobial era. Antibiotic discovery and synthesis efforts are urgently needed to counter the increasing burden of antimicrobial resistance. Staphylococcus aureus is a causative agent of a variety of clinical manifestations including bacteremia, endocarditis, soft tissue infection, osteomyelitis, and device-related infections. S. aureus infection presents additional treatment challenges due to its capacity for biofilm formation, which is a mode of growth that confers protection from antibiotics and physical elimination, and the emergence of antibiotic resistant strains, including methicillin-resistant S. aureus …
Bayesian Methods For Graphical Models With Neighborhood Selection., Sagnik Bhadury
Bayesian Methods For Graphical Models With Neighborhood Selection., Sagnik Bhadury
Electronic Theses and Dissertations
Graphical models determine associations between variables through the notion of conditional independence. Gaussian graphical models are a widely used class of such models, where the relationships are formalized by non-null entries of the precision matrix. However, in high-dimensional cases, covariance estimates are typically unstable. Moreover, it is natural to expect only a few significant associations to be present in many realistic applications. This necessitates the injection of sparsity techniques into the estimation method. Classical frequentist methods, like GLASSO, use penalization techniques for this purpose. Fully Bayesian methods, on the contrary, are slow because they require iteratively sampling over a quadratic …
Design, Evaluation, And Control Of Nexus: A Multiscale Additive Manufacturing Platform With Integrated 3d Printing And Robotic Assembly., Danming Wei
Electronic Theses and Dissertations
Additive manufacturing (AM) technology is an emerging approach to creating three-dimensional (3D) objects and has seen numerous applications in medical implants, transportation, aerospace, energy, consumer products, etc. Compared with manufacturing by forming and machining, additive manufacturing techniques provide more rapid, economical, efficient, reliable, and complex manufacturing processes. However, additive manufacturing also has limitations on print strength and dimensional tolerance, while traditional additive manufacturing hardware platforms for 3D printing have limited flexibility. In particular, part geometry and materials are limited to most 3D printing hardware. In addition, for multiscale and complex products, samples must be printed, fabricated, and transferred among different …
La Casita Center: An Accompaniment Based Approach To Social Justice And Social Service., Ben Harlan
La Casita Center: An Accompaniment Based Approach To Social Justice And Social Service., Ben Harlan
Electronic Theses and Dissertations
La Casita Center is a Louisville based nonprofit organization that accompanies Latinx immigrants in the Louisville Metro area. and that is led and staffed by Latina immigrants. In this thesis, I investigate how employees of this Latinx-immigrant led nonprofit organization, navigate challenges to both administer service and build community using the model of accompaniment. Organizations like La Casita are critically important for Latinx newcomer communities in the United States and as neoliberal and nativist-inspired policiescontinue to oppress and marginalize, La Casita provides a model for what it means to center inclusion, belonging, community, and solidarity. In a global landscape of …
Reaching Syrians In Need: An Analysis Of Humanitarian Aid In The 21st Century., James Clark
Reaching Syrians In Need: An Analysis Of Humanitarian Aid In The 21st Century., James Clark
Electronic Theses and Dissertations
The objective of this dissertation is two-fold. One is to critically consider humanitarian aid delivery to and through Syria via a lens that combines the humanities and social sciences. The fields of anthropology, political science and postcolonialism are employed to accomplish this. The second is to investigate the process involved in this delivery amid the country’s ongoing conflict. Combining these two facets provides a view of humanitarian aid as it relates to the conflict in Syria while applying a liberal arts-humanities approach. The introduction establishes the basis to discuss the existence of aid providers and those in need of aid …
The Role Of Mri In Diagnosing Autism: A Machine Learning Perspective., Yaser Elnakieb
The Role Of Mri In Diagnosing Autism: A Machine Learning Perspective., Yaser Elnakieb
Electronic Theses and Dissertations
There is approximately 1 in every 44 children in the United States suffers from autism spectrum disorder (ASD), a disorder characterized by social and behavioral impairments. Communication difficulties, interpersonal difficulties, and behavioral difficulties are the top common symptoms. Even though symptoms can begin as early as infancy, it may take multiple visits to a pediatric specialist before an accurate diagnosis can be made. In addition, the diagnosis can be subjective, and different specialists may give different scores. There is a growing body of research suggesting differences in brain development and/or environmental and/or genetic factors contribute to autism development, but scientists …
Foreign Policy In Media: An Examination Of The Captain America Films., Kat Hernandez
Foreign Policy In Media: An Examination Of The Captain America Films., Kat Hernandez
Electronic Theses and Dissertations
Popular culture and media are consumed daily by billions around the world, media which can contain meaningful and politically relevant material. The three Captain America films from the 2010s represent this phenomenon in the presentation of Captain America as a nationalist superhero with geopolitically relevant storylines. The direction and production of these films illustrate significant parallels to foreign policy choices of the United States. Through an interpretive analysis of the Captain America films: Captain America: The First Avenger, Captain America: The Winter Soldier, and Captain America: Civil War, this project seeks to analyze Captain America’s image and …
Investigation Of Human N-Acetyltransferases (Nat1 And Nat2) Genetic Polymorphisms In Susceptibility To Aromatic Amine And Alkylaniline Genotoxicity., Mariam Habil
Electronic Theses and Dissertations
Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of carcinogens. Single nucleotide polymorphisms or SNPs result in different human NAT1 and NAT2 genotypes. We hypothesize that different NATs alleles will impact levels of N-acetylation, HPRT mutations, DNA damage and oxidative stress induced by carcinogens. NER-deficient Chinese hamster ovary (CHO) cells transfected with human CYP1A2 and NAT1*4, NAT1*14B, NAT2*4, NAT2*5B or NAT2*7B have been used to investigate N-acetylation of benzidine, β-naphthylamine (BNA), and 4, 4’-methylene bis (2-chloroaniline) (MOCA) as aromatic amines and 3,4-dimethylaniline (3,4-DMA) as one of alkylanilines and their associated toxicity. Our …
The Impact Of Pegylation On Cellular Uptake And In Vivo Biodistribution Of Gold Nanoparticle Mri Contrast Agents., Nagwa El-Baz
The Impact Of Pegylation On Cellular Uptake And In Vivo Biodistribution Of Gold Nanoparticle Mri Contrast Agents., Nagwa El-Baz
Electronic Theses and Dissertations
Gold nanoparticles (GNPs) have become a pivotal platform for the delivery of pharmaceutical and diagnostic agents as well as for general therapeutic purposes. Despite their potential for use in biomedicine, their interaction with serum proteins is crucial as it could change their biological profile due to the formation of a protein corona, which can affect their delivery to target tissues in the body. Grafting the GNPs with polyethylene glycol (PEG) is widely used in research to decrease opsonization of the particles by serum proteins and decrease the uptake by the reticuloendothelial system. Here in this dissertation, we have developed a …
Effects Of Top-Down Attention And Individual Differences On Recognition Memory And Recollective Experience., Anna Kelley
Effects Of Top-Down Attention And Individual Differences On Recognition Memory And Recollective Experience., Anna Kelley
Electronic Theses and Dissertations
Memory accuracy and detail hold practical importance, and psychology has studied means to improve memory. One such means is performing visually guided saccades immediately before a memory test. Previous work has found this intervention to improve memory performance, an effect dubbed Saccade-Induced Retrieval Enhancement or SIRE. The top-down attentional control account posits that SIRE occurs because saccades activate attentional control regions in the brain, which contributes to executing top-down attentional control when searching memory. The current experiment tested this account of SIRE by attempting to replicate previous results and investigating whether a different attentional task, the Revised Attention Network Test …
A New Direction For Public Understanding Of Science: Toward A Participant-Centered Model Of Science Engagement., Christopher Rickels
A New Direction For Public Understanding Of Science: Toward A Participant-Centered Model Of Science Engagement., Christopher Rickels
Electronic Theses and Dissertations
Engaging the public with science is not an easy task. When presented, scientific findings, public health recommendations, and other scientific information filter through the personal values, beliefs, and biases of members of the public. Science communicators must contend with these differences in order to be effective in cultivating a public understanding of science. Given the importance of scientific understanding for living well in a complex world, increasing science understanding through science engagement is imperative. The field of public engagement with science is dichotomized by a public information deficit approach and a contextualist approach. The deficit approach prizes the factual content …
The Role Of Mmp-3 In Copper Oxide Nanoparticle-Induced Pulmonary Inflammation And Fibrosis., Yuanbao Zhang
The Role Of Mmp-3 In Copper Oxide Nanoparticle-Induced Pulmonary Inflammation And Fibrosis., Yuanbao Zhang
Electronic Theses and Dissertations
Copper oxide nanoparticles (Nano-CuO) are wildly used in medical and industrial fields and our daily necessities. However, the biosafety assessment of Nano-CuO is far behind their rapid development. This study was to investigate the potential mechanisms underlying Nano-CuO-induced pulmonary inflammation and fibrosis, especially to determine whether Nano-CuO exposure could dysregulate MMP-3, an important mediator in pulmonary fibrosis, and its roles in Nano-CuO-induced pulmonary inflammation and fibrosis. Aim 1 was to investigate whether exposure to Nano-CuO caused MMP-3 dysregulation in lung epithelial cells and the role of MMP-3 in Nano-CuO-induced alteration of cell junction-associated proteins. The potential mechanisms that might be …
Cadence And Range Of Motion Modulate Pedal Force In A Rat Model Of Motorized Cycling After Spinal Cord Injury., Gregory States
Cadence And Range Of Motion Modulate Pedal Force In A Rat Model Of Motorized Cycling After Spinal Cord Injury., Gregory States
Electronic Theses and Dissertations
Motorized cycling (MC) can be utilized post-spinal cord injury (SCI) in patients who lack the strength and/or stability to participate in traditional physical exercise interventions. MC has been applied with the goal of improving locomotor function or cardiovascular health in both human and animal models of SCI. However, a discrepancy exists between the results of human and animal studies of MC, particularly regarding cardiovascular outcomes. Despite the abundance of studies in both humans and animals, the mechanism behind the improvements in cardiovascular function following MC are poorly understood. We posited that increased venous return during MC is likely due to …
Self-Regulation In Young School-Aged Children With Williams Syndrome., Holley Arnold
Self-Regulation In Young School-Aged Children With Williams Syndrome., Holley Arnold
Electronic Theses and Dissertations
My dissertation included two manuscripts which broadly focused on the self-regulation abilities of young school-aged children with Williams syndrome (WS), a rare neurodevelopmental disorder. Children with WS often exhibit mild to moderate intellectual disability (Kozel et al., 2021), impairments in behavioral and emotional regulation (Greiner de Magalhães et al., 2022), low effortful control (Leyfer et al., 2012), and deficits in adaptive skills (Brawn & Porter, 2018). In the first manuscript, the performance of children with WS on a gift-wrap delay of gratification task was characterized. In the second manuscript, the concurrent effects of the ability to regulate emotions, the ability …
The Role Of Generative Adversarial Networks In Bioimage Analysis And Computational Diagnostics., Ahmed Naglah
The Role Of Generative Adversarial Networks In Bioimage Analysis And Computational Diagnostics., Ahmed Naglah
Electronic Theses and Dissertations
Computational technologies can contribute to the modeling and simulation of the biological environments and activities towards achieving better interpretations, analysis, and understanding. With the emergence of digital pathology, we can observe an increasing demand for more innovative, effective, and efficient computational models. Under the umbrella of artificial intelligence, deep learning mimics the brain’s way in learn complex relationships through data and experiences. In the field of bioimage analysis, models usually comprise discriminative approaches such as classification and segmentation tasks. In this thesis, we study how we can use generative AI models to improve bioimage analysis tasks using Generative Adversarial Networks …
Mejorar La Raza: Measuring The Implicit Anti-Black Racial Bias Of Multiracial Individuals., Katalina Traxler
Mejorar La Raza: Measuring The Implicit Anti-Black Racial Bias Of Multiracial Individuals., Katalina Traxler
Electronic Theses and Dissertations
This dissertation sought to examine if there are implicit anti-Black racial bias differences across multiracial people who identify as Black/White compared to multiracial people who do not identify as Black/White, accounting for age, citizenship, and education level. It was also determined if age, citizenship status, and education level moderate the relationship between multiracial identity and implicit anti-Black racial bias. The theories guiding this dissertation were: Heider’s Balance Theory, Multiracial Identity Development, and White Identity Development. The data were collected from Project Implicit, a non-profit organization and international collaborative of researchers who are interested in implicit social cognition. The data analysis …
Alpha, Beta-Unsaturated Aldehydes: The Underrepresented Markers Of Disease., Saurin Sutaria
Alpha, Beta-Unsaturated Aldehydes: The Underrepresented Markers Of Disease., Saurin Sutaria
Electronic Theses and Dissertations
The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that creates a complex mixture of volatile organic compounds including aldehydes. Elevated levels of reactive oxygen species in cancer cells promote random lipid peroxidation, which leads to an increase in a variety of aldehydes. Many of these volatile aldehydes are exhaled and are of interest as potential markers of disease. Chapter 1 presents a review of reported aldehydes in the exhaled breath of lung cancer patients. alpha,beta-Unsaturated aldehydes, detected primarily when derivatized during exhaled breath preconcentration, are underreported in the reviewed articles. Chapter 1 concludes with our hypothesis …
Benchmarking And Developing Novel Methods For G Protein-Coupled Receptor Ligand Discovery, Gregory Leon Szwabowski
Benchmarking And Developing Novel Methods For G Protein-Coupled Receptor Ligand Discovery, Gregory Leon Szwabowski
Electronic Theses and Dissertations
G protein-coupled receptors (GPCR) are integral membrane proteins mediating responses from extracellular effectors that regulate a diverse set of physiological functions. Consequently, GPCR are the targets of ~34% of current FDA-approved drugs.3 Although it is clear that GPCR are therapeutically significant, discovery of novel drugs for these receptors is often impeded by a lack of known ligands and/or experimentally determined structures for potential drug targets. However, computational techniques have provided paths to overcome these obstacles. As such, this work discusses the development and application of novel computational methods and workflows for GPCR ligand discovery. Chapter 1 provides an overview of …
The Impact Of Switching Schools On College-Going, Anne Walton Garrison
The Impact Of Switching Schools On College-Going, Anne Walton Garrison
Electronic Theses and Dissertations
Large urban school districts, especially those with high concentrations of minority and economically disadvantaged students, have high rates of nonstructural student mobility (nonpromotional school-switching). The students in these school districts tend to be the very ones who stand to benefit the most from college attainment. However, the extent to which nonstructural student mobility impacts students’ likelihood of going to college is not fully known. This quasi-experimental study of a class of high school graduates in one urban district fills a gap in the literature by both examining the effects of switching schools in grades 3–12 on college-going and establishing causality …
Nuclear Medicine Technologists' Motivations To Pursue Post-Primary Credentials, Donna C. Mars
Nuclear Medicine Technologists' Motivations To Pursue Post-Primary Credentials, Donna C. Mars
Electronic Theses and Dissertations
The purpose of this quantitative study was to examine the motivations guiding nuclear medicine technologists to pursue post-primary credentials in computed tomography (CT) or magnetic resonance imaging (MRI) through the framework of the expectancy-value theory. A survey was used to answer the research question: Do the values nuclear medicine technologists associate with a post-primary certification in CT or MRI predict their intention to pursue a post-primary credential? The study included certified nuclear medicine technologists from eight states in the southeastern regions of the United States. The answers from 237 respondent, which equates to 8.6% of the population, were used in …