Digital Commons Network^™

Device Design For Inducing Aneurysm-Susceptible Flow Conditions Onto Endothelial Cells, Hans F. Foelsche

Masters Theses

Aneurysms are a deadly asymptomatic cardiovascular disease that may occur especially where there are bends and bifurcations in the cerebral vasculature. A region where these features are especially prominent is the Circle of Willis (COW) in the brain, where aneurysms are known to occur. In the carotid artery, which feeds into the COW, the Reynolds number of blood flow is typically around 200-500. Even with such a low Reynolds number, turbulent-like flow, or tortuous flow, can occur due to bends, bifurcations and highly pulsatile flow which lower the effective Reynolds number where tortuous flow can occur. Highly pulsatile flow is …

The Discovery Of A Novel Bacteria From A Large Co-Assembly Of Metagenomes, Matthew Finkelberg

Masters Theses

In the summer of 2022, a co-assembly of metagenome was created using the microbes found at Barres Woods in Harvard Forest. 14 samples were taken, and sample was split into the organic and mineral layer, which totals 28 Bulk MAGs. Within this Co-assembly, 4 different genomes were found which were designated with the phylum of FCPU426. Three of which were considered medium quality and one being assigned high quality. The novel phyla first appeared in NCBI and GTDB databases in June 2018. The name FCPU426 dates to 2010 and was named based on the 16s amplicon sequencing.

The novel phylum …

Machine Learning Modeling Of Polymer Coating Formulations: Benchmark Of Feature Representation Schemes, Nelson I. Evbarunegbe

Masters Theses

Polymer coatings offer a wide range of benefits across various industries, playing a crucial role in product protection and extension of shelf life. However, formulating them can be a non-trivial task given the multitude of variables and factors involved in the production process, rendering it a complex, high-dimensional problem. To tackle this problem, machine learning (ML) has emerged as a promising tool, showing considerable potential in enhancing various polymer and chemistry-based applications, particularly those dealing with high dimensional complexities.

Our research aims to develop a physics-guided ML approach to facilitate the formulations of polymer coatings. As the first step, this …

Effect Of Metabolic Rate On Mitochondrial Efficiency During Exercise In Human Skeletal Muscle In Vivo, Muhammet Enes Erol

Masters Theses

Introduction: Recent evidence in isolated mitochondria and permeabilized muscle fibers in ex vivo using simultaneous measurements of O₂ consumption and ATP production suggest that mitochondrial efficiency provides an additional mechanism to fine-tune oxidative phosphorylation rate to ATP demand in skeletal muscle. However, in the absence of a direct measurement of both VO₂ and ATP synthesis from the same region of the contracting muscle, whether this mechanism plays a role in the skeletal muscle in vivo is still unknown. Purpose: Using a noninvasive approach combining phosphorus and proton magnetic resonance spectroscopy (³¹P/¹H-MRS), the present study …

Analog Cancellation Of A Known Remote Interference: Hardware Realization And Analysis, James M. Doty

Masters Theses

The onset of quantum computing threatens commonly used schemes for information secrecy across wireless communication channels, particularly key-based data-level encryption. This calls for secrecy schemes that can provide everlasting secrecy resistant to increased computational power of an adversary. One novel physical layer scheme proposes that an intended receiver capable of performing analog cancellation of a known key-based interference would hold a significant advantage in recovering small underlying messages versus an eavesdropper performing cancellation after analog-to-digital conversion. This advantage holds even in the event that an eavesdropper can recover and use the original key in their digital cancellation. Inspired by this …

Not All Numbers Were Created Equal: Evidence The Number One Is Unique, Jenna L. Croteau

Masters Theses

Universally across modern cultures children acquire the meaning of the words one, two, and three in order. While much research has focused on how children acquire this knowledge and what this knowledge represents, the question of why children learn numbers in order has been comparatively neglected. To address this question, a non-verbal anticipatory looking task was implemented. In this task, 35 14- to 23-month-old infants were assessed on their ability to form implicit category structures for the numbers one, two, and three. We hypothesized that children would be able to form the implicit category structure for the number one …

Sucrose Concentration And Fermentation Temperature Impact The Sensory Characteristics And Liking Of Kombucha, Gil Cohen

Masters Theses

Kombucha is a fermented tea beverage consumed for its probiotics and functional properties and has a unique sensory profile driven by the properties of tea polyphenols and fermentation products, including organic acids. Fermentation temperature and sucrose content affect the fermentation process and the production of organic acids, yet less is known about the impact on the sensory profile and consumer acceptance. Thus, we aim to examine the impact of sucrose concentration and fermentation temperature on sensory attributes and liking. For this study, kombucha tea was fermented at three different concentrations of sucrose and fermented at two temperatures for 11 days. …

Antifascist Autobiographical Writing By Three Southern European Women Writers: Natália Correia, Concha Zardoya, And Ludovica Ripa Di Meana, Jessica R. Beasley

Masters Theses

This thesis puts three antifascist writers in dialogue: Concha Zardoya, Natália Correia, and Ludovica Ripa di Meana. It does so based on their similarities as women who lived in Southern European fascist regimes, who wrote autobiographical poetry books about those regimes. Comparing and qualifying the regimes based on Umberto Eco’s Ur-Fascism, in which he highlights common “family resemblance” characteristics of fascist regimes, I set up the positionality of each women within her specific milieu. I then discuss the resulting poetry books, which all utilize a multi-temporal, teleological construction of the regime based on the writer’s own memory as someone who …

Elucidating The Priming Mechanism Of Clpxp Protease By Single-Domain Response Regulator Cpdr In Caulobacter Crescentus, Kimberly E. Barker

Masters Theses

In Caulobacter crescentus, progression through the cell cycle is regulated by the AAA+ protease ClpXP, and there are several classes of cell-cycle substrates that require adaptors in order to be degraded. CpdR, a single domain-response regulator, binds the N-terminal domain of ClpXP and primes the protease for degradation of downstream factors (Lau et al., 2015). The ability of CpdR to bind ClpX is regulated by its phosphorylation state. In the unphosphorylated state, CpdR binds ClpXP and guides its localization to the cell pole during the swarmer to stalked transition, where CpdR is mediates degradation of substrates such as PdeA. …

Memories Of Hope And Loss: “Kerhi Maa Ne Bhagat Singh Jameya”, Sheher Bano

Masters Theses

My Masters thesis focuses on socialist Indian freedom fighter Bhagat Singh’s memory in contemporary Pakistani Punjab. I use the analytical category of memory to argue that Bhagat Singh is invoked by various groups and individuals, specifically those who identify as leftists or Marxists, in contemporary Pakistan to serve a range of political purposes. My analysis particularly sheds light on how activists and writers use the figure of Bhagat Singh to highlight the erasure of regional and lingual identities in Pakistan. Their remembrances underline a perceived historical injustice; the imposition of a national identity based on Urdu language and Sunni Muslim-ness, …

Bog Turtle (Glyptemys Muhlenbergii) Population Dynamics And Response To Habitat Management In Massachusetts, Julia Vineyard

Masters Theses

The Bog Turtle (Glyptemys muhlenbergii) is a federally threatened species that occupies isolated pockets of open-canopy fens. This long-lived species is susceptible to habitat loss and degradation; thus, the conservation of known populations and management of their habitat is critical to the species’ survival. Long-term (multi-decadal) assessment is important for determining population trends and responses to ongoing habitat management. I assessed population demographics (abundance, survival) and spatial distribution (home range) of two Bog Turtle populations in Massachusetts that have been managed since the late 1990s by treating invasive species, thinning woody vegetation, and mitigating flooding. The results of …

A Latent Profile Analysis Of Four Characteristics Of Intimate Partner Violence And Associations With Posttraumatic Stress Symptoms, Ana Uribe

Masters Theses

Intimate partner violence (IPV) is a prevalent potentially traumatic experience that increases risk for posttraumatic stress symptoms (PTSS). However, there is still considerable heterogeneity in PTSS among women exposed to IPV. Research on IPV has examined the ways in which different characteristics of IPV exposure have separately related to risk for PTSS, specifically the type (physical, psychological, economic, sexual), frequency (number of incidents), severity (minor, severe), and mode of violence (in-person, online). However, it may be important to examine how the integration of these characteristics of IPV differ across ���������������������� ���� ������ ���� ������������ �������������������� �������������� ���������� The current study …

Climate Change, Giant Viruses And Their Putative Hosts, Sarah K. Tucker

Masters Theses

Viruses hold our attention for the horrific impact they have on human health and welfare. However, viruses are a critical part of our ecosystem and facilitate the cycling of carbon and other important nutrients. The cycle of virus infection, followed by host resistance and the subsequent evolution of new strains enables adaptation to changing hosts and the environment. Giant viruses, some with particle sizes large enough to be visible in light microscopes and their bewildering array of accessory genes, have captivated scientists and the general public since their discovery two decades ago. Giant viruses are part of the Nucleocytoviricota (NCV) …

Tracing Microplastics In Municipal Potable Water Across Residential Buildings, Jimmy Tran

Masters Theses

Limited research on microplastics makes it increasingly difficult to measure the potential dangers of their toxicological effect on humans and the environment. Today, evidence has revealed that microplastics have been located in highly remote areas of the world. There are few studies that examine the movement of microplastics within urban landscapes and even fewer that observe different communities within cities. To this end, a study was devised that utilized filtration, dehydration, and Laser Direct Infrared Spectroscopy to monitor drinking water microplastics found in residential buildings across different communities.

Houses and apartments of low and high-income at different distances from the …

Heat Flow In The Southern Margin Of Salar De Atacama: Deep Groundwater Temperature Distributions And The Implications For Subsurface Flow And Land Surface Energy Budgets, Graham Thomas

Masters Theses

Salar de Atacama (SdA) located in Northern Chile is home to one of the planet’s largest salar systems and lithium resources. Managing groundwater resources in salars is not obvious due to the lack of scientific understanding on the connectivity between the freshwater and brine systems. Using heat as a tracer in SdA provides a cost-effective method to further investigate groundwater flow in salars. This study employs 372 temperature-depth profiles from 90 boreholes between 2013-18 to understand the distinct thermal zones and flow between them in SdA. Three thermal zones exist within the southern margin of SdA’s thermal regime, at higher …

Fat Lowering Effects Of Piperine In Caenorhabditis Elegans, Zhoutai Teng

Masters Theses

P iperine is an alkaloid found in pepper plant, w hich exhibits many health benefits including anti aging, anti cancer, anti diabetic, and anti inflammatory effects. However, the anti obesity research of piperine is limited. Therefore, th is study was done to determine the effects of piperine on fat accumulation, using in vivo model, Caenor habditis elegans . Treatment with 100 μ M piperine reduce fat content of wild type C. elegans by 17% over control. Pumping rate was not affected by piperine, suggesting piperine has no effects on food intake of worms. Mutant strains were tested to determine t …

Caulobacter Clpxp Adaptor Popa’S Domain Interactions In The Adaptor Hierarchy Of Ctra Degradation, Thomas P. Scudder

Masters Theses

The degradation and recycling of protein is a process essential for the maintenance and regulation of cellular function. More specifically, in Caulobacter crescentus, the ClpXP protease is responsible for driving progression through the cell cycle and protein quality control. This protease utilizes three known adaptors to selectively degrade proteins that initiate different stages of development. This thesis will elaborate on the specific binding interface on one of these adaptors, PopA, with another, RcdA, and focus in on specific residues on PopA and investigate their roles in adaptor binding and delivery of CtrA, the master regulator of Caulobacter. Finally, I …

Combining Simulation And The Mspa Nanopore To Study P53 Dynamics And Interactions, Samantha A. Schultz

Masters Theses

p53 is a transcription factor and an important tumor suppressor protein that becomes activated due to DNA damage. Because of its role as a tumor suppressor, mutations in the gene that encodes it are found in over 50% of human cancers. The N-terminal transactivation domain (NTAD) of p53 is intrinsically disordered and modulates the function and interactions of p53 in the cell. Its disordered structure allows it to be controlled closely by post-translation modifications that regulate p53’s ability to bind DNA and interact with regulatory binding partners. p53 is an attractive target for developing cancer therapeutics, but its intrinsically disordered …

Participatory Wetland Governance In Ramsar – Assessing Level Of Participation In India, Seema Ravandale

Masters Theses

Due to the alarming rate of global wetland depletion, the Ramsar Convention, an international wetland conservation and management treaty, was signed in 1971. As of today, 172 countries are signatories. The intricate connection of local communities, their indigenous knowledge and hence their participation in the wetland governance has been recently recognized by Ramsar to protect the community's right over wetlands and to establish the joint stewardship of government and communities on these vital resources. Ramsar Convention provides a broader framework for participatory wetland governance; however, there needs to be more clarity on how various countries understand, perceive, and adopt community …

Microplastics In Local Communities’ Tap Water, Zachary T. Rattell

Masters Theses

Microplastics are an emerging environmental contaminant. One of the ways microplastics can get into the environment is by the breakdown of larger plastics. These plastics can come from industrial practices, discarded fabrics, agriculture, and general plastic waste. As these plastics are broken down microplastics leach into the environment. The widespread use of plastics has resulted in the spread of microplastic contaminants all over the world. Microplastics have been reported to be in drinking water, so this paper is looking at the presence of microplastics in local communities of different demographics and socioeconomic statuses. In other studies of different drinking water …

Thermal Conductivity And Mechanical Properties Of Interlayer-Bonded Graphene Bilayers, Afnan Mostafa

Masters Theses

Graphene, an allotrope of carbon, has demonstrated exceptional mechanical, thermal, electronic, and optical properties. Complementary to such innate properties, structural modification through chemical functionalization or defect engineering can significantly enhance the properties and functionality of graphene and its derivatives. Hence, understanding structure-property relationships in graphene-based metamaterials has garnered much attention in recent years. In this thesis, we present molecular dynamics studies aimed at elucidating structure-property relationships that govern the thermomechanical response of interlayer-bonded graphene bilayers.

First, we present a systematic and thorough analysis of thermal transport in interlayer-bonded twisted bilayer graphene (IB-TBG). We find that the introduction of interlayer C-C …

Mining High Impact Combinations Of Conditions From The Medical Expenditure Panel Survey, Arjun Mohan

Masters Theses

The condition of multimorbidity — the presence of two or more medical conditions in an individual — is a growing phenomenon worldwide. In the United States, multimorbid patients represent more than a third of the population and the trend is steadily increasing in an already aging population. There is thus a pressing need to understand the patterns in which multimorbidity occurs, and to better understand the nature of the care that is required to be provided to such patients.

In this thesis, we use data from the Medical Expenditure Panel Survey (MEPS) from the years 2011 to 2015 to identify …

Tea Ceremony And Girls' Education From Edo To Meiji, Yuko Mizutani

Masters Theses

This study explores the development of women's tea ceremony from the Edo (1603-1868) to the Meiji period (1868-1912) onward, focusing on its connection to the "good wife, wise mother" ideology in the Meiji period. Many girls' schools, led by Atomi school, adopted the tea ceremony around the time of establishing the “good wife, wise mother.”

During the Edo period, the population of women practitioners increased significantly. This was not limited to just women from samurai families; it extended to commoners as well. The women’s tea ceremony during the Edo period was greatly influenced by Confucianism and its expectations for women. …

Climate Change Attitudes Of United States Family Forest Owners And Their Influence On Forest Management Practices, Logan Miller

Masters Theses

Understanding family forest owners’ (FFOs’) attitudes and behaviors towards climate change will allow for more sustainable forest management practices to be implemented, helping to combat climate change and its impacts. The goals for this research are (1) to begin measuring U.S. FFO attitudes toward climate change, (2) to determine what factors impact these attitudes, and (3) to determine how they influence the FFO’s management practices using the Responsible Environmental Behavior (REB) framework (Hines et al. 1987). Chapter 1 explores the different facets of my thesis project focusing on forests and forests’ ecosystem services, forest ownership in the United States, and …

A Composability-Based Transformer Pruning Framework, Yuping Lin

Masters Theses

This thesis addresses the crucial issue of deploying large Transformer models on resource-constrained edge devices. Given the slow training speeds, the current Transformer pruning and fine-tuning process becomes tedious and time-consuming for multiple pruning configurations. To remedy this, the research proposes a novel composability-based Transformer pruning framework, aiming to significantly reduce the time required for fine-tuning pruned models across various configurations, while maintaining model performance. Unlike traditional approaches, this study explores the composability between Transformer pruning configurations, unveiling opportunities for computational reuse. It leverages this composability within a newly proposed framework, employing techniques similar to knowledge distillation and automating the …

The Impact Of Cannabidiol On Intestinal Tumorigenesis: A Pilot Study On Caco-2 Cell, Yingxue Guan

Masters Theses

Colorectal cancer (CRC) is the third most prevalent cause of cancer-related deaths worldwide. Despite the availability of early diagnosis and treatment options, which could potentially increase the 5-year survival rate, the accessibility of such CRC management measures remains limited due to cost barriers and uneven healthcare infrastructure globally. This underscores an urgent need for effective preventive methods and affordable treatments. Cannabidiol (CBD), a compound derived from cannabis, has garnered attention as a potential natural therapeutic agent. This study investigates the influence of CBD on the serotonin pathway and intestinal tumorigenesis. Serotonin, primarily produced in the intestine, is not only a …

The Tectonic Evaluation And Design Implementation Of 3d Printing Technology In Architecture, Robert Buttrick

Masters Theses

This design thesis is an assessment of the tectonic capabilities and applications of large format 3D printing, given the current available and practiced technologies. This review consists of an analysis of the technical specifications and limitations of the various forms and methods of 3D printing at all scales, followed by an in-depth analysis of technologies that have been adopted and employed at an architectural scale. A number of case studies are assessed to create a typology of tectonic types created by employing 3D printing technologies. These tectonic types: Holistic/Homogenous, Complementary/Integrative, Structural, and Sculptural are then tested to see how they …

Fingerprinting For Chiplet Architectures Using Power Distribution Network Transients, Matthew G. Burke

Masters Theses

Chiplets have become an increasingly popular technology for extending Moore's Law and improving the reliability of integrated circuits. They do this by placing several small, interacting chips on an interposer rather than the traditional, single chip used for a device. Like any other type of integrated circuit, chiplets are in need of a physical layer of security to defend against hardware Trojans, counterfeiting, probing, and other methods of tampering and physical attacks.

Power distribution networks are ubiquitous across chiplet and monolithic ICs, and are essential to the function of the device. Thus, we propose a method of fingerprinting transient signals …

Creating Dormitories With A Sense Of Home, Johnathon A. Brousseau

Masters Theses

With more people in the United States renting now than at any point since 1965, there is an amorphous temporality in the dwellings of many Americans (Cilluffo, Fry, 2022). This provides flexibility and thus, more freedom for upward mobility, an enticing attribute for younger people living on their own for the first time. However, this lack of permanence can create challenges in establishing a “sense of place”. When residents don’t feel a strong connection to their spaces, they can feel as if they don’t belong. This issue is especially prevalent in dormitories, where a feeling of belonging is vital to …

The Current State Of Practice Of Building Information Modeling, Kevin P. Brooks

Masters Theses

Building Information Modeling (BIM) has become extremely prominent in the construction industry in the past twenty years. It serves as a digital repository that can, when used to its fullest potential, combine all aspects of designing, building, and managing a structure in one place, alongside all the data produced in those processes. The construction industry has to date struggled to increase productivity alongside similar fields, such as the manufacturing industry, though the construction industry generally has far more stakeholders on one project than the manufacturing industry. Further, building designs are becoming more complex while project schedules are becoming tighter. As …