Digital Commons Network^™

T-Count Optimization Of Quantum Carry Look-Ahead Adder, Vladislav Ivanovich Khalus

Theses and Dissertations--Electrical and Computer Engineering

With the emergence of quantum physics and computer science in the 20^th century, a new era was born which can solve very difficult problems in a much faster rate or problems that classical computing just can't solve. In the 21^st century, quantum computing needs to be used to solve tough problems in engineering, business, medical, and other fields that required results not today but yesterday. To make this dream come true, engineers in the semiconductor industry need to make the quantum circuits a reality.

To realize quantum circuits and make them scalable, they need to be fault tolerant, …

Fault Location Techniques Using The Traveling Wave Method And The Discrete Wavelet Transform, Wesley Fluty

Theses and Dissertations--Electrical and Computer Engineering

Fault location within electric power systems is an important topic that helps reduce outage duration and increases reliability of the system. This paper explores the topic of fault location using traveling waves generated by fault conditions and the discrete wavelet transform used for time-frequency analysis. The single-ended and double-ended traveling wave methods are presented and evaluated on a single circuit and double circuit 500kV system modeled using MATLAB SIMULINK. Results are compared on the basis of wavelet used for analysis, sampling rate, and fault resistance.

Optimum Design Of Axial Flux Pm Machines Based On Electromagnetic 3d Fea, Narges Taran

Theses and Dissertations--Electrical and Computer Engineering

Axial flux permanent magnet (AFPM) machines have recently attracted significant attention due to several reasons, such as their specific form factor, potentially higher torque density and lower losses, feasibility of increasing the number of poles, and facilitating innovative machine structures for emerging applications. One such machine design, which has promising, high efficiency particularly at higher speeds, is of the coreless AFPM type and has been studied in the dissertation together with more conventional AFPM topologies that employ a ferromagnetic core.

A challenge in designing coreless AFPM machines is estimating the eddy current losses. This work proposes a new hybrid analytical …

Empirical Assessment Of Callous-Unemotional Traits In Preschool: A Comparison Of Confirmatory Factor Analysis And Network Analysis, Pevitr Singh Bansal

Theses and Dissertations--Psychology

Callous – unemotional (CU) traits are a key factor in understanding the persistence and severity of conduct problems. The factor structure of CU traits has been primarily examined through confirmatory factor analysis (CFA) in childhood and adolescent samples, yet little research has examined the structure of CU traits in preschool. Further, current CFA models have yielded poor – to – marginally acceptable fit, suggesting the need for a more nuanced approach in understanding the structure of CU traits in early childhood using an interitem approach (i.e., network analysis). Within a sample of 109 preschool children (M age = 4.77, …

The Effect Of Posttraumatic Stress And Trauma-Focused Disclosure On Experimental Pain Sensitivity Among Trauma-Exposed Women, Caitlyn Olivia Hood

Theses and Dissertations--Psychology

Previous studies evaluating the impact of trauma history and PTSD on pain sensitivity yield inconsistent findings; the presence of trauma-related negative affective states may account for these discrepancies. Therefore, the proposed study aimed to evaluate the effect of trauma-related negative affect and PTSD symptoms on sensory and affective components of pain sensitivity among trauma-exposed women. Adult women (N = 87) with low and high PTSD symptoms underwent an emotional disclosure paradigm, during which they wrote about a traumatic event or a neutral topic. Participants then completed a pain induction procedure. Compared to women with low PTSD symptoms, women with …

Examining The Utility Of Behavioral Economic Demand In Addiction Science, Justin Charles Strickland

Theses and Dissertations--Psychology

The marriage of perspectives from behavioral economic theory and learning theory has the potential to advance an understanding of substance use and substance use disorder. Behavioral economic demand is a central concept to this interdisciplinary approach. Evaluating demand in the laboratory and clinic can improve previous research on the relative reinforcing effects of drugs by accounting for the multi-dimensional nature of reinforcement rather than viewing reinforcement as a unitary construct. Recent advances in the commodity purchase task methodology have further simplified the measurement of demand values in human participants. This dissertation project presents a programmatic series of studies designed to …

Analysis Of Automatic Judgments Of Religious Belief, Maxine Belén Najle

Theses and Dissertations--Psychology

The measurement of religious belief has some social desirability concerns that make the development of an implicit measure of religiosity advantageous. Currently, there are few options for implicitly measuring religious belief. This study attempted to add to this literature by analyzing the automatic judgements of religious belief through the use of an implicit measure known as the MouseTrack task, allowing for the measurement of latency in the expression of these beliefs as well as the certainty of these beliefs by tracking the path taken during the decision process. A sample of 121 undergraduates was recruited from the UK SONA subject …

Do Bulimic Behaviors Increase Shame? Toward An Understanding Of Transdiagnostic Risk, Heather A. Davis

Theses and Dissertations--Psychology

Binge eating is a harmful, maladaptive behavior associated with comorbid psychopathology. Theory posits that increases in maladaptive, transdiagnostic emotions following binge eating in individuals with BN may predict the experience of comorbid symptoms. The current study served as a laboratory test of the first part of this theory: whether state increases in maladaptive emotions occur following engagement in binge eating behavior in women with BN compared with healthy controls. Women (n = 51) were recruited from the community if they met DSM-5 criteria for BN or OSFED BN (of low frequency) (n = 21) or were free of lifetime disordered …

Characterizing An In Vitro Model Of Severe Focal Traumatic Brain Injury In Hippocampal Slice Cultures: The Effects Of Ethanol And Calpain Inhibition By Mdl-28170, Julia Elaine Jagielo-Miller

Theses and Dissertations--Psychology

In the United States, 2.8 million people suffer a traumatic brain injury (TBI) annually. Between 25%-50% of TBI injuries happen under alcohol intoxication. It is not understood how alcohol impacts patient outcomes via secondary injury pathways. Secondary injury pathways offer a window for therapeutic interventions, but there has been little success finding effective medications. Slice cultures offer a way to study secondary injury mechanisms in a controlled manner. The transection injury can model excitotoxicy seen following TBI. The current studies examined the effect of alcohol intoxication and withdrawal at the time of injury, and the effect of a calpain inhibitor …

Development Of A Translational Model Of Co-Use Of Alcohol And Nicotine For Testing Potential Pharmacotherapies, Sarah Elizabeth Maggio

Theses and Dissertations--Psychology

Co-users of alcohol and nicotine are the largest group of polysubstance users worldwide. Although pharmacotherapies are available for alcohol (EtOH) or tobacco use disorders individually, it may be possible to develop a single pharmacotherapy to treat heavy drinking tobacco smokers through capitalizing on the commonalities in their mechanisms of action. Towards this goal, several models of concurrent access to EtOH and nicotine were explored as potential preclinical models of co-use using female alcohol-preferring (P) rats. Additionally, potential pharmacotherapeutics for the treatment of EtOH and nicotine co-use disorder were tested using different variations of our model. Treatments tested included (1) varenicline, …

Measuring Glutamate And Oxygen In Brain Reward Circuits In Animal Models Of Cocaine Abuse And Decision-Making, Seth Richard Batten

Theses and Dissertations--Psychology

Drug-specific reward and associated effects on neural signaling are often studied between subjects, where one group self-administers drug and a separate group self-administers a natural reinforcer. However, exposure to drugs of abuse can cause long-term neural adaptations that can affect how an organism responds to drug reward, natural reward, and their reward-associated stimuli. Thus, to isolate drug-specific effects it is important to use models that expose the same organism to all of the aforementioned. Multiple schedules provide a means of dissociating the rewarding effects of a drug from the rewarding effects of food within a single animal. Further, drug users …

Language Dysfunction In Motor Neuron Disease: Cognitive Features And Screening Sensitivity, Natasha E. Garcia-Willingham

Theses and Dissertations--Psychology

Motor neuron disease (MND) is a set of neuromuscular diseases that affect the upper and/or lower motor neurons, resulting in progressive disability. Amyotrophic lateral sclerosis (ALS) and Primary lateral sclerosis (PLS) are two forms of MND that both involve upper motor neuron degeneration, which can also accompany extra-motor changes in cognitive, behavioral, and/or emotional functioning for some individuals. Characterization of the cognitive profile of MND is still evolving, with growing interest in cognitive subtypes. The development of cognitive screens targeted to the MND cognitive profile aim to provide efficient and accurate brief assessments. However, empirical evaluation of tailored MND cognitive …

Neuropsychological Correlates Of Striatal Dopaminergic Dysfunction In Parkinson’S Disease, Brittany D. Walls

Theses and Dissertations--Psychology

Parkinson’s disease (PD) is a common neurodegenerative disorder associated with dysfunction of the basal ganglia, which contributes to a range of motor, cognitive, and affective symptoms. Striatal dopaminergic deficits are one of the core pathological mechanisms thought to contribute to the extra-motor (i.e., cognitive and affective) symptoms in early PD. The present study investigated the relationship between striatal dopaminergic integrity and cognition in 21 patients with PD and 21 age and education matched controls. Each individual underwent dopamine transporter (DaT) imaging with single photon emission computed tomography (SPECT) (i.e., DaTscan) and standardized neuropsychological testing. Strong positive associations were found between …

The Role Of Nrf2 Signalling In Cell Proliferation And Tumorigenesis Of Chromium Transformed Human Bronchial Epithelial Cells, Marco Antonio De Freitas Clementino

Theses and Dissertations--Toxicology and Cancer Biology

Hexavalent Chromium (Cr(VI) induces malignant cell transformation in normal bronchial epithelial (BEAS-2B) cells. Cr(VI)-transformed cells exhibit increased level of antioxidants, are resistant to apoptosis, and are tumorigenic. RNAseq analysis in Cr(VI)-transformed cells showed that expression of transcripts associated with mitochondrial oxidative phosphorylation is reduced, and the expression of transcripts associated with pentose phosphate pathway, glycolysis, and glutaminolysis are increased. Sirtuin-3 (SIRT3) regulates mitochondrial adaptive response to stress, such as metabolic reprogramming and antioxidant defense mechanisms. SIRT3 was upregulated and it positively regulated mitochondrial oxidative phosphorylation in Cr(VI)-transformed cells. Our results suggests that SIRT3 plays an important role in mitophagy deficiency …

Multigenerational Genomic And Epigenetic Effects Of Manufactured Silver Nanomaterials In Caenorhabditis Elegans, Anye Wamucho

Theses and Dissertations--Toxicology and Cancer Biology

There has been an increase in the incorporation of silver nanomaterials into consumer products due to their antimicrobial properties. Therefore there is potential for silver nanoparticles (Ag-NPs) to leach out into the environment during different life-cycle stages of these nanomaterial-containing products. Concern about the toxicity of Ag-NPs has led to investigations into their toxic effects on a variety of organisms mainly using acute and sub-chronic, single-generation exposures. The focus of this project was to understand the effects of long-term continuous multigenerational exposure to AgNO₃ and Ag-NPs in both pristine and environmentally transformed forms, on the model organism, Caenorhabditis elegans …

A Compromised Liver Alters Pcb Toxicity And Nutrient Metabolism, Jazmyne D. L. Barney

Theses and Dissertations--Toxicology and Cancer Biology

Environmental contamination is a public health concern. In particular persistent organic pollutants like Polychlorinated Biphenyls (PCBs) have been associated with multiple chronic inflammatory diseases, including non-alcoholic fatty liver disease (NAFLD). NAFLD prevalence has steadily increased and is expected to continue to rise with an estimated 25% of the world’s population and 80-100 million people affected in the United States alone. Importantly, the liver is the primary site for endobiotic and xenobiotic metabolism, hence its proper function is critical for the body’s response to innate and extrinsic molecules. One way to combat the deleterious effects of PCB toxicity and fatty liver …

Mechanisms Of Trinucleotide Repeat Instability During Dna Synthesis, Kara Y. Chan

Theses and Dissertations--Toxicology and Cancer Biology

Genomic instability, in the form of gene mutations, insertions/deletions, and gene amplifications, is one of the hallmarks in many types of cancers and other inheritable genetic disorders. Trinucleotide repeat (TNR) disorders, such as Huntington’s disease (HD) and Myotonic dystrophy (DM) can be inherited and repeats may be extended through subsequent generations. However, it is not clear how the CAG repeats expand through generations in HD. Two possible repeat expansion mechanisms include: 1) polymerase mediated repeat extension; 2) persistent TNR hairpin structure formation persisting in the genome resulting in expansion after subsequent cell division. Recent in vitro studies suggested that a …

Mutations Of Fus Cause Aggregation Of Rna Binding Proteins, Disruptions In Protein Synthesis, And Dysregulation Of Nonsense Mediated Decay, Marisa Elizabeth Kamelgarn

Theses and Dissertations--Toxicology and Cancer Biology

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron death and subsequent muscle atrophy. Approximately 15% of ALS cases are inheritable, and mutations in the Fused in Sarcoma (FUS) gene contribute to approximately 5% of these cases, as well as about 2% of sporadic cases. FUS performs a diverse set of cellular functions, including being a major regulator of RNA metabolism. FUS undergoes liquid- liquid phase transition in vitro, allowing for its participation in stress granules and RNA transport granules. Phase transition also contributes to the formation of cytoplasmic inclusions found in the …

Innovation Behavior Of Agri-Food Small And Medium-Sized Enterprises: Emerging Countries, Gaukhar B. Kussainova

Theses and Dissertations--Agricultural Economics

This paper examines the innovative behavior of agri-food firms located in Central and Eastern Europe. In the literature, empirical analyses on innovation activities of firms focus on various case studies from around the world. However, very few studies explored the innovation of small and medium sized enterprises (SMEs) from Central and Eastern Europe’s agri-food sector. The analysis uses the logit estimation method and firm-level data, which are obtained from ERBD-World Bank Business Environment and Enterprise Performance Survey (BEEPS). Results suggest that firms that spent some proportion of their financial budget on research and development (R&D), had workforce training programs and …

Evaluating Water Management Policy In Saudi Arabia Using A Bilevel, Multi-Objective, Multi-Follower Programming Approach, Jawad Alhashim

Theses and Dissertations--Agricultural Economics

Over the past five decades, the Saudi government has adopted many agricultural policies aimed to: achieve self-sufficiency of food, increase the participation of the agricultural sector in the economy, and reduce the consumption of irrigation water. Due to conflicts among government objectives and the incompatibility of farmers' objectives with those of some agricultural policies, the government has not been able to fully achieve its objectives.

To accomplish its goals the government, or decision maker needs to understand the farmer, or follower, reaction when s/he adopts a new decision. The dissertation aims to build a model that achieves government goals of …

Economic Impact Of Ethanol Biorefineries In The U.S. Midwest From 2001 To 2015: A Quasi-Experimental Approach, Scott W. Hall

Theses and Dissertations--Agricultural Economics

The objective of this dissertation is to analyze the economic impact of newly operational ethanol biorefineries on rural counties in the U.S. Midwest region for the period 2001 to 2015 using a quasi-experimental approach. Rapid growth in the ethanol industry expanded the number of ethanol plants located in the U.S. Midwest from 54 in 2001 to 173 in 2015. Out of the counties with 119 new ethanol biorefineries, 97 counties met the general treatment criteria defined in this dissertation, but only 56 of those counties qualified for the rural treatment criteria. Counties with ethanol biorefineries that qualified for treatment were …

Reducing Survey Hypothetical Bias Through Revealed Behavior Priming: A Case Of Student Preference For Beef Served By University Dining, Gaby De Nascimento Mandlhate

Theses and Dissertations--Agricultural Economics

Economists are still searching for methods to reduce/eliminate Hypothetical Bias (HB). Different methods have been previously applied some with success and others without. In this study, we aimed to further test the cognitive dissonance approach (CD) through a learning design method to estimate the WTP for five beef attributes: Non-quality, Kentucky Proud, Appalachian, Grass Fed and a mix of 25% Non-quality and 75% Kentucky Proud, using a one and one half bounded model. To test the CD, 881 participants from the University of Kentucky, were randomly assigned to a real/hypothetical market for a battery recycling project at first and afterwards …

Neuroprotective Strategies Following Experimental Traumatic Brain Injury: Lipid Peroxidation-Derived Aldehyde Scavenging And Inhibition Of Mitochondrial Permeability Transition, Jacqueline Renee Kulbe

Theses and Dissertations--Neuroscience

Traumatic brain injury (TBI) represents a significant health crisis. To date there are no FDA-approved pharmacotherapies available to prevent the neurologic deficits caused by TBI. Following TBI, dysfunctional mitochondria generate reactive oxygen and nitrogen species, initiating lipid peroxidation (LP) and the formation of LP-derived neurotoxic aldehydes, which bind mitochondrial proteins, exacerbating dysfunction and opening of the mitochondrial permeability pore (mPTP), resulting in extrusion of mitochondrial sequestered calcium into the cytosol, and initiating a downstream cascade of calpain activation, spectrin degradation, neurodegeneration and neurologic impairment.

As central mediators of the TBI secondary injury cascade, mitochondria and LP-derived neurotoxic aldehydes make promising …

Biology And Management Of The Soybean Stem Borer, Dectes Texanus Leconte, In Kentucky, Izabela Gomes

Theses and Dissertations--Entomology

Dectes texanus LeConte (Coleoptera: Cerambycidae) is a longhorn beetle species endemic to eastern United States. Originally described as a pest of weeds from the family Asteraceae, D. texanus has expanded its host range and is found infesting the stems of soybeans, Glycine max (L.) through the southwestern and middle United States. Female D. texanus chews a hole in the epidermis of a petiole and oviposits on it. Then, the D. texanus larva depletes all the pith of the stem making a tunnel down to the base of the plant and girdle the stem about 5 cm above the …