Digital Commons Network^™

Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal

Theses and Dissertations--Computer Science

Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying other essential relations (e.g., causation, prevention) between biomedical entities is also critical to understand biomedical processes. Hence, it is crucial to develop automated relation prediction systems that can yield plausible biomedical relations to expedite the discovery process. In this dissertation, we demonstrate three approaches to predict treatment relations between biomedical entities for the drug repositioning task …

Rule Mining And Sequential Pattern Based Predictive Modeling With Emr Data, Orhan Abar

Theses and Dissertations--Computer Science

Electronic medical record (EMR) data is collected on a daily basis at hospitals and other healthcare facilities to track patients’ health situations including conditions, treatments (medications, procedures), diagnostics (labs) and associated healthcare operations. Besides being useful for individual patient care and hospital operations (e.g., billing, triaging), EMRs can also be exploited for secondary data analyses to glean discriminative patterns that hold across patient cohorts for different phenotypes. These patterns in turn can yield high level insights into disease progression with interventional potential. In this dissertation, using a large scale realistic EMR dataset of over one million patients visiting University of …

Lattice Simplices: Sufficiently Complicated, Brian Davis

Theses and Dissertations--Mathematics

Simplices are the "simplest" examples of polytopes, and yet they exhibit much of the rich and subtle combinatorics and commutative algebra of their more general cousins. In this way they are sufficiently complicated --- insights gained from their study can inform broader research in Ehrhart theory and associated fields.

In this dissertation we consider two previously unstudied properties of lattice simplices; one algebraic and one combinatorial. The first is the Poincar\'e series of the associated semigroup algebra, which is substantially more complicated than the Hilbert series of that same algebra. The second is the partial ordering of the elements of …