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University of Kentucky

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2019

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Legacy Missions In Times Of Change: Defining And Shaping Collections In The 21st Century, Antje Mays, Oya Y. Rieger Nov 2019

Legacy Missions In Times Of Change: Defining And Shaping Collections In The 21st Century, Antje Mays, Oya Y. Rieger

Library Presentations

Despite the rapidly changing information and technology landscape, collections remain at the heart of academic libraries, signifying their enduring importance in providing access to our cultural heritage. Given broader trends in research and the current information ecology of an increasingly networked, distributed, and licensed environment, building collections and developing collection polices is increasingly ambiguous. These trends impact librarians in form of ever-expanding portfolios, diffusion of effort, weakened sense of focus, and a rising sense of persistent yet unmet needs for developing new skills. This paper outlines current research on collection trends and summarizes the interactive exchanges from the 2019 Charleston …


General Education Learning Outcomes And Demographic Correlates In University Students In Hong Kong, Lu Yu, Daniel T. L. Shek, Xiaoqin Zhu Nov 2019

General Education Learning Outcomes And Demographic Correlates In University Students In Hong Kong, Lu Yu, Daniel T. L. Shek, Xiaoqin Zhu

Pediatrics Faculty Publications

Although there are studies showing that higher education would benefit university students, empirical research that comprehensively assesses student general education learning outcomes and related demographic correlates based on longitudinal data is minimal, especially in the Chinese context. To address the research gaps, the present study was conducted to investigate learning outcomes amongst university students in one university in Hong Kong based on a four-year longitudinal design (N = 460). Four dimensions of student general education learning outcomes were measured, including effective reasoning and problem solving, leadership, moral character, and integration of learning. Results suggested a U-shaped pattern of student …


Simulated Biological Fluid Exposure Changes Nanoceria’S Surface Properties But Not Its Biological Response, Robert A. Yokel, Matthew L. Hancock, Benjamin Cherian, Alexandra J. Brooks, Marsha L. Ensor, Hemendra J. Vekaria, Patrick G. Sullivan, Eric A. Grulke Nov 2019

Simulated Biological Fluid Exposure Changes Nanoceria’S Surface Properties But Not Its Biological Response, Robert A. Yokel, Matthew L. Hancock, Benjamin Cherian, Alexandra J. Brooks, Marsha L. Ensor, Hemendra J. Vekaria, Patrick G. Sullivan, Eric A. Grulke

Pharmaceutical Sciences Faculty Publications

Nanoscale cerium dioxide (nanoceria) has industrial applications, capitalizing on its catalytic, abrasive, and energy storage properties. It auto-catalytically cycles between Ce3+ and Ce4+, giving it pro-and anti-oxidative properties. The latter mediates beneficial effects in models of diseases that have oxidative stress/inflammation components. Engineered nanoparticles become coated after body fluid exposure, creating a corona, which can greatly influence their fate and effects. Very little has been reported about nanoceria surface changes and biological effects after pulmonary or gastrointestinal fluid exposure. The study objective was to address the hypothesis that simulated biological fluid (SBF) exposure changes nanoceria’s surface properties …


[Review Of] Smart Girls: Success, School, And The Myth Of Post-Feminism. By Shauna Pomerantz And Rebecca Raby. Oakland: University Of California Press, 2017., Edward W. Morris Nov 2019

[Review Of] Smart Girls: Success, School, And The Myth Of Post-Feminism. By Shauna Pomerantz And Rebecca Raby. Oakland: University Of California Press, 2017., Edward W. Morris

Sociology Faculty Publications

No abstract provided.


Understanding Lung Cancer Resources And Barriers Among Worksites With Mostly Male Employees In Eight Rural Kentucky Counties: A Focus Group Discussion, Jennifer Redmond Knight, Lucy Hollingsworth Williamson, Debra K. Armstrong, Elizabeth A. Westbrook Nov 2019

Understanding Lung Cancer Resources And Barriers Among Worksites With Mostly Male Employees In Eight Rural Kentucky Counties: A Focus Group Discussion, Jennifer Redmond Knight, Lucy Hollingsworth Williamson, Debra K. Armstrong, Elizabeth A. Westbrook

Health Management and Policy Faculty Publications

Kentucky has the highest cancer incidence and mortality rates in the United States, and lung cancer is Kentucky's leading cause of cancer deaths. Males in Kentucky have higher lung incidence and mortality rates than females. Through support from the SelfMade Health Network, Kentucky developed a Regional Resource Lead Organization that collaboratively developed a multi-component worksite intervention on lung cancer among male populations. The intervention targets eight Kentucky counties. The first component and focus of this manuscript included focus group meetings with organizational representatives in each county that provide health, educational, and social services to men and worksites. The focus groups …


Hospital Closures And Short-Run Change In Ambulance Call Times, Sookti Chaudhary, Alison F. Davis, Kenneth R. Troske, Suzanne Troske Nov 2019

Hospital Closures And Short-Run Change In Ambulance Call Times, Sookti Chaudhary, Alison F. Davis, Kenneth R. Troske, Suzanne Troske

Rural & Underserved Health Research Center Publications

We measure one aspect of how access to emergency care through ambulance services changes for patients when a hospital closes. We empirically estimate the time needed to transport a patient to an emergency department in an ambulance in the period immediately after the hospital closes. We find urban patients in zip codes where a hospital closes have a small change in transportation time, where rural patients average an estimated 15.7 additional minutes – a 46% increase compared to the year before the closure. This increase is primarily the result of an almost 100 percent increase in the time it takes …


Aliados De La Historia: Ayudando A Proteger Su Pasado: Recursos Sobre La Gestión De Archivos Y Registros Para Organizaciones Comunitarias, Ruth E. Bryan, Sarah Dorpinghaus, Matthew Strandmark, Laura M. Cuevas Meléndez Nov 2019

Aliados De La Historia: Ayudando A Proteger Su Pasado: Recursos Sobre La Gestión De Archivos Y Registros Para Organizaciones Comunitarias, Ruth E. Bryan, Sarah Dorpinghaus, Matthew Strandmark, Laura M. Cuevas Meléndez

Library Presentations

Desde 2015, University of Kentucky Libraries Special Collections Research Center (UK SCRC) ha ofrecido talleres sobre básicos de archivos para organizaciones comunitarias en el centro del estado de Kentucky. Estos talleres, titulados "Aliados de la historia: ayudando a proteger su pasado," son gratuitos y abiertos al público y, a menudo, se organizan en colaboración con las bibliotecas públicas del área. Los asistentes han sido de iglesias afroamericanas, organizaciones LGBTQIA, grupos genealógicos, museos y más. Los temas incluyen el valor histórico de los registros de la organización, la selección de registros para la retención permanente, el inventario y el almacenamiento de …


History Allies: Helping Protect Your Past: Resources On Managing Archives & Records For Community-Based Organizations, Ruth E. Bryan, Sarah Dorpinghaus, Matthew Strandmark Nov 2019

History Allies: Helping Protect Your Past: Resources On Managing Archives & Records For Community-Based Organizations, Ruth E. Bryan, Sarah Dorpinghaus, Matthew Strandmark

Library Presentations

Since 2015, the UK Libraries Special Collections Research Center (UK SCRC) has offered “archives basics” workshops for community-based organizations in central Kentucky. These workshops, titled “History Allies: Helping Protect Your Past,” are free and open to the public and often hosted in partnership with area public libraries. Attendees have been from African American churches, LGBTQIA organizations, genealogical groups, museums, and more. Topics include the historical value of organizational records, selecting records for permanent retention, inventorying and storing physical and digital records, providing access to researchers, managing volunteers and volunteer projects, digitization methods and standards, and outreach and exhibits. The workshops …


Forage News [2019-11], Department Of Plant And Soil Sciences, University Of Kentucky Nov 2019

Optimal Combinations Of Utility Level Renewable Generators For A Net Zero Energy Microgrid Considering Different Utility Charge Rates, Evan S. Jones, Huangjie Gong, Dan M. Ionel Nov 2019

Optimal Combinations Of Utility Level Renewable Generators For A Net Zero Energy Microgrid Considering Different Utility Charge Rates, Evan S. Jones, Huangjie Gong, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

High initial investment and the intermittent nature of resources are major challenges for large scale renewable generation. The size of photovoltaic (PV) and wind turbine (WT) farms in the microgrid needs optimized to avoid curtailment and to efficiently meet the demand of a power system. Battery energy storage systems (BESSs) may also be used to improve flexibility. This paper explores the optimal sizing for PV and wind generators, as well as a BESS at the utility level for a large grid-connected net zero energy (NZE) hybrid microgrid considering characteristics such as initial investment, levelized cost of energy (LCOE), operating costs, …


Overview Of Flywheel Systems For Renewable Energy Storage With A Design Study For High-Speed Axial-Flux Permanent-Magnet Machines, Murat G. Kesgin, Peng Han, Narges Taran, Dan M. Ionel Nov 2019

Overview Of Flywheel Systems For Renewable Energy Storage With A Design Study For High-Speed Axial-Flux Permanent-Magnet Machines, Murat G. Kesgin, Peng Han, Narges Taran, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

Flywheel energy storage is considered in this paper for grid integration of renewable energy sources due to its inherent advantages of fast response, long cycle life and flexibility in providing ancillary services to the grid, such as frequency regulation, voltage support, etc. The fundamentals of the technology and recent developments are reviewed, firstly with an emphasis on the design considerations and performance metrics. Then the progress and development trends in electric motor/generators employed in flywheel energy storage systems (FESS) are summarized, showing the potential of axial-flux permanent-magnet (AFPM) machines in such applications. Design examples of high-speed AFPM machines are provided …


Explain It To Me: Tips For Effective Rule Explanation In Legal Analysis, Melissa N. Henke Nov 2019

Explain It To Me: Tips For Effective Rule Explanation In Legal Analysis, Melissa N. Henke

Law Faculty Popular Media

The process of rule explanation is an important part of legal analysis, because it informs the legal reader, be it another attorney or a judge, how the legal rule has been applied in past cases. In other words, the rule explanation is where we use case law “to define, explain, and exemplify” the legal rule that determines the outcomes of the client’s problem or dispute. Legal writing texts refer to this discussion of past cases as case illustrations, case descriptions, or case examples, and they often devote substantial space to the topic. This column highlights four tips for improving the …


Numerical, Secondary Big Data Quality Issues, Quality Threshold Establishment, & Guidelines For Journal Policy Development, Anita Lee-Post, Ram Pakath Nov 2019

Numerical, Secondary Big Data Quality Issues, Quality Threshold Establishment, & Guidelines For Journal Policy Development, Anita Lee-Post, Ram Pakath

Marketing & Supply Chain Faculty Publications

An IS researcher may obtain Big Data from primary or secondary data sources. Sometimes, acquiring primary Big Data is infeasible due to availability, accessibility, cost, time, and/or complexity considerations. In this paper, we focus on Big Data-based IS research and discuss ways in which one may, post hoc, establish quality thresholds for numerical Big Data obtained from secondary sources. We also present guidelines for developing journal policies aimed at ensuring the veracity and verifiability of such data when used for research purposes.


Post-Acquisition Processing Confounds In Brain Volumetric Quantification Of White Matter Hyperintensities, Ahmed A. Bahrani, Omar M. Al-Janabi, Erin L. Abner, Shoshana H. Bardach, Richard J. Kryscio, Donna M. Wilcock, Charles D. Smith, Gregory A. Jicha Nov 2019

Post-Acquisition Processing Confounds In Brain Volumetric Quantification Of White Matter Hyperintensities, Ahmed A. Bahrani, Omar M. Al-Janabi, Erin L. Abner, Shoshana H. Bardach, Richard J. Kryscio, Donna M. Wilcock, Charles D. Smith, Gregory A. Jicha

Neurology Faculty Publications

BACKGROUND: Disparate research sites using identical or near-identical magnetic resonance imaging (MRI) acquisition techniques often produce results that demonstrate significant variability regarding volumetric quantification of white matter hyperintensities (WMH) in the aging population. The sources of such variability have not previously been fully explored.

NEW METHOD: 3D FLAIR sequences from a group of randomly selected aged subjects were analyzed to identify sources-of-variability in post-acquisition processing that can be problematic when comparing WMH volumetric data across disparate sites. The methods developed focused on standardizing post-acquisition protocol processing methods to develop a protocol with less than 0.5% inter-rater variance.

RESULTS: A series …


Critical Path For Project Development, Steven Douglas Kreis, Bryan Gibson, Jeff Jasper, Christopher W. Van Dyke, Candice Y. Wallace, Rachel Catchings, Sarah M. Mccormack Nov 2019

Critical Path For Project Development, Steven Douglas Kreis, Bryan Gibson, Jeff Jasper, Christopher W. Van Dyke, Candice Y. Wallace, Rachel Catchings, Sarah M. Mccormack

Kentucky Transportation Center Research Report

Overseeing the delivery of highway projects at the Kentucky Transportation Cabinet (KYTC) requires the successful coordination of activities and inputs from multiple external agencies and members of the agency’s Project Development team, who have varied disciplinary backgrounds. Despite the complexity of project delivery, the Cabinet presently does not estimate hours and project milestone dates until after it has selected a design consultant. Moving forward KYTC should explore requiring consultants to develop a critical path method (CPM) schedule. To facilitate this process, this report describes a methodology for producing CPMs for design contracts/projects based on procedures outlined in A Guide to …


Las Dos Cosas Versus Exclusive Breastfeeding: A Culturally And Linguistically Exploratory Intervention Study In Hispanic Mothers Living In Kentucky, Ana Maria Linares, Diana Cartagena, Mary Kay Rayens Nov 2019

Las Dos Cosas Versus Exclusive Breastfeeding: A Culturally And Linguistically Exploratory Intervention Study In Hispanic Mothers Living In Kentucky, Ana Maria Linares, Diana Cartagena, Mary Kay Rayens

Nursing Faculty Publications

INTRODUCTION: Formula supplementation among infants of breastfeeding Hispanic immigrants is common practice known as las dos cosas. The purpose of this study was to assess the feasibility, effectiveness, and acceptability of a culturally and linguistically diverse intervention to promote exclusive breastfeeding (EBF) for the first 6 months.

METHODS: A sample of 39 Hispanic pregnant women was recruited and randomly assigned to intervention (n = 20) and control groups (n = 19). The intervention included a peer counselor and professional support, and mothers were followed from pregnancy to 6 months after birth.

RESULTS: After the study, women assigned to …


Smart Plug And Circuit Breaker Technologies For Residential Buildings In The Us, Rosemary E. Alden, Peng Han, Dan M. Ionel Nov 2019

Smart Plug And Circuit Breaker Technologies For Residential Buildings In The Us, Rosemary E. Alden, Peng Han, Dan M. Ionel

Power and Energy Institute of Kentucky Faculty Publications

A significant proportion of the total energy in conventional homes across the United States is used by electric plug loads, which include various electronic devices and home appliances, excluding the heating, ventilation and air conditioning (HVAC) units and electric water heaters. Considerable energy savings are expected to be possible by managing these plug loads effectively based on user behavior data. Smart plugs and circuit breakers that can control and monitor energy usage on a real-time basis are becoming increasingly popular alongside the rapid development of smart home energy management. This paper reviews the recent advances on the subject matter with …


Soil Net Nitrogen Mineralisation Across Global Grasslands, A. C. Risch, S. Zimmerman, R. Ochoa-Hueso, M. Schütz, B. Frey, J. L. Firn, P. A. Fay, F. Hagedorn, E. T. Borer, E. W. Seabloom, W. S. Harpole, J. M. H. Knops, Rebecca L. Mcculley, A. A. D. Broadbent, C. J. Stevens, M. L. Silveria, P. B. Adler, S. Báez, L. A. Biederman, J. M. Blair Oct 2019

Soil Net Nitrogen Mineralisation Across Global Grasslands, A. C. Risch, S. Zimmerman, R. Ochoa-Hueso, M. Schütz, B. Frey, J. L. Firn, P. A. Fay, F. Hagedorn, E. T. Borer, E. W. Seabloom, W. S. Harpole, J. M. H. Knops, Rebecca L. Mcculley, A. A. D. Broadbent, C. J. Stevens, M. L. Silveria, P. B. Adler, S. Báez, L. A. Biederman, J. M. Blair

Plant and Soil Sciences Faculty Publications

Soil nitrogen mineralisation (Nmin), the conversion of organic into inorganic N, is important for productivity and nutrient cycling. The balance between mineralisation and immobilisation (net Nmin) varies with soil properties and climate. However, because most global-scale assessments of net Nmin are laboratory-based, its regulation under field-conditions and implications for real-world soil functioning remain uncertain. Here, we explore the drivers of realised (field) and potential (laboratory) soil net Nmin across 30 grasslands worldwide. We find that realised Nmin is largely explained by temperature of the wettest quarter, microbial biomass, clay content and bulk density. …


Turning Doctoral Students Into Faculty In Gerontological Social Work: The AgeSw Experience, Nancy Kusmaul, Stephanie P. Wladkowski, Sally Hageman, Allison Gibson, Rebecca L. Mauldin, Jennifer C. Greenfield, Noelle L. Fields Oct 2019

Turning Doctoral Students Into Faculty In Gerontological Social Work: The AgeSw Experience, Nancy Kusmaul, Stephanie P. Wladkowski, Sally Hageman, Allison Gibson, Rebecca L. Mauldin, Jennifer C. Greenfield, Noelle L. Fields

Social Work Faculty Publications

Developing faculty interested in aging may help social work meet the needs of our growing aging population. However, doctoral students need a variety of supports to complete PhDs and become gerontological social work faculty. This study explored one program’s role in supporting the development of social work doctoral students to faculty in gerontology. An e-mail invitation was sent to all former participants (2010–2016 cohorts) of the Association for Gerontology Education in Social Work (AGESW) Pre-Dissertation Fellows Program (PDFP). The 38-question online survey consisted of Likert-type scales, multiple answers, and one open-ended question per section about the program’s impacts on …


Proppant For Use In Hydraulic Fracturing To Stimulate A Well, Thomas Lee Robl, Anne Elizabeth Oberlink Oct 2019

Proppant For Use In Hydraulic Fracturing To Stimulate A Well, Thomas Lee Robl, Anne Elizabeth Oberlink

Center for Applied Energy Research Faculty Patents

A proppant for use in hydraulic fracturing to stimulate a well is provided. The proppant is fly ash particles having a mean particle size (d50) of between 45 μm and 150 μm and a size distribution defined by (d10) ≤ 5 μm and (d98) ≤ 250 μm.


Grades Versus Comments: Research On Student Feedback, Thomas R. Guskey Oct 2019

Grades Versus Comments: Research On Student Feedback, Thomas R. Guskey

Educational, School, and Counseling Psychology Faculty Publications

Are comments on student work superior to grades? It depends.


Evaluation Of Meaningful Change In Bowel Movement Frequency For Patients With Carcinoid Syndrome, Stacie Hudgens, John Ramage, Matthew Kulke, Emily Bergsland, Lowell B. Anthony, Martyn Caplin, Kjell Öberg, Marianne Pavel, Jonathon Gable, Phillip Banks, Qi Melissa Yang, Pablo Lapuerta Oct 2019

Evaluation Of Meaningful Change In Bowel Movement Frequency For Patients With Carcinoid Syndrome, Stacie Hudgens, John Ramage, Matthew Kulke, Emily Bergsland, Lowell B. Anthony, Martyn Caplin, Kjell Öberg, Marianne Pavel, Jonathon Gable, Phillip Banks, Qi Melissa Yang, Pablo Lapuerta

Internal Medicine Faculty Publications

Background

Carcinoid syndrome is associated with a reduced quality of life that can be attributed to symptoms such as diarrhea and fatigue as well as social and financial issues. This study was conducted to psychometrically assess meaningful change in bowel movement frequency among carcinoid syndrome patients using data from the TELESTAR clinical study.

Methods

An anchor-based approach for deriving meaningful change thresholds consisted of mapping change from baseline bowel movement frequency to other patient-reported assessments of change. These included the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire - Core Questionnaire (QLQ-C30) Diarrhea Symptom responders, …


Co-Prescription Network Reveals Social Dynamics Of Opioid Doctor Shopping, Brea L. Perry, Kai Cheng Yang, Patrick Kaminski, Meltem Odabas, Jaehyuk Park, Michelle M. Martel, Carrie B. Oser, Patricia R. Freeman, Yong-Yeol Ahn, Jeffery C. Talbert Oct 2019

Co-Prescription Network Reveals Social Dynamics Of Opioid Doctor Shopping, Brea L. Perry, Kai Cheng Yang, Patrick Kaminski, Meltem Odabas, Jaehyuk Park, Michelle M. Martel, Carrie B. Oser, Patricia R. Freeman, Yong-Yeol Ahn, Jeffery C. Talbert

Psychology Faculty Publications

This paper examines network prominence in a co-prescription network as an indicator of opioid doctor shopping (i.e., fraudulent solicitation of opioids from multiple prescribers). Using longitudinal data from a large commercially insured population, we construct a network where a tie between patients is weighted by the number of shared opioid prescribers. Given prior research suggesting that doctor shopping may be a social process, we hypothesize that active doctor shoppers will occupy central structural positions in this network. We show that network prominence, operationalized using PageRank, is associated with more opioid prescriptions, higher predicted risk for dangerous morphine dosage, opioid overdose, …


Contributing Factors To Diabetic Brain Injury And Cognitive Decline, Nirmal Verma, Florin Despa Oct 2019

Contributing Factors To Diabetic Brain Injury And Cognitive Decline, Nirmal Verma, Florin Despa

Pharmacology and Nutritional Sciences Faculty Publications

The link of diabetes with co-occurring disorders in the brain involves complex and multifactorial pathways. Genetically engineered rodents that express familial Alzheimer's disease-associated mutant forms of amyloid precursor protein and presenilin 1 (PSEN1) genes provided invaluable insights into the mechanisms and consequences of amyloid deposition in the brain. Adding diabetes factors (obesity, insulin impairment) to these animal models to predict success in translation to clinic have proven useful at some extent only. Here, we focus on contributing factors to diabetic brain injury with the aim of identifying appropriate animal models that can be used to mechanistically dissect the …


Phenylethynyl-Substituted Benzenes And Heterocycles For The Treatment Of Cancer, David S. Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang, Markos Leggas Oct 2019

Phenylethynyl-Substituted Benzenes And Heterocycles For The Treatment Of Cancer, David S. Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang, Markos Leggas

Molecular and Cellular Biochemistry Faculty Patents

Halogenated phenylethynyl-substituted heterocycles that possess either an N-alkylamino or N,N-dialkylamino group attached to the heterocycle or halogenated phenylethynyl-substituted benzenes that a nitrogen-containing heterocycle attached to the benzene inhibit the proliferation cancer cells and are useful antineoplastic agents.


Enhancing Timeliness Of Drug Overdose Mortality Surveillance: A Machine Learning Approach, Patrick J. Ward, Peter J. Rock, Svetla Slavova, April M. Young, Terry L. Bunn, Ramakanth Kavuluru Oct 2019

Enhancing Timeliness Of Drug Overdose Mortality Surveillance: A Machine Learning Approach, Patrick J. Ward, Peter J. Rock, Svetla Slavova, April M. Young, Terry L. Bunn, Ramakanth Kavuluru

Kentucky Injury Prevention and Research Center Faculty Publications

BACKGROUND: Timely data is key to effective public health responses to epidemics. Drug overdose deaths are identified in surveillance systems through ICD-10 codes present on death certificates. ICD-10 coding takes time, but free-text information is available on death certificates prior to ICD-10 coding. The objective of this study was to develop a machine learning method to classify free-text death certificates as drug overdoses to provide faster drug overdose mortality surveillance.

METHODS: Using 2017–2018 Kentucky death certificate data, free-text fields were tokenized and features were created from these tokens using natural language processing (NLP). Word, bigram, and trigram features were created …


A Genome-Wide Assessment Of The Ancestral Neural Crest Gene Regulatory Network, Dorit Hockman, Vanessa Chong-Morrison, Stephen A. Green, Daria Gavriouchkina, Ivan Candido-Ferreira, Irving T. C. Ling, Ruth M. Williams, Chris T. Amemiya, Jeramiah J. Smith, Marianne E. Bronner, Tatjana Sauka-Spengler Oct 2019

A Genome-Wide Assessment Of The Ancestral Neural Crest Gene Regulatory Network, Dorit Hockman, Vanessa Chong-Morrison, Stephen A. Green, Daria Gavriouchkina, Ivan Candido-Ferreira, Irving T. C. Ling, Ruth M. Williams, Chris T. Amemiya, Jeramiah J. Smith, Marianne E. Bronner, Tatjana Sauka-Spengler

Biology Faculty Publications

The neural crest (NC) is an embryonic cell population that contributes to key vertebrate-specific features including the craniofacial skeleton and peripheral nervous system. Here we examine the transcriptional and epigenomic profiles of NC cells in the sea lamprey, in order to gain insight into the ancestral state of the NC gene regulatory network (GRN). Transcriptome analyses identify clusters of co-regulated genes during NC specification and migration that show high conservation across vertebrates but also identify transcription factors (TFs) and cell-adhesion molecules not previously implicated in NC migration. ATAC-seq analysis uncovers an ensemble of cis-regulatory elements, including enhancers of Tfap2B, …


Development Of A Non-Invasive Device For Swallow Screening In Patients At Risk Of Oropharyngeal Dysphagia: Results From A Prospective Exploratory Study, Catriona M. Steele, Rajat Mukherjee, Juha M. Kortelainen, Harri Pölönen, Michael Jedwab, Susan L. Brady, Kayla Brinkman Theimer, Susan Langmore, Luis F. Riquelme, Nancy B. Swigert, Philip M. Bath, Larry B. Goldstein, Richard L. Hughes, Dana Leifer, Kennedy R. Lees, Atte Meretoja, Natalia Muehlemann Oct 2019

Development Of A Non-Invasive Device For Swallow Screening In Patients At Risk Of Oropharyngeal Dysphagia: Results From A Prospective Exploratory Study, Catriona M. Steele, Rajat Mukherjee, Juha M. Kortelainen, Harri Pölönen, Michael Jedwab, Susan L. Brady, Kayla Brinkman Theimer, Susan Langmore, Luis F. Riquelme, Nancy B. Swigert, Philip M. Bath, Larry B. Goldstein, Richard L. Hughes, Dana Leifer, Kennedy R. Lees, Atte Meretoja, Natalia Muehlemann

Neurology Faculty Publications

Oropharyngeal dysphagia is prevalent in several at-risk populations, including post-stroke patients, patients in intensive care and the elderly. Dysphagia contributes to longer hospital stays and poor outcomes, including pneumonia. Early identification of dysphagia is recommended as part of the evaluation of at-risk patients, but available bedside screening tools perform inconsistently. In this study, we developed algorithms to detect swallowing impairment using a novel accelerometer-based dysphagia detection system (DDS). A sample of 344 individuals was enrolled across seven sites in the United States. Dual-axis accelerometry signals were collected prospectively with simultaneous videofluoroscopy (VFSS) during swallows of liquid barium stimuli in thin, …


Optimization Of Geometry Parameters Of Inkjet-Printed Silver Nanoparticle Traces On Pdms Substrates Using Response Surface Methodology, Jumana Abu-Khalaf, Loiy Al-Ghussain, Ahmad Nadi, Razan Saraireh, Abdulrahman Rabayah, Safwan Altarazi, Ala’Aldeen Al-Halhouli Oct 2019

Optimization Of Geometry Parameters Of Inkjet-Printed Silver Nanoparticle Traces On Pdms Substrates Using Response Surface Methodology, Jumana Abu-Khalaf, Loiy Al-Ghussain, Ahmad Nadi, Razan Saraireh, Abdulrahman Rabayah, Safwan Altarazi, Ala’Aldeen Al-Halhouli

Mechanical Engineering Graduate Research

Inkjet printing is an emerging technology with key advantages that make it suitable for the fabrication of stretchable circuits. Specifically, this process is cost-effective and less complex compared to conventional fabrication technologies. Inkjet printing has several process and geometry parameters that significantly affect the electromechanical properties of the printed circuits. This study aims to optimize the geometry parameters of inkjet-printed silver nanoparticle traces on plasma-treated polydimethylsiloxane (PDMS) substrates. The optimization process was conducted for two printed shapes, namely straight line and horseshoe patterns. The examined input factors for the straight line traces were: the number of inkjet-printed layers and line …


Altering Social Cue Perception Impacts Honey Bee Aggression With Minimal Impacts On Aggression-Related Brain Gene Expression, James W. Harrison, Joseph H. Palmer, Clare C. Rittschof Oct 2019

Altering Social Cue Perception Impacts Honey Bee Aggression With Minimal Impacts On Aggression-Related Brain Gene Expression, James W. Harrison, Joseph H. Palmer, Clare C. Rittschof

Entomology Faculty Publications

Gene expression changes resulting from social interactions may give rise to long term behavioral change, or simply reflect the activity of neural circuitry associated with behavioral expression. In honey bees, social cues broadly modulate aggressive behavior and brain gene expression. Previous studies suggest that expression changes are limited to contexts in which social cues give rise to stable, relatively long-term changes in behavior. Here we use a traditional beekeeping approach that inhibits aggression, smoke exposure, to deprive individuals of aggression-inducing olfactory cues and evaluate whether behavioral changes occur in absence of expression variation in a set of four biomarker genes …