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Articles 241 - 270 of 291
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The Prp19 U-Box Crystal Structure Suggests A Common Dimeric Architecture For A Class Of Oligomeric E3 Ubiquitin Ligases, Craig W. Vander Kooi, Melanie D. Ohi, Joshua A. Rosenberg, Michael L. Oldham, Marcia E. Newcomer, Kathleen L. Gould, Walter J. Chazin
The Prp19 U-Box Crystal Structure Suggests A Common Dimeric Architecture For A Class Of Oligomeric E3 Ubiquitin Ligases, Craig W. Vander Kooi, Melanie D. Ohi, Joshua A. Rosenberg, Michael L. Oldham, Marcia E. Newcomer, Kathleen L. Gould, Walter J. Chazin
Faculty Publications
Prp19 is an essential splicing factor and a member of the U-box family of E3 ubiquitin ligases. Prp19 forms a tetramer via a central coiled-coil domain. Here, we show the U-box domain of Prp19 exists as a dimer within the context of the Prp19 tetramer. A high-resolution structure of the homodimeric state of the Prp19 U-box was determined by X-ray crystallography. Mutation of the U-box dimer interface abrogates U-box dimer formation and is lethal in vivo. The structure of the U-box dimer enables construction of a complete model of Prp19 providing insights into how the tetrameric protein functions as an …
Whole Genome Computational Comparative Genomics: A Fruitful Approach For Ascertaining Alu Insertion Polymorphisms, Jianxin Wang, Lei Song, M. Katherine Gonder, Sami Azrak, David A. Ray, Mark A. Batzer, Sarah A. Tishkoff, Ping Liang
Whole Genome Computational Comparative Genomics: A Fruitful Approach For Ascertaining Alu Insertion Polymorphisms, Jianxin Wang, Lei Song, M. Katherine Gonder, Sami Azrak, David A. Ray, Mark A. Batzer, Sarah A. Tishkoff, Ping Liang
Faculty Publications
Alu elements are the most active and predominant type of short interspersed elements (SINEs) in the human genome. Recently inserted polymorphic (for presence/absence) Alu elements contribute to genome diversity among different human populations, and they are useful genetic markers for population genetic studies. The objective of this study is to identify polymorphic Alu insertions through an in silico comparative genomics approach and to analyze their distribution pattern throughout the human genome. By computationally comparing the public and Celera sequence assemblies of the human genome, we identified a total of 800 polymorphic Alu elements. We used polymerase chain reaction-based assays to …
Temperature Dependence And Thermodynamics Of Klenow Polymerase Binding To Primed-Template Dna, Kausiki Datta, Andy J. Wowor, Allison J. Richard, Vince J. Licata
Temperature Dependence And Thermodynamics Of Klenow Polymerase Binding To Primed-Template Dna, Kausiki Datta, Andy J. Wowor, Allison J. Richard, Vince J. Licata
Faculty Publications
DNA binding of Klenow polymerase has been characterized with respect to temperature to delineate the thermodynamic driving forces involved in the interaction of this polymerase with primed-template DNA. The temperature dependence of the binding affinity exhibits distinct curvature, with tightest binding at 25-30°C. Nonlinear temperature dependence indicates Klenow binds different primed-template constructs with large heat capacity (ΔCp) values (-870 to -1220 cal/mole K) and thus exhibits large temperature dependent changes in enthalpy and entropy. Binding is entropy driven at lower temperatures and enthalpy driven at physiological temperatures. Large negative ΔCp values have been proposed to be a 'signature' of site-specific …
Quantum Interpretations, A. R.P. Rau
Quantum Interpretations, A. R.P. Rau
Faculty Publications
Difficulties and discomfort with the interpretation of quantum mechanics are due to differences in language between it and classical physics. Analogies to the special theory of relativity, which also required changes in the basic world-view and language of nonrelativistic classical mechanics, may help in absorbing the changes called for by quantum physics. There is no need to invoke extravagances such as the many-worlds interpretation or specify a central role for consciousness or neural microstructures. The simple, but basic, acceptance that what is meant by the state of a physical system is different in quantum physics from what it is in …
Humboldt In The Americas, Andrew Sluyter, Kent Mathewson
Humboldt In The Americas, Andrew Sluyter, Kent Mathewson
Faculty Publications
No abstract provided.
Early Maize (Zea Mays L.) Cultivation In Mexico: Dating Sedimentary Pollen Records And Its Implications, Andrew Sluyter, Gabriela Dominguez
Early Maize (Zea Mays L.) Cultivation In Mexico: Dating Sedimentary Pollen Records And Its Implications, Andrew Sluyter, Gabriela Dominguez
Faculty Publications
A sedimentary pollen sequence from the coastal plain of Veracruz, Mexico, demonstrates maize cultivation by 5,000 years ago, refining understanding of the geography of early maize cultivation. Methodological issues related to bioturbation involved in dating that record combine with its similarity to a pollen sequence from the coastal plain of Tabasco, Mexico, to suggest that the inception of maize cultivation in that record occurred as much as 1,000–2,000 years more recently than the previously accepted 7,000 years ago. Our analysis thereby has substantive, theoretical, and methodological implications for understanding the complex process of maize domestication. Substantively, it demonstrates that the …
The Recent Intellectual Structure Of Geography, Andrew Sluyter, Andrew D. Augustine, Michael C. Bitton, Thomas J. Sullivan, Fei Wang
The Recent Intellectual Structure Of Geography, Andrew Sluyter, Andrew D. Augustine, Michael C. Bitton, Thomas J. Sullivan, Fei Wang
Faculty Publications
An active learning project in an introductory graduate course used multidimensional scaling of the name index in Geography in America at the Dawn of the 21st Century, by Gary Gaile and Cort Willmott, to reveal some features of the discipline's recent intellectual structure relevant to the relationship between human and physical geography. Previous analyses, dating to the 1980s, used citation indices or Association of American Geographers spe- cialty-group rosters to conclude that either the regional or the methods and environmental subdisciplines bridge human and physical geography. The name index has advantages over those databases, and its analysis reveals that the …
Traveling/Writing The Unworld With Alexander Von Humboldt., Andrew Sluyter
Traveling/Writing The Unworld With Alexander Von Humboldt., Andrew Sluyter
Faculty Publications
No abstract provided.
Humboldt's Mexican Texts And Landscapes, Andrew Sluyter
Humboldt's Mexican Texts And Landscapes, Andrew Sluyter
Faculty Publications
While in New Spain from 1803 to 1804, Alexander von Humboldt interacted with some of its landscapes and the texts that represented them. Analysis of those interactions regarding the Basin of Mexico and the Gulf lowlands demonstrates what purely text-based studies of the production of places cannot: The contrasting landscape elements and patterns that had emerged over millennia during precolonial times in those two places, their relative degrees of depopulation during the colonial era, and the relative degrees of rigor Humboldt applied to interacting with the resulting landscapes and the texts that represented them greatly affected his representations of those …
Matroid Packing And Covering With Circuits Through An Element, Manoel Lemos, James Oxley
Matroid Packing And Covering With Circuits Through An Element, Manoel Lemos, James Oxley
Faculty Publications
In 1981, Seymour proved a conjecture of Welsh that, in a connected matroid M, the sum of the maximum number of disjoint circuits and the minimum number of circuits needed to cover M is at most r*(M) + 1. This paper considers the set Ce(M) of circuits through a fixed element e such that M/e is connected. Let νe(M) be the maximum size of a subset of Ce(M) in which any two distinct members meet only in {e}, and let θe(M) be the minimum size of a subset of Ce(M) that covers M. The main result proves that νe(M) + …
Atomic Physics With Attosecond Pulses, A. L'Huillier, T. Remetter, P. Johnsson, J. Mauritsson, K. Varjú, T. Ruchon, Y. Ni, F. Lépine, E. Gustafsson, M. Kling, J. Khan, R. López-Martens, K. J. Schafer, M. J.J. Vrakking
Atomic Physics With Attosecond Pulses, A. L'Huillier, T. Remetter, P. Johnsson, J. Mauritsson, K. Varjú, T. Ruchon, Y. Ni, F. Lépine, E. Gustafsson, M. Kling, J. Khan, R. López-Martens, K. J. Schafer, M. J.J. Vrakking
Faculty Publications
No abstract provided.
Bec-Bcs Crossover In "Magnetized" Feshbach-Resonantly Paired Superfluids, Daniel E. Sheehy, Leo Radzihovsky
Bec-Bcs Crossover In "Magnetized" Feshbach-Resonantly Paired Superfluids, Daniel E. Sheehy, Leo Radzihovsky
Faculty Publications
We map out the detuning-magnetization phase diagram for a magnetized (unequal number of atoms in two pairing hyperfine states) gas of fermionic atoms interacting via an s-wave Feshbach resonance (FR). The phase diagram is dominated by the coexistence of a magnetized normal gas and a singlet-paired superfluid with the latter exhibiting a BCS-Bose Einstein condensate crossover with reduced FR detuning. On the BCS side of strongly overlapping Cooper pairs, a sliver of finite-momentum paired Fulde-Ferrell-Larkin-Ovchinnikov magnetized phase intervenes between the phase-separated and normal states. In contrast, for large negative detuning a uniform, polarized superfluid, that is, a coherent mixture of …
Matter-Antimatter Asymmetry Generated By Loop Quantum Gravitye, Gaetano Lambiase, Parampreet Singh
Matter-Antimatter Asymmetry Generated By Loop Quantum Gravitye, Gaetano Lambiase, Parampreet Singh
Faculty Publications
We show that Loop Quantum Gravity provides new mechanisms through which observed matter-antimatter asymmetry in the Universe can naturally arise at temperatures less than GUT scale. This is enabled through the introduction of a new length scale L much greater than Planck length (lP), to obtain semi-classical weave states in the theory. This scale which depends on the momentum of the particle modifies the dispersion relation for different helicities of fermions and leads to lepton asymmetry.
Action Principle Formulation For Motion Of Extended Bodies In General Relativity, Jeeva Anandan, Naresh Dadhich, Parampreet Singh
Action Principle Formulation For Motion Of Extended Bodies In General Relativity, Jeeva Anandan, Naresh Dadhich, Parampreet Singh
Faculty Publications
We present an action principle formulation for the study of motion of an extended body in General Relativity in the limit of weak gravitational field. This gives the classical equations of motion for multipole moments of arbitrary order coupling to the gravitational field. In particular, a new force due to the octupole moment is obtained. The action also yields the gravitationally induced phase shifts in quantum interference experiments due to the coupling of all multipole moments.
Kπ = 0 + 2.29 S Isomer In Neutron-Rich Tm174, R. S. Chakrawarthy, P. M. Walker, J. J. Ressler, E. F. Zganjar, G. C. Ball, M. B. Smith, A. N. Andreyev, S. F. Ashley, R. A.E. Austin, D. Bandyopadhyay, J. A. Becker, J. J. Carroll, D. S. Cross, D. Gohlke, J. J. Daoud, P. E. Garrett, G. F. Grinyer, G. Hackman, G. A. Jones, R. Kanungo, W. D. Kulp, Y. Litvinov, A. C. Morton, W. J. Mills, C. J. Pearson, R. Propri, C. E. Svensson, R. Wheeler, S. J. Williams
Kπ = 0 + 2.29 S Isomer In Neutron-Rich Tm174, R. S. Chakrawarthy, P. M. Walker, J. J. Ressler, E. F. Zganjar, G. C. Ball, M. B. Smith, A. N. Andreyev, S. F. Ashley, R. A.E. Austin, D. Bandyopadhyay, J. A. Becker, J. J. Carroll, D. S. Cross, D. Gohlke, J. J. Daoud, P. E. Garrett, G. F. Grinyer, G. Hackman, G. A. Jones, R. Kanungo, W. D. Kulp, Y. Litvinov, A. C. Morton, W. J. Mills, C. J. Pearson, R. Propri, C. E. Svensson, R. Wheeler, S. J. Williams
Faculty Publications
Gamma-ray and conversion-electron spectroscopy have established the existence of a 2.29(1) s, Kπ=0+, isomeric state in neutron-rich Tm174. The isomer deexcites via 100- and 152-keV electromagnetic transitions. First results from a newly commissioned Si(Li) detector array have established their M1 and E3 multipolarities, respectively. The single-particle configurations of the excited states suggest that the E3 transition originates from a πh11/2-1→πd3/2 configuration change, whereas the M1 transition occurs between members of a Gallaghar-Moszkowski doublet. From the measured half-life, the deduced B(E3) value of 0.024(2) W.u. is highly hindered. The reported measurements resolve ambiguities in the previously proposed β decay scheme of …
High-Fidelity Linear Optical Quantum Computing With Polarization Encoding, Federico M. Spedalieri, Hwang Lee, Jonathan P. Dowling
High-Fidelity Linear Optical Quantum Computing With Polarization Encoding, Federico M. Spedalieri, Hwang Lee, Jonathan P. Dowling
Faculty Publications
We show that the KLM scheme [Knill, Laflamme, and Milburn, Nature 409, 46 (2001)] can be implemented using polarization encoding, thus reducing the number of path modes required by half. One of the main advantages of this new implementation is that it naturally incorporates a loss detection mechanism that makes the probability of a gate introducing a non-detected error, when non-ideal detectors are considered, dependent only on the detector dark-count rate and independent of its efficiency. Since very low dark-count rate detectors are currently available, a high-fidelity gate (probability of error of order 10-6 conditional on the gate being successful) …
Fgf2 Binding, Signaling, And Angiogenesis Are Modulated By Heparanase In Metastatic Melanoma Cells, Jane Reiland, Doty Kempf, Madhuchhanda Roy, Yvonne Denkins, Dario Marchetti
Fgf2 Binding, Signaling, And Angiogenesis Are Modulated By Heparanase In Metastatic Melanoma Cells, Jane Reiland, Doty Kempf, Madhuchhanda Roy, Yvonne Denkins, Dario Marchetti
Faculty Publications
Heparanase (HPSE) and fibroblast growth factor-2 (FGF2) are critical regulators of melanoma angiogenesis and metastasis. Elevated HPSE expression contributes to melanoma progression; however, further augmentation of HPSE presence can inhibit tumorigenicity. HPSE enzymatically cleaves heparan sulfate glycosaminoglycan chains (HS) from proteoglycans. HS act as both low-affinity FGF2 receptors and coreceptors in the formation of high-affinity FGF2 receptors. We have investigated HPSE's ability to modulate FGF2 activity through HS remodeling. Extensive HPSE degradation of human metastatic melanoma cells (70W) inhibited FGF2 binding. Unexpectedly, treatment of 70W cells with low HPSE concentrations enhanced FGF2 binding. In addition, HPSE-unexposed cells did not phosphorylate …
Parenting And Peer-Group Behavior In Cultural Context, David A. Nelson, Larry J. Nelson, Craig H. Hart, Chongming Yang, Shenghua Jin
Parenting And Peer-Group Behavior In Cultural Context, David A. Nelson, Larry J. Nelson, Craig H. Hart, Chongming Yang, Shenghua Jin
Faculty Publications
© Cambridge University Press 2006 and Cambridge University Press, 2009. Whether specific patterns of parenting are similarly associated with child peer group behavior in diverse cultural contexts has been a fascinating topic of inquiry. From classic anthropological studies dating back to the early twentieth century to the current interest in cross-cultural studies, knowledge concerning the question of universality and cultural variation in parenting linkages to childhood adjustment has expanded at an unprecedented rate (e.g., Harkness & Super, 2002). As the general field of parenting research has uncovered distinctions in parenting styles and practices (e.g., Darling & Steinberg, 1993; Hart, Newell, …
Relations Between Chinese Mothers' Parenting Practices And Social Withdrawal In Early Childhood, Larry J. Nelson, Craig H. Hart, Bo Wu, Chongming Yang, Susanne Olsen Roper, Shenghua Jin
Relations Between Chinese Mothers' Parenting Practices And Social Withdrawal In Early Childhood, Larry J. Nelson, Craig H. Hart, Bo Wu, Chongming Yang, Susanne Olsen Roper, Shenghua Jin
Faculty Publications
Researchers have identified specific parenting practices used by parents of preschoolers in mainland China (e.g., physical coercion, overprotection, shaming, directiveness, encouragement of modesty). Some of the intrusive practices have been linked to social withdrawal in western societies (e.g., United States, Canada). It seemed important to examine these associations in China because recent research suggests that young Chinese children who exhibit wariness in peer settings may be at risk for negative outcomes such as peer rejection. Therefore, the purpose of this study was to examine the relation between Chinese parenting practices and preschoolers' social withdrawal. Mothers of preschool-age children from mainland …
Sequence Variation In The Coding Region Of The Melanocortin-1 Receptor Gene (Mc1r) Is Not Associated With Plumage Variation In The Blue-Crowned Manakin (Lepidothrix Coronata), Z. A. Cheviron, Shannon J. Hackett, Robb T. Brumfield
Sequence Variation In The Coding Region Of The Melanocortin-1 Receptor Gene (Mc1r) Is Not Associated With Plumage Variation In The Blue-Crowned Manakin (Lepidothrix Coronata), Z. A. Cheviron, Shannon J. Hackett, Robb T. Brumfield
Faculty Publications
Avian plumage traits are the targets of both natural and sexual selection. Consequently, genetic changes resulting in plumage variation among closely related taxa might represent important evolutionary events. The molecular basis of such differences, however, is unknown in most cases. Sequence variation in the melanocortin-1 receptor gene (MC1R) is associated with melanistic phenotypes in many vertebrate taxa, including several avian species. The blue-crowned manakin (Lepidothrix coronata), a widespread, sexually dichromatic passerine, exhibits striking geographic variation in male plumage colour across its range in southern Central America and western Amazonia. Northern males are black with brilliant blue crowns whereas southern males …
Disruption Of Cortical Microtubules By Overexpression Of Green Fluorescent Protein-Tagged Α-Tubulin 6 Causes A Marked Reduction In Cell Wall Synthesis, David H. Burk, Ruiqin Zhong, W. Herbert Morrison, Zheng Hua Ye
Disruption Of Cortical Microtubules By Overexpression Of Green Fluorescent Protein-Tagged Α-Tubulin 6 Causes A Marked Reduction In Cell Wall Synthesis, David H. Burk, Ruiqin Zhong, W. Herbert Morrison, Zheng Hua Ye
Faculty Publications
It has been known that the transverse orientation of cortical microtubules (MTs) along the elongation axis is essential for normal cell morphogenesis, but whether cortical MTs are essential for normal cell wall synthesis is still not clear. In the present study, we have investigated whether cortical MTs affect cell wall synthesis by direct alteration of the cortical MT organization in Arabidopsis thaliana. Disruption of the cortical MT organization by expression of an excess amount of green fluorescent protein-tagged α-tubulin 6 (GFP-TUA6) in transgenic Arabidopsis plants was found to cause a marked reduction in cell wall thickness and a decrease in …
Phytochrome Genes In Higher Plants: Structure,Expression, And Evolution, Robert A. Sharrock, Sarah Mathews
Phytochrome Genes In Higher Plants: Structure,Expression, And Evolution, Robert A. Sharrock, Sarah Mathews
Faculty Publications
© 2006 Springer. All Rights Reserved. Phytochromes play critical roles in monitoring light quantity, quality, and periodicity in plants and they relay this photosensory information to a large number of signaling pathways that regulate plant growth and development. Given these complex functions, it is not surprising that the phytochrome apoproteins are encoded by small multigene families and that different forms of phytochrome regulate different aspects of photomorphogenesis. Over the course of the last decade, progress has been made in defining the number, molecular properties, and biological activities of the photoreceptors that constitute a plant R/FR sensing system. This chapter summarizes …
Human Genomic Deletions Mediated By Recombination Between Alu Elements, Shurjo K. Sen, Kyudong Han, Jianxin Wang, Jungnam Lee, Hui Wang, Pauline A. Callinan, Matthew Dyer, Richard Cordaux, Ping Liang, Mark A. Batzer
Human Genomic Deletions Mediated By Recombination Between Alu Elements, Shurjo K. Sen, Kyudong Han, Jianxin Wang, Jungnam Lee, Hui Wang, Pauline A. Callinan, Matthew Dyer, Richard Cordaux, Ping Liang, Mark A. Batzer
Faculty Publications
Recombination between Alu elements results in genomic deletions associated with many human genetic disorders. Here, we compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage since the human-chimpanzee divergence ∼6 million years ago. Combining computational data mining and wet-bench experimental verification, we identified 492 human-specific deletions (for a total of ∼400 kb) attributable to this process, a significant component of the insertion/deletion spectrum of the human genome. The majority of the deletions (295 of 492) coincide with known or predicted genes (including 3 that deleted functional exons, as compared with …
Plasmid-Mediated High-Level Gentamicin Resistance Among Enteric Bacteria Isolated From Pet Turtles In Louisiana, María Alejandra Díaz, Richard Kent Cooper, Axel Cloeckaert, Ronald John Siebeling
Plasmid-Mediated High-Level Gentamicin Resistance Among Enteric Bacteria Isolated From Pet Turtles In Louisiana, María Alejandra Díaz, Richard Kent Cooper, Axel Cloeckaert, Ronald John Siebeling
Faculty Publications
The sale of small turtles is banned by the Food and Drug Administration from the U.S. market due to concerns about their excretion of Salmonella spp. To produce a safe pet for the export market, the Louisiana pet turtle industry uses gentamicin sulfate baths (1,000 μg/ml) to eradicate Salmonella spp. from turtle eggs. In 1999, we analyzed bacterial samples recovered from turtle farms and found that strains of Salmonella enterica subsp. arizonae and other bacteria, such as Enterobacter cloacae, Citrobacter freundii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia, were resistant to high concentrations of gentamicin (>2,000 μg/ml) and to other aminoglycosides. …
Squeezed-State Source Using Radiation-Pressure-Induced Rigidity, Thomas Corbitt, Yanbei Chen, Farid Khalili, David Ottaway, Sergey Vyatchanin, Stan Whitcomb, Nergis Mavalvala
Squeezed-State Source Using Radiation-Pressure-Induced Rigidity, Thomas Corbitt, Yanbei Chen, Farid Khalili, David Ottaway, Sergey Vyatchanin, Stan Whitcomb, Nergis Mavalvala
Faculty Publications
We propose an experiment to extract ponderomotive squeezing from an interferometer with high circulating power and low mass mirrors. In this interferometer, optical resonances of the arm cavities are detuned from the laser frequency, creating a mechanical rigidity that dramatically suppresses displacement noises. After taking into account imperfection of optical elements, laser noise, and other technical noise consistent with existing laser and optical technologies and typical laboratory environments, we expect the output light from the interferometer to have measurable squeezing of 5 dB, with a frequency-independent squeeze angle for frequencies below 1 kHz. This squeeze source is well suited for …
The Ligo Gravitational Wave Observatories: Recent Results And Future Plans, G. M. Harry, R. Adhikari, S. Ballmer, K. Bayer, J. Betzwieser, B. Bochner, R. Burgess, L. Cadonati, S. Chatterji, T. Corbitt, P. Csatorday, P. Fritschel, K. Goda, Y. Hefetz, E. Katsavounidis, R. Lawrence, M. Macinnis, A. Marin, K. Mason, N. Mavalvala, R. Mittleman, D. J. Ottaway, M. Pratt, T. Regimbau, S. Richman, J. Rollins, D. H. Shoemaker, M. Smith, M. Van Putten, R. Weiss, C. Aulbert, S. J. Berukoff, C. Cutler
The Ligo Gravitational Wave Observatories: Recent Results And Future Plans, G. M. Harry, R. Adhikari, S. Ballmer, K. Bayer, J. Betzwieser, B. Bochner, R. Burgess, L. Cadonati, S. Chatterji, T. Corbitt, P. Csatorday, P. Fritschel, K. Goda, Y. Hefetz, E. Katsavounidis, R. Lawrence, M. Macinnis, A. Marin, K. Mason, N. Mavalvala, R. Mittleman, D. J. Ottaway, M. Pratt, T. Regimbau, S. Richman, J. Rollins, D. H. Shoemaker, M. Smith, M. Van Putten, R. Weiss, C. Aulbert, S. J. Berukoff, C. Cutler
Faculty Publications
The LIGO interferometers are operating as gravitational wave observatories, with a noise level near an order of magnitude of the goal and the first scientific data recently taken. This data has been analyzed for four different categories of gravitational wave sources; millisecond bursts, inspiralling binary neutron stars, periodic waves from a known pulsar, and stochastic background. Research and development is also underway for the next generation LIGO detector, Advanced LIGO.
Initiation Of Apoptosis And Autophagy By Photodynamic Therapy, David Kessel, M. Graça H. Vicente, John J. Reiners
Initiation Of Apoptosis And Autophagy By Photodynamic Therapy, David Kessel, M. Graça H. Vicente, John J. Reiners
Faculty Publications
This study was designed to examine modes of cell death after photodynamic therapy (PDT). Murine leukemia L1210 cells and human prostate Box-deficient DU-145 cells were examined after PDT-induced photodamage to the endoplasmic reticulum (ER). Previous studies indicated that this treatment resulted in a substantial loss of Bcl-2 function. Both apoptosis and autophagy occurred in L1210 cells after ER photodamage with the latter predominating after 24 hr. These processes were characterized by altered cellular morphology, chromatin condensation, loss of mitochondrial membrane potential and formation of vacuoles containing cytosolic components. Western blots demonstrated processing of LC3-I to LC3-II, a marker for autophagy. …
Chiral Separation Of Norlaudanosoline, Laudanosoline, Laudanosine, Chlorthalidone, And Three Benzoin Derivatives Using Amino Acid Based Molecular Micelles, Fereshteh Haddadian Billiot, Eugene J. Billiot, Kwun Ng Yuen, Isiah M. Warner
Chiral Separation Of Norlaudanosoline, Laudanosoline, Laudanosine, Chlorthalidone, And Three Benzoin Derivatives Using Amino Acid Based Molecular Micelles, Fereshteh Haddadian Billiot, Eugene J. Billiot, Kwun Ng Yuen, Isiah M. Warner
Faculty Publications
In this study, 18 polymeric single amino acid and dipeptide surfactants are examined, and their performances, in terms of enantioselectivity, are compared for norlaudanosoline, laudanosoline, laudanosine, chlorthalidone, benzoin, benzoin methyl, and benzoin ethyl enantiomers. Several aspects of amino acid-based polymeric surfactants including comparison of single amino acid versus dipeptide, amino acid order, steric effect, and effect of the position of the chiral center of dipeptide surfactants on the chiral selectivity of these optically active compounds are discussed.
Regularization Of Hyperfunctions, Ricardo Estrada
Regularization Of Hyperfunctions, Ricardo Estrada
Faculty Publications
We show that there are no continuous regularization procedures for the extension of hyperfunctions. We also show that there is a continuous projection operator from the space of hyperfunctions with support in a given compact set onto the subspace of hyperfunctions with support on a given closed subset if and only if the subset is a countable intersection of sets that are closed and open. © European Mathematical Society.
Introduction: Self-Organization In Nonequilibrium Chemical Systems, Irving R. Epstein, John A. Pojman, Oliver Steinbock
Introduction: Self-Organization In Nonequilibrium Chemical Systems, Irving R. Epstein, John A. Pojman, Oliver Steinbock
Faculty Publications
The field of self-organization in nonequilibrium chemical systems comprises the study of dynamical phenomena in chemically reacting systems far from equilibrium. Systematic exploration of this area began with investigations of the temporal behavior of the Belousov-Zhabotinsky oscillating reaction, discovered accidentally in the former Soviet Union in the 1950s. The field soon advanced into chemical waves in excitable media and propagating fronts. With the systematic design of oscillating reactions in the 1980s and the discovery of Turing patterns in the 1990s, the scope of these studies expanded dramatically. The articles in this Focus Issue provide an overview of the development and …