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Tc-99m Pyrophosphate Imaging Of Poloxamer-Treated Electroporated Skeletal Muscle In An In Vivo Rat Model, Kenneth L. Matthews, John N. Aarsvold, Robert A. Mintzer, Chin Tu Chen, Raphael C. Lee
Tc-99m Pyrophosphate Imaging Of Poloxamer-Treated Electroporated Skeletal Muscle In An In Vivo Rat Model, Kenneth L. Matthews, John N. Aarsvold, Robert A. Mintzer, Chin Tu Chen, Raphael C. Lee
Faculty Publications
Objective: This study investigates whether 99mTc pyrophosphate (PYP) imaging provides a quantitative non-invasive assessment of the extent of electroporation injury, and of the effect of poloxamer in vivo on electroporated skeletal muscle. Methods: High-voltage electrical shock was used to produce electroporation injury in an anesthetized rat's hind limb. In each experiment, the injured limb was treated intravenously by either poloxamer-188, dextran, or saline, and subsequently imaged with 99mTc PYP. The radiotracer's temporal behavior among the experimental groups was compared using curve fitting of time-activity curves from the dynamic image data. Results: The washout kinetics of 99mTc PYP changed in proportion …
Tc-99m Pyrophosphate Imaging Of Poloxamer-Treated Electroporated Skeletal Muscle In An In Vivo Rat Model, Kenneth L. Matthews, John N. Aarsvold, Robert A. Mintzer, Chin Tu Chen, Raphael C. Lee
Tc-99m Pyrophosphate Imaging Of Poloxamer-Treated Electroporated Skeletal Muscle In An In Vivo Rat Model, Kenneth L. Matthews, John N. Aarsvold, Robert A. Mintzer, Chin Tu Chen, Raphael C. Lee
Faculty Publications
Objective: This study investigates whether 99mTc pyrophosphate (PYP) imaging provides a quantitative non-invasive assessment of the extent of electroporation injury, and of the effect of poloxamer in vivo on electroporated skeletal muscle. Methods: High-voltage electrical shock was used to produce electroporation injury in an anesthetized rat's hind limb. In each experiment, the injured limb was treated intravenously by either poloxamer-188, dextran, or saline, and subsequently imaged with 99mTc PYP. The radiotracer's temporal behavior among the experimental groups was compared using curve fitting of time-activity curves from the dynamic image data. Results: The washout kinetics of 99mTc PYP changed in proportion …