Nanotechnology Commons^™

Chitosan-Based Hydrogels In Drug Delivery, Salma A. Fereig, Mona Mohamed Ahmed Abdelmottaleb

Pharmacy

Hydrogels are three-dimensional cross-linked hydrophilic polymers that are able to absorb large quantities of water and swell. They have various properties like biocompatibility, low toxicity, and mostly biodegradability, which make them attractive for drug delivery applications. Chitosan hydrogels are especially attractive due to the inherent activities of the chitosan itself like the antibacterial, anti-inflammatory, and tissue regeneration enhancement capacity. Therefore, chitosan hydrogels have been proposed for the delivery of various drugs, genes, cytokines, and stem cells via various routes of administration for the treatment of various diseases as well as different forms of degeneration.

Arsenic Contamination Needs Serious Attention: An Opinion And Global Scenario, Abhijnan Bhat School Of Food Science And Environmental Health, Kamna Ravi Health, Engineering & Materials Sciences (Hems) Hub, Furong Tian Nanolab Research Centre, Baljit Singh Micra Biodiagnostics Technology Gateway

Articles

Arsenic (As) contamination is a serious global concern, polluting our natural resources, including water and soil, and posing a danger to the environment and public health. Arsenic is present in the groundwater of several countries and this contaminated water is used for irrigation, drinking, and food preparation, which poses the greatest threat to public health. Nearly 106 countries are affected by groundwater arsenic contamination and an estimated 230 million individuals worldwide are exposed to its adverse health effects, including increased cancer risks, associated cardiovascular disease and diabetes, skin lesions, neurological effects, kidney damage, and foetal or cognitive development-related complications. Arsenic …

Building For Safety: Design Considerations For Refuge Areas In Tall Buildings From Quality Management Perspective, Enass. A. Salama, Heba. M. Gaber, Ahmed. M. Selim

Journal of Engineering Research

New El Alamein City is one of the largest urban projects in Egypt, and the largest project on the north coast. Tall buildings (super high-rise buildings) are considered the prevailing trend by architectural designers to obtain the maximum view of the Mediterranean Sea. The provision of safety evacuation in emergencies for these buildings’ occupants is a crucial challenge from the Quality management point of view. In contrast, there are no sufficient architectural design guidelines for the tall buildings provided by the Egyptian code for protecting buildings from fire, especially the design of the refuge areas. This study aims to investigate …

Effect Of Organic Compounds Additives For Biodiesel Fuel Blends On Diesel Engine Vibrations And Noise Characteristics, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi Prof. Dr. Eng., E. A. El Shenawy Prof. Dr., Mahmoud Soliman Eng.

Journal of Engineering Research

The extensive consumption of petroleum fuel directly correlates with both hazardous exhaust emissions affecting human health and contributing to global warming. Initially, biodiesel fuels were proposed as a viable alternative to address these issues. This perspective finds support in numerous published studies that highlight how the significant catalytic effect of nanoparticles allows for their integration into biodiesel blends, resulting in improved combustion characteristics, reduced exhaust emissions, and enhanced performance. This study investigates the impact of additives on biodiesel fuel properties and its effects on engine performance metrics such as brake power, brake thermal efficiency, exhaust gas concentration, engine vibration, and …

Investigation Into The Impact Of Ammonia Hydroxide On Performance And Emissions In Compression Ignition Engines Utilizing Diesel/Biodiesel Blends, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Mohammed Osama Elsamadony Dr. Eng., Abdallah Salem Abdalhadi

Journal of Engineering Research

In recent times, there has been a surge in scientific endeavors aimed at combating global warming. Various methods have been employed to address this issue, including the substitution of fossil fuels with more environmentally sustainable alternatives and the combination of different fuel types. This can be achieved through the integration of innovative injection systems and the simultaneous combustion of alternative fuels alongside fossil fuels, or by modifying fuel injection systems such as in the PCCI, RCCI, or HCCI systems. In a particular research investigation, a blend of ammonia hydroxide and diesel, with volume percentages of 7.5% and 92.5% respectively, was …

Enhancing Diesel Engine Performance By Directly Injecting Blends Of Ammonium Hydroxide And Including Liquid Petroleum Gas As A Partially Premixed Charge, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Mohammed Osama Elsamadony Dr. Eng., Abdallah Salem Abdalhadi

Journal of Engineering Research

Recently, scientists have made significant strides in addressing or mitigating environmental issues. Researchers have adopted various approaches to tackle these issues, such as replacing fossil fuels with more environmentally friendly alternatives or blending multiple fuel types. This can be achieved by either integrating these two trends through the use of new injection systems and simultaneous combustion of alternative fuels with fossil fuels or by modifying fuel injection systems, exemplified by the PCCI, RCCI, or HCCI systems. Consequently, these methods have proven effective in reducing environmental pollutants, enhancing thermal efficiency, and decreasing specific fuel consumption. In this study, ammonia hydroxide and …

Experimental Investigation On Combustion And Emission Characteristics Of Co-Combustion Of Pulverized Biomass With Diesel Fuel In An Industrial Burner, Medhat Elkelawy Prof. Dr, Eng., Hagar Alm-Eldin Bastawissi, Ahmed Abou El-Yazied Prof. Dr., Saad El-Malla Dr. Eng.

Journal of Engineering Research

This study presents the combustion and emission results obtained from a laboratory furnace equipped with a 35 kW industrial burner that utilizes co-combustion of pulverized biomass and diesel fuel. The experiment compared the co-combustion of pulverized biomass and diesel fuel with diesel fuel alone. Three different loading ratios of pulverized biomass from residual beet samples were used. Temperatures were measured at various positions inside the furnace to analyze combustion performance. It was observed that increasing the biomass loading ratios led to higher flame temperatures and improved combustion compared to diesel fuel alone. The concentrations of pollutants such as Co, HC, …

Analyse Permeability And Integration In Architectural Landscapes To Create A Seamless Environment, Ensuring Ease Of Movement And Blending With The Surrounding Environment., Amira Fawzy Helmy Almaz

Journal of Engineering Research

The study explores the understanding of connectedness, integration, and axial route selection in urban parks using space syntax. It uses the Theory of Space Syntax to analyze georeferenced photographs and urban morphology data. The findings suggest that creating rules for integration and linkage that directly influence users' decision-making processes could lead to significant improvements in urban parks.

The study discusses space syntax as an architectural concept that views architecture as an interface between public and private spaces, analyzing landscapes through mirroring and focusing on internal configurations and exteriors. The study proposes a method to measure permeability and integration in urban …

Cfd Study On Two-Phase Flow Patterns In A Pipe With 90º Elbow In Different Operating Conditions, Hagar Alm-Eldin Bastawissi, Mohammed Ahmed Khafagy, E. A. El Shenawy Prof. Dr., Ahmed M. Salem Dr

Journal of Engineering Research

Recently, CFD has offered a technological solution for modelling multi-phase flow in which we can make endless simulations with reduced expenses and effort in high accuracy results; we shall also mention that experimental studies have limitations for safety considerations when experimenting with flow in high temperature or pressure values or medium nature as in nuclear or chemical flows.In this paper, we used the ANSYS FLUENT CFD program to simulate the two-phase flow in a pipe to study the effect of attaching a 90-degree elbow fitting to the piping system, seeking to find out the change in the pattern and resulting …

تقنيات الاضاءة الصناعية وتأثيرها فى الفراغ السكنى على السلوك الانسانى, Samah Kamal Elfeky, Walaa Ahmad Nour, Lobna Abdelfatah Agha

Journal of Engineering Research

* Lighting is considered of main items in daily life begining from natural Lighting to industrial lighting. with all of it's different shapes . it is considerdone of the most important data that point Blank spaces and works to show architectural spaces, aesthetic values through being sharp and weak, ensure borders show texture or hide Features, suggest wideness, narrowness of space as the most beautiful design don't see beautiful without good lighting which designed carefully.Due to diversity of human activities, architictums spaces and it is wideness. Increased dependence on industrial Lighting to strengthen Job of performance, beauty of internal, external …

An Injectable In Situ Forming Collagen/Alginate/Caso4 Composite Hydrogel For Tissue Engineering Applications: Optimization, Characterization And In Vitro Assessments, Samar A. Salim, Samar A. Salim

Nanotechnology Research Centre

In situ injectable hydrogels are effectively employed to fill irregular cavitary bone defects with initiating bone growth in targeted areas. Herein, an injectable composited hydrogel composed of collagen and alginate cross-linked in situ using different concentrations of calcium sulfate (0.15, 0.3 and 0.6%, wt./v) was synthesized. Recently, CaSO4 is frequently supported as a bone graft material for bone regeneration, owing to its biocompatibility and osteoconductive properties. Moreover, hydroxyapatite (Hap) after salinization-step by (3-Aminopropyl) triethoxysilane (APTES) was incorporated for further enhancing the osteoconductive property of injected hydrogels. All fabricated hydrogels were characterized by SEM, FTIR and XRD analyses. While physiochemical characteristics …

Development Of Liposomes Using Microfluids For Delivery Of Mir-205, Victoria Herrera, Rahul Tiwari, Meghana Kolli, Neeraj Chauhan, Amber M. Garza, Eswara Naga Hanuma Kumar Ghali, Subhash C. Chauhan, Murali Yallapu

Research Symposium

Background: The therapeutic application of microRNA(s) in the field of cancer has generated significant attention in research. miR-205 is a tumor suppressor in various cancers. However, the delivery of miR-205 is an unmet clinical need. Thus, the development of liposomal formulation platform to deliver miR-205 is highly sought. The most common applications of liposome formulations are vaccines and anticancer formulations (e.g., mRNA, small molecule drugs). However, large-scale production with precise control of size and size distribution of the lipid-based drug delivery systems (DDSs) is one of the major challenges in the pharmaceutical industry. The objective of this study is to …

Remodeling Anaplastic Thyroid Cancer's Aggressive Profile And Metabolic Signature By Natural Alkaloid Berberine, Tara Elizabeth Jarboe

NYMC Student Theses and Dissertations

Anaplastic thyroid cancer is a rare, fatal cancer with a five-year survival of 4%. Universally diagnosed at stage IV, anaplastic thyroid cancer is characterized by its lack of differentiation, rapid proliferative rate, highly inflammatory tumor microenvironment, and metabolic dysregulation. Refractory to all established therapies, anaplastic thyroid cancer requires a novel therapeutic approach that targets all of these drivers of anaplastic thyroid cancer carcinogenesis. We propose natural alkaloid berberine as a therapeutic with multitarget efficacy to alter mitochondrial metabolism and reprogram anaplastic thyroid cancer’s aggressive phenotype. Our in vitro model uses monocyte cell line U937, anaplastic thyroid cancer cell lines T238 …

Characterization Of Biological Particles Using An Integrated Hyperspectral Imaging And Machine Learning, Kaeul Lim, Arezoo Ardekani

Graduate Industrial Research Symposium

Hyperspectral imaging (HSI) is a promising modality in medicine with many potential applications. This study focuses on developing a label-free lipid nanoparticle characterization method using a convolutional neural network (CNN) analysis of HSI images. The HSI data, hypercube, consists of a series of images acquired at different wavelengths for the same field of view, providing continuous spectra information for each pixel. Three distinct liposome samples were collected for analysis. Advanced image preprocessing and classification methods for HSI data were developed to differentiate liposomes based on their material compositions. Our machine learning-based classification method was able to distinguish different liposome types …

Using Imaging Modalities To Predict Nanoparticle Distribution And Treatment Efficacy In Solid Tumors: The Growing Role Of Ultrasound, Michaela B. Cooley, Dana Wegierak, Agata A. Exner

Faculty Scholarship

Nanomedicine in oncology has not had the success in clinical impact that was anticipated in the early stages of the field's development. Ideally, nanomedicines selectively accumulate in tumor tissue and reduce systemic side effects compared to traditional chemotherapeutics. However, this has been more successful in preclinical animal models than in humans. The causes of this failure to translate may be related to the intra- and inter-patient heterogeneity of the tumor microenvironment. Predicting whether a patient will respond positively to treatment prior to its initiation, through evaluation of characteristics like nanoparticle extravasation and retention potential in the tumor, may be a …

Nanoparticles For Applications In Specific Diagnostics And Precision Medicine, Naxhije Berisha

Dissertations, Theses, and Capstone Projects

Heterogeneity is common in the expression of cancer and treatment response. Precision medicine enables healthcare providers to tailor medical care to an individual's distinct genetic and environmental makeup. This customization has the potential to result in more efficient treatments while minimizing side effects. We believe that by studying the interface of nanotechnology and cancer medicine we can elucidate innovative solutions that address the challenges of disease heterogeneity. This includes advancements in drug delivery, formulations development, and diagnostic sensing. We highlight three studies that use nanotechnology for applications in precision medicine. In Chapter 2, we highlight design optimization of drug formulations …

Age-Associated Disparity In Phagocytic Clearance Affects The Efficacy Of Cancer Nanotherapeutics, Yifan Wang, Weiye Deng, Daeyong Lee, Long Yan, Yifei Lu, Shiyan Dong, Kristin Huntoon, Abin Antony, Xuefeng Li, Rui Ye, Yan Zhao, Feiyan Zhao, Benjamin R Schrank, Jonghoon Ha, Minjeong Kang, Mingming Yang, Ping Gong, Philip L Lorenzi, Lin Tan, Thomas D Gallup, Sarah K Tang, Zhaogang Yang, Jing Li, Nina N Sanford, Hongmei Wang, Betty Y S Kim, Wen Jiang

Faculty, Staff and Student Publications

Nanomedicines have been approved to treat multiple human diseases. However, clinical adoption of nanoformulated agents is often hindered by concerns about hepatic uptake and clearance, a process that is not fully understood. Here we show that the antitumour efficacy of cancer nanomedicine exhibits an age-associated disparity. Tumour delivery and treatment outcomes are superior in old versus young mice, probably due to an age-related decline in the ability of hepatic phagocytes to take up and remove nanoparticles. Transcriptomic- and protein-level analysis at the single-cell and bulk levels reveals an age-associated decrease in the numbers of hepatic macrophages that express the scavenger …

Phosphomolybdic Acid-Doped Zeolitic Imidazolate Framework-8 Hybrid: Nanostructured Material With Synergistic Antibacterial Effect, Mariam Mohammad Abdelkhalek

Theses and Dissertations

Bacterial infections represent a major global health concern, causing millions of deaths and significant economic burdens. The development of nanostructured surfaces with antibacterial activity can revolutionize infection control practices. In this study, a hybrid material of Zeolitic imidazolate framework-8 (ZIF-8) doped with phosphomolybdic acid (PMA) was synthesized and characterized by FESEM, EDS, XRD, FTIR, and N2 sorption isotherm. The antibacterial activity against Escherichia coli as a model organism was tested by colony forming unit (CFU) reduction assay, minimum inhibitory concentration (MIC), and time-kill curve. PMA@ZIF-8 performance as an antibacterial agent was superior to its individual constituents, suggesting synergistic effect of …

The Influence Of Green Building Design On Tourists' Intention To Stay In Eco-Friendly Hotels: A Study On Perceptions And Preferences, Enas Al Sayed Salama Dr., Gehad Nasr Abdelsalam Dr.

Journal of Engineering Research

Green building design involves integrating sustainable and environmentally friendly practices into the construction and operation of buildings, including hotels, with the goal of minimizing the adverse impact on the environment. This paper delves into the pivotal role of green building design and eco-service provision within the context of green hotels. The aim is to investigate the interconnections among tourists' environmental concerns, their perceived significance of green building design, and their intention to choose green hotels.

To enhance the understanding of tourist behavior and its implications for tourism in Egypt, a questionnaire was administered in Sharm El Sheikh, a prominent Egyptian …

Experimental Study Of Bent Glass Curtain Walls., Sarah Said Abd El Kariem, Moustafa El Shami, Mahmoud El Nagar

Journal of Engineering Research

A Bent Laminated Glass is commonly used in the residential and commercial structures, its methodology is not present in the curves and tables at the ASTM E1300. Therefore, it has become a need for architects to use basis for this type of glass. To the best of authors ‘knowledge, no one study the bent laminated glass in details. A variety of safety glass that has lately gained popularity in the construction sector is modern laminated glass. Given that it offers a safe failover capability, it is perfect for the automotive industry. Double-lite glass is produced using two or more …