Substance Abuse and Addiction Commons^™

Opioid Use In Rhode Island - Review And Suggestions, Vanessa S. Kolb

Senior Honors Projects

It is estimated that over two million Americans have an opioid-related substance abuse disorder. Nationally, 91 people die every day from an opioid overdose, and 60% of drug overdoses involve an opioid. Rhode Island has enacted some of the strictest opioid-prescribing guidelines in the country, but since 2011 the number of overdose deaths within the state that involve illicit opioids has increased by 250%. In 2015, Governor Gina Raimondo established a special task force whose goal is to reduce the number of opioid-related overdose deaths in Rhode Island by one-third by 2018.

In this project, I analyze and compare best …

Prevalence Of Communication Disorders In Children With Neonatal Abstinence Syndrome On School Speech-Language Pathology Caseloads: A National Survey, Brittany V. Ratliff

Electronic Theses and Dissertations

There is concern about the recently increasing number of infants born with Neonatal Abstinence Syndrome (NAS), yet little is known about its long-term neurodevelopmental effects. School-based speech-language pathologists (SLPs) are in a unique position to comment on potential long-term consequences of NAS because their caseloads include children with a variety of communication disorders and comorbidities. School-based SLPs across the United States (N = 258) responded to a survey about the presence of children with NAS on their caseloads and their perceptions of the children’s communication disorders and comorbidities. Results revealed that children with NAS currently are being treated by …

Characteristics Of Online Treatment Seekers Interested In A Text Messaging Intervention For Problem Drinking: Adults 51 And Older Versus Middle-Aged And Younger Adults, Alexis Kuerbis, Katherine Van Stolk-Cooke, Frederick J. Muench

Publications and Research

According to the Institute of Medicine, the vast older adult population is estimated to have mental health and substance use disorders at unprecedented rates and will place high demand on an unprepared healthcare system. Online and mobile health interventions, such as text messaging, could provide an alternative form of frontline intervention that could alleviate some of the burden on the healthcare system; however, it remains unknown what are characteristics of adults over 50 who might be interested in a mobile health behavioral intervention and how they may differ from their younger counterparts. To explore the characteristics of those interested in …

Modeling The Trauma-Antisociality Relationship As Mediated By World Assumptions: Associations With Gender And Drinking Outcomes, Kathryn Fokas

Psychology ETDs

Previous research has established links between traumatic experiences and externalizing pathology including substance use and antisocial behavior, but little is known about potential mechanisms linking these phenomena. This study proposed a novel conceptual model linking these phenomena via the cognitive mechanism of negative world assumptions, or beliefs about the inherent dangerousness and unpredictability of life and others. Given previous mixed findings, this study also sought to explore potential interactions between gender and these phenomena. It was hypothesized that, within a sample of adults seeking alcohol treatment, world assumptions would mediate and gender would moderate the trauma-antisociality association. It also was …

Effectiveness Of Methadone For Treatment Of Heroin Use Disorder, Megan M. Newberry

Honors Capstones

Capstone submitted as a requirement for BSU Honors Program.

Lack Of Preventive Health Behaviors In The Early Forties: The Role Of Earlier Trajectories Of Cigarette Smoking From Adolescence To Adulthood, Chenshu Zhang, Judith S. Brook, Carl G. Leukefeld, Mario De La Rosa, David W. Brook

Behavioral Science Faculty Publications

Objective: To study the degree to which individuals in different trajectories of cigarette smoking from adolescence to the early forties are similar or different in terms of lack of preventive health behaviors (e.g., underuse of preventive health services, unhealthy eating habits) in early midlife. Methods: Participants came from a community-based random sample of residents in two upstate New York counties (N = 548). Data were collected from adolescence to early midlife (mean age = 43 years, standard deviation [SD] = 2.8) at seven time points. Using growth mixture modeling, we statistically identified the number of smoking trajectories. …

Psychosocial Factors Related To The Intergenerational Transmission Of Externalizing Behaviors In Early Midlife, Chenshu Zhang, Judith S. Brook, Neo K. Morojele, Mario De La Rosa, Carl G. Leukefeld, David W. Brook

Behavioral Science Faculty Publications

Background: To study the intergenerational transmission of externalizing behaviors. Methods: Participants came from a community-based random sample of residents in two upstate New York counties (N = 548). Data were collected from mothers at mean age 40 and from their children from adolescence (mean age = 14, SD = 2.8) to early midlife (mean age = 43, SD = 2.8) at seven time points. Structural equation modeling (SEM) was used to study the psychosocial factors as related to externalizing behaviors in early midlife. Results: First, maternal externalizing behaviors were indirectly associated with the offspring's externalizing behaviors …

Thujone Inhibits The Function Of Α7-Nicotinic Acetylcholine Receptors And Impairs Nicotine-Induced Memory Enhancement In One-Trial Passive Avoidance Paradigm, Ahmed Sultan, Keun-Hang Susan Yang, Dmytro Isaev, Eslam El Nebrisi, Nurulain Syed, Nadia Khan, Christopher F. Howarth, Bassem Sadek, Murat Oz

Mathematics, Physics, and Computer Science Faculty Articles and Research

Effects of thujone, a major ingredient of absinthe, wormwood oil and some herbal medicines, were tested on the function of α7 subunit of the human nicotinic acetylcholine (α7 nACh) receptor expressed in Xenopus oocytes using the two-electrode voltage-clamp technique. Thujone reversibly inhibited ACh (100 μM)-induced currents with an IC50 value of 24.7 μM. The effect of thujone was not dependent on the membrane potential and did not involve Ca2+-dependent Cl- channels expressed endogenously in oocytes. Inhibition by thujone was not reversed by increasing ACh concentrations. Moreover, specific binding of [125I] -bungarotoxin was not altered by thujone. Further experiments in SH-EP1 …

Trauma & Substance Use, Kaitlyn Arnold

Thinking Matters Symposium Archive

Research Question: How is trauma and substance use connected?

Racialization Of Heroin Use And The Emergence Of A Public Health Issue, Ellen Pogson

Thinking Matters Symposium Archive

How is race used as a tool in newspaper publications to shape public opinion of the heroin epidemic in Portland, Maine, between the years 2014-­‐2016?

How does the portrayal of the heroin user inform public policy and health care interventions?

Prevention Of Drug Use And Treatment Of Drug Use Disorders In Rural Settings, John A. Gale Ms

Mental Health / Substance Use Disorders

This Guide on Prevention of Drug Use and Treatment of Drug Use Disorders in Rural Settings was prepared by the United Nations Office on Drugs and Crime (UNODC) Drug Prevention and Health Branch (DHB), in the context of the global project Treatnet II: OFID-UNODC Programme to prevent HIV/AIDS through Treatnet Phase II, with the aim of providing an awareness-raising tool and guidance for policymakers, public health officials, local authorities and other stakeholders in dealing with substance use issues in rural settings in their respective countries. This Guide will serve as an awareness-raising tool and guidance for policymakers, public health officials, …

Ua12/2/2 2017 Talisman: Well Being, Wku Student Affairs

WKU Administration Documents

2017 Talisman yearbook.

• Kaetzel, Kylee. Editor’s Note
• Upton, Jordan. His Hands
• Watkins, Abby. The Meal Plan – Recipes
• Eastham, Lillie. New Hieghts – Reed Mattison, Rock Climbing
• Robb, Hayley. A Life Transformed – Annabeth Welborn
• Robb, Hayley. 6:00 AM Bright & Early – Exercise
• Doyel, Rachael. Redifining Ability – Jacob Holt
• Upton, Jordan. Yom Kippur at Happy Hills Buddhist Temple
• Wegert, Sally. Inner Peace – Allison Adams, Yoga
• Mattingly, Evan. The Future’s in Your Hands – Bianca Williams, Psychics
• Frint, Hunter. Too Often Silenced – Unity Walk
• Doyel, Rachael. Changing Tides
• Wells, Spencer. Struggle & Rebirth – Trey Farlee, Musicians …

A Bottom-Up Approach To Effectively Implementing A Good Samaritan Policy At Bryant University, Jessica Fleet

Honors Projects in History and Social Sciences

The rising numbers of substance consumption on college campuses are becoming a public concern for higher educational institutions across the United States. The thesis studies the relationship between state laws and private higher education institution laws in regards to substance abuse. Examining state laws and private universities Medical Amnesty and Good Samaritan laws were used to determine what would effectively replace Bryant University’s current Substance Abuse Policy. The current policy lacks an educational element along with stressing the word of mouth ideology that students are protected when in need of drug or alcohol assistance in a medical situation. This is …

What May Be Associated With Young Adult E-Cigarette Use? Examination Of Key Correlates, Diane J. Martinez, Monique M. Turner, Kathleen Roche, Kimberly Horn

GW Research Days 2016 - 2020

Given increasing rates of e-cigarette use among young adults, research is needed on the attitudes and beliefs that drive use among this age group. Tobacco control approaches used to prevent cigarette smoking may not work as effectively for preventing e-cigarette use. To address this research gap, the present study applied the Integrated Behavior Model (IBM) encompassing the affect heuristic theory to examine the individual-level determinants (i.e., attitude, perceived norm, personal agency, intention, and e-cigarette risk perception) of young adults' e-cigarette use. The 2013-2014 Population Assessment of Tobacco and Health (PATH) Study Wave 1 baseline adult dataset consisted of 9,112 young …

E-Cigarettes And Smoking Cessation Among Pregnant Women: Insights From A Secondary Analysis Of A Randomized Controlled Trial, Shawn Chiang, Lorien Abroms

GW Research Days 2016 - 2020

Background: The use of electronic cigarettes is a rapidly expanding phenomenon. Currently, there is a scarcity of data to help guide decisions regarding the potential harm and benefits of e-cigarettes. This study examines whether pregnant smokers who used e-cigarettes are more likely to quit smoking than those who had never used e-cigarettes.

Methods: Data were drawn from the Quit4Baby study, a text-message-based smoking cessation randomized controlled trial. The sample was comprised of 481 participants with complete follow-up data at 1 month follow-up. Linear and logistics regression models to control for confounds were conducted to evaluate the association between e-cigarette use …

The Surgeon General's Facing Addiction Report: An Historic Document For Healthcare, S. Levy, J. P. Seale, Victoria A. Osborne, K. L. Kraemer, D. P. Alford, J. Baxter, D. S. Finnell, H. Kunins, A. Y. Walley, D. C. Lewis, D. Maclane-Baeder, A. J. Gordon

School of Social Work Faculty Publications

The publication of Facing Addiction in America: The Surgeon General's Report on Alcohol, Drugs, and Health presents an historic moment not only for the field of addiction medicine, but also for the United States as a nation. The Board of Directors of the Association for Medical Education and Research in Substance Abuse (AMERSA), on behalf of our organization, would like to express our appreciation of the efforts of Dr. Vivek Murthy and the Surgeon General's Office to publish the first surgeon general's report covering substance misuse and substance use disorders.

Buprenorphine Physician Supply: Relationship With State-Level Prescription Opioid Mortality, Hannah K. Knudsen, Jennifer R. Havens, Michelle R. Lofwall, Jamie L. Studts, Sharon L. Walsh

Behavioral Science Faculty Publications

Background: Buprenorphine is an effective treatment for opioid use disorder but the supply of buprenorphine physicians is currently inadequate to address the nation’s prescription opioid crisis. Perception of need due to rising opioid overdose rates is one possible reason for physicians to adopt buprenorphine. This study examined associations between rates of growth in buprenorphine physicians and prescription opioid overdose mortality rates in US states.

Methods: The total buprenorphine physician supply and number of physicians approved to treat 100 patients (per 100,000 population) were measured from June 2013 to January 2016. States were divided into two groups: those with rates of …

Regulation Of System Xc-By The Neuropeptide Pacap: Implications For Glutamate Transmission In Drug Addiction, Linghai Kong

Dissertations (1934 -)

Drug addiction is a chronic brain disorder characterized by heightened relapse susceptibility. Drug-induced aberrant glutamate signaling in corticostriatal circuitry contributes to behaviors in virtually every preclinical model of drug seeking and correlates with drug craving in human. Here, we propose that glutamate signaling is a product of integrated activity between neurons and astrocytes, such that disruptions within astrocytes can stem from abnormal neuronal signaling (e.g., altered corticostriatal firing) and be the source of additional disruptions in other neuronal circuits. The astrocytic mechanism studied in these experiments is system xc- (Sxc) since drug-induced changes to this non-vesicular glutamate release mechanism contribute …

Tobacco Product Use Among Lesbian, Gay, And Bisexual Adolescents., Hongying Dai

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: Sexual minority youth face health disparities and a high risk of substance abuse. This study sought to fully characterize the disparity of tobacco use and risk factors in this high-risk subpopulation.

METHODS: Using data from the 2015 Youth Risk Behavior Survey, the current use of various tobacco products (cigarettes, smokeless tobacco, cigars, and e-cigarettes) was compared according to sex and distinct sexual identities (lesbian, gay, bisexual, and unsure). Heterosexual/straight adolescents served as the control group.

RESULTS: Of 14 703 respondents, 88.8% were heterosexual/straight, 2.0% were lesbian or gay, 6.0% were bisexual, and 3.2% were unsure about their sexual identity. …

A Prototypical First-Generation Electronic Cigarette Does Not Reduce Reports Of Tobacco Urges Or Withdrawal Symptoms Among Cigarette Smokers, Arit M. Harvanko, Catherine A. Martin, Richard J. Kryscio, William W. Stoops, Joshua A. Lile, Thomas H. Kelly

Psychology Faculty Publications

It is unknown whether first-generation electronic cigarettes reduce smoking urges and withdrawal symptoms following a 24 h deprivation period. This study tested whether a first-generation electronic cigarette reduces smoking urges and withdrawal symptoms in cigarette smokers. Following 24 h of tobacco deprivation, using a within-subjects design, eight nontreatment seeking tobacco cigarette smokers (3 females) administered 10 puffs from a conventional cigarette or a first-generation electronic cigarette containing liquid with 0, 8 or 16 mg/ml nicotine. Conventional cigarettes ameliorated smoking urges and electronic cigarettes did not, regardless of nicotine concentration. First-generation electronic cigarettes may not effectively substitute for conventional cigarettes in …