Mental and Social Health Commons^™

Prefrontal Glutamate Neurotransmission In Ptsd: A Novel Approach To Estimate Synaptic Strength In Vivo In Humans, Lynnette A Averill, Lihong Jiang, Prerana Purohit, Anastasia Coppoli, Christopher L Averill, Jeremy Roscoe, Benjamin Kelmendi, Henk M De Feyter, Robin A De Graaf, Ralitza Gueorguieva, Gerard Sanacora, John H Krystal, Douglas L Rothman, Graeme F Mason, Chadi G Abdallah

Staff and Researcher Publications

Background: Trauma and chronic stress are believed to induce and exacerbate psychopathology by disrupting glutamate synaptic strength. However, in vivo in human methods to estimate synaptic strength are limited. In this study, we established a novel putative biomarker of glutamatergic synaptic strength, termed energy-per-cycle (EPC). Then, we used EPC to investigate the role of prefrontal neurotransmission in trauma-related psychopathology.

Methods: Healthy controls (n = 18) and patients with posttraumatic stress (PTSD; n = 16) completed 13C-acetate magnetic resonance spectroscopy (MRS) scans to estimate prefrontal EPC, which is the ratio of neuronal energetic needs per glutamate neurotransmission cycle (VTCA/VCycle).

Results: Patients …

Defining Patient-Level Molecular Heterogeneity In Psoriasis Vulgaris Based On Single-Cell Transcriptomics, Yale Liu, Hao Wang, Christopher Cook, Mark A Taylor, Jeffrey P North, Ashley Hailer, Yanhong Shou, Arsil Sadik, Esther Kim, Elizabeth Purdom, Jeffrey B Cheng, Raymond J Cho

Staff and Researcher Publications

Identifying genetic variation underlying human diseases establishes targets for therapeutic development and helps tailor treatments to individual patients. Large-scale transcriptomic profiling has extended the study of such molecular heterogeneity between patients to somatic tissues. However, the lower resolution of bulk RNA profiling, especially in a complex, composite tissue such as the skin, has limited its success. Here we demonstrate approaches to interrogate patient-level molecular variance in a chronic skin inflammatory disease, psoriasis vulgaris, leveraging single-cell RNA-sequencing of CD45+ cells isolated from active lesions. Highly psoriasis-specific transcriptional abnormalities display greater than average inter-individual variance, nominating them as potential sources of clinical …

Turning Data Into Better Mental Health: Past, Present, And Future, Nidal Moukaddam, Akane Sano, Ramiro Salas, Zakia Hammal, Ashutosh Sabharwal

Staff and Researcher Publications

In this mini-review, we discuss the fundamentals of using technology in mental health diagnosis and tracking. We highlight those principles using two clinical concepts: (1) cravings and relapse in the context of addictive disorders and (2) anhedonia in the context of depression. This manuscript is useful for both clinicians wanting to understand the scope of technology use in psychiatry and for computer scientists and engineers wishing to assess psychiatric frameworks useful for diagnosis and treatment. The increase in smartphone ownership and internet connectivity, as well as the accelerated development of wearable devices, have made the observation and analysis of human …

A Novel Approach To Link Genetics And Human Mri Identifies Akap7-Dependent Subicular/Prefrontal Functional Connectivity As Altered In Suicidality, Guillermo Poblete, Tien Nguyen, Savannah Gosnell, Olutayo Sofela, Michelle Patriquin, Sanjay J Mathew, Alan Swann, David A Nielsen, Thomas R Kosten, Ramiro Salas

Staff and Researcher Publications

Background: Brain imaging and genetics are fields acquiring data at increasing speed, but more information does not always result in a better understanding of the underlying biology. We developed the ProcessGeneLists (PGL) approach to use genetics and mRNA gene expression data to generate regions of interest for imaging studies.

Methods: We applied PGL to past suicide attempt (ATT): We averaged the mRNA expression levels of genes (n = 130) possibly associated with ATT (p ≤ 10-3 in a published genome-wide association study, GWAS) in each brain region studied in the Human Allen Brain Atlas (6 ex-vivo brains, 158 to 946 …

Proceedings Of The 10th Annual Deep Brain Stimulation Think Tank: Advances In Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Interventional Psychiatry, And Women In Neuromodulation, Joshua K Wong, Helen S Mayberg, Doris D Wang, R Mark Richardson, Casey H Halpern, Lothar Krinke, Mattia Arlotti, Lorenzo Rossi, Alberto Priori, Sara Marceglia, Ro'ee Gilron, James F Cavanagh, Jack W Judy, Svjetlana Miocinovic, Annaelle D Devergnas, Roy V Sillitoe, Stephanie Cernera, Carina R Oehrn, Aysegul Gunduz, Wayne K Goodman, Erika A Petersen, Helen Bronte-Stewart, Robert S Raike, Mahsa Malekmohammadi, David Greene, Petra Heiden, Huiling Tan, Jens Volkmann, Valerie Voon, Luming Li, Pankaj Sah, Terry Coyne, Peter A Silburn, Cynthia S Kubu, Anna Wexler, Jennifer Chandler, Nicole R Provenza, Sarah R Heilbronner, Marta San Luciano, Christopher J Rozell, Michael D Fox, Coralie De Hemptinne, Jaimie M Henderson, Sameer A Sheth, Michael S Okun

Faculty, Staff and Students Publications

The deep brain stimulation (DBS) Think Tank X was held on August 17–19, 2022 in Orlando FL. The session organizers and moderators were all women with the theme women in neuromodulation. Dr. Helen Mayberg from Mt. Sinai, NY was the keynote speaker. She discussed milestones and her experiences in developing depression DBS. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging DBS technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think …

Evaluation Of A Comprehensive Diabetes Mellitus Protocol At A Rural, Federally Qualified Health Center In Southern West Virginia, Hannah D. Davis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Diabetes mellitus is a chronic disease that affects nearly 34 million Americans. In rural Appalachia, the population is affected disproportionately at a rate of 14% compared to the national average of 10%. Diabetes is a lifelong, chronic condition managed best by a multidisciplinary team-based approach to achieve optimal disease control. Best practices in the care of diabetes support the use of evidenced based care protocols and leveraging technology to decrease the burden of disease. Type 2 diabetes mellitus (T2DM) is the most common type, making it the focal population for evaluation.

Purpose: The purpose of this project was to …

Raising Awareness Of Second Victim Phenomenon And Supportingyou: A Quality And Safety Initiative, Megan Renee Bryant

Graduate Theses, Dissertations, and Problem Reports (ETD)

Current literature has established a need for practice change in management of healthcare-related critical incidents. Peer-support programs have been cited as the most impactful resource healthcare professionals request following a critical incident (Daniels & McCorkle, 2016). SupportingYOU, a peer-support program, is in the process of expansion at a large academic children’s hospital in northern West Virginia in anticipation for the opening of a new facility. The specific aim of this project was to raise awareness of second victim phenomenon (SVP), SupportingYOU, and perception of awareness of resiliency. Interventions included multi-formatted educational sessions on SVP and SupportingYOU via PowerPoints, brochures, flyers, …

The Silent Pandemic: The Impact Of Covid-19 On The Mental Health Of Adolescents Living With Hiv, Florence Anabwani-Richter, Trina Swanson, Sandile Dlamini, Kizito Katulege, Chikabachi Daire, Geeta Singhal

Faculty, Staff and Students Publications

PURPOSE OF REVIEW: The pandemic caused by the coronavirus disease (COVID-19) has resulted in millions of confirmed cases and likely more than six million deaths globally Worldometer (2022). We sought to understand secondary mental effects in adolescents living with HIV (ALHIV) on the African continent caused by lockdowns, school closures, and other restriction measures for infection control. We reviewed the broader literature and conducted 86 retrospective chart reviews of mental health disorders of ALHIV and interventions utilized at a pediatric clinic in Eswatini.

RECENT FINDINGS: ALHIVs are disproportionately affected by mental health disorders. The COVID-19 pandemic has exacerbated adverse mental …

Private And Federated Deep Learning: System, Theory, And Applications For Social Good, Han Hu

Dissertations

During the past decade, drug abuse continues to accelerate towards becoming the most severe public health problem in the United States. The ability to detect drug­abuse risk behavior at a population scale, such as among the population of Twitter users, can help to monitor the trend of drug­abuse incidents. However, traditional methods do not effectively detect drug­abuse risk behavior in tweets, mainly due to the sparsity of such tweets and the noisy nature of tweets. In the first part of this dissertation work, the task of classifying tweets as containing drug­abuse risk behavior or not, is studied. Millions of public …

Developing A Community-Based Rehabilitation Programs In Elderly Nursing Home: A Brief Descriptive Analysis, Melinda Harini, Dosmaria Dosmaria, Herry Herry, Lisa Emilda, Listyani Herman, Nelfidayani Nelfidayani, Putu K. Mahardini, Shynta D. Hantogo, Widya Meiliana, Ikhsan Johnson, Peggy Peggy, Wanarani Aries, Widjajalaksmi Kusumaningsih, Luh K. Wahyuni

ASEAN Journal of Community Engagement

The need for rehabilitation services in nursing homes (NH) for the elderly is increasing each year, and this need is fulfilled both with ordinary clinical rehabilitation center visits, as well as community-based rehabilitation (CBR) inside the facility. However, a proper situation analysis is needed to establish a well-delivered CBR program in the NH, a niche to be fulfilled in this study. This study used a descriptive measurement and cross-sectional design to target the elderly who are living in the NHs. Consecutive sampling was done in the largest NH in Jakarta, in Cipayung District. Participants who were dependently ambulated were assessed …

Acknowledgment Of Culture And Stereotypes: Black Participants’ Perceptions Of Specific Therapist Behaviors, Tsotso T. Ablorh

Graduate Masters Theses

Mental health disparities for Black people of diverse ethnicities compared to people of other racial identities has been well-documented (Alegría et al., 2008; Maura & Weisman de Mamani, 2017). Research addressing this pervasive systemic and interpersonal problem often focuses on client-related factors that create or intensify barriers to care. However clinician-related factors (i.e., racial identity, multicultural training, implicit biases, behavior, etc.) also have a significant impact on barriers to care, retention in therapy, and clinical outcomes for people of African descent (Larrison & Schoppelrey, 2011; Owen, Imel, Adelson, & Rodolfa, 2012). Researchers suggest that the favoring of historically white perspectives, …

Hiv Viral Suppression Among People Living With Hiv On Antiretroviral Therapy In Haut-Katanga And Kinshasa Provinces Of Democratic Republic Of Congo, Gulzar H. Shah, Lievain Maluantesa, Gina D. Etheredge, Kristie C. Waterfield, Osaremhen Ikhile, Roger Beni, Elodie Engetele, Astrid Mulenga

Health Policy & Community Health: Faculty Publications

Human immunodeficiency virus (HIV) infections and less-than-optimal care of people living with HIV (PLHIV) continue to challenge public health and clinical care organizations in the communities that are most impacted by HIV. In the era of evidence-based public health, it is imperative to monitor viral load (VL) in PLHIV according to global and national guidelines and assess the factors associated with variation in VL levels. Purpose: This study had two objectives—(a) to describe the levels of HIV VL in persons on antiretroviral therapy (ART), and (b) to analyze the significance of variation in VL by patients’ demographic and clinical characteristics, …

Social Media Usage And Transitioning Into Online Classes During Covid-19- A Survey Of Undergraduate Students In Georgia, United States, Sylvia Ofori, Janet Choongo, Mario Kekop, Gulzar H. Shah, Haresh Rochani, Joseph Telfair

Health Policy & Community Health: Faculty Publications

Previous studies on the use of social media (SM) during the COVID-19 pandemic have focused on the use in sustaining academic communication. This study aimed to assess the association between SM and the ease of transitioning to online classes during the COVID-19 pandemic using survey data from 872 undergraduate students. The findings showed that Snapchat and Instagram were the most preferred social media sites among participants. Compared to students who use SM for < 2 hours a day, use for > 5 hours (AOR= 2.44; 95% CI, 1.13 – 5.25) or 3 to 5 hours a day (AOR = 2.01, 95% CI 1.06-3.81) increased the odds of easily …

Depression And Behavioral Changes Associated With Social Media Dependency During Covid-19 Pandemic Among University Students In Bangladesh: A Cross- Sectional Study, Sushmita Karmokar, Md. Ashraful Islam, Mohammad Hamid Al Muktadir, Rakibul Hasan, Abu Montakim Tareq, Mohammad Nurul Amin, Talha Bin Emran

Makara Journal of Health Research

Background: With its rapid spread, the coronavirus disease 2019 (COVID-19) pandemic had a detrimental effect on students’ psychological well-being, depression, and behavioral changes due to indefinite educational leaves, lockdowns, restricted outdoor activities, and excess use of social media. This study aims to assess the relationship of social media exposure with the psychological well-being, depression, and behavioral changes of Bangladeshi university students.

Methods: A web-based cross-sectional survey was carried out on 530 students from June 17 to July 10, 2020, to evaluate psychological well-being, depression, behavioral changes, and social media exposure via self-reported measures.

Results: The prevalence of …

An Investigation Into Caffeine Consumption And Self-Reported Dependency In The Republic Of Ireland, Gavin Buckley, Ciara Murphy, Nora O'Sullivan, Róisín Spriggs

International Undergraduate Journal of Health Sciences

Objectives: To explore the consumption of caffeine containing beverages by the Irish population and to investigate their self-perceived dependency on such products.

Methodology: An online survey was distributed with national access to Irish adults which was open to responses from 25^th February to 7^th March 2021 inclusive. A total of 417 responses from participants over 18 years of age were validated and analysed using Microsoft Excel.

Results: Tea was the most commonly consumed caffeinated product among the Irish population, with the majority of respondents stating their consumption began before 10 years old. The majority of respondents did not …

Exploration On High School Students’ Grit: Its Effects On The Students’ Potential Development, Ahmad Yudiar, Eka Sakti Yudha, Sartono Sartono

Jurnal Kajian Bimbingan dan Konseling

The education process in Indonesia has been implemented using a variety of modern tools, but it should be understood that the quality of learning activities in the classroom is also influenced by the interactions that occur in the classroom. Teachers must understand that to create interaction in the classroom, they must first understand the grit level that can help make learning fun. The purpose of this study was to determine the grit level of high school students in Bangka Belitung Province, Indonesia. This research is survey research conducted in Bangka Belitung Province and involves 770 respondents. The results showed that …

College Students’ Academic Procrastination During The Covid-19 Pandemic: Focusing On Academic Achievement, Abd Basith, Md Shahinoor Rahman, Usina Robert Moseki

Jurnal Kajian Bimbingan dan Konseling

This research aims to describe the level of college students’ academic procrastination, analyze differences in academic procrastination among the college students, and analyze the relationship between academic procrastination and academic achievement. This research uses a quantitative method with a survey and correlational design. The research population is 620 Sekolah Tinggi Keguruan dan Ilmu Pendidikan Singkawang (STKIP) Singkawang college students. The sample is taken using a simple random sampling technique as many as 352 college students (76 male and 276 female). The instrument used in data collection is the academic procrastination scale and great point academic. The data are analyzed using …

The Effectiveness Of Solution-Focused Brief Therapy To Reduce Generation Z Anxiety In The Age Of Disruption, Rizqi Lestari, Budi Astuti

Jurnal Kajian Bimbingan dan Konseling

Generation Z’s use of technology inevitably allows them to get a lot of information from all over the world. Excessive information that has not been verified can cause anxiety. This study aims to determine the effectiveness of the solution-focused brief therapy approach to reducing anxiety experienced by Generation Z in the era of disruption. This research is an experimental research type of single-subject research. The research subjects were three counselees who were selected using purposive sampling with the initials NI, TS, and WD. The data collection technique in this study was obtained based on the self-assessment sheet that was conducted …

Developing Specialization Model Applications For High School Students, Agus Triyanto, Septinda Rima Dewanti, Widya Juwita Sari

Jurnal Kajian Bimbingan dan Konseling

This study aims to produce a model application of specialization for the majors of high school students. The research method used is the Borg and Gall development research method. The research procedure was carried out by conducting a literature review and preliminary study, planning, developing, validating, revising, testing on research subjects, revising, and finalizing and socializing the application specialization model. The research instrument used is a rating scale. Data analysis was carried out by averaging expert judgments on applying the specialization model that had been developed. In addition, data were also obtained from the results of student interest. The expert …

I Am Tired Of Teaching: Relationship Between Teachers’ Boredom And Their Psychological Disorders During Covid-19 Pandemic, Imam Ariffudin, Ajeng Intan Nur Rahmawati

Jurnal Kajian Bimbingan dan Konseling

The continuous practice of online learning potentially carries boredom and negative effects on teachers’ psychology. This study investigates the effects of boredom on teachers’ psychological disorders during online learning. This correlational study used an explanatory design, involving 113 teachers from different educational levels (junior, senior, and vocational schools) in Malang, Indonesia. The participants were selected through cluster random sampling technique. The data collection process was carried out using two standardized instruments, the DASS 21 (Depression, Anxiety, and Stress Scale) and ABS-10 (Academic Boredom Scale). The obtained data were analyzed using correlation and linear regression analysis to examine the relationship and …