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Genotype And Cardiovascular Phenotype Correlations With Tbx1 In 1,022 Velo-Cardio-Facial/Digeorge/22q11.2 Deletion Syndrome Patients, Tingwei Guo, Donna McDonald-McGinn, Anna Blonska, Alan L. Shanske, Anne S. Bassett, Eva Chow, Mark Bowser, Molly Sheridan, Frits Beemer, Koen Devriendt, Ann Swillen, Jeroen Breckpot, Maria C. Digilio, Bruno Marino, Bruno Dallapiccola, Courtney Carpenter, Xin Zheng, Jacob Johnson, Jonathan Chung, Anne Marie Higgins, Nicole Philip, Tony J. Simon, Karlene Coleman, Damian Heine-Suner, Jordi Rosell, Wendy R. Kates, Marcella Devoto, Elizabeth Goldmuntz, Elaine Zackai, Tao Wang, Robert J. Shprintzen, Beverly Emanuel, Bernice Morrow, The International Chromosome 22q11.2 Consortium 2011 Sacred Heart University

Genotype And Cardiovascular Phenotype Correlations With Tbx1 In 1,022 Velo-Cardio-Facial/Digeorge/22q11.2 Deletion Syndrome Patients, Tingwei Guo, Donna Mcdonald-Mcginn, Anna Blonska, Alan L. Shanske, Anne S. Bassett, Eva Chow, Mark Bowser, Molly Sheridan, Frits Beemer, Koen Devriendt, Ann Swillen, Jeroen Breckpot, Maria C. Digilio, Bruno Marino, Bruno Dallapiccola, Courtney Carpenter, Xin Zheng, Jacob Johnson, Jonathan Chung, Anne Marie Higgins, Nicole Philip, Tony J. Simon, Karlene Coleman, Damian Heine-Suner, Jordi Rosell, Wendy R. Kates, Marcella Devoto, Elizabeth Goldmuntz, Elaine Zackai, Tao Wang, Robert J. Shprintzen, Beverly Emanuel, Bernice Morrow, The International Chromosome 22q11.2 Consortium

Communication Disorders Faculty Publications

Haploinsufficiency of TBX1, encoding a T-box transcription factor, is largely responsible for the physical malformations in velo-cardio-facial /DiGeorge/22q11.2 deletion syndrome (22q11DS) patients. Cardiovascular malformations in these patients are highly variable, raising the question as to whether DNA variations in the TBX1 locus on the remaining allele of 22q11.2 could be responsible. To test this, a large sample size is needed. The TBX1 gene was sequenced in 360 consecutive 22q11DS patients. Rare and common variations were identified. We did not detect enrichment in rare SNP (single nucleotide polymorphism) number in those with or without a congenital heart defect. One exception …


Vocational Experiences Of Survivors Of Severe Tbi With Diverse Employment Patterns: An Explanatory Mixed Method Design, Erin J. Bush 2011 University of Nebraska-Lincoln

Vocational Experiences Of Survivors Of Severe Tbi With Diverse Employment Patterns: An Explanatory Mixed Method Design, Erin J. Bush

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Employment status is a salient outcome following traumatic brain injury (TBI). A return to productive activity relates in complex ways to quality of life, and loss of employment competence has potentially devastating effects on survivors. Currently, inadequate information exists about the distribution of occupations held by survivors, post-injury employment stability, and the frequency that survivors return to their pre-injury occupations. The research presented herein addressed these issues. This study consisted of two phases. Through Phase 1, the researcher gathered quantitative employment data regarding a pool of 283 survivors of severe TBI. She then conducted telephone interviews of family members of …


Let's Talk Speech! Volume 4 Issue 1, Barbara T. Schmidt Ph.D. 2011 Molloy College

Let's Talk Speech! Volume 4 Issue 1, Barbara T. Schmidt Ph.D.

Communication Sciences and Disorders Newsletter

Dear Friends, I would like to take this opportunity to thank all of you for your support as the Speech-Language Pathology Department continues to grow. The department would not be able to expand and flourish without the encouragement of the administrators, faculty, students, alumni and our affiliates and friends. This newsletter will keep you informed regarding our new faculty, our new SLP scholarship initiative, our first class of master’s students, as well as the efforts and activities of the Molloy College Chapter of the National Student Speech, Language and Hearing Association (NSSLHA). The Rising Star Scholarship was established in 2011 …


The Relation Between Children‟S Socio-Economic Status And Their Performance On The Passive Subtest Of The Diagnostic Evaluation Of Language Variation – Norm Referenced, Maggie Faulk Deville 2011 Louisiana State University

The Relation Between Children‟S Socio-Economic Status And Their Performance On The Passive Subtest Of The Diagnostic Evaluation Of Language Variation – Norm Referenced, Maggie Faulk Deville

Honors Capstones

No abstract provided.


The Development Of A Neonatal Communication Intervention Tool, Esedra Strasheim, Alta Kritzinger, Brenda Louw 2011 University of Pretoria

The Development Of A Neonatal Communication Intervention Tool, Esedra Strasheim, Alta Kritzinger, Brenda Louw

ETSU Faculty Works

Neonatal communication intervention is important in South Africa, which has an increased prevalence of infants born with risks for disabilities and where the majority of infants live in poverty. Local literature showed a dearth of information on the current service delivery and roles of speech-language therapists (SLTs) and audiologists in neonatal nurseries in the South African context. SLTs have the opportunity to provide the earliest intervention, provided that intervention is well-timed in the neonatal nursery context. The aim of the research was to compile a locally relevant neonatal communication intervention instrument/tool for use by SLTs in neonatal nurseries of public …


Effects Of Degree And Configuration Of Hearing Loss On The Contribution Of High- And Low-Frequency Speech Information To Bilateral Speech Understanding, Benjamin W. Y. Hornsby, Earl E. Johnson, Erin Picou 2011 Vanderbilt University

Effects Of Degree And Configuration Of Hearing Loss On The Contribution Of High- And Low-Frequency Speech Information To Bilateral Speech Understanding, Benjamin W. Y. Hornsby, Earl E. Johnson, Erin Picou

ETSU Faculty Works

Objectives: The purpose of this study was to examine the effects of degree and configuration of hearing loss on the use of, and benefit from, information in amplified high- and low-frequency speech presented in background noise.

Design: Sixty-two adults with a wide range of high- and low-frequency sensorineural hearing loss (5 to 115+ dB HL) participated in the study. To examine the contribution of speech information in different frequency regions, speech understanding in noise was assessed in multiple low- and high-pass filter conditions, as well as a band-pass (713 to 3534 Hz) and wideband (143 to 8976 Hz) condition. To …


Grammatical Morphology In School-Age Children With And Without Language Impairment: A Discriminant Function Analysis, Maura Jones Moyle, Susan Ellis Weismer, Brenda K. Gorman 2011 Marquette University

Grammatical Morphology In School-Age Children With And Without Language Impairment: A Discriminant Function Analysis, Maura Jones Moyle, Susan Ellis Weismer, Brenda K. Gorman

Speech Pathology and Audiology Faculty Research and Publications

Purpose: The purpose of this study was to test Bedore and Leonard's (1998) proposal that a verb morpheme composite may hold promise as a clinical marker for specific language impairment (SLI) in English speakers and serve as an accurate basis for the classification of children with and without SLI beyond the preschool level.

Method: The language transcripts of 50 school-age children with SLI (Mage = 7;9 [years;months]) and 50 age-matched typically developing peers (Mage = 7;9) were analyzed. Following the Bedore and Leonard (1998) procedure, 3 variables were measured: a finite verb morpheme composite, a noun …


Cleft Palate, Retrognathia And Congenital Heart Disease In Velo-Cardio-Facial Syndrome: A Phenotype Correlation Study, Marcia A. Friedman, Nathanial Miletta, Cheryl Roe, Dongliang Wang, Bernice Morrow, Wendy R. Kates, Anne Marie Higgins, Robert J. Shprintzen 2011 Sacred Heart University

Cleft Palate, Retrognathia And Congenital Heart Disease In Velo-Cardio-Facial Syndrome: A Phenotype Correlation Study, Marcia A. Friedman, Nathanial Miletta, Cheryl Roe, Dongliang Wang, Bernice Morrow, Wendy R. Kates, Anne Marie Higgins, Robert J. Shprintzen

Communication Disorders Faculty Publications

Objective: Velo-cardio-facial syndrome (VCFS) is caused by a microdeletion of approximately 40 genes from one copy of chromosome 22. Expression of the syndrome is a variable combination of over 190 phenotypic characteristics. As of yet, little is known about how these phenotypes correlate with one another or whether there are predictable patterns of expression. Two of the most common phenotypic categories, congenital heart disease and cleft palate, have been proposed to have a common genetic relationship to the deleted T-box 1 gene (TBX1). The purpose of this study is to determine if congenital heart disease and cleft palate are correlated …


A Critical Review Of Audiological Outcome Measures For Infants And Children, Marlene P. Bagatto, Sheila T. Moodie, Richard C. Seewald, Doreen J. Bartlett, Susan D. Scollie 2011 National Centre for Audiology, Faculty of Health Sciences, University of Western Ontario

A Critical Review Of Audiological Outcome Measures For Infants And Children, Marlene P. Bagatto, Sheila T. Moodie, Richard C. Seewald, Doreen J. Bartlett, Susan D. Scollie

Communication Sciences and Disorders Publications

Outcome evaluation is an important stage in the pediatric hearing aid fitting process, however a systematic way of evaluating outcome in the pediatric audiology population is lacking. This is in part due to the need for an evidence-based outcome evaluation guideline for infants and children with hearing loss who wear hearing aids. As part of the development of a guideline, a critical review of the existing pediatric audiology outcome evaluation tools was conducted. Subjective outcome evaluation tools that measure auditory-related behaviors in children from birth to 6 years of age were critically appraised using a published grading system (Andresen, 2000). …


Temperamental Profiles Of Children With Communication Impairment., Whitney Charlena Lau 2011 East Tennessee State University

Temperamental Profiles Of Children With Communication Impairment., Whitney Charlena Lau

Electronic Theses and Dissertations

The temperament literature available that involves children with communication impairments is limited but promising. The purpose of this study was to investigate the temperamental profiles of children with autism spectrum disorders, primary language impairments, phonological/articulation impairments, and combined phonological and language impairments. Participants included 38 children who attended the East Tennessee State University Speech-Language-Hearing Clinic at the time of the study or in the past 10 years. Parents of eligible participants were asked to complete demographic and temperament questionnaires about their children. Results indicated that the temperamental profiles of children with communication impairments differed significantly from typically developing children in …


A Preliminary Report On Disordered Speech With Deep Brain Stimulation In Individuals With Parkinson's Disease, Christopher Dromey, Suzy Bjarnason 2011 Brigham Young University

A Preliminary Report On Disordered Speech With Deep Brain Stimulation In Individuals With Parkinson's Disease, Christopher Dromey, Suzy Bjarnason

Faculty Publications

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has proven effective in treating the major motor symptoms of advanced Parkinson's disease (PD). The aim of this study was to learn which laryngeal and articulatory acoustic features changed in patients who were reported to have worse speech with stimulation. Six volunteers with PD who had bilateral STN electrodes were recorded with DBS turned on or off. Perceptual ratings reflected poorer speech performance with DBS on. Acoustic measures of articulation (corner vowel formants, diphthong slopes, and a spirantization index) and phonation (perturbation, long-term average spectrum) as well as verbal fluency scores …


The Efficacy Of Social Communication Intervention In Improving Emotion Inferencing For School-Aged Children With Language Impairment, Matthew Keith Frank 2011 Brigham Young University - Provo

The Efficacy Of Social Communication Intervention In Improving Emotion Inferencing For School-Aged Children With Language Impairment, Matthew Keith Frank

Theses and Dissertations

Children with language impairment (LI) have demonstrated several language problems, including receptive and expressive deficits. A growing body of research has further demonstrated emotion understanding and, more specifically, emotion inferencing deficits that negatively affect the ability of this population to use language successfully in social interactions. Consequently, the present study examines social communication intervention focused on improving emotion inferencing for children with a diagnosis of LI or Autism Spectrum Disorder (ASD), as similar social communication deficits are occasionally seen in children with these diagnoses. Study participants were identified from the caseload of a practicing certified speech-language pathologist (SLP) and qualified …


The Effects Of Gender And Elicitation Method On The Prosodic Cues Used By 7- To 11-Year-Old Children To Signal Sentence Type, Lacey Ann Powell 2011 Brigham Young University - Provo

The Effects Of Gender And Elicitation Method On The Prosodic Cues Used By 7- To 11-Year-Old Children To Signal Sentence Type, Lacey Ann Powell

Theses and Dissertations

The purpose of this study was to examine the prosodic cues used by 7 to 11 year-old children to signal questions and declarative statements in terms of changes in fundamental frequency (F0), duration, and intensity. Additional aims were to evaluate how children's use of prosody changes as a function of gender and method of elicitation. A group of 16 children participated in three different types of elicitation tasks (imitative, reading, and naturalistic). An acoustic analysis revealed that the participants produced the different sentence types using a variety of acoustic cues. Not only do children vary the mean of F0 and …


Quantifying Articulatory Distinctiveness Of Vowels, Jun Wang, Jordan R. Green, Ashok Samal, David B. Marx 2011 University of Nebraska-Lincoln

Quantifying Articulatory Distinctiveness Of Vowels, Jun Wang, Jordan R. Green, Ashok Samal, David B. Marx

Department of Special Education and Communication Disorders: Faculty Publications

The articulatory distinctiveness among vowels has been frequently characterized descriptively based on tongue height and front-back position; however, very few empirical methods have been proposed to characterize vowels based on time-varying articulatory characteristics. Such information is not only needed to improve knowledge about the articulation of vowels but also to determine the contribution of articulatory imprecision to poor speech intelligibility. In this paper, a novel statistical shape analysis was used to derive a vowel space that depicted the quantified articulatory distinctiveness among vowels based on tongue and lip movements. The effectiveness of the approach was supported by vowel classification accuracy …


Network Modulation During Complex Syntactic Processing, Dirk B. den Ouden, Dorothee Saur, Wolfgang Mader, Björn Schelter, Sladjana Lukic, Eisha Wali, Jens Timmer, Cynthia K. Thompson 2011 Chapman University

Network Modulation During Complex Syntactic Processing, Dirk B. Den Ouden, Dorothee Saur, Wolfgang Mader, Björn Schelter, Sladjana Lukic, Eisha Wali, Jens Timmer, Cynthia K. Thompson

Communication Sciences and Disorders Faculty Articles and Research

Complex sentence processing is supported by a left-lateralized neural network including inferior frontal cortex and posterior superior temporal cortex. This study investigates the pattern of connectivity and information flow within this network. We used fMRI BOLD data derived from 12 healthy participants reported in an earlier study (Thompson, C. K., Den Ouden, D. B., Bonakdarpour, B., Garibaldi, K., & Parrish, T. B. (2010b). Neural plasticity and treatment-induced recovery of sentence processing in agrammatism. Neuropsychologia, 48(11), 3211–3227) to identify activation peaks associated with object-cleft over syntactically less complex subject-cleft processing. Directed Partial Correlation Analysis was conducted on time series …


The Effects Of A Literature-Based Emotion Recognition Program On Teacher Report Of Sociability Withdrawal For Six Children With Social Communication Difficulties, Jennifer Lynn Harris 2011 Brigham Young University - Provo

The Effects Of A Literature-Based Emotion Recognition Program On Teacher Report Of Sociability Withdrawal For Six Children With Social Communication Difficulties, Jennifer Lynn Harris

Theses and Dissertations

Children with language impairment (LI) often demonstrate difficulties in social communication. Although a number of general social communication interventions have been suggested, there is relatively little work done to examine the efficacy of these interventions for school-age children with LI, and none reported to target general emotional competence. The purpose of this study was to examine the effects on teacher perception of an intervention designed to improve emotion understanding. The intervention was centered on the presentation and use of children's stories to introduce and practice aspects of emotion understanding. The withdrawn and sociable subscales of the Teacher Behavior Rating Scale …


Objective Vs. Subjective Hearing Screening Measures In Schools, Brittany S. Brown 2011 Louisiana Tech University

Objective Vs. Subjective Hearing Screening Measures In Schools, Brittany S. Brown

Doctoral Dissertations

The primary aim of this study was to demonstrate the need for objective hearing screening procedures within traditional school based hearing screenings through literature review. It is believed that objective hearing screenings would provide a better, less-invasive way to screen hearing with minimal participation required from the children, and less interpretation needed from the examiner. A review of the literature suggested that ideal screening measures would include otoacoustic emissions (OAEs) and tympanometry. Currently, the gold standard for school hearing screenings, as described by the American Speech Language Hearing Association (ASHA) (1997), centers on behavioral responses observed by the examiner during …


Characterizing And Predicting Outcomes Of Communication Delays In Infants And Toddlers: Implications For Clinical Practice, Rhea Paul, Forma P. Roth 2011 Sacred Heart University

Characterizing And Predicting Outcomes Of Communication Delays In Infants And Toddlers: Implications For Clinical Practice, Rhea Paul, Forma P. Roth

Communication Disorders Faculty Publications

Purpose: This article focuses on using currently available data to assist speech-language pathologists (SLPs) in making decisions regarding a child's eligibility and considerations for recommended "dosage" of early intervention (El) services. Method: Literature describing the characteristics of infants and toddlers who are likely recipients of El services was reviewed. Results: Current literature provides information that can be used to inform clinical decisions for infants and toddlers with established medical conditions, as well as those with risk factors, for oral language, communication, and subsequent literacy disabilities. This information is summarized. Conclusion: Extant literature suggests that El makes a critical difference in …


Sally J. Rogers And Geraldine Dawson: Review Of Early Start Denver Model For Young Children With Autism: Promoting Language, Learning And Engagement (Book Review), Rhea Paul 2011 Sacred Heart University

Sally J. Rogers And Geraldine Dawson: Review Of Early Start Denver Model For Young Children With Autism: Promoting Language, Learning And Engagement (Book Review), Rhea Paul

Communication Disorders Faculty Publications

Book review by Rhea Paul:

Rogers, Sally R. and Geraldine Dawson. Early Start Denver Model for Young Children with Autism: Promoting Language, Learning and Engagement. New York: Guilford Press, 2010. 9781606236321; 9781606234914 (pbk.)


Speaking Rate Effects On Normal Aspects Of Articulation: Outcomes And Issues, Jeffrey J. Berry 2011 Marquette University

Speaking Rate Effects On Normal Aspects Of Articulation: Outcomes And Issues, Jeffrey J. Berry

Speech Pathology and Audiology Faculty Research and Publications

The articulatory effects of speaking rate have been a point of focus for a substantial literature in speech science. The normal aspects of speaking rate variation have influenced theories and models of speech production and perception in the literature pertaining to both normal and disordered speech. While the body of literature pertaining to the articulatory effects of speaking rate change is reasonably large, few speaker-general outcomes have emerged. The purpose of this paper is to review outcomes of the existing literature and address problems related to the study of speaking rate that may be germane to the recurring theme that …


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