School Psychology Commons^™

The Medial Temporal Memory System In Down Syndrome: Translating Animal Models Of Hippocampal Compromise, Caron A.C. Clark, Fabian Fernandez, Stella Sakhon, Goffredina Spano, Jamie O. Edgin

Department of Educational Psychology: Faculty Publications

Recent studies have highlighted the dentate gyrus as a region of increased vulnerability in mouse models of Down syndrome (DS). It is unclear to what extent these findings are reflected in the memory profile of people with the condition. We developed a series of novel tasks to probe distinct medial temporal functions in children and young adults with DS, including object, spatial, and temporal order memory. Relative to mental age-matched controls (n=45), individuals with DS (n=28) were unimpaired on subtests involving short-term object or configural recall that was divorced from spatial or temporal contexts. By contrast, …