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Parkinson’S Disease And Processing Speed Theory Does Processing Speed Mediate Higher-Order Cognitive Functioning?, Priscilla Cuellar-Rocha May 2025

Parkinson’S Disease And Processing Speed Theory Does Processing Speed Mediate Higher-Order Cognitive Functioning?, Priscilla Cuellar-Rocha

Electronic Theses, Projects, and Dissertations

Parkinson’s disease (PD) is a neurodegenerative disorder resulting in both motor and cognitive deficits. Salthouse (1990) proposed the Information Processing Speed (IPS) Theory that a reduced cognitive processing speed is a significant factor that accounts for the negative relationship between age-related variance and cognition. Parkinson’s is an idiopathic disorder, meaning that the cause is unknown, with most patients being 60 years and older. If the IPS theory suggests that an increased age affects the slowing of IPS, which then impairs cognition, PD, a disorder involving older adults, should also follow this pattern. However, no studies have assessed the IPS theory …


Cognitive Differences In Parkinson’S Disease With Amyloid Positivity And Negativity, Kenya Luna Dec 2024

Cognitive Differences In Parkinson’S Disease With Amyloid Positivity And Negativity, Kenya Luna

Electronic Theses, Projects, and Dissertations

In Parkinson’s Disease (PD), research has shifted to investigate how biomarkers commonly seen in Alzheimer’s Disease (AD), such as amyloid beta (AB), may be associated with cognitive functioning in PD. AB is considered a reliable biomarker for AD pathology, however in PD there is a lacking biomarker that can accurately reflect severity of cognitive impairment. AD research has shown an association between low AB and cognitive decline, but the data in PD has mixed results. Most studies that analyze cognitive decline and biomarkers do not use a cutoff level and the few that do have a threshold vary greatly in …


Impact Of Subjective Cognitive Complaints On Mci Diagnostic Criteria In Alzheimer’S Disease, Rhiannon Rivas Aug 2023

Impact Of Subjective Cognitive Complaints On Mci Diagnostic Criteria In Alzheimer’S Disease, Rhiannon Rivas

Electronic Theses, Projects, and Dissertations

Alzheimer’s disease (AD) is the most commonly occurring neurodegenerative disease characterized by deficits in patient cognition. Mild cognitive impairment (MCI) is defined as an intermediate stage between cognitively normal (CN) and dementia in which the individual experiences some impairment but can function independently. Gold standard MCI criteria requires a subjective cognitive complaint (SCC) in which a patient acknowledges a decline in cognitive ability, however past findings on its validity as a measure of objective impairment have been inconsistent. Biomarkers found in cerebrospinal fluid (CSF) and indicative of neurodegeneration are also used to examine AD progression. Our study investigates if inclusion …