Experimental Analysis of Behavior Commons^™

Corticostriatal Pathway Inactivation And Connections To Associative Learning With Nicotine Stimulus In Rats, Anna Kalinowski

Honors Theses and Capstones

The main concern of this study is looking into the neural mechanisms of associative learning with a nicotine stimulus. The goal of this study was to find out if inactivating the corticostriatal pathway through DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) inhibited goal-tracking behavior in rats. In this experiment, rats underwent two surgeries. One was to inject DREADDs into the infralimbic cortex and the other in the dorsomedial caudate-putamen (dmCPu). Rats were initially trained on levers through water deprivation. Once they reached the criterion, they moved on to the self-administration phase. After the rats were trained in self-administration sessions …