Experimental Analysis of Behavior Commons^™

Neural Hyperactivity During Value-Based Decision-Making In People With Daily/Near Daily Cannabis Use, Miranda Ramirez

Theses and Dissertations--Psychology

Value-based decision-making involves the coordinated effort of multiple brain regions to guide future choices based on past experiences. These processes are disrupted in cannabis use disorder, where individuals continue to use cannabis despite negative consequences. Reinforcement learning (RL) paradigms can be used to capture changes in the value of available options and may inform how the brain is impacted by frequent cannabis use. This study combined fMRI with behavioral modeling of probabilistic choice task data to compare value-based choices between young adults reporting daily/near daily cannabis use (CAN) and controls (CTRL). Participants selected one of two options reinforced ($0.25) at …

Withdrawal From Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities To Behavioral Deficits And Neurochemical Perpetuators Of Neurotoxicity And Drug Seeking Behavior, Nicoletta K. Memos

Dissertations, Theses, and Capstone Projects

MA is a potent, highly addictive psychomotor stimulant known to produce neurotoxic effects on the brain leading to neurological impairments^1-6 characterized by neurodegeneration of dopaminergic fibers, cell bodies and pathways, as well as brain regions such as the hippocampus, frontal cortex, and midbrain^1,5.

In MA addiction, women are more vulnerable to the behavioral and cognitive effects of MA compared to men. Adult human literature reveals gender differences in usage patterns and women demonstrate increased vulnerability to the neurotoxic effects and health effects of MA use. Women begin drug use at an earlier age, escalate drug use quicker, …

Effects Of Proton Radiation And Pomegranates On Hippocampus And Behavior, Melissa S. Dulcich

Loma Linda University Electronic Theses, Dissertations & Projects

Exposure to ionizing radiation may have deleterious effects on physical and mental health, with an increased risk of proton radiation for astronauts traveling outside Earth's atmosphere into lower earth orbit. In animal models, radiation has been shown to suppress neurogenesis in the subgranular zone of the hippocampus, a key area for learning and memory. Furthermore, some evidence suggests that compounds found in fruits and vegetables (e.g. polyphenols) may offer some protection against the cellular effects of radiation. Few studies have looked at the effects of proton radiation on the central nervous system, even though proton radiation is the most prevalent …