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Full-Text Articles in Experimental Analysis of Behavior

Representation Of Reward And Risk In The Brain’S Motor System: Studies In Adolescents And Adults, Xingjie Chen Jun 2021

Representation Of Reward And Risk In The Brain’S Motor System: Studies In Adolescents And Adults, Xingjie Chen

Doctoral Dissertations

In the neuroscience of economic decision making, the brain’s motor system has been ascribed a role in implementing choice actions. However, recent work has revealed canonical motor signals much in advance of choice action, possibly indicating their role in evaluation of decision options. In the current dissertation, we applied multimodal neuroimaging combining EEG and fMRI and used a novel paradigm that temporally separated the evaluation phase from the action phase of a decision-making process to investigate the mechanisms through which the motor control system contributes to decision making. Additionally, we further examined the developmental changes during the two phases of …


Studies On High-Throughput Single-Neuron Rna Sequencing And Circadian Rhythms In The Nudibranch, Berghia Stephanieae, Thi Bui Feb 2021

Studies On High-Throughput Single-Neuron Rna Sequencing And Circadian Rhythms In The Nudibranch, Berghia Stephanieae, Thi Bui

Masters Theses

One of the goals of neuroscience is to classify all of the neurons in the brain. Neuronal types can be defined using a combination of morphology, electrophysiology, and gene expression profiles. Gene expression profiles allow differentiation between cells that share similar characteristics. Leveraging the advantage of Berghia stephanieae (Gastropoda; Nudibranchia), which has around 28,000 neurons, I constructed high-throughput single-neuron transcriptomes for its whole brain. I produced a single-cell dissociation protocol and a custom data analysis pipeline for data of this nature. Around 129,000 cells were collected from 18 rhinophore ganglia and 20 circumesophageal ring ganglia (brain), consisting of the cerebropleural, …