Experimental Analysis of Behavior Commons^™

The Effects Of Social And Nonsocial Contextual Stimuli On The Renewal Of Cocaine Seeking, Bree Humburg

Theses and Dissertations--Psychology

Those with substance use disorders can undergo craving and relapse when re-exposed to a drug-associated context. This study determined if renewal of cocaine seeking is differentially controlled by contexts consisting of social and/or nonsocial stimuli. Experiment 1, rats self-administered cocaine in Context A which included a social peer and house light illumination. Following self-administration, rats were randomly assigned to an AAA or ABA group for extinction and renewal. For the AAA rats, context was similar to self-administration; for ABA rats, the drug-associated stimuli (peer and house light) were removed (Context B). Following extinction, renewal of cocaine seeking was examined by …

The Effects Of Escalated Fentanyl Intake On Decision-Making Dynamics, Trinity Shaver

Theses and Dissertations--Psychology

Opioid Use Disorder is characterized partially as a decision-making disorder. Decision-making theories, such as habit theory and relative value theory, have aimed to better understand the shift in preference for drug over other alternatives. In order to compare these two contrasting theories, an allomorphic concurrent choice task will run in tandem with an escalation procedure. Male and female Sprague-Dawley rats were tested for choice differences in an allomorphic choice procedure. Reward dimensions, such as relative reward rate, were manipulated within sessions, and magnitude (remifentanil dose), was manipulated between sessions. To study the effects of escalated fentanyl intake on relative valuation, …

Role Of Prior Knowledge In Timing Of Computer-Generated Feedback, Julie Faye Shirah

Theses and Dissertations--Psychology

Although often helpful, feedback sometimes has neutral or negative effects on learning (Hattie & Timperley, 2007; Kluger & DeNisi, 1996). For example, Fyfe and colleagues have found that the effects of feedback timing are moderated by students’ prior knowledge such that feedback has been useful for students with low prior knowledge, but has mixed effects on students with high prior knowledge (e.g., Fyfe et al., 2012; Fyfe, 2016). In this study, I extended Fyfe’s work by re-conceptualizing prior knowledge as knowledge of more familiar foundational concepts a learner brings to a learning task (Sidney & Alibali, 2017), which can be …

The Effects Of Escalated Cocaine Intake On Decision-Making Dynamics, Mcallister Stephens

Theses and Dissertations--Psychology

Cocaine Use Disorder (CUD) is characterized partly by the use of cocaine at the expense of other alternatives, in other words, it is a decision-making pathology (Kalivas & Volkow, 2005). Concurrent choice tasks assess decision-making in a dynamic scenario that more closely resembles real life. Value-based decision-making is an important facet of understanding the addictive properties of drugs of abuse. In order to compare two value-based theories of addiction (habit theory and relative value theory), a concurrent choice task was run in tandem with an escalation procedure. First, animals were trained on a choice task until stable, then trained on …

Pharmacokinetics And Reward-Related Behaviors Of Ethanol In Male And Female Japanese Quail (Coturnix Japonica), Shannon Eaton

Theses and Dissertations--Psychology

Ethanol is one of the most widely used and abused drugs. Problem use is associated with many different health problems and the economic burden is in the billions of dollars. Additionally, many people have difficulty controlling their ethanol consumption and about 5% of adults end up with an alcohol use disorder (AUD). Many people with an AUD often find themselves in a cycle of binge, remission, and relapse.

Following ethanol consumption ethanol enters the bloodstream from the small intestine where it gets distributed to peripheral tissues. Ethanol in the bloodstream is cleared from the system by the liver. The primary …

The Midsession Reversal Task With Pigeons: Effects Of A Brief Delay Between Choice And Reinforcement, Megan Ashley Halloran

Theses and Dissertations--Psychology

During a midsession reversal task, the session begins with a simple simultaneous discrimination in which one stimulus (S1) is correct and the alternate stimulus (S2) is incorrect (S1+/S2-). At the halfway point, the discrimination reverses and S2 becomes the correct choice (S2+/S1-). When choosing optimally, a pigeon should choose S1 until the first trial in which it is not reinforced and then shift to S2 (win-stay/lose-shift). With this task pigeons have been shown to respond suboptimally by anticipating the reversal (anticipatory errors) and continuing to choose S1 after the reversal (perseverative errors). This suboptimal behavior may result from a pigeon’s …

Examining The Utility Of Behavioral Economic Demand In Addiction Science, Justin Charles Strickland

Theses and Dissertations--Psychology

The marriage of perspectives from behavioral economic theory and learning theory has the potential to advance an understanding of substance use and substance use disorder. Behavioral economic demand is a central concept to this interdisciplinary approach. Evaluating demand in the laboratory and clinic can improve previous research on the relative reinforcing effects of drugs by accounting for the multi-dimensional nature of reinforcement rather than viewing reinforcement as a unitary construct. Recent advances in the commodity purchase task methodology have further simplified the measurement of demand values in human participants. This dissertation project presents a programmatic series of studies designed to …

When And Why We Protect Our Honor, Brian Michael Enjaian

Theses and Dissertations--Psychology

Men from a culture of honor often use physical aggression in response to threats as a way of restoring lost honor. Threats can range from being called an offensive name to someone flirting with their romantic partner. On the other hand, women from a culture of honor are expected to be submissive and avoid situations that can result in harm to their reputation. However, a recent meta-analytic review of the literature suggests that women do not always avoid situations that can harm their reputation. Rather, women in a culture of honor also use physical aggression in response to threats. In …

Neurobehavioral Measurements Of Natural And Opioid Reward Value, Aaron Paul Smith

Theses and Dissertations--Psychology

In the last decade, (non)prescription opioid abuse, opioid use disorder (OUD) diagnoses, and opioid-related overdoses have risen and represent a significant public health concern. One method of understanding OUD is as a disorder of choice that requires choosing opioid rewards at the expense of other nondrug rewards. The characterization of OUD as a disorder of choice is important as it implicates decision- making processes as therapeutic targets, such as the valuation of opioid rewards. However, reward-value measurement and interpretation are traditionally different in substance abuse research compared to related fields such as economics, animal behavior, and neuroeconomics and may be …

Measuring Glutamate And Oxygen In Brain Reward Circuits In Animal Models Of Cocaine Abuse And Decision-Making, Seth Richard Batten

Theses and Dissertations--Psychology

Drug-specific reward and associated effects on neural signaling are often studied between subjects, where one group self-administers drug and a separate group self-administers a natural reinforcer. However, exposure to drugs of abuse can cause long-term neural adaptations that can affect how an organism responds to drug reward, natural reward, and their reward-associated stimuli. Thus, to isolate drug-specific effects it is important to use models that expose the same organism to all of the aforementioned. Multiple schedules provide a means of dissociating the rewarding effects of a drug from the rewarding effects of food within a single animal. Further, drug users …

Development Of A Translational Model Of Co-Use Of Alcohol And Nicotine For Testing Potential Pharmacotherapies, Sarah Elizabeth Maggio

Theses and Dissertations--Psychology

Co-users of alcohol and nicotine are the largest group of polysubstance users worldwide. Although pharmacotherapies are available for alcohol (EtOH) or tobacco use disorders individually, it may be possible to develop a single pharmacotherapy to treat heavy drinking tobacco smokers through capitalizing on the commonalities in their mechanisms of action. Towards this goal, several models of concurrent access to EtOH and nicotine were explored as potential preclinical models of co-use using female alcohol-preferring (P) rats. Additionally, potential pharmacotherapeutics for the treatment of EtOH and nicotine co-use disorder were tested using different variations of our model. Treatments tested included (1) varenicline, …

The Self-Reported And Behavioral Effects Of Propylene Glycol And Vegetable Glycerin In Electronic Cigarette Liquids, Arit M. Harvanko

Theses and Dissertations--Psychology

Little is known about how electronic cigarette (EC) users manipulate device parameters, what factors drive their use, and how non-nicotine ingredients influence the stimulus effects of EC aerosols. The ingredients propylene glycol (PG) or vegetable glycerin (VG) serve as the base for virtually all electronic cigarette liquids, and information on how they affect the using experience would provide important groundwork for the study of other ingredients. In this dissertation, results from a survey and laboratory study focused on the stimulus effects of ECs, and the influence of PG and VG, will be discussed. A total of 522 regular EC users …

Alcohol-Induced Impairment Of Simulated Driving Performance And Behavioral Impulsivity In Dui Offenders, Nicholas A. Van Dyke

Theses and Dissertations--Psychology

Licensed drivers arrested for driving under the influence (DUI) of alcohol have increased rates of vehicle crashes, moving violations, traffic tickets, and contribute to an estimated 120 million occurrences of impaired driving per year (Evans, 2004; Jewett et al., 2015). Survey research on DUI offenders indicates traits of impulsivity (e.g., sensation seeking). Together, these pieces of evidence suggest that DUI offenders display patterns of impulsive action and risk-taking while driving. However, to-date DUI offenders are rarely studied in a laboratory setting, and not much is known about how they respond to a dose of alcohol. The present study examined the …

Is Pecking Aversive To A Pigeon Or Is It Only The Delay To Reinforcement?, Danielle M. Andrews

Theses and Dissertations--Psychology

The principle of least effort suggests that animals should minimize effort to reinforcement. Thus, not pecking should be preferred over pecking. However, pigeons often peck when it is allowed but not required (e.g., fixed time schedules) but pecking may be adventitiously reinforced. In the present experiment, to better compare a schedule of reinforcement that requires pecking with one that requires the absence of pecking, we compared a fixed-interval (FI) schedule in which reinforcement follows the first peck after the interval has elapsed and a differential-reinforcement-of-other behavior (DRO) schedule which requires pigeons abstain from pecking for a similar interval. The delay …

Effects Of Social Interaction On Morphine Conditioned Place Preference In Adolescent Male Rats, Virginia G. Weiss

Theses and Dissertations--Psychology

The fact that adolescents commonly initiate drug use in social settings is well established. Both clinical and preclinical research has investigated how social interaction is altered by a variety of drugs of abuse. What is less understood is how the rewarding value of drugs of abuse is affected by the presence of social peers. This dissertation aimed to investigate the interaction of morphine and social play on conditioned place preference (CPP) in adolescent male Sprague Dawley rats, using both behavioral and immunohistochemistry (IHC) methods. Rats were exposed to morphine (0, 1, or 3 mg/kg; s.c.), social interaction, or a combination …

The Influence Of Cocaine-Related Images On Inhibitory Control In Cocaine Users, Erika Pike

Theses and Dissertations--Psychology

Cocaine users display impaired inhibitory control. The influence of cocaine-related stimuli on inhibitory control has not been assessed. The Attentional Bias-Behavioral Activation (ABBA) task uses cocaine and neutral images as cues to determine if drug-related images impair inhibitory control in cocaine users. This dissertation was designed to assess the influence of cocaine images on inhibitory control in cocaine users through the conduct of studies designed to address four aims. The first aim was to demonstrate that cocaine users display impaired inhibitory control following cocaine images compared to neutral images on the ABBA task. This was accomplished through the conduct of …

The Effects Of Alcohol-Related Visual Stimuli On Inhibitory Control And Attentional Bias: Testing The Roles Of Classical Conditioning And Semantic Priming, Ramey G. Monem

Theses and Dissertations--Psychology

Alcohol research has shown that alcohol-related stimuli can disrupt behavioral control and attract more attention in alcohol drinkers. Stimuli typically used in tasks assessing these mechanisms are likely representative of an individual's history. Responses to visual stimuli that no longer closely resemble an individual's history may help shed light on whether these behaviors are due to classical conditioning or processes such as semantic priming. Hypotheses were tested using typical visual stimuli and modified, abstract versions in these tasks. 41 participants were exposed to these stimuli types while using a visual dot probe task. The difference in degree of attentional bias …

Effects Of Headings On Processing Of Audio Texts, Hung-Tao Chen

Theses and Dissertations--Psychology

Text-to-speech devices often do a poor job of translating signals such as headings from visual into audio mode. Previous research studies have attempted to address this problem but these studies have mainly used heading detection tasks. The current study seeks to investigate 1) whether listeners find the presence of audio headings useful in natural learning tasks, and 2) the type of heading rendering that is most useful in natural learning tasks. The three learning tasks in this study include note-taking, cued recall, and knowledge transfer. Results from this study reveal that listeners find audio headings useful in the note-taking task. …

The Behavioral Effects Of First-Generation Electronic Cigarettes After 24-Hour Tobacco Deprivation, Arit M. Harvanko

Theses and Dissertations--Psychology

Little is currently known about the ability of electronic cigarettes to manage tobacco withdrawal symptoms and their abuse liability. In the current study eight conventional cigarette smokers completed nine within-subject study sessions. In the first session participants practiced using an electronic cigarette containing 16 mg/ml of nicotine over six 10-puff bouts. Remaining study sessions were comprised of four two-day blocks (one for each condition), which assessed measures of tobacco withdrawal symptoms and abuse liability following unrestricted cigarette smoking and 24-hour tobacco deprivation. Study conditions included an electronic cigarette with 0, 8, or 16 mg/ml nicotine concentrations, or preferred brand of …

The Balloon Analogue Risk Task And Behavioral Correlates In Pigeons, Aaron P. Smith

Theses and Dissertations--Psychology

Individuals experience risk ubiquitously, but measuring risk taking is difficult. The balloon analogue risk task (BART) was developed in order to assess risk taking through having subjects press a key that accrues reward but also risk losing all reward with each press. In humans, greater responding in this task is associated with other maladaptive risk taking behaviors. The present research modeled this relationship in pigeons due to their previously shown propensity towards risk taking behavior. Experiment 1 used an unsignaled balloon task in which losing could only occur after 5 pecks. Results showed below optimal performance with greater pecks associated …

Acute Effects Of Alcohol On Simulated Driving Performance And Self-Perceptions Of Impairment In Dui Offenders, Nicholas A. Van Dyke

Theses and Dissertations--Psychology

Licensed drivers arrested for driving under the influence (DUI) of alcohol have increased rates of vehicle crashes, moving violations, and traffic tickets (Evans, 2004). To date, no research has examined specific self-regulatory mechanisms of the DUI driver under a dose of alcohol that might underlie risky driving behavior. The present study examined the degree to which DUI drivers display an increased sensitivity to the acute impairing effects of alcohol on driving performance and overestimate their driving fitness following alcohol consumption. Adult drivers with a history of DUI and a demographically-matched group of control drivers without a DUI were tested following …

Does Botox Buffer The Negative Effects Of Social Rejection?: A Test Of The Facial Feedback Hypothesis, Vicki Sharif

Theses and Dissertations--Psychology

Can a common facial cosmetic procedure buffer against the negative impact of adverse social interactions? This pilot tested the hypothesis that an injection of botulinum toxin (Botox) to the corrugator supercilii muscles used in anger, compared to a placebo injection to the same location, will reduce the impact of social rejection on mood, self-esteem, control, meaningful existence, and aggression. Freezing facial musculature was hypothesized to alter the first physical signal of negative emotional reactions, thereby reducing the impact of social rejection on distress and aggression. This was the first study using Botox to examine the effects of reduced facial feedback …

Characterizing Consumption, Dependence, And The Role Of Glucocorticoids In An Animal Model Of Voluntary Ethanol Consumption, Lynda Sharrett-Field

Theses and Dissertations--Psychology

Alcohol abuse disorders (AUD) represent a serious worldwide health problem with far reaching social, financial, and interpersonal implications. One of the most devastating facets of these disorders is the propensity to relapse following periods of abstinence. Ethanol withdrawal (EWD) is believed to promote relapse by increasing anxiety and craving, and may contribute to the development of cognitive decline associated with long-term dependence. Clinical data suggest that stress also plays a main role in both the development of AUD as well as relapse to drinking. As a physiological stressor, EtOH elevates levels of stress hormones (cortisol in humans, corticosterone (CORT) in …