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Full-Text Articles in Experimental Analysis of Behavior
Biobehavioral Predictors Of Cannabis Use In Adolescence, Philip Aaron Spechler
Biobehavioral Predictors Of Cannabis Use In Adolescence, Philip Aaron Spechler
Graduate College Dissertations and Theses
Cannabis use initiated during adolescence may precipitate lasting consequences on the brain and behavioral health of the individual. However, research on the risk factors for cannabis use during adolescence has been largely cross-sectional in design. Despite the few prospective studies, even less is known about the neurobiological predictors. This dissertation improves on the extant literature by leveraging a large longitudinal study to uncover the predictors of cannabis use in adolescent samples collected prior to exposure. All data were drawn from the IMAGEN study and contained a large sample of adolescents studied at age 14 (N=2,224), and followed up at age …
Examining The Roles Of Sex, Methamphetamine, And Degree Of Training In Habit Formation In Rats, Hannah Schoenberg
Examining The Roles Of Sex, Methamphetamine, And Degree Of Training In Habit Formation In Rats, Hannah Schoenberg
Graduate College Dissertations and Theses
Addiction is characterized by a progressive loss of executive control over drug-seeking and consumption, and may be associated with a behavioral shift from instrumental goal-directed actions to stimulus-response habits. Sex differences in drug addiction have been linked to changing hormone levels across the estrous cycle, and females exhibit a particular vulnerability to psychostimulants such as cocaine and amphetamines. Psychostimulants and estrogen both influence dopaminergic activity in the dorsal striatum, a region of the brain in which dopamine activity is thought to mediate the shift from action to habit. In the present set of experiments, we examined the roles of sex, …
Learning Related Regulation Of A Voltage-Gated Ion Channel In The Cerebellum, Jason R. Fuchs
Learning Related Regulation Of A Voltage-Gated Ion Channel In The Cerebellum, Jason R. Fuchs
Graduate College Dissertations and Theses
The neural mechanisms that support learning and memory are still poorly understood. Much work has focused on changes in neurotransmitter receptor expression, while changes in voltage-gated ion channel expression have been largely unexplored, despite the fact that voltage-gated ion channels govern neuronal excitability. Here we used eyeblink conditioning (EBC) in rats, a model of learning and memory with a well-understood neural circuit, to examine regulation of voltage-gated ion channels as a consequence of learning. EBC is a form of classical conditioning that involves pairings of a behaviorally neutral conditioned stimulus (CS) and an eyeblink eliciting unconditioned stimulus (US) over many …