Experimental Analysis of Behavior Commons^™

Motivational And Physiological Dysregulation Due To Development And Onset Of Obesity Via Melanocortin 4 Receptor +/- Haploinsufficiency, Alex Steiner

Theses and Dissertations

Obesity is one of the leading most health risks around the world, being especially problematic in the United States. A combination of high-fat diets and genetic abnormalities are to blame for the ever-growing number of obese individuals.

Melanocortin 4 receptors are vital for regulating energy expenditure and feeding behaviors; mutations of the receptors have been found to be the leading monogenetic cause of obesity. Using MC4R +/- haploinsufficient rats being fed a range of dietary fat, we investigated the physiological and motivational differences using a locomotor task, an operant task with fixed and progressive ratios, as well as a distraction …

Alterations To Taste Preference In Mc4r Haploinsufficiency Manifest Prior To Dietary Induced Obesity And Are Accompanied By Dendritic Spine Alterations To Medium Spiny Neurons Of The Nucleus Accumbens In Adulthood, Robert Francis Roscoe Jr.

Theses and Dissertations

Obesity has reached epidemic proportions in the United States and has become an increasing public health concern for developed nations. Haploinsufficiency of melanocortin receptor 4 has been identified as the single most common monogenetic cause of obesity in humans. Using the MC4R +/- haploinsufficient rat, we sought to determine potential alterations in body weight and morphology, locomotor activity, sucrose concentration preference, and progressive-ratio operant testing in a dietary-induced obesity environment. Rats were placed on four separate diets corresponding to 1.7% saturated fat with 12.2% total kcal/fat, 6% saturated fat with a 40% total kcal/fat, 12% saturated fat with a 40% …