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Development Of A Translational Model Of Co-Use Of Alcohol And Nicotine For Testing Potential Pharmacotherapies, Sarah Elizabeth Maggio
Development Of A Translational Model Of Co-Use Of Alcohol And Nicotine For Testing Potential Pharmacotherapies, Sarah Elizabeth Maggio
Theses and Dissertations--Psychology
Co-users of alcohol and nicotine are the largest group of polysubstance users worldwide. Although pharmacotherapies are available for alcohol (EtOH) or tobacco use disorders individually, it may be possible to develop a single pharmacotherapy to treat heavy drinking tobacco smokers through capitalizing on the commonalities in their mechanisms of action. Towards this goal, several models of concurrent access to EtOH and nicotine were explored as potential preclinical models of co-use using female alcohol-preferring (P) rats. Additionally, potential pharmacotherapeutics for the treatment of EtOH and nicotine co-use disorder were tested using different variations of our model. Treatments tested included (1) varenicline, …
The Self-Reported And Behavioral Effects Of Propylene Glycol And Vegetable Glycerin In Electronic Cigarette Liquids, Arit M. Harvanko
The Self-Reported And Behavioral Effects Of Propylene Glycol And Vegetable Glycerin In Electronic Cigarette Liquids, Arit M. Harvanko
Theses and Dissertations--Psychology
Little is known about how electronic cigarette (EC) users manipulate device parameters, what factors drive their use, and how non-nicotine ingredients influence the stimulus effects of EC aerosols. The ingredients propylene glycol (PG) or vegetable glycerin (VG) serve as the base for virtually all electronic cigarette liquids, and information on how they affect the using experience would provide important groundwork for the study of other ingredients. In this dissertation, results from a survey and laboratory study focused on the stimulus effects of ECs, and the influence of PG and VG, will be discussed. A total of 522 regular EC users …
The Behavioral Effects Of First-Generation Electronic Cigarettes After 24-Hour Tobacco Deprivation, Arit M. Harvanko
The Behavioral Effects Of First-Generation Electronic Cigarettes After 24-Hour Tobacco Deprivation, Arit M. Harvanko
Theses and Dissertations--Psychology
Little is currently known about the ability of electronic cigarettes to manage tobacco withdrawal symptoms and their abuse liability. In the current study eight conventional cigarette smokers completed nine within-subject study sessions. In the first session participants practiced using an electronic cigarette containing 16 mg/ml of nicotine over six 10-puff bouts. Remaining study sessions were comprised of four two-day blocks (one for each condition), which assessed measures of tobacco withdrawal symptoms and abuse liability following unrestricted cigarette smoking and 24-hour tobacco deprivation. Study conditions included an electronic cigarette with 0, 8, or 16 mg/ml nicotine concentrations, or preferred brand of …