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Experimental Analysis of Behavior Commons™
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Full-Text Articles in Experimental Analysis of Behavior
Sucrose Demand And Essential Value In Mice With Early-Life Exposure To Risperidone, Megan Federoff
Sucrose Demand And Essential Value In Mice With Early-Life Exposure To Risperidone, Megan Federoff
LSU Master's Theses
Second-generation antipsychotics (SGAs), such as risperidone, are widely prescribed to children, but the long-term effects of SGA treatment are not well understood. This study investigated the impact of early-life risperidone treatment on sucrose demand in mice in adulthood. Mice were administered risperidone or vehicle from postnatal day (PND) 33 to 60 and trained in adulthood (>PND 120) to nose poke for a sucrose solution reinforcer. The fixed ratio (FR) value (the number of responses required to produce sucrose delivery; the “price” of sucrose) was varied from 1 to 45, and the resulting consumption versus FR value data were analyzed …
Does Chronic Risperidone Administration Affect Food Reinforcement In Adulthood In Mice?, Francis Torres, Paul Soto
Does Chronic Risperidone Administration Affect Food Reinforcement In Adulthood In Mice?, Francis Torres, Paul Soto
LSU Master's Theses
Second-generation antipsychotics (SGAs) increase weight gain and food consumption in humans and non-human animals. It has been speculated that SGAs increase the reinforcing effects of food, which increases food consumption and drives weight gain. The current study evaluated the effects of risperidone on sucrose reinforcement in male and female C57BL/6J mice using economic demand assessments. Demand for sucrose was measured by varying the fixed ratio (FR) value required to produce sucrose delivery across experimental sessions using five FR values: 1, 5, 15, 30, and 45. The effects of acute risperidone administration on demand for sucrose were first assessed by orally …