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Full-Text Articles in Experimental Analysis of Behavior
S-Equol: A Novel Therapeutic For Hiv-1 Induced Gut Dysbiosis, Mason T. Rodriguez
S-Equol: A Novel Therapeutic For Hiv-1 Induced Gut Dysbiosis, Mason T. Rodriguez
Theses and Dissertations
HIV-1 infection affects approximately 38 million people around the world. The advent of cART has greatly improved the quality of life of infected individuals; however, roughly 50% of these individuals will still experience HIV-1 associated neurocognitive disorders (HAND). Additionally, the gut microbiome has been reported to be dysbiotic in HIV-1 infected individuals, regardless of adherence to cART. Current research has pointed to the gut-brain-microbiota axis as a potential target to treat both cognitive deficits and microbial changes. The present study investigated S-equol (SE) as a potential therapeutic for HAND by modulating the gut microbiome. The study included 21 HIV-1 Tg …
Escitalopram Treatment To The Hiv-1 Transgenic Rat: Spine Dynamics, Telomere Quantification And Neurogenesis, Adam Ray Denton
Escitalopram Treatment To The Hiv-1 Transgenic Rat: Spine Dynamics, Telomere Quantification And Neurogenesis, Adam Ray Denton
Theses and Dissertations
HIV is a serious viral infection that persists in the brain despite treatment. Approximately half of all seropositive patients will experience some degree of comorbid depression, as well as HIV associated neurocognitive disorders. The present research sought to evaluate the therapeutic efficacy of escitalopram, a selective serotonin reuptake inhibitor in ameliorating neuroanatomical and biochemical markers associated with HIV infection. The central purpose of this research is to characterize the effects of escitalopram treatment upon dendritic spine proliferation in the nucleus accumbens. Previous research has consistently demonstrated impaired synaptodendritic integrity in this region, with underlying mechanisms remaining unclear. A secondary focus …
Application Of The “Idisco” Full-Brain Tissue Clearing Method: A View Of Dopamine And Inflammation In The Hiv-1 Transgenic Rat, Kristin Nickole Kirchner
Application Of The “Idisco” Full-Brain Tissue Clearing Method: A View Of Dopamine And Inflammation In The Hiv-1 Transgenic Rat, Kristin Nickole Kirchner
Theses and Dissertations
The iDISCO (immunolabeling-enabled three-dimensional imaging of solvent-cleared organs) method is a quick, inexpensive, and easily adaptable tissue staining and clearing procedure that allows neuroscientists to study a protein of interest in a whole, unaltered tissue sample. While the iDISCO method was initially tested and validated for mice embryos and brains, the current experiment sought to adapt the method for use in the rat using HIV-1 transgenic (Tg) rat brain tissue. Antibodies for tyrosine hydroxylase and Iba-1 were validated in the HIV-1 Tg rat and in F344/N control rats using iDISCO. Confocal images were taken of tyrosine hydroxylase positive neurons in …
Behavioral And Voltammetric Analysis Of Chronic Escitalopram Treatment To The Hiv-1 Transgenic Rat: Implications For Comorbid Hiv-1 And Clinical Depression, Adam R. Denton
Theses and Dissertations
HIV-1 infection is a serious condition affecting approximately 37 million individuals. Between 30% and 60% of seropositive individuals will develop symptoms of clinical depression. These individuals are five times more likely to commit suicide than non-seropositive clinically depressed patients. Dysfunction in serotonergic and dopaminergic transmission has consistently been implicated in the pathogenesis of depression. Specifically, dysfunction in the prefrontal cortex and in the nucleus accumbens core region have been shown to be underlying factors in the trajectory of depression. Given these underlying neurological features, the present research employed behavioral testing and electrochemical recording in an attempt to elucidate the therapeutic …