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Experimental Analysis of Behavior Commons™
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Full-Text Articles in Experimental Analysis of Behavior
Nmda Receptor Blockade Specifically Impedes The Acquisition Of Incentive Salience Attribution, Jonathan J. Chow, Joshua S. Beckmann
Nmda Receptor Blockade Specifically Impedes The Acquisition Of Incentive Salience Attribution, Jonathan J. Chow, Joshua S. Beckmann
Psychology Faculty Publications
Glutamatergic signaling plays an important role in learning and memory. Using Pavlovian conditioned approach procedures, the mechanisms that drive stimulus-reward learning and memory have been investigated. However, there are instances where reward-predictive stimuli can function beyond being solely predictive and can be attributed with “motivational value” or incentive salience. Using a Pavlovian conditioned approach procedure consisting of two different but equally predictive stimuli (lever vs. tone) we investigated the role NMDA receptor function has in the attribution of incentive salience. The results revealed that the administration of MK-801, an NMDA receptor antagonist, during acquisition of Pavlovian conditioned approach promoted goal-tracking …
Effects Of Social Interaction On Morphine Conditioned Place Preference In Adolescent Male Rats, Virginia G. Weiss
Effects Of Social Interaction On Morphine Conditioned Place Preference In Adolescent Male Rats, Virginia G. Weiss
Theses and Dissertations--Psychology
The fact that adolescents commonly initiate drug use in social settings is well established. Both clinical and preclinical research has investigated how social interaction is altered by a variety of drugs of abuse. What is less understood is how the rewarding value of drugs of abuse is affected by the presence of social peers. This dissertation aimed to investigate the interaction of morphine and social play on conditioned place preference (CPP) in adolescent male Sprague Dawley rats, using both behavioral and immunohistochemistry (IHC) methods. Rats were exposed to morphine (0, 1, or 3 mg/kg; s.c.), social interaction, or a combination …