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Articles 1 - 2 of 2
Full-Text Articles in Experimental Analysis of Behavior
Does Chronic Risperidone Administration Affect Food Reinforcement In Adulthood In Mice?, Francis Torres, Paul Soto
Does Chronic Risperidone Administration Affect Food Reinforcement In Adulthood In Mice?, Francis Torres, Paul Soto
LSU Master's Theses
Second-generation antipsychotics (SGAs) increase weight gain and food consumption in humans and non-human animals. It has been speculated that SGAs increase the reinforcing effects of food, which increases food consumption and drives weight gain. The current study evaluated the effects of risperidone on sucrose reinforcement in male and female C57BL/6J mice using economic demand assessments. Demand for sucrose was measured by varying the fixed ratio (FR) value required to produce sucrose delivery across experimental sessions using five FR values: 1, 5, 15, 30, and 45. The effects of acute risperidone administration on demand for sucrose were first assessed by orally …
Evaluation Of Hippocampal Allostatic Load-Associated Factors In Animal Models Of Post-Traumatic Stress Disorder: Relevance To Human Ptsd, Dennis Parker Kelley
Evaluation Of Hippocampal Allostatic Load-Associated Factors In Animal Models Of Post-Traumatic Stress Disorder: Relevance To Human Ptsd, Dennis Parker Kelley
LSU Doctoral Dissertations
Post-traumatic stress disorder (PTSD) is associated with elevated allostatic load, nearly double the risk for metabolic syndrome, reduced hippocampal volume, and contextual memory processing deficits. Emerging evidence suggests that these stress effects may predispose individuals to the development of PTSD, and there is a known relationship between chronic stress and metabolic dysfunction. In this work, we utilized two rat models of PTSD to explore these connections. We used an acute predator odor stressor to investigate the relationship between PTSD-like behaviors and mitochondrial dysfunction in the hippocampus of rats, and we observed that conditioned place avoidance was associated with reduced mitochondrial …