Experimental Analysis of Behavior Commons^™

Assessment And Classification Of Idiosyncratic Behavioral Sequences In Rodent Navigation, Max G. Segal

Psychology ETDs

The Morris Water Task (MWT) has been the gold standard assessment of place learning and memory for over four decades, yet the processes that contribute to successful navigation are not completely understood. It is generally posited that rats learn to navigate directly to a place; however, navigation is not perfectly direct but contains variation in swim speed and trajectory resulting in efficient, yet suboptimal paths. Gonçalves-Garcia et al. (2024) demonstrated that path topography is quantitatively similar across trials within individual rats for a given start location, and dissimilar between rats and different start locations within rat. This suggests rats may …

Rhythms Of Hippocampal Function And Memory After Moderate Prenatal Alcohol Exposure, Lilliana May Sanchez

Psychology ETDs

Fetal Alcohol Spectrum Disorders involve morphologic and neurobiological abnormalities in offspring subjected to prenatal alcohol exposure. Although not as well studied as high exposure, moderate prenatal alcohol exposure represents the most common and undetected form in humans. While learning and memory deficits have been well characterized at the behavioral level in humans with Fetal Alcohol Spectrum Disorders and in animal models of moderate prenatal alcohol exposure, few studies have determined the circuit or systems level mechanisms of the behavioral deficits. A complete understanding of the neural bases of memory deficits after moderate prenatal alcohol exposure is needed to ultimately identify …

The Evolution Of Self-Awareness In Conscious Organisms, Robert A. Dielenberg

Journal of Conscious Evolution

Self-awareness in conscious organisms remains an enduring puzzle for philosophers and neuroscientists. This paper proposes a tripartite evolutionary model tracing its emergence through three sequential types: the sensory self (primitive egocentric, valence-tagged awareness of sensory states), the bodily self (external objectification of the body as a distinct entity, evidenced by mirror self-recognition in select species), and the cognitive self (internal objectification of the mind enabling recursive self-transformation). Adopting a monist framework, the model treats consciousness as the biological substrate of delayed neural apperception (the “Delayed Present”), within which selves emerge as increasingly sophisticated models. It distinguishes non-human metacognition—implicit, online regulation—from …

Investigating The Relationship Between Noun Classes And Plant Folk Taxonomy In Chasu Language Of Kilimanjaro Region In Tanzania, Peter Rabson Mziray

Journal of Humanities and Social Sciences

The current study investigates the relationship between noun classes and plant folk taxonomy in Chasu (G 22). The study focuses on two objectives: the first objective is to describe the plant folk taxonomy in Chasu and the second objective is to determine the relationship between noun classes and plant folk taxonomy in Chasu. Data were collected from rural villages in Same and Mwanga districts by using free listing, field interviews (jungle-walk-and-identify), and written texts containing Chasu plant names. The findings reveal that Chasu folk taxonomy reflects different ethnobotanical categories; including a unique beginner which is mmea/mimea ‘plant(s)’, and three life …

Investigating Prefrontal Cortex Neuronal Signatures Of Opioid-Induced Risk-Taking Behavior, Cana Quave

Dissertations and Theses (Open Access)

Opioid use disorder occurs alongside impaired risk-related decision-making, but the underlying neural correlates are unclear. We developed an approach-avoidance conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the saline-exposed control group avoided cat odor, the morphine group included two subsets of rats that either maintained a preference for the paired side despite the presence of …

Effects Of Perinatal Exposure To Lipopolysaccharide And Acetaminophen On Learning In Adult Long-Evans Rats, Lucy A. Sivils

College of Graduate Studies: Theses & Dissertations

The present study investigated the individual and combined effects of elevated perinatal inflammation, oxidative stress caused by acetaminophen (APAP) exposure, or elevated inflammation and oxidative stress on adult learning behaviors in Long-Evans rats. While prior studies have examined these factors independently, the combined effects of inflammation and oxidative stress via APAP exposure during early development on learning-related behaviors remain unexplored. The present research aimed to address this gap by the analysis of potential long-term neurodevelopmental consequences of lipopolysaccharide (LPS)-induced inflammation and APAP-induced oxidative stress. LPS, APAP, or LPS + APAP was administered during the perinatal period: postnatal days (PD) 9, …

The Role Of The Individual In Animal Collectives, Tanya T. Shoot

Theses and Dissertations (Comprehensive)

Animals form groups for a variety of reasons, primarily as a way to increase access to food, mates, and safety. An important attribute of these groups is their personality composition. Personality is defined as repeatable traits over time and context, and has been found across multiple taxa. Traits have been found to be heritable, and are thus a unit for natural selection to act upon. Having a heterogeneous group may be beneficial for survival in a changing environment. The question of how the personality composition of the group affects group behaviour has rarely been asked in the field of animal …

Terpenes Mitigate Thc-Induced Working Memory Deficits: Behavioural Evidence Of The Entourage Effect Using A 2-Component Operant Memory Task, Lara Mitchell

Theses and Dissertations (Comprehensive)

Most research on cannabis and cognitive function has focused on delta-9-tetrahydrocannabinol (THC). However, this approach overlooks the complex chemical composition of cannabis products consumed by the public, which often includes cannabidiol (CBD) and various terpenes. These additional constituents may interact with THC to modulate its effects, a phenomenon known as the entourage effect. While this theory has gained traction, experimental evidence for the cognitive impact of terpenes in combination with THC remains limited. This study aimed to assess whether terpenes can mitigate THC-induced cognitive deficits using a 2-Component Operant Memory task. Male Sprague-Dawley rats received intraperitoneal injections of either …

Extinction Bursts Reexamined: The Role Of Consummatory Time And Response Reallocation, Braden Toler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Two experiments were conducted to examine how the removal of the opportunity to consume reinforcement and the reallocation of that time might account for extinction bursts during within-session transitions from FR 1 to extinction. In Experiment 1, rats and pigeons were trained under FR 1 schedules and subsequently exposed to within-session extinction. Total counts of responses suggested that extinction bursts occurred for each subject, but when adjusted to exclude responses that would have overlapped with food consumption, no bursts were observed. In Experiment 2, pigeons experienced four extinction arrangements: conventional extinction, response-independent reinforcement, conditioned reinforcement, and differential reinforcement of alternative …

Opioid System's Potential Involvement In Ketamine's Cognitive And Antidepressant-Like Effects In Rats, Fan Zhang

Theses and Dissertations

Depression stands as one of the most pervasive mental health challenges worldwide, including the United States. Conventional antidepressants typically display a delayed onset of therapeutic action (4-8 weeks) and lack efficacy in a substantial portion of patients (over 40% of depressed patients are treatment-resistant). The dissociative anesthetic ketamine, which is a glutamatergic N-methyl-D-aspartate (NMDA) antagonist, has emerged as a promising novel treatment due to its rapid and prolonged antidepressant effects, and it is especially beneficial for treatment-resistant depression. Nevertheless, the precise neurochemical mechanisms underlying ketamine’s antidepressant properties remain elusive, hampering the development of safer and more efficacious treatments. The present …

Repeated Treatment With 5-Ht1a And 5-Ht1b Receptor Agonists: Evidence Of Tolerance And Behavioral Sensitization, Jordan Taylor

Electronic Theses, Projects, and Dissertations

Serotonin has been found to regulate several cognitive and physiological functions, and its role in depression and other neuropsychiatric disorders has been a focus of research. More specifically, a wealth of research regarding serotonin focuses on serotonergic medications in the treatment of neuropsychiatric disorders, such as depression and anxiety, and stimulates the 5-HT_1A and 5-HT_1B receptors. Within the last decade, there has been an increase in prescriptions of psychotropic medication for children, however, the efficacy and adverse effects of these drugs have not been evaluated in younger populations. While antidepressants reduce symptoms of depression in adults, they are …

Intermittent Sucrose Access: Sweetness Versus Calories, Jarret Folmer, Rudy Eikelboom

Theses and Dissertations (Comprehensive)

Nondeprived rats receiving every 3^rd day access (E3DA) to 4% sucrose solution consume more sucrose on access days compared to rats with everyday access (EDA). Rats receiving EDA or E3DA to 16% sucrose do not consume different amounts, but if placed on every 2^nd day access (E2DA) to 4% sucrose E3DA-group rats consume more than EDA rats (Eikelboom, Hewitt, & Adams, 2022). E3DA affects rats’ value of sucrose but effects appear hidden with high sucrose concentrations. Valyear and Eikelboom (2021) suggested that calorie ceilings limit E3DA-induced consumption with high sucrose, but this ceiling could also be caused by …

The Effects Of Overshadowing In Drosophila Melanogaster With Experimentally Evolved Preference, Jill Lee

Theses

As seen in decades of psychology research, preferences play a major role in driving the decision-making process in both humans and animals. Researchers have advocated for using the technique of experimental evolution as a way to address some of the foundational questions on preferences. These preferences can also affect what is later learned and how well new experiences are learned. Salience is usually mentioned as an important component of what could influence preferences. Animals such as Drosophila melanogaster, that lay eggs without any additional maternal or paternal care, it is important to be selective when deciding where to lay …

Simulated Owl Predation During Foraging Differentially Alters Choice And Fear Behavior Between Sex In Rats, Meghan M. Olsen

Research Psychology Theses

Existing research on the predator cue circuit has indicated there are observed differences between sexes of animals either directly or indirectly exposed to a predator stimulus. Exposure increases predator directed attention, and overrides other motivational systems (hunger, pain, reproductive behavior). Little research has explored whether exposure to predation is associated with differential responses to non-predator related decision-making across a variety of tasks. Therefore, understanding the prioritization of motivational states when a predator stressor is present can aid in understanding sex differences in these processes in both adaptative and maladaptive conditions. To determine how repeated exposure to a predator stressor differentially …

Evaluation Of Hippocampal Allostatic Load-Associated Factors In Animal Models Of Post-Traumatic Stress Disorder: Relevance To Human Ptsd, Dennis Parker Kelley

LSU Doctoral Dissertations

Post-traumatic stress disorder (PTSD) is associated with elevated allostatic load, nearly double the risk for metabolic syndrome, reduced hippocampal volume, and contextual memory processing deficits. Emerging evidence suggests that these stress effects may predispose individuals to the development of PTSD, and there is a known relationship between chronic stress and metabolic dysfunction. In this work, we utilized two rat models of PTSD to explore these connections. We used an acute predator odor stressor to investigate the relationship between PTSD-like behaviors and mitochondrial dysfunction in the hippocampus of rats, and we observed that conditioned place avoidance was associated with reduced mitochondrial …

The Effects Of Venlafaxine And Voluntary Exercise On Chronic Unpredictable Stress Induced Anxiety, Marly Mcgowan

Senior Independent Study Theses

Anxiety disorders can impair cognition and emotional control, particularly in the face of novel situations, which is concerning due to the high prevalence of such diagnoses. Exposure to unpredictable chronic stress can provide a way to induce anxiety-like behaviors in rodents by disrupting the stress response systems, including the HPA axis and autonomic nervous system. Pharmacological treatments, including SNRIs like venlafaxine, and voluntary exercise are both anxiolytic treatments that can alleviate the impacts of chronic stress. Using unpredictable chronic stress to mimic the human condition, and exposure to venlafaxine and exercise to mitigate the stress, the open field and elevated …

A Monte Carlo Simulation Of Rat Choice Behavior With Interdependent Outcomes, Michelle A. Frankot

Graduate Theses, Dissertations, and Problem Reports (ETD)

Preclinical behavioral neuroscience often uses choice paradigms to capture psychiatric symptoms. In particular, the subfield of operant research produces nested datasets with many discrete choices in a session. The standard analytic practice is to aggregate choice into a continuous variable and analyze using ANOVA or linear regression. However, choice data often have multiple interdependent outcomes of interest, violating an assumption of general linear models. The aim of the current study was to quantify the accuracy of linear mixed-effects regression (LMER) for analyzing data from a 4-choice operant task called the Rodent Gambling Task (RGT), which measures decision-making in the context …

Pushing It To The Limit: Determining Asian Elephant (Elephas Maximus) Olfactory Sensitivity And Discrimination Through A Behavioral Choice Task, Matthew S. Rudolph

Theses and Dissertations

Elephants have shown remarkable olfactory capabilities. Their sense of smell impacts their foraging choices, behavior, and ultimately, survival. Being able to detect a target odor can allow elephants to locate specific resources, identify threats, and find receptive conspecifics. Previous studies have shown that elephants can consistently detect target odors, but have not identified the limits of this detection. Thus, to investigate the extent of elephants’ odor detection capabilities, we tested Asian elephants in a two-step odor discrimination task. First, we investigated whether elephants could detect odors at varying levels of dilution after a training procedure, and then whether they could …

Sugar Glider (Petaurus Breviceps) Behavior In Red Vs Blue Lighting, Elisa Hillman

Honors Thesis

Sugar gliders are an exotic pet that is increasing in popularity in households as well as in zoos. One challenge that caregivers have to manage is their nocturnal circadian rhythm. In order for people to view or interact with sugar gliders during their active time, many zoos will reverse their diurnal cycle with lights. The discovery of intrinsically photosensitive retinal ganglion cells (ipRGCs) which seems to have an increased sensitivity to blue light and how these cells affect the hypothalamic suprachiasmatic nucleus (SCN) and circadian rhythm has led to an increase in awareness on the health effects of being exposed …

Jackpot Reinforcers And The Operant Behavior Of Siamese Fighting Fish (Betta Splendens), Jackson Carter Fox

Capstones and Honors Theses

Jackpot reinforcers are an intriguing yet seldom studied area of operant conditioning with many potential applications in the scope of behavioral research. In this study, two Siamese fighting fish (Betta s.) were presented with the visual stimulus of a mirror upon completion of a target response, providing the opportunity to display an agonistic behavior towards their own mirror image. This opportunity for agonistic display to the mirror served as the primary reinforcer of the target response, which was simply swimming in a particular direction over a bar suspended in the center of the tank. This over-the-bar swimming was …

Corticostriatal Pathway Inactivation And Connections To Associative Learning With Nicotine Stimulus In Rats, Anna Kalinowski

Honors Theses and Capstones

The main concern of this study is looking into the neural mechanisms of associative learning with a nicotine stimulus. The goal of this study was to find out if inactivating the corticostriatal pathway through DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) inhibited goal-tracking behavior in rats. In this experiment, rats underwent two surgeries. One was to inject DREADDs into the infralimbic cortex and the other in the dorsomedial caudate-putamen (dmCPu). Rats were initially trained on levers through water deprivation. Once they reached the criterion, they moved on to the self-administration phase. After the rats were trained in self-administration sessions …

Variation In Personality Among Semi-Wild Myanmar Timber Elephants, Sateesh Venkatesh

Theses and Dissertations

This study examines two personality traits: exploration and neophobia, which could influence human-elephant conflicts. Thirty-one semi-wild elephants were tested over two trials using a custom novel puzzle tube containing three tasks and three rewards. Our studies show that elephants do vary significantly between individuals in both exploration and neophobia.

Using Object-Choice Tasks To Investigate Sensory Perception In Sunda Pangolins (Manis Javanica), Joshua Dipaola

Theses and Dissertations

Pangolins are one of the most heavily poached, yet least understood mammals in the world. In this study, we used an object-choice task to assess the ecological relevance and use of sensory information in Sunda pangolin foraging behavior. This is the first controlled experiment on pangolin behavior to our knowledge.

The Maze Of Personality: Latency And Electric Organ Discharge In A Mormyrid Fish, Gnathonemus Petersii Gunther 1862 (Mormyridae, Teleostei), Abbey C. Lipe

Theses and Dissertations

Personality is individual differences in behavior, consistent across contexts. Among Gnathonemus petersii we investigated, we hypothesized that fish could be grouped by: (1) slow/fast maze performance, (2) low/high electric frequencies, (3) correlated latency and frequency. Our first two hypothesis were not supported. Our third hypothesis was partially supported.

130— Reducing Stereotypic Behavior With A Ketogenic Diet, Anna Beltramini, Andrew Guido, Alicia Bauers, Joe Spano

GREAT Day Posters

Now a popular fad diet, the ketogenic diet (KD) is a high-fat, low-carb diet that for decades has been used for treatment of intractable epilepsy. Recent therapeutic applications of KD in animal models include treatment of dementia, obsessive-compulsive disorder, and autism. These disorders are associated with stereotypic behaviors (repetitive, invariant behaviors with no apparent function) that are life-impairing and stigmatizing. However, little is known about their underlying mechanisms and no effective pharmacological treatments are available. Here, we present a novel application of KD to reduce stereotypic behavior in an inbred strain of mice (FVBN/J) that displays a prominent repetitive circling …

The Midsession Reversal Task With Pigeons: Effects Of A Brief Delay Between Choice And Reinforcement, Megan Ashley Halloran

Theses and Dissertations--Psychology

During a midsession reversal task, the session begins with a simple simultaneous discrimination in which one stimulus (S1) is correct and the alternate stimulus (S2) is incorrect (S1+/S2-). At the halfway point, the discrimination reverses and S2 becomes the correct choice (S2+/S1-). When choosing optimally, a pigeon should choose S1 until the first trial in which it is not reinforced and then shift to S2 (win-stay/lose-shift). With this task pigeons have been shown to respond suboptimally by anticipating the reversal (anticipatory errors) and continuing to choose S1 after the reversal (perseverative errors). This suboptimal behavior may result from a pigeon’s …

Behavioural Risks In Female Dogs With Minimal Lifetime Exposure To Gonadal Hormones, Melissa J. Starling, Anne Fawcett, Bethany Wilson, James Serpell, Paul Mcgreevy

Physiology Collection

Spaying of female dogs is a widespread practice, performed primarily for population control. While the consequences of early spaying for health are still being debated, the consequences for behaviour are believed to be negligible. The current study focused on the reported behaviour of 8981 female dogs spayed before 520 weeks (ten years) of life for reasons other than behavioural management, and calculated their percentage lifetime exposure to gonadal hormones (PLGH) as a proportion of their age at the time of being reported to the online Canine Behavioral Assessment and Research Questionnaire (C-BARQ). We found that 23 behaviours differed between entire …

Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander

All NMU Master's Theses

This study attempted to further explore the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to discriminate 1.25 mg/kg clozapine from vehicle were able to acquire the discrimination in 19.1 sessions. The clozapine cue partially generalized (63.13% drug lever responding [SEM = ± 18.91]) to the antimalarial drug methylene blue at the 7.5 mg/kg dose, but not to the antimalarial quinacrine. …

Its Skin Is My Skin, Bryan Page

Graduate School of Art Theses

This text examines the complexity of attempting to empathize with bodies that are vastly othered from my own. This broad yet nuanced subject crosses epistemological boundaries and complicates the dualities between both the mind and body, and between the corporeal and the virtual. My desire to better understand the conditions of another’s experience originates from a painful traumatic loss which caused me to feel isolated and incomplete. In response to this suffering, I long to emotionally connect with other beings and create artwork that attempts to bridge the qualia of individual experience.

I am interested in the capacity (or lack …

Bottlenose Dolphin (Tursiops Truncatus) Vocal Responses To Sonar And Spectrally Pink Background Noise, Maria Zapetis

Dissertations

As human populations rise, the level of man-made noise increases globally. Naval sonar and boat traffic are underwater sound sources of particular concern to marine mammal welfare. To better understand the impact of these noise increases on cetaceans, studies can explore animals’ behavioral changes in response to noise. Studies have investigated the ‘dose-response’ relationship between the received sound pressure level of sonar signals and the behavior of cetaceans in the wild, but exposure studies in controlled environments are limited. The studies in this dissertation examined bottlenose dolphin vocal modifications during various experimental noise treatments. Acoustic recordings previously obtained for bottlenose …