Developmental Psychology Commons^™

Diagnosis And Treatment Of Trauma In Adolescents: A Doctoral-Level Clinical Psychology Course, Jasmine M. Cervantes

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Adolescent trauma is a significant mental health concern that can profoundly disrupt emotional, cognitive, social, and developmental functioning. Although evidence-based interventions for adolescent trauma are well established, doctoral-level psychology training programs may provide limited instruction focused specifically on the unique developmental, cultural, and clinical considerations required when treating traumatized adolescents. This paper presents the development of a ten-week doctoral-level elective course designed to address this gap in clinical training. The curriculum provides foundational knowledge regarding the prevalence, developmental impact, diagnosis, and treatment of adolescent trauma, with an emphasis on posttraumatic stress disorder (PTSD) and complex posttraumatic stress disorder (CPTSD). Students …

Promoting Developmentally Informed Justice: A Developmental Assessment Referral Framework For Juvenile Transfer Decisions, Carly F. Colman

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The transfer of youth between juvenile courts and adult courts is one of the most consequential decisions made in the American legal system, as it will influence the youth’s legal outcomes, developmental trajectories, and long-term well-being. Advances in adolescent brain science show that there are many factors associated with youthful offending, including developmental immaturity, susceptibility to external influences, and ongoing neurobiological development—all of which are related to age, rather than being fixed criminal traits. Despite this growing body of evidence, legal decision-making in juvenile transfer and sentencing does not consistently incorporate individualized developmental data. This paper examines the important role …

Infant Hippocampal And Amygdala Volume In An Observational Follow-Up From A Randomized Clinical Trial For Maternal Prenatal Depression, Catherine H. Demers, Benjamin L. Hankin, Lillybelle K. Deer, Robert J. Gallop, Mercedes Hoeflich Haase, M. Camille Hoffman, Martin A. Styner, Nancy K. Grote, Elysia Poggi Davis

Psychology: Data Sets

Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. In an observational follow-up of a randomized clinical trial of a prenatal depression intervention (the CARE Project; ClinicalTrials.gov NCT03011801), brain development and subsequent negative emotionality were examined among 109 infants born to mothers randomized during pregnancy to brief interpersonal psychotherapy or enhanced usual care. These data include MRI-derived hippocampal and amygdala volumes at approximately 6 weeks of age and a laboratory-based assessment of infant negative emotionality at 6 months.

Resulting Publication: Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial …

Mothers’ Childhood Maltreatment And Developmentally Appropriate Attributions Of 12-Month-Old Infants, Katelyn M. Lamberton

Undergraduate Theses, Capstones, and Recitals

This study examined associations between developmentally appropriate attributions (DAAs), an understudied construct, with maternal history of childhood maltreatment and maternal reflective functioning (RF) with their 12-month-old infants. The study examined if 1) DAAs at 12 months were concurrently associated with parental RF at 12 months for construct validity, and 2) higher levels of maternal childhood maltreatment were associated with lower DAAs for predictive validity. Participants were 156 mothers (40.0% White, 25.5% Latinx, 14.9% Black, 5.5% Asian, 2.1% Native-American, 12.0% biracial/multiracial) and their 12- to 15-month infants. Childhood maltreatment and RF were assessed by parental self-report at three-months and 12-months postpartum …

Lost In Loss: A Supportive Handbook For Teens Grieving The Suicide Of A Loved One, Gabriella Potter

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Adolescence is a complex developmental time. For adolescents grieving a suicide death, there can be added layers of complexity in navigating this developmental period, due to unique challenges and stigma, family disruption, trauma, unanswerable questions, feelings of rejection, abandonment, responsibility, and anger that can result from a suicide death loss. Through a literature review of the available research on adolescent suicide bereavement, this doctoral paper examines models of grief, adolescent development, and suicide loss, aiming to bridge the literature in all these domains. Despite the high prevalence of bereavement in young people, there are limited, tailored resources designed to support …

Neonatal Striatal Volume Is Associated With Infant Anhedonia, Melissa Nevarez-Brewster, Catherine H. Demers, Jessica L. Irwin, Laura M. Glynn, Martin A. Styner, Mercedes Hoeflich Haase, M. Camille Hoffman, Diego A. Pizzagalli, Benjamin L. Hankin, Elysia Poggi Davis

Psychology: Faculty Scholarship

Anhedonia is increasingly recognized as a transdiagnostic risk factor for psychopathology. New evidence demonstrates that anhedonia is present in infancy and early childhood. Structural variability in striatal regions involved in reward processing and pleasure seeking is concurrently linked to anhedonia, yet few studies have examined whether striatal differences presage anhedonia, and none have examined prospective associations before middle childhood. The present study examined whether neuroanatomical markers that confer risk for anhedonia can be detected as early as the neonatal period. Specifically, we tested whether the volume of striatal regions in neonates predicted the emergence of infant anhedonic behaviors at six …

The Experiences Of School Psychologists Serving Students With Traumatic Brain Injuries: A Phenomenology, E. Grace Ritchie

Electronic Theses and Dissertations

Traumatic Brain Injury (TBI) is a complex experience associated with a diverse constellation of symptoms and challenges. TBI scholars have extensively explored the varying needs of youth in the aftermath of a head injury. Likewise, recent literature details recommendations for school psychological services in support of these students. Such recommendations largely reflect insights drawn from broader TBI and disability research, integrated with the established scope of school psychologists’ practice (e.g., the National Association of School Psychologists Practice Model). Nevertheless, school psychologists’ perceptions of these students’ challenges have been inadequately examined. Such perspectives are likely valuable, given school psychologists’ unique training …

Emotional Eating Behaviors And Parental Feeding Practices In Three-Year-Old Children And Their Association With Body Composition One Year Later, Keely Wright, Kenia Rivera, Elysia Poggi Davis

Undergraduate Theses, Capstones, and Recitals

Emotional eating – eating in response to negative emotions regardless of hunger – is an obesogenic trait that often develops in childhood and remains a habit through adulthood. Greater emotional eating is associated with a higher body mass index (BMI; kg/m2) in 7-12-year-old children (Webber et al., 2009). However, few studies have examined the relations between emotional eating and weight gain in preschool-aged children. Moreover, there is limited research on parental feeding practices and weight gain in preschool-aged children. The current work investigated the association of emotional eating behaviors during an emotional eating task in three-year-old children with change in …

The Role Of Adolescent Depression Heterogeneity And Resilience Resources In Adulthood Cardiometabolic Health And Depressive Symptoms, Samantha R. Scott

Electronic Theses and Dissertations

Depression in adolescence is a major public health problem and is a risk factor for early-onset cardiometabolic disease. Although adolescent depression is a risk factor for poor cardiometabolic health, depression is heterogeneous and associations may differ by sex. Additionally, if risk factors such as depression can predict adulthood cardiometabolic health, resilience factors (e.g., social, school, neighborhood) that are protective for depression may also be protective for physical health, but this is an ongoing area of research. The goals of the current dissertation were to gain a better understanding of what depressive symptom presentations in adolescents are most concerning for adulthood …

Minority Stressors And Internalizing Symptoms In Sexual And Gender Minority Adolescents: A Systematic Review And Meta-Analysis, Anni R. Subar

Electronic Theses and Dissertations

Sexual and gender minority (SGM) adolescents are at elevated risk for internalizing symptoms, such as anxiety and depression, due in part to chronic exposure to minority stress. To provide a comprehensive synthesis of this literature, we conducted a meta-analysis of 32 studies, yielding 162 effect sizes from 41,360 participants aged 8– 22. All included studies examined the association between minority stress, defined as stigma-related stressors such as discrimination, victimization, and internalized stigma, and internalizing outcomes in SGM youth. The random-effects meta-analysis revealed a small but significant association (r = .25) between minority stress and internalizing symptoms, consistent across stressor …

Young Adults’ Metaperceptions Of Their Childhood Caregivers’ Appraisals And Young Adulthood Mental Health, Cassandra Svelnys

Electronic Theses and Dissertations

Early experiences and relationships have enduring impacts on the development of self and later mental health and wellbeing. In social relationships and interactions, the developing individual is continuously assessing how they view themself, how they view the other person, and how they believe the other person views them. Metaperceptions represent the latter construct: how an individual thinks another person perceives them. Childhood self-esteem, parent-child attachment, and metaperceptions are foundational constructs for the developing individual, yet metaperceptions have not previously been tested as a predictor for adulthood mental health while also accounting for childhood self-esteem and parent-child attachment. This study introduced …

A Relational Developmental Theory Of Human-Animal Interaction: A Meta-Synthesis And Grounded Theory, Erin Flynn, Miriam G. Valdovinos, Megan K. Mueller, Kevin N. Morris

Graduate School of Social Work: Faculty Scholarship

Limited research has explored youths’ relationships with animals as a possible ecological asset. We conducted a qualitative meta-synthesis of studies published before 2022 that examined how youth-animal interactions are described as shaping youth social-emotional health in education and therapeutic settings. We compared and combined the patterns of findings to determine which mechanisms within youth-animal coaction might be theorized to shape social, emotional, and behavioral development for youth in education and therapy contexts. We used a grounded theory approach to further analyze the primary data and compare it with extant relational developmental systems literature to suggest a new theoretical model for …

A Phenomenological Examination Of The Perception Of Psychopathological Misdiagnosis In Gifted Men, Tina Glass

Electronic Theses and Dissertations

While the exact prevalence of psychopathological misdiagnosis in gifted children is unknown, it is an occurrence within the gifted population (Amend & Beljan, 2009; Batstra et al., 2012; Bishop & Rinn, 2019; Bishop & Rinn, 2020; Coon, 2014; Webb et al., 2016). However, there is a gap in the literature related to psychopathological misdiagnosis specific to gifted males. (Desmet & Pereira, 2021; Ecklund et al., 2014; Eren et al., 2018; Neu & Weinfeld, 2007; OECD, 2015; Preckel et al., 2015; Watts, 2022). This transcendental phenomenological study leveraged Bronfenbrenner’s Bioecological Model for Human Development (Bronfenbrenner & Morris, 2006) as a theoretical …

Cannabis Exposure During Pregnancy And Neural Mechanisms Of Parenting: Assessing Neural Responses To Infant Cues And Parenting Outcomes, Shannon Powers

Electronic Theses and Dissertations

As legalization of cannabis and cannabinoids spreads in the United States, access and use of cannabis during the prenatal period has increased. There is limited knowledge on the effects of prenatal cannabis use on the parental brain. One way to identify potential effects of cannabis on parenting is through studying parenting brain functions and behavior. Cannabis use disorder (CUD) has been shown to be associated with lower positive parenting and lower sensitivity to infants, but it is unclear by what mechanisms. The following two studies address this gap in knowledge by examining the association between cannabis use during the prenatal …

Playing With Weplay!: Adapting A Caregiver-Child Group For Caregivers Of Young Children With Early Signs Of Autism Spectrum Disorder, Louisa A. Cahn-Gambino

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

WePlay! Denver, a collaboration between the University of Denver’s Graduate School of Professional Psychology and the Children’s Museum of Denver, Marsico Campus, began providing caregiver-infant playgroups to the community in 2019. WePlay! and Nosotros Jugamos, the English and Spanish-speaking groups, teach caregivers with young children about play-based exploration, provide psychoeducation, and offer resources. Qualitative data from WePlay! Denver’s initial groups and input from the WePlay! Denver team emphasized interest in expanding WePlay! to include families with children of varying developmental stages and who have specific developmental needs and considerations (Gross et al., 2021), such as autism spectrum disorder (ASD). ASD …

Preconception Maternal Posttraumatic Stress And Child Negative Affectivity: Prospectively Evaluating The Intergenerational Impact Of Trauma, Danielle A. Swales, Elysia Poggi Davis, Nicole E. Mahrer, Christine M. Guardino, Madeleine Shalowitz, Sharon L. Ramey, Christine Dunkel Schetter

Psychology: Faculty Scholarship

The developmental origins of psychopathology begin before birth and perhaps even prior to conception. Understanding the intergenerational transmission of psychopathological risk is critical to identify sensitive windows for prevention and early intervention. Prior research demonstrates that maternal trauma history, typically assessed retrospectively, has adverse consequences for child socioemotional development. However, very few prospective studies of preconception trauma exist, and the role of preconception symptoms of posttraumatic stress disorder (PTSD) remains unknown. The current study prospectively evaluates whether maternal preconception PTSD symptoms predict early childhood negative affectivity, a key dimension of temperament and predictor of later psychopathology. One hundred and eighteen …

"What Works For Whom" In Family Support Programs: Leveraging Administrative Data To Improve Precision Matching, Elly M. Miles

Electronic Theses and Dissertations

Family support programs (FSPs) are designed to stabilize and strengthen families on a range of outcomes to promote well-being. Paradoxically, families with the greatest need are more likely to drop out or experience reduced benefit on average. This study examines patterns of differential benefit for families experiencing elevated stress through a cross-program evaluation of “what works for whom” in FSPs.

Family Resource Center Family Development Services (FDSs), Colorado Community Response (CCR), Promoting Safe and Stable Families (PSSF), Head Start (HS), and SafeCare Case Management Pilot (Safe CMP) contributed data on 15,771 participants enrolled in services from 2014-2020. Program samples were …

Mis-Specification Of Functional Forms In Growth Mixture Modeling: A Monte Carlo Simulation, Richa Ghevarghese

Electronic Theses and Dissertations

Growth mixture modeling (GMM) is a methodological tool used to represent heterogeneity in longitudinal datasets through the identification of unobserved subgroups following qualitatively and quantitatively distinct trajectories in a population. These growth trajectories or functional forms are informed by the underlying developmental theory, are distinct to each subgroup, and form the core assumptions of the model. Therefore, the accuracy of the assumed functional forms of growth strongly influences substantive research and theories of growth. While there is evidence of mis-specified functional forms of growth in GMM literature, the weight of this violation has been largely overlooked. Current solutions to circumvent …

Exposure To Prenatal Maternal Distress And Infant White Matter Neurodevelopment, Catherine H. Demers, Maria M. Bagonis, Khalid Al-Ali, Sarah E. Garcia, Martin A. Styner, John H. Gilmore, M. Camille Hoffman, Benjamin L. Hankin, Elysia Poggi Davis

Psychology: Faculty Scholarship

The prenatal period represents a critical time for brain growth and development. These rapid neurological advances render the fetus susceptible to various influences with life-long implications for mental health. Maternal distress signals are a dominant early life influence, contributing to birth outcomes and risk for offspring psychopathology. This prospective longitudinal study evaluated the association between prenatal maternal distress and infant white matter microstructure. Participants included a racially and socioeconomically diverse sample of 85 mother–infant dyads. Prenatal distress was assessed at 17 and 29 weeks’ gestational age (GA). Infant structural data were collected via diffusion tensor imaging (DTI) at 42–45 weeks’ …

Maternal Hpa Axis Function During Parenting Is Associated With Reduced Brain Activation To Infant Cry And More Intrusive Parenting Behavior, Andrew Erhart

Electronic Theses and Dissertations

Previous research indicated that maternal cortisol function and maternal brain response to infant stimuli are separately related to differences in parenting behavior. Evidence from animal models have demonstrated that chronically high cortisol concentration alters brain structure and function, suggesting that studying these two mechanisms together may further improve understanding of parental behavior in human mothers. First time mothers of infants aged 1-7 months old (M age = 3 months) were recruited to participate. Mother’s cortisol concentration was measured during a naturalistic interaction with their infant and their behavior was coded for maternal sensitivity and nonintrusiveness. In a separate session using …

Sensitive Periods For Psychosocial Risk In Childhood And Adolescence And Cardiometabolic Outcomes In Young Adulthood, Jenalee R. Doom, Kenia M. Rivera, Estela Blanco, Raquel Burrows, Paulina Correa-Burrows, Patricia L. East, Betsy Lozoff, Sheila Gahagan

Psychology: Faculty Scholarship

Greater psychosocial risk in childhood and adolescence predicts poorer cardiometabolic outcomes in adulthood. We assessed whether the timing of psychosocial risk from infancy through adolescence predicts cardiometabolic outcomes in young adulthood. Young adults and their mothers participated in a longitudinal study beginning in infancy in Santiago, Chile (N = 1040). At infancy, 5 years, 10 years, and adolescence, mothers reported on depressive symptoms, stressful experiences, support for child development in the home, father absence, parental education, and socioeconomic status (SES) to create a psychosocial risk composite at each time point. Young adults (52.1% female; 21–27 years) provided fasting serum samples …

The Effects Of Adverse Childhood Experiences On Behavioral Outcomes, Jennifer Thomas

Electronic Theses and Dissertations

This study intends to explore the intersection of two vulnerable populations, early childhood development and risks associated with exposure to adverse childhood experiences (ACEs). This study examines how age plays a role in the long-term relationship between ACEs and internal and external behaviors. This study seeks to answer the question of: How does age influence the relationship between number of ACEs and internal and external behaviors? The participants in this study include those aged 0 – 16 from the National Survey of Child and adolescent Well-Being (NSCAW) dataset. The NSCAW study consists of five waves of data where Wave I …

Socioeconomic Disadvantage And Brain Structure In Adulthood, Alexander J. Dufford

Electronic Theses and Dissertations

Socioeconomic disadvantage in childhood has been associated with difficulties in physical and mental health later in life. A potential pathway underlying this association is through variations in brain development. While associations between concurrent socioeconomic disadvantage and brain structural development have been established, it is unclear if there are prospective associations between childhood disadvantage and brain structure later in life (adulthood). The following studies address these gaps in the knowledge by examining the prospective association between childhood socioeconomic status and brain structure in adulthood. Study One examines the association between average family income across childhood and brain structural morphometry in adulthood. …

Across Continents And Demographics, Unpredictable Maternal Signals Are Associated With Children's Cognitive Function, Elysia Poggi Davis, Riikka Korja, Linnea Karlsson, Laura M. Glynn, Curt A. Sandman, Brian Vegetabile, Eeva-Leena Kataja, Saara Nolvi, Eija Sinervä, Juho Pelto, Hasse Karlsson, Hal S. Stern, Tallie Z. Baram

Psychology: Faculty Scholarship

Background

Early life experiences have persisting influence on brain function throughout life. Maternal signals constitute a primary source of early life experiences, and their quantity and quality during sensitive developmental periods exert enduring effects on cognitive function and emotional and social behaviors. Here we examined if, in addition to established qualitative dimensions of maternal behavior during her interactions with her infant and child, patterns of maternal signals may contribute to the maturation of children's executive functions. We focused primarily on effortful control, a potent predictor of mental health outcomes later in life.

Methods

In two independent prospective cohorts in Turku, …

Genome-Wide Association Scan Identifies New Variants Associated With A Cognitive Predictor Of Dyslexia, Alessandro Gialluisi, Till F. M. Andlauer, Nazanin Mirza-Schreiber, Kristina Moll, Jessica Becker, Per Hoffmann, Kerstin U. Ludwig, Darina Czamara, Beate St Pourcain, William Brandler, Ferenc Honbolygó, Dénes Tóth, Valéria Csépe, Guillaume Huguet, Andrew P. Morris, Jacqueline Hulslander, Erik G. Willcutt, John C. Defries, Richard K. Olson, Shelley D. Smith, Bruce F. Pennington, Anniek Vaessen, Urs Maurer, Heikki Lyytinen, Myriam Peyrard-Janvid, Paavo H. T. Leppänen, Daniel Brandeis, Milene Bonte, John F. Stein, Joel B. Talcott, Fabien Fauchereau, Arndt Wilcke, Clyde Francks, Thomas Bourgeron, Anthony P. Monaco, Franck Ramus, Karin Landerl, Juha Kere, Thomas S. Scerri, Silvia Paracchini, Simon E. Fisher, Johannes Schumacher, Markus M. Nöthen, Bertram Müller-Myhsok, Gerd Schulte-Körne

Psychology: Faculty Scholarship

Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562–3468). We observed a genome-wide significant effect (p <  1 × 10−8) on rapid automatized naming of letters (RANlet) for variants on 18q12.2, within MIR924HG (micro-RNA …

Brief Report: Attentional Cueing To Images Of Social Interactions Is Automatic For Neurotypical Individuals But Not Those With Asc, Marcus Neil Morrisey, Catherine L. Reed, Daniel N. Mcintosh, M. D. Rutherford

Psychology: Faculty Scholarship

Human actions induce attentional orienting toward the target of the action. We examined the influence of action cueing in social (man throwing toward a human) and non-social (man throwing toward a tree) contexts in observers with and without autism spectrum condition (ASC). Results suggested that a social interaction enhanced the cueing effect for neurotypical participants. Participants with ASC did not benefit from non-predictive cues and were slower in social contexts, although they benefitted from reliably predictive cues. Social orienting appears to be automatic in the context of an implied social interaction for neurotypical observers, but not those with ASC. Neurotypical …

How Socioeconomic Disadvantages Get Under The Skin And Into The Brain To Influence Health Development Across The Lifespan, Pilyoung Kim, Gary W. Evans, Edith Chen, Gregory Miller, Teresa Seeman

Psychology: Faculty Scholarship

Socioeconomic disadvantage (SED) has adverse impacts on physical (Adler and Rehkopf 2008; Blair and Raver 2012; Braverman and Egerter 2008; Cohen et al. 2010; Poulton et al. 2002) and psychological (Adler and Rehkopf 2008; Bradley and Corwyn 2002; Grant et al. 2003) health development. SED is similar to low socioeconomic status (SES) which is based on occupation, income, and education or a composite of more than one of these indicators (McLoyd 1998). However, we conceptualize SED more broadly than socioeconomic status to also include subjective perception of social position and contextual indicators of disadvantage, such as neighborhood deprivation. One of …

Family Income, Cumulative Risk Exposure, And White Matter Structure In Middle Childhood, Alexander J. Dufford, Pilyoung Kim

Psychology: Faculty Scholarship

Family income is associated with gray matter morphometry in children, but little is known about the relationship between family income and white matter structure. In this paper, using Tract-Based Spatial Statistics, a whole brain, voxel-wise approach, we examined the relationship between family income (assessed by income-to-needs ratio) and white matter organization in middle childhood (N = 27, M = 8.66 years). Results from a non-parametric, voxel-wise, multiple regression (threshold-free cluster enhancement, p < 0.05 FWE corrected) indicated that lower family income was associated with lower white matter organization [assessed by fractional anisotropy (FA)] for several clusters in white matter tracts involved in cognitive and emotional functions including fronto-limbic circuitry (uncinate fasciculus and cingulum bundle), association fibers (inferior longitudinal fasciculus, superior longitudinal fasciculus), and corticospinal tracts. Further, we examined the possibility that cumulative risk (CR) exposure might function as one of the potential pathways by which family income influences neural outcomes. Using multiple regressions, we found lower FA in portions of these tracts, including those found in the left cingulum bundle and left superior longitudinal fasciculus, was significantly related to greater exposure to CR (β = -0.47, p < 0.05 and β = -0.45, p < 0.05).

General And Emotion-Specific Alterations To Cognitive Control In Women With A History Of Childhood Abuse, Kristen L. Mackiewicz Seghete, Roselinde H. Kaiser, Anne P. Deprince, Marie T. Banich

Psychology: Faculty Scholarship

Background

Although limited, the literature suggests alterations in activation of cognitive control regions in adults and adolescents with a history of childhood abuse. The current study examined whether such alterations are increased in the face of emotionally-distracting as compared to emotionally neutral information, and whether such alterations occur in brain regions that exert cognitive control in a more top-down sustained manner or a more bottom-up transient manner.

Methods

Participants were young adult women (ages 23–30): one group with a history of childhood physical or sexual abuse (N = 15) and one with no trauma exposure (N = 17), as assessed …

Abnormal Dendritic Maturation Of Developing Cortical Neurons Exposed To Corticotropin Releasing Hormone (Crh): Insights Into Effects Of Prenatal Adversity?, Megan M. Curran, Curt A. Sandman, Elysia Poggi Davis, Laura M. Glynn, Tallie Z. Baram

Psychology: Faculty Scholarship

Corticotropin releasing hormone (CRH) produced by the hypothalamus initiates the hypothalamic-pituitary-adrenal (HPA) axis, which regulates the body’s stress response. CRH levels typically are undetectable in human plasma, but during pregnancy the primate placenta synthesizes and releases large amounts of CRH into both maternal and fetal circulations. Notably, placental CRH synthesis increases in response to maternal stress signals. There is evidence that human fetal exposure to high concentrations of placental CRH is associated with behavioral consequences during infancy and into childhood, however the direct effects on of the peptide on the human brain are unknown. In this study, we used a …