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Behavioral Effects Of Tyrosine During Sustained Wakefulness, D. L. Wiegmann, D. F. Neri, R. R. Stanny, S. A. Shappell, A. H. Mccardie, D. L. Mckay

Publications

The fatigue and cognitive performance deficits associated with sleep loss and stress, like that experienced during sustained flight operations and nighttime flying, have motivated the search for effective nonpharmacological countermeasures. The behavioral effects of the potential countermeasure tyrosine, an amino-acid precursor to dopamine and norepinephrine, were examined during an episode of continuous nighttime work involving one night's sleep loss. Volunteers performed nine iterations of a battery of cognitive and subjective tasks for approximately 13 h, beginning at 1930 and ending at 0820 the following morning. Subjects remained awake throughout the day on which the experiment began and were awake for …