Biological Psychology Commons^™

A Mouse Model Of Toluene Abstinence-Induced Pathology, Sean Callan

Wayne State University Dissertations

The intentional misuse of volatile solvents is a persistent public health concern. Limited self-report data suggests that chronic inhalant abusers experience withdrawal symptoms including anxiety and seizure symptoms. However, these symptoms have never been explored in a preclinical model and are not considered part of the DSM-V criteria for an Inhalant Use Disorder. For this experiment, 76 young adult male Swiss Webster mice were exposed to either 5,000 ppm toluene vapor or air (0 ppm) for 24 consecutive hours beginning on postnatal day (PND) 30. Following the 24 hour exposure, mice were allowed to recover for 3 hours before behavioral …