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Nicotine And Methylphenidate Chornic Exposure On Adult Cannabinoid Receptor Agonist (Cp 55,940) Place Conditioning In Male Rats, Christopher P. Plant

Electronic Theses, Projects, and Dissertations

A problematic connection has been reported between those who use nicotine related products alone or in combination with ADHD medications, like methylphenidate (MPH), in late childhood or early adolescence and the increased likelihood of later marijuana abuse in adulthood. Pre-clinical studies have found that the use of nicotine during the early adolescence period produces enduring changes to the endocannabinoid system in the brain. Since CB agonists, like marijuana, exert their effect through the eCB system, it is possible that early nicotine use may alter the rewarding nature of CB agonists in adulthood. In addition, MPH has also been shown to …