Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Biological Psychology
Effects Of Chronic Paroxetine And Fluoxetine Treatment On Markers Of Suicidal Behavior In Adolescent Rats, Leslie Renee Horn
Effects Of Chronic Paroxetine And Fluoxetine Treatment On Markers Of Suicidal Behavior In Adolescent Rats, Leslie Renee Horn
Theses Digitization Project
Major depression is a common problem in adolescents. Unfortunately, one of the most effective antidepressants in adults, the selective serotonin reuptake inhibitor (SSRI) paroxetine, is not clinically effective in pediatric populations. There are many variables that increase the risk of suicide including genetic, social, psychological, and biological factors, making the evaluation of the effect of SSRIs on suicidal behavior difficult to assess in human adolescents. The goal of the present investigation was to compare the effects of paroxetine and fluoxetine in adolescent rats on markers associated with depression and suicidal behavior in humans.
Consequences Of Early Methylphenidate Exposure On Opioid System Functioning In Adult Rats, Matthew Scott Herbert
Consequences Of Early Methylphenidate Exposure On Opioid System Functioning In Adult Rats, Matthew Scott Herbert
Theses Digitization Project
Methylphenidate is the preferred treatment for attention-deficit hyperactivity disorder in preschool-aged children, even though few human studies have assessed the long-term consequences of early methyphenidate use. In rats, exposure to methylphenidate during a developmental period that approximates early childhood increases morphine-induced antinociception in adulthood. However, because morphine activates three distinct opioid receptors it is unknown which receptor is resonsible for this methylphenidate effect. The purpose of the present study was to assess the long-term effects of early methylphenidate exposure on DAMGO- and U50, 488-induced antinociception, a mu-opioid and kappa-opioid selective agonist.