Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Biological Psychology
Biconditional Discrimination Learning In Rats With 192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis, Michael Ryan Kitto
Biconditional Discrimination Learning In Rats With 192 Igg-Saporin Lesions Of The Nucleus Basalis Magnocellularis, Michael Ryan Kitto
Theses Digitization Project
The experiment tested the hypothesis that 192 IgG-saporin lesions of the nucleus basalis magnocellularis (NBM) in rats would impair performance in a biconditional visual discrimination task, which requires configural association learning. Experiment used 22 male Long-Evan rats (Harlan Sprague-Dawley). Behavioral testing was conducted in two identical T-mazes. Rats were randomly assigned to either a bilateral 192 IgG-saporin lesion group (n = 10) or to a control group (n = 12). Results support the hypothesis that NBM is critically involved in configural but not simple association learning and suggest that NBM may be involved more generally in cognitive flexibility.