Biological Psychology Commons^™

Cognitive Differences In Parkinson’S Disease With Amyloid Positivity And Negativity, Kenya Luna

Electronic Theses, Projects, and Dissertations

In Parkinson’s Disease (PD), research has shifted to investigate how biomarkers commonly seen in Alzheimer’s Disease (AD), such as amyloid beta (AB), may be associated with cognitive functioning in PD. AB is considered a reliable biomarker for AD pathology, however in PD there is a lacking biomarker that can accurately reflect severity of cognitive impairment. AD research has shown an association between low AB and cognitive decline, but the data in PD has mixed results. Most studies that analyze cognitive decline and biomarkers do not use a cutoff level and the few that do have a threshold vary greatly in …

Neuroanatomy In Mild Cognitive Impairment: Relationship To Functional Skills, Treatment Expectancy, And Comorbid Depression, Sara Rushia

Dissertations, Theses, and Capstone Projects

Mild cognitive impairment (MCI) is a neurocognitive disorder defined by cognitive decline in older adults. Although MCI has been studied for decades, there remain important areas to be explored in order to adequately characterize aspects of this disorder that provide information valuable for possible interventions and disease progression to dementia, including a better understanding of the neuroanatomical variables relevant to this disorder. Such neuroanatomical variables include cortical thickness, hippocampal volume, and white matter hyperintensities (WMHs). This dissertation consists of three separate studies aimed at addressing gaps in the literature on MCI in relation to brain morphometrics and under-studied characteristics involved …

The Biological, Psychological, Cognitive, And Social Perspectives On Aging: The Design Of A Healthy Aging Program For Older Adults, Melissa Santiago

Dissertations

Aging is an inevitable process, accompanied by changes in physiological, cognitive, psychological, and social facets. Researchers have investigated the physiological, cognitive, psychological, and social risk factors associated with aging and have encouraged the use of physical activity, cognitive training, and dietary interventions to alleviate risk factors. However, holistic programs dedicated to promoting successful aging among older adults are uncommon. This review sought to promote successful aging by identifying physiological, cognitive, psychological, and social risk factors that affect older adults and develop a comprehensive program to holistically mitigate these risk factors. Risk factors associated with unsuccessful aging include the development of …

The Impact Of Traumatic Brain Injury On Neuropsychological Functioning And Tau Accumulation Later In Life In Military Veterans, Lindsay Eatman

Dissertations

Abstract The following study examines aging veterans that experience a TBI while in service and

compares to older veteran without a history of TBI. The objective is to look at cognitive profile later in life for military veterans with moderate to severe TBI different and compared to older veterans with no history of TBI. Is there a difference in tau accumulations on neuroimaging in military veterans with moderate to severe TBI compared to older veterans without a history of TBI? What is the relationship between the cognitive profile and tau imaging correlates for military veterans with moderate to severe TBI …

Exercise Engagement And Longitudinal Change In Alzheimer's Disease Biomarkers, Regional Brain Structure, And Cognitive Functioning, Marta Stojanovic

Arts & Sciences Electronic Theses and Dissertations

No abstract provided.

Effects Of 17Β-Estradiol On Learning And Memory And Strategy Use During A Hole Board Spatial Navigation Task In Aged Male Rats, Megan Berthiaume

Seton Hall University Dissertations and Theses (ETDs)

Treatment with 17β- estradiol has been shown to ameliorate age related deficits in spatial learning and memory as well as to promote the use of an allocentric strategy during spatial navigation. While the majority of research using 17β- estradiol has been done using females rodents, there have been studies showing an improvement in spatial learning and memory and promoted use of allocentric strategies in spatial navigation in males as well. In males testosterone (T) is metabolized into estradiol by aromatase. As circulating levels of T decline with aging there is less available T to be metabolized into estradiol. The current …

Changes In Cerebral White Matter, Vascular Risk And Cognition Across The Adult Lifespan, Andrew Robert Bender

Wayne State University Dissertations

Numerous studies over the past decade have used diffusion tensor imaging (DTI) to examine associations between age, diffusion and anisotropy measures of cerebral white matter (WM), and cognitive performance. However, few have examined relationships between intra-individual change in DTI measures of WM and cognitive function. It is possible that the extant cross-sectional findings are a poor representation of age-related change in WM and cognition. The present study used latent difference-score modeling (LDM) to assess change over two years in DTI indices fractional anisotropy (FA), radial diffusivity (DR), axial diffusivity (DA) and mean diffusivity (MD). In addition, we examined the effects …